Sphingosine-1-phosphate signaling in immunology and infectious diseases

著者

• Oldstone, Michael B. A.
• Rosen, Hugh

書誌事項

Sphingosine-1-phosphate signaling in immunology and infectious diseases

Michael B.A. Oldstone, Hugh Rosen, editors

（Current topics in microbiology and immunology, 378）

Springer, c2014

注記

Includes bibliographical references and index

内容説明・目次

内容説明

This volume focuses on the role of sphingosine-1-phosphate (S1P) and its analogs in the induced sequestration of lymphocytes in secondary lymphoid organs or in the microenvironment of tissues involved in infection or autoimmune disease. Initial chapters define the pathways to understand S1P signaling. They cover the organization of signaling systems, the structural biology of the S1P1 receptor, and the chemical and genetic tools that are available and useful to explore this area of research and therapeutics. The later chapters highlight S1P and endothelial integrity, lymphocyte migration in the spleen, and S1P agonist in controlling immunopathologic manifestations of acute respiratory influenza virus infection (in the lung), and its accompanying cytokine storm as well as immunopathologic disease of the central nervous system, including the beginning of treatments in multiple sclerosis. One chapter reveals the possible involvement of other lipid molecules, their use for better understanding lipid signaling, and their potential in the modulation of immune responses.

目次

1 The organization of the sphingosine-1-phosphate signaling system Hugh Rosen, M. Germana Sanna, Pedro J. Gonzalez-Cabrera and Edward Roberts# 2 Structural biology of the S1P1 receptor Michael A. Hanson and Robert Peach 3 Chemical and genetic tools to explore S1P biology Stuart M. Cahalan 4 S1P control of endothelial integrity Yuquan Xiong and Timothy Hla 5 Blood, sphingosine-1-phosphate and lymphocyte migration dynamics in the spleen Tal I. Arnon and Jason G. Cyster 6 Cytokine storm plays a direct role in the morbidity and mortality from influenza virus infection and is chemically treatable with a single sphingosine-1-phosphate agonist molecule Michael B.A. Oldstone and Hugh Rosen 7 Sphingosine-1-phosphate and central nervous system Roland Martin and Mireia Sospedra 8 RORs in autoimmune disease M. Chang, H. Rosen and Patrick Griffin

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詳細情報

• NII書誌ID(NCID): BB15621352
• ISBN:
  • 9783319058788
• 出版国コード: gw
• タイトル言語コード: eng
• 本文言語コード: eng
• 出版地: Heidelberg
• ページ数/冊数: vii, 184 p.
• 大きさ: 24 cm
• 親書誌ID:
  • BA00773360