Antibiotics : actions, origins, resistance
著者
書誌事項
Antibiotics : actions, origins, resistance
ASM Press, c2003
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注記
Includes bibliographical references (p. 297-328) and index
収録内容
- Antibiotics : initial concepts
- Introduction to major antibiotic classes and modes of action
- Antibiotics that act on cell wall biosynthesis
- Antibiotics that block bacterial protein biosynthesis
- Antibiotics that block DNA replication and repair : the Quinolones
- Other targets of antibacterial drugs
- Natural and producer immunity versus acquired resistance
- Enzymatic destruction or modification of the antibiotic by resistant bacteria
- Antibiotic resistance by efflux pumps
- Antibiotic resistance by replacement or modification of the antibiotic target
- Regulation of antibiotic biosynthesis in producer organisms
- Polyketide antibiotic biosynthesis : assembly line enzymology
- Enzymatic assembly lines for nonribosomal peptide antibiotics
- Biosynthesis of other classes of antibiotics
- New looks at targets
- New molecules
- Contexts and challenges for the use of new antibiotics
内容説明・目次
内容説明
This is the first comprehensive book on antibiotics since the 1981 classic by Gale et al. It focuses on the increased interest in antibiotics due to emerging bacterial diseases and resistance. It shows how antibiotics work on targets; gives new insights into antibiotic modification and design; and reviews strategies for finding novel antibiotics.
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