Translation to clinical application
著者
書誌事項
Translation to clinical application
（Progress in brain research, v. 230-231 . Functional neural transplantation ; 4）
Elsevier, 2017
- pt. A
- pt. B
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注記
Includes bibliographical references and index
内容説明・目次
- 巻冊次
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pt. A ISBN 9780128117385
内容説明
Functional Neural Transplantation IV: Translation to Clinical Application, Volume 230 provides the current status of cell transplantation in the nervous system, with a focus on the conditions for achieving structural repair and functional recovery after brain damage or in neurodegenerative disease. New to this release are chapters that delve into the Mechanisms and Use of Neural Transplants for Brain Repair, Reprogramming of Somatic Cells: iPS and iN Cells, Brain Repair from Intrinsic Cell Sources: Turning Reactive Glia into Neurons, and Ex Vivo Gene Therapy for the Treatment of Neurological Disorders, Preparation, Characterization and Banking of Clinical-grade Cells for Neural Transplantation.
As the fourth in a periodic series of updates at 5-7 year intervals, this volume highlights recent developments related to the application of advances in cellular and molecular science, providing an understanding of the fundamental principles of neuroplasticity and regeneration in the brain and spinal cord, and also addressing the topic of the power of pluripotent stem cells to generate new sources of precisely specified neurons for utilization in brain repair.
目次
1. Mechanisms and Use of Neural Transplants for Brain Repair Stephen B. Dunnett and Anders Bjoerklund 2. Reprogramming of Somatic Cells: iPS and iN Cells Vania Broccoli 3. Brain Repair from Intrinsic Cell Sources: Turning Reactive Glia into Neurons Olof Torper and Magdalena Goetz 4. Ex Vivo Gene Therapy for the Treatment of Neurological Disorders Genevieve Gowing , Soshana Svendsen and Clive N. Svendsen 5. Preparation, Characterization and Banking of Clinical-grade Cells for Neural Transplantation: Scale Up, Fingerprinting and Genomic Stability of Stem Cell Lines Ammar Natalwala and Tilo Kunath 6. Regulatory Considerations for Pluripotent Stem Cell Therapies Melissa K. Carpenter 7. Strategies for Bringing Stem Cell-derived Dopamine Neurons to the Clinic: A European Approach (STEM-PD) Agnete Kirkeby, Malin Parmar and Roger A. Barker 8. Strategies for Bringing Stem Cell-derived Dopamine Neurons to the Clinic: The NYSTEM Trial Lorenz Studer 9. Strategies for Bringing Stem Cell-derived Dopamine Neurons to the Clinic: The Kyoto Trial Jun Takahashi 10. From Open to Large-Scale Randomised Cell Transplantation Trials in Huntingtons Disease: Lessons from the Multicentric Intracerebral Grafting in Huntington's Disease Trial (MIG-HD) and Previous Pilot Studies Anne-Catherine Bachoud-Levi 11. Pluripotent Stem Cell-derived neurons for Transplantation in HuntingtonS Disease Meng Li and Anne E. Rosser 12. Advanced Imaging of Transplant Survival, Fate, Differentiation, and Integration Nadja Van Camp, Elsa Diguet and Philippe Hantraye 13. Rehabilitation Training in Neural Restitution Susanne Clinch, Monica Busse, Mate D. Doebroessy and Stephen B. Dunnett
- 巻冊次
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pt. B ISBN 9780128138793
内容説明
Functional Neural Transplantation IV: Translation to Clinical Application, Part B, Volume 231 provides the current status of cell transplantation in the nervous system, focusing on the conditions for achieving structural repair and functional recovery. New to this edition are chapters on Plasticity and Regeneration in the Injured Spinal Cord After Cell Transplantation Therapy, Transplantation of GABAergic Interneurons for Cell-Based Therapy, Rebuilding CNS Inhibitory Circuits to Control Chronic Neuropathic Pain and Itch, From Transplanting Schwann Cells in Experimental Rat Spinal Cord Injury to their Transplantation into Human Injured Spinal Cord in Clinical Trials, and the Recruitment of Endogenous CNS Stem Cells for Regeneration in Demyelinating Disease.
As the fourth in a periodic series of updates at 5-7 year intervals, this volume highlights recent developments in cellular and molecular science, providing the fundamental principles of neuroplasticity and regeneration in the brain and spinal cord, while also addressing the power of pluripotent stem cells to generate new sources of precisely specified neurons for utilization in brain repair.
目次
1. Stem Cell Transplantation for Spinal Cord Injury Repair
Paul Lu
2. Plasticity and Regeneration in the Injured Spinal Cord After Cell Transplantation Therapy
Satoshi Nori, Masaya Nakamura and Hideyuki Okano
3. Transplantation of GABAergic Interneurons for Cell-Based Therapy
Julien Spatazza, Walter R. Mancia Leon and Arturo Alvarez-Buylla
4. Rebuilding CNS Inhibitory Circuits to Control Chronic Neuropathic Pain and Itch
Joao M. Braz, Alex Etlin, Dina Juarez-Salinas, Ida J. Llewellyn-Smith and Allan I. Basbaum
5. From Transplanting Schwann Cells in Experimental Rat Spinal Cord Injury to their Transplantation into Human Injured Spinal Cord in Clinical Trials
Mary B. Bunge, Paula V. Monje, Aisha Khan and Patrick M. Wood
6. Recruitment of Endogenous CNS Stem Cells for Regeneration in Demyelinating Disease
Natalia A. Murphy and Robin J.M. Franklin
7. Progenitor Cell-Based Treatment of Glial Disease
Steven A. Goldman
8. Pluripotent Stem Cells and their Utility in Treating Photoreceptor Degenerations
Nozie D. Aghaizu, Kamil Kruczek, Anai Gonzalez-Cordero, Robin R. Ali and Rachael A. Pearson
9. Stem Cell-Derived Retinal Pigment Epithelium Transplantation for Treatment of Retinal Disease
Britta Nommiste, Kate Fynes, Victoria E. Tovell, Conor Ramsden, Lyndon da Cruz and Peter Coffey
10. Transplantation of Reprogrammed Neurons for Improved Recovery After Stroke
Zaal Kokaia, Daniel Tornero and Olle Lindvall
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