Handbook of human molecular evolution

著者

• Cooper, David N., Dr
• Kehrer-Sawatzki, Hildegard
• Dawkins, Richard

書誌事項

Handbook of human molecular evolution

editors David N. Cooper, Hildegard Kehrer-Sawatzki ; [with a foreword by Richard Dawkins]

John Wiley & Sons, c2008

• : [set]
• v. 1
• v. 2

タイトル別名

Encyclopedia of life sciences

注記

Includes bibliographical references and index

"A compendium of recent and topical articles from Wiley's landmark Encyclopedia of life sciences (ELS)"--Prelim

内容説明・目次

内容説明

"This splendid compendium ... will be the standard reference work for years to come: a handbook to browse, to consult, to look things up in, and to read with pleasure, wonder and post-Darwinian exhilaration." -Richard Dawkins "This is a marvellous book... It should be in every university library - preferably in several copies - and every reader of this journal should add it to their next grant application. It really is that good.... I have already found this book to be invaluable.... For many years to come, these two volumes will be the starting point for anyone wishing to find out about virtually any subject relating to human genetics.... Any scientist working on humans or other animals will find many things in these pages that will stimulate, inform and inspire. The authors, editors and publishers are to be congratulated for their work... order a copy now!" -HUMAN GENETICS "The publishers and editors deserve to be congratulated for publishing this major book which coincides with the 200th anniversary of the birth of Charles Darwin. The book is well-timed, with biologists, theologians and sociologists engaged in intense debate on the Darwinian Theory on the origin of species, evolution and natural selection... There is little doubt that this marvellous publication should be in the library of universities and academic institutions dealing with basic and applied biology research and education.... It will not be surprising if the individual academic or researcher decides to invest in this resource and enrich their personal collection of leading books in genetics and genomics." -GENOMIC MEDICINE A Unique Collection of High-Quality Articles - Derived from the Acclaimed Encyclopedia of Life Sciences The revolution in human molecular genetics which has taken place over the last three decades has yielded a wealth of information not only on the structure and function of our genes, but also on gene expression, mutation and polymorphic variation. Over the last five years, the focus has moved from genes to genomes. Even though the annotation of our ~30,000 genes is still in progress, genome-wide studies have already yielded abundant evidence for the signatures of past selection and adaptive evolution within human gene sequences. Further, the completion of the sequencing of the 3 billion base-pair human genome, coupled with the increasing availability of other vertebrate genome sequences, has ushered in a new era of comparative genomics. We are now able to identify many of the molecular events (from the chromosomal level down to the single base-pair) that have occurred during vertebrate, mammalian, primate and hominid evolution. Indeed, the detailed comparison of the human and chimpanzee genomes has begun to reveal some of the genetic changes that have been involved in the development of human lineage-specific traits. We are thus acquiring the ability to ask searching questions about our origins, about the demographic processes associated with the global radiation of humankind, as well as some of the unique adaptations that make us human. Evolutionary biology has become so broad that its impact may be felt across the spectrum of the biological sciences. The aim of the Handbook of Human Molecular Evolution is relatively straightforward: to bring together under the same cover the many and varied strands of our knowledge of human/primate/vertebrate molecular evolution. Hence, the 282 chapters that comprise this essential reference work have been thematically arranged into twelve sections, covering the whole scope of research into human molecular evolution: General Concepts in Evolutionary Genetics Mutation, Adaptation and Natural Selection Evolutionary and Population Genetics Human Evolution Human Genome Evolution Evolution of Human Gene Structure and Function Evolution of Gene Expression Mitochondrial Genome Evolution Chromosomal Evolution Comparative Genomics Evolution and Disease Susceptibility Analysis of Ancient DNA This conceptual outline informed the selection of the chapters themselves and the connections between them. Some of these chapters are intended to be introductory, aimed at undergraduates and non-specialists. They provide basic information and a list of recommended further reading to encourage the reader to explore a topic in more depth. This approach helps the student reader progress from textbook material to primary literature. Some chapters are overviews that address topics of broad interest and importance, while others focus on quite specialized topics. These chapters are written for postgraduate students and research workers; they contain more detailed information and key references allowing the reader to investigate a specific area in more depth. This format allows professionals to use the books as a quick reference source. The chapters are richly supplied with website information to allow access to relevant data sources over the internet. The self-contained, peer-reviewed articles in this unique handbook have been written by leading scientists in each field. Key topics include the evolution of enzyme function, the use of nucleic acid divergence as a "molecular clock", the origin of non-functional or junk DNA, the role of gene duplication in the emergence of novel gene function and the identification of molecular changes responsible for various human characteristics especially those pertaining to infection, cognition, disease and disease susceptibility. The Handbook of Human Molecular Evolution has adopted an integrated approach to the study of human evolution and seeks throughout to emphasize the interplay between molecular genetic concepts and principles on the one hand, and information acquisition and interpretation on the other. In this way, it is hoped that the 'documents of evolutionary history' written into the fabric of our genome, will become accessible to the widest possible audience.

目次

• General Concepts in Evolutionary Genetics Views of Evolution James F Crow Evolution: Selectionist View Andreas Wagner Evolution: Neutralist View Andreas Wagner The Neo-selectionist Theory of Genome Evolution Giorgio Bernardi Fitness and Selection Brian Charlesworth Genetic Drift in Human Populations Andrew J Bohonak Heterozygosity Wen-Hsiung Li Effective Population Size Michael C Whitlock Population Differentiation: Measures Stefano Mona, Giorgio Bertorelle Evolutionary Distance Wen-Hsiung Li Gene Trees and Species Trees Wen-Hsiung Li Homologous, Orthologous and Paralogous Genes Wen-Hsiung Li Evolution: Convergent and Parallel Evolution Caro-Beth Stewart Mutation, Adaptation and Natural Selection Genetic Variation: Polymorphisms and Mutations Alan F Wright Polymorphisms: Origins and Maintenance Kenneth M Weiss Molecular Evolution: Introduction David Penny Molecular Evolution: Overview Jan Klein Molecular Evolution: Genetics of Adaptation Michael Travisano Neutral Theory of Molecular Evolution Naoyuki Takahata Molecular Evolution: Nearly Neutral Theory Tomoko Ohta Molecular Evolution: Rates Lindell Bromham Molecular Evolution: Patterns and Rates Lindell Bromham Nucleotide Substitution: Rate of Wen-Hsiung Li Synonymous and Nonsynonymous Rates Soojin Yi Mutational Change in Evolution Dan Graur Mutations and New Variation: Overview Mark O Johnston Single-base Mutation Dan Graur Mutation Rate Bertram Muller-Myhsok Mutation Rates: Evolution David Metzgar Spectrum of Mutations in the Human Genome Inferred by Single Nucleotide Polymorphisms Zhao Zhongming Mutational Biases Lev Y Yampolsky, Arlin Stoltzfus Mutations: Dating Roberto Colombo Diffusion Theory Gil McVean Molecular Clocks in Mammals Wen-Hsiung Li, Kateryna D Makova Molecular Clocks Andrew Peter Martin Purifying Selection: Action on Silent Sites R Nielsen, H Akashi Selection against Amino Acid Replacements in Human Proteins Sankar Subramanian Identifying Regions of the Human Genome that Exhibit Evidence for Positive Selection Ryosuke Kimura, Jun Ohashi Positive Selection on Genes in Humans as Compared to Chimpanzees Margaret A Bakewell, Jianzhi Zhang Selection Operating on Protein-coding Genes in the Human Genome Diogo Meyer, Eugene E Harris Selective and Structural Constraints Austin L Hughes Substitution Matrices Stephen F Altschul Fixation Probabilities and Times Sarah P Otto, Michael C Whitlock Genetic Code: Evolution Edward N Trifonov Codon Usage in Molecular Evolution Richard L Grantham Linkage Disequilibrium Peter JP Croucher Recombination and Human Genetic Diversity Chris CA Spencer Comparison of Rates and Patterns of Meiotic Recombination between Human and Chimpanzees Jan Freudenberg Rapid Evolution of Genes on the Human X-chromosome Erika M Kvikstad, Kateryna D Makova Evolutionary and Population Genetics Gene Flow, Haplotype Patterns and Modern Human Origins Alan R Templeton HapMap Project Bryan J Traynor, Andrew Singleton Migration Guido Barbujani Nonrandom Mating Dennis H O'Neil Human Population Stratification and its Assessment by Microarray Genotyping Marc Bauchet Sequence Alignment Julie D Thompson, Olivier Poch Sequence Similarity Jaap Heringa Phylogenetics Wen-Hsiung Li Phylogenetic Footprinting Wyeth W Wasserman, Wynand Alkema Molecular Phylogeny Reconstruction Sudhir Kumar, Alan Filipski Evolutionary Distance: Estimation Masatoshi Nei, Jianzhi Zhang Coalescent Theory Simon Tavare Stationary Allele Frequency Distributions Bruce Rannala Developmental Evolution Susan Lindsay Morphological Diversity: Evolution Graham Budd Male-driven Evolution Hans Ellegren Coevolution: Molecular Ronald M Adkins Concerted Evolution Daiqing Liao Sociobiology, Evolutionary Psychology and Genetics Patrick Bateson Are Humans Still Evolving? Floyd A Reed Human Evolution Hominids: Molecular Phylogenetics Ulfur Arnason, Morgan Kullberg Human Evolution: Overview Bernard A Wood Molecular Clocks: Determining the Age of the Human--Chimpanzee Divergence Michael I Jensen-Seaman, Kathryn A Hooper-Boyd On the Number of Ancestral Human Species Darren Curnoe Human Evolution: Early Radiations Bernard A Wood Human Evolution: Radiations in the Last 300000 Years Osbjorn M Pearson Modern Humans: Origin and Evolution Todd R Disotell Modern Human Origins: The `Out of Africa' Debate John H Relethford Origin of Modern Humans: Interpreting the Molecular Evidence Henry C Harpending Human Populations: Evolution Rebecca L Cann Human Populations: Origins and Evolution Rosalind M Harding, John H Relethford Humans: Demographic History Henry Harpending DNA Markers and Human Evolution Rebecca L Cann Reconstructing Human History Using Autosomal, Y-Chromosomal and Mitochondrial Markers Bryndis Yngvadottir, Denise R Carvalho-Silva Population History and Linkage Disequilibrium Sebastian Zollner Human Population Genetics: Drift and Migration Ranajit Chakraborty Human Genetics and Languages David Comas, Elena Bosch, Francesc Calafell Surnames and Genetics Mark A Jobling Population History of Europe: Genetics Guido Barbujani Genetic Diversity in Africa Alicia Sanchez-Mazas, Estella S. Poloni Genetic Diversity in the German Population Michael Krawczak, Timothy T Lu, Sascha Willuweit, Lutz Roewer Genetics and the History of the Basque People Santos Alonso Genetics and the Origins of the British Population Martin Richards, Cristian Capelli, James F Wilson Genetics and the Origins of the Chinese Qing-Peng Kong, Hui Pan, Ya-Ping Zhang Genetics and the Origins of the Finns Reijo Norio Genetics and the Origins of the Irish Brian McEvoy, Daniel G Bradley Genetics and the Origins of the Polynesians Geoffrey K Chambers Origins of the Australian and New Guinean Aborigines Sheila M van Holst Pellekaan Origins of the Austro-Asiatic Populations B Mohan Reddy, Vikrant Kumar Peopling of India: Insights from Genetics Partha P Majumder Population Genetics of the Ashkenazim Marina Faerman Roma (Gypsies): Genetic Studies Bharti Morar, Luba Kalaydjieva The Peopling of the Americas as Revealed by Molecular Genetic Studies Theodore G Schurr Primates and the Origin of Culture WC McGrew Human Genome Evolution Evolution of Genome Organization Wolfgang Stephan Genome Organization of Vertebrates Giorgio Bernardi Evolutionary History of the Human Genome Giorgio Bernardi Sequencing the Human Genome: Novel Insights into its Structure and Function Hildegard Kehrer-Sawatzki, David N Cooper Single Nucleotide Polymorphism (SNP) Anthony J Brookes Human Genetic Diversity Lynn B Jorde Human and Chimpanzee Nucleotide Diversity Henrik Kaessmann Divergence between the Human and Chimpanzee Genomes and its Impact on Protein and Transcriptome Evolution Hildegard Kehrer-Sawatzki, David N Cooper Indels in the Evolution of the Human and Chimpanzee Genomes Anna Wetterbom, Lucia Cavelier, Tomas F Bergstroem Inferring the Process of Human--Chimpanzee Speciation K Ryo Takahasi, Hideki Innan Human Genome Diversity Project (HGDP) Morris W Foster Blocks of Limited Haplotype Diversity Newton E Morton Gene Conversion during Primate Evolution Yoko Satta Biased Gene Conversion and its Impact on Human Genome Evolution Nicolas Galtier, Laurent Duret Repetitive DNA: Evolution Wolfgang Stephan, J Bruce Walsh Simple Sequence Repeats in the Human Genome: Evolution Donald E Riley, John N Krieger Evolution of Microsatellite DNA Iris M Vargas Jentzsch, Andrew Bagshaw, Emmanuel Buschiazzo, Angelika Merkel, Neil J Gemmell Evolution of Alpha Satellite DNA Duroica Ugarkovic Comparative Genetics of Trinucleotide Repeats in the Human and Ape Genomes Loris Mularoni, Macarena Toll-Riera, M Mar Alba Endogenous Retroviral Sequences
• their Evolutionary Contribution to the Human Genome Jens Mayer Human Endogenous Retroviruses
• Evolutionary Dynamics, Chromosomal Location and Host Benefit Paul Nelson, Graham Freimanis, Denise Roden Evolutionary History and Impact of Human DNA Transposons Cedric Feschotte Evolution of Human Retrosequences: Alu Astrid M Roy-Engel, Mark A Batzer, Prescott L Deininger Long Interspersed Nuclear Elements (LINEs): Evolution Anthony V Furano, Stephane Boissinot Bacterial DNA in the Human Genome Jan O Andersson Chromosome-specific Repeats (Low-copy Repeats) M-C Potier, G Golfier, EE Eichler Telomere Christa Lese Martin, David H Ledbetter Telomeric and Subtelomeric Repeat Sequences Dmitri Churikov, Carolyn M Price Subtelomeres: Evolution in the Human Genome M Katharine Rudd The Evolution of Centromeric DNA Sequences Joshua J Bayes, Harmit S Malik Segmental Duplications and Their Role in the Evolution of the Human Genome Yali Xue, Chris Tyler-Smith Copy Number Variation in the Human Genome Hildegard Kehrer-Sawatzki Gene Duplication: Evolution Wen-Hsiung Li Gene Families: Formation and Evolution Tomoko Ohta Gene Families: Multigene Families and Superfamilies Tomoko Ohta Gene Clustering in Eukaryotes Jeffrey G Lawrence, Thomas Blumenthal Clustering of Highly Expressed Genes in the Human Genome Hinco J Gierman, Rogier Versteeg Gene Distribution in Human Chromosomes Giorgio Bernardi, Salvatore Saccone Evolution of Gene Deserts in the Human Genome James Taylor The Impact of Gene Duplication on Human Genome Evolution James A Cotton Genetic Redundancy David C Krakauer DNA Methylation: Evolution Aharon Razin, Ruth Shemer Evolution of Imprinting: Imprinted Gene Function in Human Disease Benjamin JA Dickins, Gavin Kelsey Imprinting: Evolution Hamish G Spencer Epigenetic Variation in Humans Jon F Wilkins Dosage Compensation Mechanisms: Evolution Ignacio Marin Evolution of X-chromosome Inactivation Alexander I Shevchenko, Suren M Zakian Ultraconserved DNA Sequence Elements in the Human Genome Alison P Lee, B Venkatesh The Biological Significance of Conserved Non-Generic DNA Emmanouil T Dermitzakis Evolutionarily Conserved Noncoding DNA Anil G Jegga, Bruce J Aronow Human-specific Accelerated Evolution of Noncoding Sequences Matthew T Webster Rapidly Evolving Regions of the Human Genome Subhash Mohan Agarwal GC-Rich Isochores in the Interphase Nucleus Salvatore Saccone, Giorgio Bernardi Evolution of Human Gene Structure and Function Gene Structure: Evolution Tomoko Ohta Gene Evolution and Human Adaptation Eugene E Harris The Evolution of Introns in Human Genes Elodie Gazave, Olga Fernando, Arcadi Navarro Intron Evolution in Duplicated Human Genes Kamel Jabbari, Edda Rayko Intron Loss and Gain Tobias Mourier, Daniel C Jeffares Introns: Movements Manyuan Long, Rudiger Cerff Introns: Phase Compatibility Laszlo Patthy Evolutionarily Conserved Intronic Splicing Regulatory Elements in the Human Genome Eric L Van Nostrand, Gene W Yeo Evolutionary Conservation of Splice Sites Michelle L. Hastings, Ravi Sachidanandam Alternative Splicing: Evolution Laszlo Patthy Alternative Splicing in the Human Genome and its Evolutionary Consequences Liliana Florea Dual-coding Regions in Alternatively Spliced Human Genes Han Liang, Laura F Landweber Birth and Evolution of Human Exons Maria Dulcetti Vibranovski, Noboru Jo Sakabe, Manyuan Long Exons and Protein Modules Laszlo Patthy Insertion and Deletion of Exons During Human Gene Evolution David N Cooper Exons: Shuffling Laszlo Patthy Pseudoexons Manyuan Long Domain Duplication and Gene Elongation Wen-Hsiung Li Kateryna D Makova The Contribution of Frameshift Translation to the Generation of Novel Human Proteins Kohji Okamura, Stephen W Scherer Transposable Element-driven Duplications during Hominoid Genome Evolution Bud Mishra The Contribution of Transposable Elements to Human Proteins Jean-Nicolas Volff Evolutionary Emergence of Genes Through Retrotransposition Richard Cordaux, Mark A Batzer Multigene Families: Evolution J Bruce Walsh, Wolfgang Stephan Paralogous Genes and Chromosomal Regions Lars-Gustav Lundin, Dan Larhammar, Finn Hallboeoek Bi-directional Gene Pairs in the Human Genome Kanako O Koyanagi, Tadashi Imanishi, Takashi Gojobori Gene Fusion Esther Betran Protein Families: Evolution Richard R Copley Fibroblast Growth Factors: Evolution David M Ornitz Globin Genes: Evolution Ross C Hardison Hox Genes and Body Plan: Evolution Ella Tour, William McGinnis Pax Genes: Evolution and Function Maxime Bouchard, Alexander Schleiffer, Frank Eisenhaber, Meinrad Busslinger Low-density Lipoprotein Receptor (LDLR) Family: Genetics and Evolution Wolfgang Johann Schneider Major Histocompatibility Complex (MHC) Genes: Evolution Austin L Hughes Major Histocompatibility Complex (MHC) Genes: Polymorphism Diogo Meyer Steven J Mack Vertebrate Immune System: Evolution Austin L Hughes Evolution of the Human Immune System Nadia Danilova Complement System: Evolution Masaru Nonaka Somatic Hypermutation of Antigen Receptor Genes: Evolution Marilyn Diaz, Laurent K Verkoczy Neuropeptides and their Receptors: Evolution Charles HV Hoyle Nuclear Receptor Genes: Evolution Gareth I Owen Olfactory Receptor Genes: Evolution Yoshihito Niimura Visual Pigment Genes: Evolution Shozo Yokoyama Bitter Taste Sensitivity in Humans and Chimpanzees Maik Behrens, Wolfgang Meyerhof Evolution of Skin Pigmentation Differences in Humans Heather Norton Population Genetics of Lactase Persistence and Lactose Intolerance Catherine Janet Ellen Ingram, Dallas Mary Swallow Defensins: Evolution Austin L Hughes Cystic Fibrosis Transmembrane Conductance Regulator Sequences: Comparative Analysis Jian-Min Chen, Guillaume Lecointre, Erick Denamur, Claude Ferec ATP-binding Cassette (ABC) Transporter Supergene Family: Genetics and Evolution Michael Dean Proteases: Evolution Christopher Southan Serpins: Evolution Gary A Silverman, David J Askew, James A Irving, Cliff J Luke, Dion Kaiserman, Phillip I Bird, James C Whisstock Adaptive Evolution of Primate Sperm Proteins Nathaniel L Clark Drug Metabolism: Evolution Daniel W Nebert rRNA Genes: Evolution Iris L Gonzalez, James E Sylvester MicroRNA Evolution in the Human Genome Bing Su, Rui Zhang Pseudogene Evolution in the Human Genome Zhaolei Zhang, Deyou Zheng Human Lineage-specific Gene Inactivation Wendy E Grus, Jianzhi Zhang Pseudogenes: Age Allen R Rhoads, Felix Friedberg Pseudogenes: Patterns of Mutation Rosa Martinez-Arias, Francesc Calafell, Jaume Bertranpetit Processed Pseudogenes and Their Functional Resurrection in the Human and Mouse Genomes Hiroaki Sakai, Takeshi Itoh, Takashi Gojobori Evolution of Gene Expression Transcriptional Regulation: Evolution Gregory A Wray Promoters: Evolution Deborah L Gumucio Evolution of Human Gene Expression Control Courtney C Babbitt, Gregory A Wray Positive Selection and the Evolution of Prodynorphin Matthew V Rockman Human Transcriptome Evolution Xun Gu, Yong Huang Evolution of Gene Expression in Human and Chimpanzee Brains Naoki Osada, Sugano Sumio, Yutaka Suzuki Human and Chimpanzee Transcriptomes: Comparative Evolution Philipp Khaitovich, David Cooper, Hildegard Kehrer-Sawatzki Human and Macaque Transcriptiomes: A comparison Stephen J Walker Transcription Factor-binding Sites: Recent Evolution in the Human Lineage Berthold Goettgens Alternative Polyadenylation in the Human Genome: Evolution Bin Tian Mitochondrial Genome Evolution Mitochondrial Genome: Evolution Mark Stoneking Mitochondrial Non-Mendelian Inheritance: Evolutionary Origin and Consequences C William Birky Jr Mitochondrial Genome Sequences and Their Phylogeographic Interpretation Vincent Macaulay, Martin Richards Mitochondrial Origins of Human Nuclear Genes and DNA Sequences William F Martin Chromosomal Evolution Chromosomes in Mammals: Diversity and Evolution Johannes Wienberg, Stefan Muller Chromosome Numbers in Mammals Harry Scherthan Chromosome Rearrangement Patterns in Mammalian Evolution Johannes Wienberg, Stefan Muller Hotspots of Mammalian Chromosome Evolution Lutz Froenicke, Leslie A Lyons Chromosomal Rearrangements in Primates Roscoe Stanyon, Francesca Bigoni Chromosomal Rearrangements in the Human and Chimpanzee Lineages Hildegard Kehrer-Sawatzki, David N Cooper Human Chromosome Evolution Gerald P Holmquist, Johannes Wienberg Polyploid Origin of the Human Genome Masanori Kasahara Chromatin Structure and Human Genome Evolution Colin AM Semple Mammalian Sex Chromosome Evolution Gerald J Wyckoff, Christine M Malcom Evolution of the Mammalian X Chromosome Paul D Waters, Terence J Robinson Y Chromosome Evolution Vladimir A Gvozdev X and Y Chromosomes: Homologous Regions Nisrine El-Moghabel, Jennifer A M Graves Evolution of Common Fragile Sites Anne Helmrich Comparative Genomics Comparative Cytogenetics Matthew Breen, Cordelia Langford Comparative Cytogenetics Technologies Stefan Muller, Johannes Wienberg Reconstruction of Ancestral Genomes Roscoe Stanyon, Fiorella Garofalo, Francesca Bigoni Comparative Human Genomics I King Jordan, Eugene V Koonin Orthologues, Paralogues and Xenologues in Human and Other Genomes Olga Zhaxybayeva, J Peter Gogarten, Lorraine Olendzenski Comparing the Human and Sea Urchin Genomes R Andrew Cameron Comparing the Human and Fish Genomes Yoichiro Nakatani, Shinichi Morishita Comparing the Human and Medaka Genomes Takashi Sasaki, Nobuyoshi Shimizu Fugu: The Pufferfish Model Genome B Venkatesh The Mouse Genome as a Rodent Model in Evolutionary Studies Jessica Vamathevan, Joanna D Holbrook, Richard D Emes The Rat Genome as a Rodent Model in Evolutionary Studies Kim Fechtel Comparing the Human and Canine Genomes Marek Switonski, Izabela Szczerbal Primate Phylogenetics Todd R Disotell The Sequencing of the Rhesus Macaque Genome and its Comparison with the Genome Sequences of Human and Chimpanzee Richard A Gibbs, Kim C Worley, Hildegard Kehrer-Sawatzki, David N Cooper The Chimpanzee Genome Project David N Cooper, Hildegard Kehrer-Sawatzki Comparing the Human and Chimpanzee Genomes Monica Uddin, Derek E Wildman, Morris Goodman Nucleotide Sequence Divergence between Humans and Chimpanzees Feng-Chi Chen, Trees-Juen Chuang Human-specific Changes of Genome Structure R Alan Harris, Aleksandar Milosavljevic Evolution and Disease Susceptibility Evolutionary Thinking in the Medical Sciences Stephen C Stearns Darwinian Medicine George C Williams Pathological Missense Mutations Provide New Insights into the Evolution of Trypsinogen Genes Jian-Min Chen, David N Cooper, Claude Ferec Balancing Selection in Human Evolution Eric J Vallender, Welkin E Johnson Selective Constraints on Human Disease Mutations and Polymorphisms Hernan Dopazo Genetic of Large Populations and Association Studies Pauline Helene Garnier-Gere, Lounes Chikhi Genetic Disease in the Ashkenazim: Role of a Founder Effect Inbal Kedar-Barnes, Paul Rozen, Mordechai Shohat Hagit N Baris Single Nucleotide Polymorphisms in Human Disease and Evolution: Phylogenies and Genealogies Paul D Thomas Structural Diversity of the Human Genome and Disease Susceptibility Richard S Smith, Maria Gutierrez-Arcelus, Charles W Tran, Stephanie Park, Cheryn J Couter, Charles Lee Segmental Duplications and Genetic Disease Beverly S Emanuel, Tamim H Shaikh Genetics of Susceptibility to Human Infectious Diseases Richard A Kaslow, Sadeep Shrestha, Jianming 'James' Tang The Genetics of Malarial Resistance and Susceptibility Brian C Verrelli The Evolution of Fatness and Susceptibility to Obesity Jonathan CK Wells Thrifty Genotype Hyphothesis and Complex Genetic Disease Pnina Varidi, Konstantin Bloch An Evolutionary Framework for Common Disease Francesca Luca, Anna Di Rienzo On Sequence Variants that Influence the Risk of Common Diseases Kari Stefansson, Jeffrey R Gulcher An Evolutionary Genetic Framework for Heritable Disorders Matthew C Keller Analysis of Ancient DNA Ancient DNA: Recovery and Analysis Susanne Hummel Ancient DNA: Phylogenetic Applications Michael Knapp, Linda Vigilant, Michael Hofreiter Neanderthal Mitochondrial DNA William Goodwin, Igor Ovchinnikov Reconstructing Ancient DNA Sequences in Silico Jian Ma

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詳細情報

• NII書誌ID(NCID): BA87748828
• ISBN:
  • 9780470517468
• 出版国コード: uk
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: Chichester, West Sussex
• ページ数/冊数: 2 v. (xxxii, 1717 p.)
• 大きさ: 28 cm
• 分類:
  • LCC : QH325
  • NLM : QU 475
  • DC22 : 572.8/38
• 件名:
  • LCSH : Molecular evolution -- Handbooks, manuals, etc
  • MESH : Evolution, Molecular