Introduction to biomedical engineering
著者
書誌事項
Introduction to biomedical engineering
Prentice Hall, c2010
2nd ed
- : hbk.
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注記
Previous ed.: 2004
内容説明・目次
内容説明
For freshman and limited calculus-based courses in Introduction to Biomedical Engineering or Introduction to Bioengineering.
Substantial yet reader-friendly, this introduction examines the living system from the molecular to the human scale-presenting bioengineering practice via some of the best engineering designs provided by nature, from a variety of perspectives. Domach makes the field more accessible for students, helping them to pick up the jargon and determine where their skill sets may fit in. He covers such key issues as optimization, scaling, and design; and introduces these concepts in a sequential, layered manner. Analysis strategies, science, and technology are illustrated in each chapter.
目次
PART I: OVERVIEW OF BIOENGINEERING
AND MODERN BIOLOGY 1
0 What Is Bioengineering? 3
0.1 Purpose of This Chapter 3
0.2 Engineering versus Science 4
0.3 Bioengineering 4
0.4 Career Opportunities 11
0.5 Further Consideration of the Ethical Dimensions
of Bioengineering 15
1 Cellular, Elemental, and Molecular Building Blocks
of Living Systems 19
1.1 Purpose of This Chapter 19
1.2 Origins and Divergence of Basic Cell Types 20
1.3 Elemental and Molecular Composition of a Cell 23
1.4 Molecules That Contain Information 25
1.5 Unique versus Interchangeable Parts Leads to Molecular-Based
Classification 28
1.6 Cellular Anatomy 29
1.7 Cellular Physiological Lifestyles 30
1.8 Viruses 31
1.9 Prions 31
PART II: SYSTEM PRINCIPLES OF LIVING
SYSTEMS 35
2 Mass Conservation, Cycling, and Kinetics 37
2.1 Purpose of This Chapter 37
2.2 Open versus Closed Systems 39
2.3 Steady State versus Unsteady State 39
2.4 Approaches to Performing Mass Balances 40
2.5 Recycle, Bypass, and Purge 44
2.6 Kinetics 47
2.7 Unsteady-State Mass Balances 50
2.8 Review of Moles, Molecular Formulas,
and Gas Compositions 53
3 Requirements and Features of a Functional
and Coordinated System 58
3.1 Purpose of This Chapter 58
3.2 Chemical Reaction Rate Acceleration 59
3.3 Energy Investment to Provide Driving Forces
for Nonspontaneous Processes 61
3.4 Control and Communication Systems 63
4 Bioenergetics 70
4.1 Purpose of This Chapter 72
4.2 Bioenergetic Units 72
4.3 Sensible versus Latent Heat 73
4.4 The First Law of Thermodynamics Works on All Scales 73
4.5 Using the First Law in Energy Balancing 74
4.6 Bioenergetics at the Human Scale 74
4.7 How Energy Is Produced, Stored, and Transduced
at the Cellular Level 80
4.8 Representative Energetic Values at the Cellular
Level 85
4.9 More Sophisticated Chemical Energy Accounting
(Optional) 86
4.10 Electrochemical Potential Calculation Examples
and Applications (Optional) 89
4.11 Why Coupling between Energy Evolving Reactions and ATP
Formation Is Imperfect (Optional) 93
4.12 Biological and Medical Applications of Membrane
Energetization 94
PART III: BIOMOLECULAR AND CELLULAR
FUNDAMENTALS AND ENGINEERING
APPLICATIONS 99
5 Molecular Basis of Catalysis and Regulation 101
5.1 Purpose of This Chapter 102
5.2 Binding in the Biological Context 102
5.3 Binding Is Dynamic 103
5.4 Different Venues in Which Binding Operates 104
6 Analysis of Molecular Binding Phenomena 111
6.1 Purpose of This Chapter 111
6.2 General Strategy for Problem Formulation and Solution 112
6.3 Analysis of a Single Ligand-Single Binding Site System 114
6.4 How to Decide What the Free Ligand Concentration Is 116
6.5 Examples of Binding Calculations 117
6.6 Analysis of Binding When Enzyme Catalysis Occurs 117
6.7 A Protein with Multiple Binding Sites 120
6.8 Further Thoughts on How Living Systems Are Designed
and Function 123
7 Applications and Design in Biomolecular
Technology 128
7.1 Purpose of This Chapter 128
7.2 Binding Applications 129
7.3 Enzyme Catalysis Application 132
7.4 Using Enzymes in Food Processing 138
7.5 Bioresource Engineering 138
7.6 Immobilized Enzymes in Chemical Weapon Defense
and Toxic Chemical Destruction 139
8 Cellular Technologies and Bioinformatics Basics 144
8.1 Purpose of This Chapter 144
8.2 Microbial Metabolic Engineering 145
8.3 Tissue Engineering 154
8.4 Gene Therapy and DNA Vaccines 160
8.5 An Experimental Facet of Bioinformatics 161
8.6 Computational Component to Bioinformatics:
Eigenvalue-Based Methods 164
8.7 Future Studies 169
PART IV: MEDICAL ENGINEERING 173
9 Primer on Organs and Function 175
9.1 Purpose of This Chapter 175
9.2 Basic Parameters and Inventories in the Human Body 176
9.3 Digestive System 178
9.4 Circulatory Systems 182
9.5 Heart Structure and Function 183
9.6 Removal versus Preservation of Substances in the Blood 184
9.7 Activity Coordination: Endocrine System 187
9.8 Follow-On Biomedical Engineering Considerations 188
10 Biomechanics 192
10.1 Purpose of This Chapter 192
10.2 Power Expenditure in Walking 194
10.3 Optimization Illustration: Least Power Expenditure
Stride Length 196
10.4 Scaling the Result in an Ergonomic Analysis 197
10.5 Using the Solution to Solve a Larger Problem 200
11 Biofluid Mechanics 205
11.1 Purpose of This Chapter 205
11.2 Mechanics of Fluid Flow 206
11.3 Blood versus Water 213
11.4 Example: How Much Force Is Needed to Inject
a Drug? 214
11.5 Example: How Does the Heart Compare to a Lawn
Mower Engine in Horsepower? 215
11.6 Example: What Is the Stress on a Red Blood Cell? 216
11.7 Operation and Design of the Circulatory System 217
11.8 Biomedical Engineering Applications, Accomplishments,
and Challenges 220
12 Biomaterials 231
12.1 Purpose of This Chapter 231
12.2 Three Basic Quantifiable Features of Biomaterials 233
12.3 Body Response to Wounding 237
12.4 Immune System Defense 240
12.5 Examples of the Role of Mechanical Properties
of Biomaterials 242
12.6 Examples of Biomaterials Engineering Strategies That Attempt
to Minimize Clotting Through Surface Modification 242
12.7 Examples of Immune System Links to Biomaterials 246
13 Pharmacokinetics 252
13.1 Purpose of This Chapter 252
13.2 Pharmacokinetic Modeling Basics 254
13.3 Limits of Pharmacokinetic Models and Gaining
More Predictive Power 258
13.4 Appendix: Solution of Pharmacokinetic Model 260
14 Noninvasive Sensing and Signal Processing 263
14.1 Purpose of This Chapter 264
14.2 Physics of NMR 265
14.3 Signal Processing: Converting Raw Signal into Useful
Information 272
14.4 NMR Applications 275
Index 287
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