Recent developments in biomolecular NMR

著者

    • Clore, Marius
    • Potts, Jennifer (Jennifer R.)

書誌事項

Recent developments in biomolecular NMR

edited by Marius Clore, Jennifer Potts

(RSC biomolecular sciences, no. 25)

RSC Publishing, c2012

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注記

Includes bibliographical references and index

内容説明・目次

内容説明

NMR spectroscopy is widely used in biomolecular science particularly for structure determination of proteins, nucleic acids and carbohydrates. Much of the innovation within NMR spectroscopy has been within the field of protein NMR spectroscopy, an important technique in structural biology. Filling a gap in the literature, this book draws together experts in the field to discuss the real advances in NMR methods that have occurred or have an impact on the biomolecular field in the last few years. The coverage includes recent developments in using NMR for determination of protein structures, membrane proteins, the dynamics of RNA and advances in NMR in drug discovery. Edited by leading biological NMR spectroscopists, the book is essential reference for researchers in industry and academia interested in or joining this bioanalytical field.

目次

  • Isotope-labelling of Methyl Groups for NMR Studies of Large Proteins
  • Low y-nuclei detection experiments for biomolecular NMR
  • Making the most of chemical shifts
  • Protein Structure Determination using sparse NMR data
  • NMR Studies of Disordered but Functional Proteins
  • Paramagnetic NMR Spectroscopy and Lowly Populated States
  • NMR Relaxation Dispersion Studies of Large Enzymes in Solution
  • Residual Dipolar Couplings as a Tool for the Study of Protein Conformation and Conformational Flexibility
  • Characterizing RNA Dynamics using NMR Residual Dipolar Couplings
  • Non-canonical ligand-binding events as detected by NMR
  • Advances in Biomolecular NMR for Drug Discovery
  • NMR of membrane proteins
  • Recent Developments in Biomolecular Solid-state NMR
  • Subject Index

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