Cancer stem cells : Novel concepts and prospects for tumor therapy
Author(s)
Bibliographic Information
Cancer stem cells : Novel concepts and prospects for tumor therapy
（Ernst Schering Foundation symposium proceedings, 5）
Springer, c2007
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Description and Table of Contents
Description
Cancer stem cells have originally been identified in leukemia and later in several solid tumor types. They have very different properties from the bulk of the tumor as they divide much more slowly and have very efficient drug resistance mechanisms. Current treatments might largely spare cancer stem cells. This book looks at recent developments in the field of cancer stem cells and the possible impact for the identification of novel treatment paradigms for cancer.
Table of Contents
Niche for Normal and Cancer Stem Cells.- c-Myc and Activated Ras During Skin Tumorigenesis: Cooperation at the Cancer Stem Cell Level?.- Wnt Signaling in Stem Cells and Lung Cancer.- Bone Morphogenetic Proteins Regulate Tumorigenicity in Human Glioblastoma Stem Cells.- Strategies to Induce Nuclear Reprogramming.- The Intestinal Stem Cell Niche Studied Through Conditional Transgenesis.- The Migrating Cancer Stem Cells Model - A Conceptual Explanation of Malignant Tumour Progression.- Bone Marrow Niche and Leukemia.- Breast Stem Cells and Cancer.- Prostate Cancer Stem Cells: A Target for New Therapies.- The Hedgehog Signaling Network, Mammary Stem Cells, and Breast Cancer: Connections and Controversies.- Strategies to Eliminate Cancer Stem Cells.- DNA Repair in Stem Cell Maintenance and Conversion to Cancer Stem Cells.- Tumorigenic Epithelial Stem Cells and Their Normal Counterparts.
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