Cardiac drug development guide

著者

書誌事項

Cardiac drug development guide

edited by Michael K. Pugsley

（Methods in pharmacology and toxicology / Mannfred A. Hollinger, series editor）

Humana Press, c2003

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注記

Includes bibliographical references and index

HTTP:URL=http://www.loc.gov/catdir/toc/fy041/2003012876.html Information=Table of contents

内容説明・目次

内容説明

Cardiac Drug Development Guide outlines, in detail, the therapeutics of cardiac medicine currently at the cutting edge of scientific research and development around the world. This volume integrates basic and clinical cardiac pharmacology by c- bining, for the first time, both classical and molecular aspects of therapeutic drug development. The chapters comprise a broad spectrum of therapeutic areas and hence involve a comprehensive discussion of molecular, biochemical, and electrophy- ological concepts based on years of in vitro as well as in vivo pharmacological st- ies. In addition, the latter part of the book includes comprehensive clinical cardiac chapters that describe important topics in molecular medicine. These chapters also discuss current clinical therapeutic trends in medicine and provide an evaluation of the efficacy of novel drugs in these areas. Cardiac Drug Development Guide has many distinctive and outstanding features that set it apart from other cardiac pharmacology books. This book introduces topics in an easily understandable format for researchers in many varying disciplines by integrating and thereby simplifying concepts not usually discussed across a broad range of cardiac disciplines and in a highly technical field. Each chapter not only introduces and describes the physiology, pharmacology, and pathophysiology of the disease, but also overviews the clinical implications of drug development, what stages these areas are currently in, and also reviews some of the methodologies involved in drug discovery and development. As a result, this book provides a comprehensive overview of the most advanced procedures in cardiac pharmacology today.

目次

I. Introduction Cardiac Drug Development: From Animal Models to Clinical Trials Michael K. Pugsley II . Novel Molecular Targets for Cardiac Drug Development The Role of Cardiac Pacemaker Currents in Antiarrhythmic Drug Discovery David A. Saint Oxygen Free Radicals in Heart Disease: Novel Therapies Elizabeth Roth and Laszlo Hejjel Mitogen-Activated Protein Kinases-Mediated Signaling in Cardiac Pathology: A Perspective of Novel Therapeutic Targets? Tanya Ravingerova, Miroslav Barancik, and Monika Strniskova Development of Anti-Inflammatory Drugs for Cardiovascular Disease Melanie B. Smith and David J. Lefer Development and Use of Platelet Glycoprotein Antagonists in Heart Disease Joel S. Bennett The Sodium-Hydrogen Exchange System in the Heart: A Target for the Protection of the Ischemic and Reperfused Heart and Inhibition of Heart Failure Morris Karmazyn Nitric Oxide and Cardiac Ischemia Mariarosaria Bucci, Inmaculada Posadas Mayo, and Giuseppe Cirino III. Functional Endpoints Evaluating Cardiac Drug Activity Ionic Mechanisms of Atrial Fibrillation J. Christian Hesketh and David Fedida Targeting Ischemic Ventricular Arrhythmias Michael J. A. Walker and Leon J. Guppy Biochemical Mediators of Ventricular Arrhythmias in Ischemic Heart Disease Hugh Clements-Jewery and Michael J. Curtis Heterologous Expression Systems and Screening Technologies in Ion Channel Drug Discovery Maurizio Taglialatela Molecular Diversity of Ion Channels in the Mouse Heart: A Suitable Model for Cardiac Drug Development? Jeanne M. Nerbonne Delayed Protection of the Myocardium: A Novel Therapeutic Window for Cardiac Drug Development Laszlo Szekeres and James Parratt IV. Clinical Aspects in Cardiac Drug Development Cardiac TroponinTesting for Detection of Myocardial Infarction: Clinical Utility and Analytical Issues Fred S. Apple A Genetic Basis for Cardiac Arrhythmias: Current Status and the Future Jeffrey A. Towbin, Matteo Vatta, Hua Li, and Neil E. Bowles Myocardial Adenoviral Vector Delivery for Cardiovascular Gene Therapy Hendrik T. Tevaearai, Andrea D. Eckhart, and Walter J. Koch The Role of Pharmacometrics in Cardiovascular Drug Development Paul J. Williams, Amit Desai, and Ene Ette Gender Differences in Heart Failure: Concerns for Drug Development Mark A. Sussman Angiogenesis Therapies for Coronary Artery Disease: Trials and Tribulations Michael Simons Index

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