MicroRNAs : biology, function, and expression
Author(s)
Bibliographic Information
MicroRNAs : biology, function, and expression
（The nuts & bolts series）
DNA Press, 2007
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Note
Includes bibliographical references and index
Description and Table of Contents
Description
Providing a comprehensive overview of a fast-emerging field, this description of the biological role of microRNAs discusses methods for identifying and characterizing their functions and looks at potential applications of microRNA research in medicine and pharmacology. First identified a decade ago, microRNAs (miRNAs) are small, noncoding RNA molecules that appear to regulate gene expression. Found in plant and animal species and possibly traceable back to ancient forms of life, miRNAs are now estimated to regulate a third or more of human genes. Neil J. Clarke, PhD, is a molecular biologist and the manager of gene interference research for GlaxoSmithKline. Philippe Sanseau, PhD, is a molecular biologist specializing in cancer and immunogenetics. He is the director of bioinformatics at GlaxoSmithKline.
Table of Contents
1: Basic miRNA Biology and Biogenesis (Thimmaiah P. Chendrimada and Ramin Shiekhattar)2: RISC Biology (Yu Xiang and Guiliang Tang)3: Genomic Localization of Vertebrate microRNA Genes (Michael Weber)4: Structural Features of miRNAs and Their Precursors (Jacek Krol et al.)5: The Role of microRNA in Regulating mRNA Stability (Qing Jing and Jiahuai Han)6: An in vivo Perspective on microRNAs: Lessons From the Worm (Helge Grosshans)7: Virus Encoded microRNAs (Mihaela Zavolan)8: Plant microRNAs (Wonkeun Park and Milo J. Aukerman)9: Evolution of microRNA Biogenesis (Dennis Murphy, Barry Dancis, James R. Brown)10: miRNAs and Their Involvement in Stem cell Division (Steve D. Hatfield et al.)11: microRNAs in Cancer (Michael D. Mattie)12: Expression Analysis of miRNAs with Microarrays (Jaclyn Shingara et al.)13: MicroRNA Quantitation by TaqMan(R) Real-Time PCR (Caifu Chen and Karl J. Guegler)14: The miRBase database: microRNA Sequences, Targets & Nomenclature (Sam Griffiths-Jones)15: The Passionate Race for microRNA Detection and Function Deciphering (Olivier Delfour et al.)16: Computational Prediction of microRNA Targets (Anton Enright)
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