Essentials of glycobiology

著者

書誌事項

Essentials of glycobiology

edited by Ajit Varki ... [et al.]

Cold Spring Harbor Laboratory Press, c2009

2nd ed

大学図書館所蔵 件 / 全58件

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注記

Other editor: Richard D. Cummings, Jeffrey, D. Esko, Hudson H. Freeze, Pamela Stanley, Carolyn R. Bertozzi, Gerald W. Hart, Marilynn E. Etzler

Includes bibliographical references and index

内容説明・目次

内容説明

The sugar chains of cells-known collectively as glycans-play a variety of impressive, critical, and often surprising roles in biological systems. Glycobiology is the study of the roles of glycans in the growth and development, function, and survival of an organism. Glyco-related processes, described in vivid detail in the text, have become increasingly significant in many areas of basic research as well as biomedicine and biotechnology. This new edition of Essentials of Glycobiology covers the general principles and describes the structure and biosynthesis, diversity, and function of glycans and their relevance to both normal physiologic processes and human disease. Several new chapters present significant advances that have occurred since the publication of the first edition. Three sections of note describe organismal diversity, advances in our understanding of disease states and related therapeutic applications, and the genomic view of glycobiology. Glycomics, analogous to genomics and proteomics, is the systematic study of all glycan structures of a given cell type or organism and paves the way for a more thorough understanding of the functions of these ubiquitous molecules. The first edition of Essentials of Glycobiology represented also a notable experiment in publishing, as it became one of the first electronic textbooks. And, now, in recognition of its wide audience and the changing ways in which researchers and students learn and access information, the new edition of Essentials will be made available online simultaneously with the print edition. This novel experiment is the result of the collaborative efforts of the Cold Spring Harbor Laboratory Press, the National Center for Biotechnology Information, and the editors of the book. Written and edited by glycobiologists with experience in teaching and in research, this volume will be an invaluable resource, both for students and for established investigators in fields such as developmental biology, cell biology, neuroscience, immunology, and biochemistry who require a complete yet concise introduction to this burgeoning field.

目次

Foreword Preface GENERAL PRINCIPLES 1. Historical Background and Overview A. Varki and N. Sharon 2. Structural Basis of Glycan Diversity C.R. Bertozzi and D. Rabuka 3. Cellular Organization of Glycosylation A. Varki, J.D. Esko, and K.J. Colley 4. Glycosylation Precursors H.H. Freeze and A.D. Elbein 5. Glycosyltransferases and Glycan-processing Enzymes J.M. Rini, J.D. Esko, and A. Varki 6. Biological Roles of Glycans A. Varki and J.B. Lowe 7. A Genomic View of Glycobiology B. Henrissat, A. Surolia, and P. Stanley STRUCTURE AND BIOSYNTHESIS 8. N-Glycans P. Stanley, H. Schachter, and N. Taniguchi 9. O-GalNAc Glycans I. Brockhausen, H. Schachter, and P. Stanley 10. Glycosphingolipids R.L. Schnaar, A. Suzuki, and P. Stanley 11. Glycosylphosphatidylinositol Anchors M.A.J. Ferguson, T. Kinoshita, and G.W. Hart 12. Other Classes of ER/Golgi-derived Glycans H.H. Freeze and R.S. Haltiwanger 13. Structures Common to Different Glycans P. Stanley and R.D. Cummings 14. Sialic Acids A. Varki and R. Schauer 15. Hyaluronan V. Hascall and J.D. Esko 16. Proteoglycans and Sulfated Glycosaminoglycans J.D. Esko, K. Kimata, and U. Lindahl 17. Nucleocytoplasmic Glycosylation G.W. Hart and C.M.West 18. The O-GlcNAc Modification G.W. Hart and Y. Akimoto ORGANISMAL DIVERSITY 19. Evolution of Glycan Diversity A. Varki, H.H. Freeze, and P. Gagneux 20. Eubacteria and Archaea J.D. Esko, T.L. Doering, and C.R.H. Raetz 21. Fungi R.D. Cummings and T.L. Doering 22. Viridiplantae M.E. Etzler and D. Mohnen 23. Nematoda R.D. Cummings and J.D. Esko 24. Arthropoda M. Tiemeyer, S.B. Selleck, and J.D. Esko 25. Deuterostomes H.H. Freeze, V.D. Vacquier, and J.D. Esko GLYCAN-BINDING PROTEINS 26. Discovery and Classification of Glycan-binding Proteins A. Varki, M.E. Etzler, R.D. Cummings, and J.D. Esko 27. Principles of Glycan Recognition R.D. Cummings and J.D. Esko 28. R-type Lectins R.D. Cummings and M.E. Etzler 29. L-type Lectins M.E. Etzler, A. Surolia, and R.D. Cummings 30. P-type Lectins A. Varki and S. Kornfeld 31. C-type Lectins R.D. Cummings and R.P. McEver 32. I-type Lectins A. Varki and P.R. Crocker 33. Galectins R.D. Cummings and F.-T. Liu 34. Microbial Lectins: Hemagglutinins, Adhesins, and Toxins J.D. Esko and N. Sharon 35. Proteins that Bind Sulfated Glycosaminoglycans J.D. Esko and R.J. Linhardt GLYCANS IN PHYSIOLOGY AND DISEASE 36. Glycans in Glycoprotein Quality Control H.H. Freeze, J.D. Esko, and A.J. Parodi 37. Free Glycans as Signaling Molecules M.E. Etzler and J.D. Esko 38. Glycans in Development and Systemic Physiology A. Varki, H.H. Freeze, and V.D. Vacquier 39. Bacterial and Viral Infections V. Nizet and J.D. Esko 40. Parasitic Infections R.D. Cummings and S. Turco 41. Genetic Disorders of Glycan Degradation H.H. Freeze 42. Genetic Disorders of Glycosylation H.H. Freeze and H. Schachter 43. Glycans in Acquired Human Diseases A. Varki and H.H. Freeze 44. Glycosylation Changes in Cancer A. Varki, R. Kannagi, and B.P. Toole METHODS AND APPLICATIONS 45. Antibodies and Lectins in Glycan Analysis R.D. Cummings and M.E. Etzler 46. Glycosylation Mutants of Cultured Cells J.D. Esko and P. Stanley 47. Structural Analysis of Glycans B. Mulloy, G.W. Hart, and P. Stanley 48. Glycomics C.R. Bertozzi and R. Sasisekharan 49. Chemical and Enzymatic Synthesis of Glycans and Glycoconjugates P.H. Seeberger, N. Finney, D. Rabuka, and C.R. Bertozzi 50. Chemical Tools for Inhibiting Glycosylation J.D. Esko and C.R. Bertozzi 51. Glycans in Biotechnology and the Pharmaceutical Industry C.R. Bertozzi, H.H. Freeze, A. Varki, and J.D. Esko Glossary Study Guide Index

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