Search Results 261-280 of 668

  • Practical Synthesis of 1-(7-Chlorobenzothiazol-2-yl)-1-methylethylamine, a Key Synthetic Intermediate for the Production of New Oxazine Herbicide, MI-3069

    IKEGUCHI Masahiko , SAWAKI Masahiko , MAEDA Kazuyuki , KIKUGAWA Hiroshi

    Practical synthetic routes for the preparation of 1-(7-chlorobenzothiazol-2-yl)-1-methylethylamine (<b>VII</b>), a key intermediate of the barnyardgrass-controlling herbicide, 3-[[1-(7-chlorobenzothiazol-2-yl)-1-methyl]ethyl]-2, 3-dihydro-6-methyl-5-phenyl-4<i>H</i>-1, 3-oxazin-4-one (MI-3069), were investigated. As the result, the intermediate <b>VII</b> was prepared in an excellent overall yield by cyclization of 2-amino-2-methylpropionitrile with 2-amino-6-chlorothiophenol, which was synthesized by hydrogenation of 2-nitro-6-chlorothiophenol derived from 2, 3-dichloronitrobenzene. This practical route consisted of shorter steps with relatively cheaper reactants than the reported method.

    Journal of Pesticide Science 26(1), 21-27, 2001-02-20

    J-STAGE  NDL Digital Collections  JASI  References (11)

  • Developmental Characteristics of a Freshwater Goby, Micropercops swinhonis, from Korea

    IWATA Akihisa , SAKAI Harumi , SHIBUKAWA Kouichi , JEON Sang-Rin

    The embryonic and larval development of a freshwater goby, Micropercops swinhonis (Odontobutidae; Gobioidei), from Korea are described. One female spawned several times from mid-April to early July. About 100 to 500 eggs per batch were laid on the under surface of the nest guarded by a male. Eggs hatched 12 days after spawning. Larvae, about 3.7 mm in total length (TL) just after hatching, passed the exogenous feeding larval stage, and reached the juvenile stage of about 16 mm TL in about one month. The developmental process of M. swinhonis is quite different from that of the fluvial Odontobutis of the same family, which skips the exogenous feeding larval stage, but is rather similar to that of amphidromous Gobiidae. On the other hand, the left and right pelvic fin buds of M. swinhonis appear distant from each other as in Odontobutis, rather than Gobiidae.

    ZOOLOGICAL SCIENCE 18(1), 91-97, 2001-01-20

    IR  J-STAGE  NDL Digital Collections  References (15) Cited by (2)

  • Development of Support System for Machining in Parallel Mechanism Type Machine Tools -Determination of Location of Workpiece-  [in Japanese]

    ZHAO Xiaoming , SHIBUKAWA Tetsuro , HATTORI Kazuya , TOYAMA Taizo , OTSUBO Kazuyoshi , TSUTSUMI Masaomi

    This paper uses HexaM made by Toyoda Machine Works Co. as an analytical model of parallel mechanism type machine tools. Much collision may be generated for its complicated structure and working space, when a workpiece is machined using this machine. For example, those collisions are generated between the moving components of the parallel mechanism, between the moving components and a workpiece and between the moving components aril the tool storage for automatic changing. In this paper, an algorithm for detecting and avoiding those collisions are proposed. The method for avoiding the collisions is conducted by readjusting the location of the workpiece without amending the tool path. It is confirmed through experimental works that the proposed algorithm is useful to detect the collisions prior to the actual machining.

    Journal of the Japan Society for Precision Engineering 67(1), 86-90, 2001-01-05

    J-STAGE  References (6)

  • Annotated Checklist of the Deepwater Fishes from Tosa Bay, Japan

    SHINOHARA G. , Endo Hiromitsu , Matsuura Keiichi , Machida Yoshihiko , Honda Hitoshi

    Deepwater fishes were collected by trawl from Tosa Bay off the Pacific coast of Shikoku Island, Japan, during the periods from 1997 to 2000. The specimens plus subsequent literature survey resulted in 599 deepwater fish species for the region. This figure is much greater than the 487 species recorded of Suruga Bay, Honshu, based on the 1997 report by the National Science Museum.

    National Science Museum Monographs 20, 283-343, 2001

    Cited by (8)

  • <Bull. Natn. Sci. Mus., Tokyo>Terrestrial Globe Made by Harumi Shibuawa in Edo Era and Making of its Replica  [in Japanese]

    SAIJO Keiichi

    Terrestrial globe made by Harumi Shibukawa at 1695 in Edo era, in the possesion of National Science Museum, is the oldest terrestrial globe remainning in Japan made by Japanese manufacturers. Harumi Shibukawa (1639-1715) is first official astronomer in the Tokugawa shogunate. He carried out geographic research together with astronomical ones. Therefore, this globe is expected to reflect his research and was registered as an important caltural property in 1990. Accompanied with this registration, making of its replica for exhibition was planned but materialized last year. In this paper, I describe several characteristics of this globe and the process of making replica.

    Bulletin of the National Science Museum Ser. E Physical Sciences & Engineering 24, 13-24, 2001

  • CHARCTERIZATION OF UDP-GLUCURONOSYLTRANSFERASES (UGTS) INVOLVED IN THE METABOLISM OF TROGLITAZONE IN RATS AND HUMANS

    YOSHIGAE Yasushi , KONNO Kumiko , TAKASAKI Wataru , IKEDA Toshihiko

    UDP-glucuronosyltransferases(UGTs)involved in troglitazone glucuronidation in rats and humans have been characterized to support the previous toxicity study on troglitazone in Gunn rats and to examine whether the UGT polymorphism or inhibition of bilirubin metabolism is related to the clinically reported rare cases of liver failure. The experiments using Gunn rats revealed that UGT1 enzymes are not involved in troglitazone glucuronidation and that the responsible enzyme in rats was suggested to be UGT2B2, an androsterone UGT, by inhibition sudies. In humans, contribution of UGT1A1 was estimated to be about 30% of the total troglitazone glucuronidation by UGTs, using human liver microsomes and recombinant UGTs. Other UGT1 and UGT2 enzymes seem to be responsible for the rest of the troglitazone glucuronidation in humans. The multiplicity of UGTs involved in troglitazone glucuronidation in humans may allow even patients lacking bilirubin UGT(UGT1A1)activity to produce troglitazone glucuronide. These observations suggest that the polymorphism of UGT is not the reason behind the liver failure induced by the troglitazone treatment, and troglitazone does not inhibit bilirubin glucuronidation in clinical treatment. In addition, the increased bilirubin level in the blood of patients who have troglitazone-induced liver failure is a consequence of liver injury and not due to inhibition of bilirubin glucuronidation by troglitazone.

    The Journal of Toxicological Sciences 25(5), 433-441, 2000-12-01

    J-STAGE  Ichushi Web  References (32) Cited by (1)

  • Type Collection in the Herbarium of National Science Museum, Tokyo(TNS) Plantaginales, Dipsacales and Campanulales

    Koyama Hiroshige

    This is a list of the type collection of Plantaginales, Dipsacales and Campanulales in the Herbarium of National Science Museum, Tokyo (TNS) at Tsukuba campus. Fourty eight type specimens are confirmed. In the Plantaginales, one type is of Plantago. In the Dipsacales, 38 types are of Abelia, Lonicera, Sambucus, Triose-tum, Viburnum and Weigela (Caprifoliaceae), and of Scabiosa (Dipsacaceae). In the Campanulales, 9 types are of Adenophora, Campanula, Codonopsis, Cyananthus and Lobelia (Camapanulaceae).

    Bulletin of the National Science Museum Ser. B Botany 26(4), 155-159, 2000-12

  • Development of High Speed Ball Bearing Spindle for Machining Center  [in Japanese]

    Sugimoto Futoshi , Matsunaga Shigeru , Teramura Tetsuo , Shibukawa Tetsuro

    This paper describes the development of a ultra-high speed spindle using ceramic ball bearing. Recently, rotational speed of ball bearing spindle for machining center must be increased to satisfy the requirement of high-productivity. In this paper, we present two types high speed spindles which are a 50000 (min)^<-1> spindle with a diameter of 50mm, and a 20000 (min)^<-1> spindle with a diameter of 90mm.

    The Proceedings of The Manufacturing & Machine Tool Conference 2000.2(0), 67-68, 2000

    J-STAGE 

  • Correlation of Magnetic Resonance Imaging and Histological Findings in a Large Basilar Tip Aneurysm After Coil Embolization -Case Report-

    ASAI Jun-ichirou , SUZUKI Ryuta , FUJIMOTO Tsukasa , MIYO Takayasu , NAGASHIMA Goro , HOKAKU Hiromu , TAKEI Atsuko , CHANG Chi-wei , KURATA Akira

    A 73-year-old female with a large basilar tip aneurysm underwent endovascular coil embolization with interlocking detachable coils (IDCs). The patient subsequently died of pneumonia 25 days after the embolization, and the aneurysm specimen was obtained at autopsy. Histological examination showed that the intraaneurysmal structure consisted of three layers. The outer layer was mildly organized thrombus surrounding the coils, the middle layer was disorganized clot, and the inner layer consisted of fresh blood clot. Gradient-echo magnetic resonance (MR) imaging taken before death had demonstrated a central region of high intensity and a peripheral low intensity region corresponding to the inner and middle-outer layers of the aneurysm, respectively. Intraaneurysmal placement of IDCs leads to the formation of a clot surrounding the coils. However, clot formation may be inadequate where the packing of the IDCs is incomplete. Comparison of the MR imaging and histological findings in this case show that gradient-echo MR imaging can assess thrombus and residual blood flow within the aneurysm.

    Neurologia medico-chirurgica 40(10), 519-523, 2000-10-15

    J-STAGE  Ichushi Web  References (18)

  • Secondary Metabolism of Dinitrobenzyl Glucuronide Related to Production of Genotoxic Compounds of Dinitrotoluene in Male Wistar Rat

    MORI Masa-aki , SHOJI Miki , SAYAMA Michio , KONDO Takashi , INOUE Masami , KODAIRA Ken-ichi

    Urinary and biliary metabolites of male Wistar rats dosed orally with 2,4-dinitrobenzyl glucuronide (2,4-DNB-G) and 2,6-dinitrobenzyl glucuronide (2,6-DNB-G) which are major compounds excreted in bile after administration of carcinogenic 2,4-dinitrotoluene (2,4-DNT) and 2,6-dinitrotoluene (2,6-DNT) were examined by HPLC. The object of this study is to determine whether mutagenic 2,4-dinitrobenzaldehyde (2,4-DNBA1) and genotoxic 2-amino-6-nitrobenzyl alcohol (2A6NB) are produced in the secondary metabolism of 2,4-DNB-G and 2,6-DNB-G. Data from HPLC indicated that 2,4-DNAB1 (about1%), in addition to 2,4-DNB-G (about 8.6%), 2,4-dinitrobenzyl alcohol (2,4-DNB, about 0.1%), two aminonitrotoluenes (about 0.2%), two aminonitrobenzyl alcohols (about 0.1%), 4-acetylamino-2-nitrobenzoic acid (4AA2NBA, about 7.4%) and 4-acetylamino-2-aminobenzoic acid (4AA2ABA, about 1.8%) was excreted in the urine or bile after dosing 2,4-DNB-G. This result, together with previous findings, indicates that 2,4-DNBA1 is produced not only by oxidation of 2,4-DNB formed from 2,4-DNT, but by oxidation of 2,4-DNB formed from 2,4-DNB-G excreted in bile. In addtion, the formation of carcinogenic 2,4-diaminotoluene (2,4-DAT) was ascertained from the metabolic pathway of 2,4-DNB-G based on the metabolites detected. No 2A6NB was found in the urine and bile after dosing 2,6-DNB-G. However, 2-amino-6-nitrobenzoic acid (2A6NBA, about 0.2%), in addition to 2,6-dinitrobenzyl alcohol (2,6-DNB, <0.1%) and 2,6-DNB-G (about 18%), was detected in the urine or bile after dosing 2,6-DNB-G. This result, together with previous findings, indicates that 2A6NB is an intermediate in the production of 2A6NBA from 2,6-DNB, and further suggests that the production of 2A6NB in the metabolism of 2,6-DNT is coupled to the enterohepatic circulation of 2,6-DNB. The results of this investigation suggest that the production of 2,4-DNBA1 and 2,4-DAT, and 2A6NB from 2,4-DNB-G and 2,6-DNB-G may play a role in the hepatocarcinogenicities of 2,4-DNT and 2,6-DNT.

    Journal of Health Science 46(5), 329-335, 2000-10-01

    Ichushi Web  References (25)

  • Study of Kinematic Calibration Method for Parallel Mechanism (2nd Report)-Kinematic Calibration Using Forward Kinematics-  [in Japanese]

    OTA Hiromichi , SHIZBUKAWA Teturo , TOOYAMA Taizo , UCHIYAMA Masaru

    This paper describes a newly developed forward kinematic calibration method for parallel mechanisms which identifies the kinematic parameters using the pose data measured by a Double Ball Bar (DBB) system. The parameter identification procedure using forward kinematics does not require full pose data and, therefore, can make the measurement procedure simple. The measurement using the DBB system allows for large traveling plate orientations and enables simple and precise calibration. The principle of this method is first described, then the validity of this method is presented through simulations and experiments performed on a parallel mechanism based milling machine, named HexaM.

    Journal of the Japan Society for Precision Engineering 66(10), 1568-1572, 2000-10-05

    J-STAGE  References (12) Cited by (8)

  • Preparation of Pb(Zr_<0.53>Ti_<0.47>)O_3 Thick Films by an Interfacial Polymerization Method on Silicon Substrates and Their Electric and Piezoelectric Properties

    TSURUMI Takaaki , OZAWA Shuichi , ABE Goro , OHASHI Naoki , WADA Satoshi , YAMANE Masayuki

    Japanese Journal of Applied Physics Pt. 1 Regular Papers, Short Notes & Review Papers 39(9), 5604-5608, 2000-09-01

    References (30) Cited by (2)

  • Aspects of Japanese Astronomy and its Education in the Genroku Period (1688-1702) : Based on the Records between Jinzan Tani Corresponded with Harumi Shibukawa.  [in Japanese]

    KAWAWADA Akiko

    Harumi Shibukawa accomplished in 1684 the first domestic calendar-reform, the Jyokyo Kaireki that enabled him to get the newly established post in the Tokugawa Shogunate, Tenmon-Kata, specializing in the calender making and astronomical observation. Though several studies have been made on the scientific achievement of Harumi in modern Japan, many of them lack the synthetic approach to the astronomical knowledge at that time, paying little attention to such points as Nee-Confucianism and the social values in Pre-modern Japan. Jinzan Tani, a Confucian scholar who resided in Tosa and had long been eager to take astronomical lecture from Harumi, began in 1694 to correspond with Harumi in Yedo. He mastered all course of Harumi's astronomy in eight years and classified the correspondence under such topics as the reckoning adopted in Jyokyo calendar, the motion of the seven planets, the measuring longitudinal difference between Kyoto and Kagoshima, the phenomena of solar and lunar eclipse and Shintoism. He also compiled some books or rolls. Analysis of these records leads us to understand how the astronomical knowledge was transmitted in the beginning of the 18th century in Japan. Harumi's lecture covered not only the scientific measurements of the time and space but also the metaphysical importance of the pursuit of universe. Also we can see Harumi was under the influence of the thought of Ansai Yamazaki, who had sterted as a Zhuzi Confucian and later formed the Suika-Shintoism that advocated perfect correlation of the Heaven and the Ground. Harumi's pupils transmitted both the astronomical technologies and the knowledge of the Suika-Shintoism to the people in their home country. They contributed much to the education of natural sciences and moralities in the provinces.

    Journal of history of science, Japan. Series II 39(215), 129-143, 2000-09-28

  • A basic study of objective method to diagnose senile dementia of Alzheimer's type by MR brain images  [in Japanese]

    KODAMA Naoki , HIWATASHI Kei , KOBAYASHI Yoshio , SHIMADA Tetsuo , HIYOSHI Isao , SHIBUKAWA Makoto , KAWASE Yasuhiro , OKAMOTO Koichiro , FUKUMOTO Ichiro

    We try to diagnose SDAT by MRI (magnetic resonance imaging) brain images. Ventricular Area Index (VAI) and Hippocampus Area Index (HAI) were calculated for the parameter diagnosing. Axial T2-waighted images and Coronal T1-waited images were obtained in 55 patients with SDAT and 15 control subjects. We have found significant differences between the two groups especially in the VAI and HAI. From these findings it may useful for the objective diagnosis of SDAT by MRI brain images.

    IEICE technical report. ME and bio cybernetics 100(330), 17-22, 2000-09-22

    Ichushi Web  References (15) Cited by (1)

  • Physiologically-based Pharmacokinetic Analysis of Grepafloxacin

    NAKAJIMA Yukiko , HATTORI Kenji , SHINSEI Machido , MATSUNAGA Noriko , IIZASA Hisashi , SASABE Hiroyuki , AKIYAMA Hitoshi , MIYAMOTO Gohachiro , NAKASHIMA Emi

    Grepafloxacin (GPFX) is a synthetic new quinolone antimicrobial agent that possesses an extensive tissue distribution and exhibits a strong antibacterial activity in vivo. In this study, the tissue distribution characteristics of GPFX were examined using tissue concentration-time profiles following intravenous administration to rats. Subsequently, the pharmacokinetics of GPFX were analyzed based on the physiological pharmacokinetic model. The tissue-to-plasma partition coefficients (K<SUB>p</SUB>) of GPFX in rats were high in all tissues except brain. A pharmacokinetic model for rabbits, monkeys and dogs was constructed using the tissue-to-plasma free concentration ratio (K<SUB>p, f</SUB>) of GPFX in rats to simulate the GPFX concentration-time profile in plasma following intravenous administration of GPFX to each animal. The calculation-derived concentrations correlated well with the experimentally-derived data, suggesting that there are no interspecies differences in the high tissue distribution characteristics of GPFX. The clearance rates of GPFX in humans were predicted from the pharmacokinetic parameters of rats, rabbits, monkeys and dogs by an animal scale-up method and a pharmacokinetic model for humans was constructed. The GPFX concentration-time profiles in plasma, following oral administration of GPFX to humans, were predicted within 0.5-1.0 h of mean absorption time and the calculation-derived results were in good agreement with the experimental data. Thus, it is suggested that the concentration-time profile in plasma and all human organs can be predicted from the pharmacokinetic data of animals.

    Biological and Pharmaceutical Bulletin 23(9), 1077-1083, 2000-09-01

    J-STAGE  Ichushi Web  References (24) Cited by (3)

  • Development of a New Herbicide, Nicosulfuron  [in Japanese]

    MURAI Shigeo , SAKASHITA Nobuyuki , HONDA Chimoto

    Journal of pesticide science 25(3), 332-342, 2000-08

    NDL Digital Collections  References (25) Cited by (1)

  • Growth Technique of Ce : YIG Thin Films on Amorphous Substrates  [in Japanese]

    NOGE Satoru , UNO Takehiko

    Cerium substituted yttrium iron garnet (Ce:YIG) is a promising naterial for high performance magneto-optic devices because of its high Faraday rotation coefficient. Ce:YIG was fabricated by only a sputtering process on a garnet substrate such as GGG. This paper presents a method to growth Ce:YIG thin film on an amorphous substrate. The Ce:YIG film was growtn through two steps. The first step was deposition of the amorphous CeY_2Fe_5O_<12> film on a SiO_2 substrate by RF magnetron sputtering process. The second step was crystallization by thermal treatment in vacuum. In the thermal treatment process, a small chip of GGG plate was placed on the film. The treatment temperature was 600 ℃. In spite of placing a small chip of about 1mm^2, the crystallization occurred in a large area of more than 1cm^2. Faraday rotation for the saturated magnetization was about 2.300 deg/mm at 630 nm light wave length.

    IEICE technical report. Component parts and materials 100(271), 43-48, 2000-08-17

    References (8)

  • Optical Memory Media Based on Excitation-Time Dependent Luminescence from a Thin Film of Semiconductor Nanocrystals

    MAENOSONO Shinya , DUSHKIN Ceco Danov , SAITA Soichiro , YAMAGUCHI Yukio

    Japanese Journal of Applied Physics Pt. 1 Regular Papers, Short Notes & Review Papers 39(7), 4006-4012, 2000-07-01

    References (20)

  • Clinical use of Astragali root and Hedysari root and these pharmacological studies  [in Japanese]

    SONG Qing-Hua , ITOKAZU Nanae , CYONG Jong-Chol

    The formulations group of tonic actions in Kampo medicine, called "hozai", are in the limelight recently. Especially, formulations including Astragali root (黄耆 , Huang Qi ; Ougi) which is represented in Jingi-zai (参耆剤) (formulations including Ginseng root with Astragali root) play important role in the treatment of elderly patients. There are two herbs which have been used as Ougi, Astragali root and Hedysari root (晋耆 , Jing Qi ; Shingi) . Although Astragali root and Hedysari root have no similarity botanically, they have been used as comparatively in the clinical scene and even historically, Hedysari root was regarded as being better than Astragalus root. There is no systematic review which explicates the difference and similarity of the two herbs. In this report, we attempt to compare Astragalus root and Hedysari root clinically and pharmacologically, and discuss about the historical and theoretical basis of their clinical applications.

    和漢医薬学雑誌 = Journal of traditional medicines 17(3), 101-107, 2000-06-30

    NDL Digital Collections  Ichushi Web  References (51) Cited by (1)

  • <Original Paper>Quantitative Analysis of Creatinine and the Metabolites of Toluene and Styrene by High-Performance Capillary Electrophoresis  [in Japanese]

    FUJII Toshiko , KAWABE Satoko

    The aim of this study was to assess the possibility of using high-performance capillary electrophoresis ( HPCE ) to determine the urinary metabolites of toluene and styrene in the field of occupational hygiene, while at the same time determining the endogenous urinary metabolite, creatinine. HPCE was used to determine creatinine and hippuric acid in the urine specimens of 56 subjects exposed to toluene vapors, and urinary creatinine and mandelic acid of 13 subjects exposed to styrene vapors. The compounds were well separated from each other on a fused silica capillary utilizing a 20mM sodium tetraborate buffer ( pH 9.65 ) with 15mM β-cyclodextrin. Separation was achieved with a constant voltage of 15kV with a current of 50-55μA and UV absorption was determined at 200 and 225nm. Results obtained with the cyclodextrin electrokinetic chromatography ( CDEKC ) method showed a good correlation with those by the high-performance liquid chromatography( HPLC )method with respect to urinary concentrations of creatinine, hippuric acid and mandelic acid. Furthermore, urinary creatinine concentrations determined by CDEKC correlated well with those determined by the Folin method.

    Kawasaki medical welfare journal 10(1), 147-154, 2000

    IR  DOI  Ichushi Web 

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