Molecular and cellular mechanisms of human hypersensitivity and autoimmunity : proceedings of a Cetus-Upjohn-UCLA Symposium, held at Keystone, Colorado, April 17-23, 1988

A molecular and cellular biological approach to human immuno-deficiency and autoimmunity. Coverage includes descriptions of the cytokines and cellular mediators necessary for integrated and well-regulated immune responses. The antigenic stimuli, histocompatibility variants, lymphocytic defects and effector cell abnormalities central to selected human hypersensitivity and autoimmune diseases are also covered, as are molecular strategies to novel therapies for immune diseases using monoclonal antibodies or receptor-specific immunotoxins.

• Partial table of contents:
• MOLECULAR AND CELLULAR DETERMINANTS OF IMMUNITY
• Mechanisms of Lymphocyte-Mediated Lysis (S. Joag, et al.)
• Prenatal and Postnatal Expression of Adenosine Deaminase in Mice (V. Ramamurthy, et al.)
• Regulation of IgE Synthesis (K. Ishizaka)
• Role of B Cells as Antigen-Presenting Cells In Vivo (Y. Ron & J. Sprent)
• MEDIATORS OF HUMAN IMMUNITY AND HYPERSENSITIVITY
• Role for Interleukin-1 in the Pathogenesis of Hypersensitivity Diseases (C. Dinarello & S. Endres)
• Molecular and Cellular Analysis of Histamine H1 Receptors on Cultured Smooth Muscle Cells (M. Mitsuhashi & D. Payan)
• Role of Growth Factors in Inflammation and Repair (S. Wahl, et al.)
• AUTOIMMUNITY AND IMMUNODEFICIENCY: MECHANISMS AND NOVEL THERAPEUTIC APPROACHES
• Normal and Mutant Human Adenosine Deaminase Genes (A. Akeson, et al.)
• The Role of the Idiotypic Network in the Induction of Experimental Systemic Lupus Erythematosus (E. Mozes, et al.)
• HLA Class II Variants Predisposing to Type I Diabetes and Rheumatoid Arthritis (G. Nepom)
• Therapeutic Strategies That Target the Interleukin 2 Receptor (V. Kelley, et al.)
• Index.