Protein structure and function
著者
書誌事項
Protein structure and function
（Primers in biology）
New Science Press , Blackwell , Sinauer Associates, c2004
- : (paperback) New Science Press
- : (paperback) Blackwell Publishing
- : (paperback) Sinauer Associates
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注記
Editors: Eleanor Lawrence and Miranda Robertson
Managing editor: Karen Freeland
Editorial Assistants: Amy Austin, Vivien Chen, Alexandra King
Production manager: Liam Lynch
Design and illustration: Matthew McClements, Blink Studio, London
Structure graphics: Ezra Peisach
Indexer: Liza Furnival
Manufacturing: Adrienne Hanratty
Bibliography: p. 181-188
Includes index
内容説明・目次
内容説明
Protein Structure and Function considers the key concepts of protein structure and function and the relationship between sequence, structure and function with clear, concise explanations and full colour illustrations.
Written by two outstanding names in the field, Gregory Petsko and Dagmar Ringe.
Considers the principles of protein structure and folding, functional properties of proteins and regulation of protein function, and introduces the basic principles whereby structure and function are deduced from sequence.
Fully up-to-date with emphasis on what sequence can tell you about structure and function.
Ideal for undergraduates and graduates studying the fundamental principles of protein structure and function in departments of biochemistry and molecular biology, and working scientists needing an up-to-date introduction to the field.
All 240 illustrations from Protein Structure and Function are available on the web as jpgs and downloadable tifs for teaching, at http://www.new-science-press.com/browse/protein/resources/
SPECIAL OFFER:
For instructors adopting the book for courses with enrolments of ten or more students we offer free access to the following online resources:
the full text online for a year, for personal use only
updates - revised, expanded, or new sections and updated references available online only
PowerPoint functionality allowing instructors to compile any selection of illustrations into a slide show
interactive true-false and multiple-choice self-test questions with answers
目次
1. From Sequence to Structure:. Overview: Protein Function and Architecture.
Amino Acids.
Genes and Proteins.
The Peptide Bond.
Bonds that Stablize Folded Proteins.
Importance and Determinants of Secondary Structure.
Properties of the Alpha Helix.
Properties of the Beta Sheet.
Prediction of Secondary Structure.
Folding.
Tertiary Structure.
Membrane Protein Structure.
Protein Stability 1: Weak Interactions and Flexibility.
Protein Stability 2: Post-Translational Modifications.
The Protein Domain.
The Universe of Protein Structures.
Protein Motifs.
Alpha Domains and Beta Domains.
Alpha/Beta, Alpha+Beta and Cross-Linked Domains.
Quaternary Structure: General Principles.
Quaternary Structure: Intermolecular Interfaces.
Quaternary Structure: Geometry.
Protein Flexibility.
2. From Structure to Function:.
Overview: The Structural Basis of Protein Function.
Recognition, Complementarity and Active Sites.
Flexibility and Protein Function.
Location of Binding Sites.
Nature of Binding Sites.
Functional Properties of Structural Proteins.
Catalysis: Overview.
Active-site Geometry.
Proximity and Ground-State Destabilization.
Stabilization of Transition States and Exclusion of Water.
Redox Reaction.
Addition/Elimination, Hydrolysis and Decarboxylation.
Active-Site Chemistry.
Cofactors.
Multi-Step Reactions.
Multifunctional Enzymes.
Multifunctional Enzymes with Tunnels.
3. Control of Protein Function:.
Overview: Mechanisms of Regulation.
Protein Interaction Domains.
Regulation by Location.
Control by pH and Redox Environment.
Effector Ligands: Competitive Binding and Cooperativity.
Effector Ligands: Conformational Change and Allostery.
Protein Switches Based on Nucleotide Hydrolysis.
GTPase Switches: Small Signaling G proteins.
GTPase Switches: Signal Relay by Heterotrimeric GTPases.
Gtpase Switches: Protein Synthesis.
Motor Protein Switches.
Regulation by Degradation.
Control of Protein Function by Phosphorylation.
Regulation of Signaling Protein Kinases: Activation Mechnism.
Regulation of Signaling Protein Kinases: Cdk Activation.
Two-Component Signaling Systems in Bacteria.
Control by Proteolysis: Activation of Precursors.
Protein Splicing: Autoproteolysis by Inteins.
Glycosylation.
Protein Targeting by Lipid Modification.
Methylation, N-acetylation, Sumoylation and Nitrosylation.
4. From Sequence to Function:.
Overview: From Sequence to Function in the Age of Genomics.
Sequence Alignment and Comparison.
Protein Profiling.
Deriving Function from Sequence.
Experimental Tools for Probing Protein Function.
Divergent and Convergent Evolution.
Structure from Sequence: Homology Modeling.
Structure from Sequence: Profile-Based Threading and "Rosetta".
Deducing Function from Structure: Protein Superfamilies.
Strategies for Identifying Binding Sites.
Strategies for Identifying Catalytic Residues.
TIM Barrels: One Structure with Diverse Functions.
PLP Enzymes: Diverse Structures with One Function.
Moonlighting: Proteins with More Than One Function.
Chameleon Sequences: One Sequence with More than One Fold.
Prions, Amyloids and Serpins: Metastable Protein Folds.
Functions for Uncharacterized Genes: Galactonate Dehydratase.
Starting from Scratch: A Gene Product of Unknown Function.
5. Structure Determination:.
The Interpretation of Structural Information.
Structure Determination by X-Ray Crystallography and NWR.
Quality and Representation of Crystal and NMR Structures
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