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v. 5 ISBN 9780470711996
内容説明
Highlights the progress made in finding new and exciting metalloproteins 10 years after the original publication of the Handbook of Metalloproteins Volumes 1 & 2, and following publication of Volume 3 in 2004, comes the latest two volumes...
Presents detailed descriptions of the most exciting newly discovered metalloproteins, including:
New metalloproteins involved in photosynthesis, e.g. photosystem I and II, cytochromes
New Copper Metalloproteins involved in the formation of Alzheimer's disease and are leads to new medication
New metalloproteins essential in understanding the function of nerves and muscles
Researching the structure and function of metalloproteins is one of the biggest challenges in modern biological chemistry - and several Nobel Prizes have been awarded to research in the field, including to the Co-Editor Robert Huber in 1988.
Volumes 4 & 5 help bring together the very latest new and exciting metalloproteins in two volumes to help keep you up-to-date in this continually expanding field, including:
New metalloproteins involved in photosynthesis
Photosynthesis is vital for life on earth. Contributions on photosystem I and II as well as on cytochrome b6f, which are main components of the oxygenic photosynthetic machinery in plants, algae and cyanobacteria, unravel the role of metals and metal cofactors in this fascinating fundamental process
New Copper Metalloproteins
The role of copper in connection with the amyloid precursor protein for Alzheimer's disease
New metalloproteins essential in understanding the function of nerves and muscles
Contributions on Mg2+, Na+ and K+ channels/transporters have been included to highlight their formidable significance in biological systems. Na+, K+-ATPase is e.g. very abundant in heart muscle tissues and represents the target for drugs against heart insufficiency like digitalis drugs
Metalloproteins used in metal ion transport and storage
Metal ion transport, storage and incorporation have been deeper considered in a row of new articles. The metal ions include iron, zinc, nickel and copper.
Factor VIII
Factor VIII is an essential blood clotting factor. Some defects might cause a lack of this factor and result in hemophelia A.
The new two volumes contain articles published online in the Handbook of Metalloproteins (HMET) from 2007 - 2010, these cover a wide range of newly discovered and exciting metalloproteins since publication of HMET in 2006.
These new additional volumes will provide essential reading to all experienced researchers in bioinorganic chemistry and should give the newcomer a good entry into the field in the following areas: Metalloproteins, Proteins, Proteomics, Coordination Chemistry, Bioinorganic Chemistry, Biochemistry, Drug Development, Enzymology.
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v. 3 ISBN 9780470849842
内容説明
Volume 1 & 2 of the "Handbook of Metalloproteins", focuses on a number of metals, including iron, nickel, manganese, cobalt, copper and vanadium. Now volume 3 extends the wealth of knowledge to focus on proteins found in the redox-inactive ions of zinc and calcium. While there are more than two hundred known 3D structures of zinc enzymes, the handbook focuses on contributions for those enzymes most relevant in research today. Also covered extensively, is the role of calcium ions as secondary messengers in controlling the many biological processes. Each metalloprotein included is supported by extensive detail, including;* Colour graphical representations of the 3D structure* Functional class* Occurrence* Spectroscopic data Reviews from Volumes 1 & 2 "it is a pleasure just to read this handsome and carefully produced work" (Angewandte Chemie, Vol.41, 2002) "...it is a pleasure to use ...this excellent, authoritative, and valuable text...I regard this work as essential for library purchase..." (Natural Products Report, Vol.19, No.4, 2002) "...highly recommended as a resource for bioinorganic chemistry. It will have lasting value for researchers in the field..."
(The Alchemist - Chemweb, 2002)
目次
ZINC. Oxidoreductases. Transferases. Hydrolases: Acting on ester bonds. Hydrolases: Acting on peptide bonds. Hydrolases: Acting on carbon-nitrogen bonds, other than peptide bonds. Lyases. Zinc-fingers. Zinc storage. Other zinc proteins. General aspects. CALCIUM. EF-hand Ca2+-binding proteins. EGF-domains. GLA-domains. C2-like-domains. Dockerin-domains. Hemopexin domains. Annexins. Other Ca-proteins. List of contributors. PDB code list. Index.
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v. 2 ISBN 9780471627432
内容説明
This two-volume handbook covers 105 major metalloproteins. Content is presented in both a large format and full colour and covers the most relevant transition metals such as iron, nickel, copper, cobalt, molybdenum, manganese tungsten and vanadium. It includes a computer-modelled structure for each compound, with information on the sequence information, synthesis and spectroscopic properties, functional aspects as well as key chemical, biological, physical and medical properties of the compound described. It draws together contributions from over 200 internationally renowned researchers that include names such as Douglas Rees and Charles Stout as well as Nobel Prize winner Robert Huber.
目次
- Volume 1
- IRON
- Heme Proteins: Oxygen Storage and Oxygen Transport Proteins
- Heme Proteins: Cytochromes
- Heme Proteins: Cytochrome Peroxidases
- Heme Proteins: Cytochrome P-450
- Heme Proteins: Oxidoreductases
- Non-Heme Proteins: Iron-Sulfur Clusters
- Non-Heme Proteins: Mononuclear Iron Proteins
- Volume 2
- IRON continued
- Non-Heme Proteins: Dinuclear Iron Proteins
- Non-Heme Proteins: Iron Storage
- Non-Heme Proteins: Iron Transport
- NICKEL
- MANGANESE
- COBALT
- MOLYBDENUM/TUNGSTEN
- COPPER
- Cupredoxins (Type-1 Copper Proteins)
- Type-2 Copper Enzymes
- Binuclear Copper: Type-3 Copper Enzymes
- Binuclear Copper: CuA Copper
- Multicopper Enzymes
- Copper Storage and Transport
- VANADIUM.
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