書誌事項

Intrinsic immunity

edited by Bryan R. Cullen

(Current topics in microbiology and immunology, 371)

Springer, 2013

  • hbk.

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内容説明・目次

内容説明

Recent research has focused attention on the importance of intrinsic antiviral immunity, i.e. immunity mediated by factors that are constitutively expressed in many cells. In this volume, leading experts provide a comprehensive overview of this relatively new and rapidly evolving field. They cover intrinsic proteinaceous antiviral immune effectors, such as the APOBEC3 and TRIM protein families as well as Tetherin and SAMHD1, which were initially discovered by researchers studying HIV-1. Furthermore, the role of RNA interference in antiviral defense in plants and invertebrates, as well as the interplay between microRNAs and viruses in mammalian cells, are analysed. One chapter discusses how intrinsic immunity and viral countermeasures to intrinsic immune effectors drive both pathogen and host evolution, and finally the emerging evidence that DNA damage response proteins restrict infection by DNA viruses is highlighted.

目次

The APOBEC3 Family of Retroelement Restriction Factors Eric W. Refsland and Reuben S. Harris Inhibition of Retroviral Replication by Members of the TRIM Protein Family Adam J Fletcher and Greg J Towers The Antiviral Activities of Tetherin Stuart J D Neil Restriction of Retroviral Infection of Macrophages Mark Sharkey Rapid Adversarial Co-Evolution of Viruses and Cellular Restriction Factors Welkin E. Johnson RNA Interference-Mediated Intrinsic Antiviral Immunity in Plants Szittya Gyoergy and Jozsef Burgyan RNA Interference-Mediated Intrinsic Antiviral Immunity in Invertebrates Arabinda Nayak, Michel Tassetto, Mark Kunitomi and Raul Andino Roles of MicroRNAs in the Life Cycles of Mammalian Viruses Eva Gottwein Interplay Between DNA Tumor Viruses and the Host DNA Damage Response Karyn McFadden and Micah Luftig

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  • Current topics in microbiology and immunology

    Springer-Verlag 1967-

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詳細情報

  • NII書誌ID(NCID)
    BB12875037
  • ISBN
    • 9783642377648
  • 出版国コード
    gw
  • タイトル言語コード
    eng
  • 本文言語コード
    eng
  • 出版地
    Berlin ; Heidelberg
  • ページ数/冊数
    vii, 262p.
  • 大きさ
    25cm
  • 分類
  • 件名
  • 親書誌ID
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