Search Results 1-20 of 40

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  • Comprehensive toxicity evaluation of cyclopentyl methyl ether (CPME) for establishing a permitted daily exposure level

    Inoue Kaoru , Suzuki Hiroshi , Yamada Takashi

    … <p>Cyclopentyl methyl ether (CPME, CAS No. 5614-37-9) is used as an alternative to other ethereal solvents in pharmaceutical chemical process development. … Sprague-Dawley (SD) rats were treated with CPME by gavage at doses of 50, 150, or 450 mg/kg/day in the reproductive/developmental toxicity study or at doses of 15, 150, and 700 mg/kg/day in the 28-day study. …

    Fundamental Toxicological Sciences 6(5), 145-165, 2019

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  • Genotoxicity evaluation of oil prepared from the internal organs of the Japanese giant scallop (<i>Patinopecten yessoensis</i>)

    Sugimoto Koki , Hosomi Ryota , Fukunaga Kenji , Shimono Takaki , Kanda Seiji , Nishiyama Toshimasa , Yoshida Munehiro , Yoshioka Takeya , Takahashi Koretaro

    … <p>Discarded scallop internal organs, especially the hepatopancreas, are rich in n-3 polyunsaturated fatty acids such as eicosapentaenoic acid and docosahexaenoic acid. … We have successfully prepared a high-quality scallop oil (SCO) from the internal organs of the Japanese giant scallop (<i>Patinopecten yessoensis</i>), including the hepatopancreas without Cd and DST. …

    Fundamental Toxicological Sciences 6(4), 137-143, 2019

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  • Genotoxicity and subchronic toxicity studies of <i>Taiwanofungus camphoratus</i> extract

    Lin Jian-Yu , Chen Mei-Chun , Chiu Emerson

    … <p><i>Taiwanofungus camphoratus</i> … is an edible and medicinal mushroom originating in Taiwan. … Several researches have revealed <i>T. … camphoratus</i> … Recently, it has been widely used in food supplements and drug development for its health benefits and medicinal properties. …

    Fundamental Toxicological Sciences 6(3), 81-106, 2019

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  • Effect of the metabolic capacity in rat liver S9 on the positive results of <i>in vitro</i> micronucleus tests

    Kishino Yuki , Hasegawa Tomoko , Arakawa Shingo , Shibaya Yukari , Yamoto Takashi , Mori Kazuhiko

    … <p>A high incidence of positive results is obtained with <i>in vitro</i> … genotoxicity tests, which do not correlate with the <i>in vivo</i> … negative results in many cases. … Furthermore, the <i>in vitro</i> …

    The Journal of Toxicological Sciences 44(3), 145-153, 2019

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  • Genotoxicity Evaluation of a Quercetin Glucoside, alpha-Glycosyl Isoquercitrin  [in Japanese]

    KOYANAGI Mihoko , HOBBS Cheryl , SWARTZ Carol , DAVIS Jeffrey , RECIO Leslie , KASAMOTO Sawako , MARONPOT Robert R , HAYASHI Shim-mo

    … However, incorporation of natural quercetin glycosides into food and beverage products has been limited by poor miscibility in water. … Enzymatic conjugation of multiple glucose moieties to isoquercitrin to produce <i>alpha</i>-glycosyl isoquercitrin (AGIQ) enhances solubility and bioavailability. … AGIQ is used in Japan as a food additive and has been granted generally recognized as safe (GRAS) status by US-FDA. …

    Annual Meeting of the Japanese Society of Toxicology 45.1(0), O-31, 2018

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  • Genetic, acute and subchronic toxicity studies of matured hop extract produced by extraction from heat-treated hops

    Suzuki Shigeo , Morimoto-Kobayashi Yumie , Takahashi Chika , Taniguchi Yoshimasa , Katayama Mikio

    … <p>It has been demonstrated that successive ingestion of matured hop extract (MHE), produced by extraction from heat-treated hops, results in body fat reduction in animals and humans; … In this study, we conducted <i>in vitro</i> … and <i>in vivo</i> …

    The Journal of Toxicological Sciences 43(7), 473-484, 2018

    J-STAGE  Ichushi Web 

  • Genotoxicity testing of the natural food colorant, gardenia blue, and its derivation precursor, genipin  [in Japanese]

    KOYANAGI Mihoko , HOBBS Cheryl A , SWARTZ Carol , DAVIS Jeffrey , MARONPOT Robert R , RECIO Leslie , HAYASHI Shim-mo

    … Gardenia blue is widely used in Eastern Asia as a natural food colorant. … The genotoxic potential of gardenia blue, and genipin, the natural starting material for its production, was evaluated in a GLP- and OECD-compliant test battery. … No evidence of mutagenicity of gardenia blue was measured in a 5-strain Ames assay, with or without metabolic activation; …

    Annual Meeting of the Japanese Society of Toxicology 44.1(0), O-12, 2017

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  • Validation of retrospective evaluation method for false genotoxic chemicals with strong cytotoxicity: re-evaluation using <i>in vitro</i> micronucleus test

    Fujita Yurika , Ito Yuichi , Morita Osamu , Honda Hiroshi

    … <p>To reduce the false positives in <i>in vitro</i> … mammalian genotoxicity tests for chromosomal damage, which is caused by severe cytotoxicity, OECD test guidelines have adopted new cytotoxicity indices, and we developed a retrospective evaluation workflow that can be used to identify false positives that are ultimately deemed negative when the new indices are used. …

    Fundamental Toxicological Sciences 3(6), 251-256, 2016

    J-STAGE  Ichushi Web 

  • Ethoxyquin:Summary

    Food Safety Commission of Japan

    … The data from all the <i>in vitro</i> … reverse mutation tests were negative, while positive results were obtained in chromosomal aberration tests using Chinese hamster ovary cells and human peripheral blood lymphocytes and also in the mouse lymphoma TK test. …

    Food Safety 2(1), 14-15, 2014

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  • Genotoxicity of Rice Bran Oil Extracted by Supercritical CO<sub>2</sub> Extraction

    Choi Jae-Suk , Cheon Eun Jin , Kim Tae-Uk , Moon Woi-Sook , Kim Joo-Wan , Kim Mi-Ryung

    … extraction (RB-SCE) reportedly exhibits pharmacological activities such as antioxidant and <i>in vivo</i> … The aim of this study was to investigate the potential genotoxic effects of RB-SCE in three short-term mutagenicity assays (bacterial reverse mutation assay, <i>in vitro</i> …

    Biological and Pharmaceutical Bulletin 37(12), 1963-1970, 2014

    J-STAGE  Ichushi Web 

  • Toxicological Assessment of Chinese Cherry (<i>Cerasus Pseudocerasus</i> L.) Seed Oil

    Chen Qian , Yin Yanlei , Zhu Chuanhe , Yu Guoyong

    … The potential toxic properties and safety of Chinese cherry seed oil (CSO) were investigated by <i>in vitro</i> … and <i>in vivo</i> … The acute oral toxicity study revealed no significant difference for the macroscopic results, the mortality and the body weight gain at 4000 mg CSO/kg bw (<i>p</i> …

    Food Science and Technology Research 20(1), 101-108, 2014

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  • Genotoxicity studies of 2,6-dinitrotoluene (2,6-DNT)

    SUZUKI Hiroshi , IMAMURA Tadashi , KOEDA Akiko , MORIMOTO Kiyoshi , WAKASA Yoshio , TAKEI Yoshihiro , AMEMIYA Rie , HATAKEYAMA Hirofumi , SATOH Hiroshi , SATO Shin-ichi

    … The potential genotoxicity of the rodent liver carcinogen 2,6-dinitrotoluene (2,6-DNT) was evaluated in compliance with the guidelines for genotoxicity studies of drugs (Notification No. 1604, Nov. 1, 1999, Ministry of Health and Welfare, Japan) and the OECD guidelines for the testing of chemicals by performing the bacterial reverse mutation (Ames) assay, the <i>in vitro</i> …

    The Journal of Toxicological Sciences 36(4), 499-505, 2011-08-01

    J-STAGE  Ichushi Web  References (18)

  • Evaluation of high-throughput screening in vitro micronucleus test using fluorescence-based cell imaging system.  [in Japanese]

    Shibai Aya , Kakinuma Chihaya , Hioki Takanori , Kasahara Toshihiko

    … <I>in vitro</I>小核試験は遺伝毒性の検出に重要な試験法であり、染色体異常試験の代替法として使用されている。 … そこで、我々は共焦点イメージングプレートリーダーIN Cell Analyzer1000を使って小核試験のバリデーション試験を実施した。 …

    Annual Meeting of the Japanese Society of Toxicology 38(0), 20163-20163, 2011

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  • Genotoxicity Evaluation of Carbon Nanotubes  [in Japanese]

    … The present paper summarizes the data available in the literature concerning the genotoxicity of carbon nanotubes(CNTs), whose potential applications and uses are wide and varied, including CNT-enhanced plastics, electromagnetic interference/radio-frequency (EMI/RFI)shielding, antistatic material, flexible fibers and advanced polymers, medical and health applications, and scanning probe microscopy. … All data in this review were previously published in openly available scientific literature. …

    Japanese Journal of Environmental Toxicology 14(1), 81-97, 2011

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  • Indium Chloride-induced Micronuclei in In Vivo and In Vitro Experimental Systems

    Takagi Ryo , Suzuki Yuji , Seki Yoshiko , Ikehata Masateru , Kajihara Chieko , Shimizu Hidesuke , Yanagisawa Hiroyuki

    … InCl<sub>3</sub>) using the <i>in vivo</i> … bone marrow micronucleus test and the <i>in vitro</i> … CHL/IU cell micronucleus test. …

    Journal of Occupational Health 53(2), 102-109, 2011

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  • The use of an automated hematology analyzer to observe cell growth in the chromosome aberration test using human lymphocytes

    OGAWA Izumi , FURUKAWA Satoshi , ABE Masayoshi , HAGIO Soichiro , HAYASHI Seigo , USUDA Koji

    … Human lymphocytes have been frequently used for <i>in vitro </i>chromosome aberration or micronucleus tests on whole-blood culture. …

    The Journal of Toxicological Sciences 35(6), 923-927, 2010-12-01

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  • Mutagenic and Antimutagenic Effects of the Traditional Herb Used for Treating Erectile Dysfunction, Butea superba Roxb

    CHERDSHEWASART Wichai , SUTJIT Wandee , PULCHAROEN Kade , CHULASIRI Malyn

    … <I>Butea superba</I> … We investigated the mutagenic and antimutagenic potentials of a <I>B. … superba</I> … extract by using the pre-incubation method of the Ames test. … <I>Salmonella typhimurium</I> … strains TA 98 and TA 100 were applied as the tester strains in the presence and absence of an S9 mixture. …

    Bioscience, Biotechnology, and Biochemistry 74(5), 923-927, 2010-05-23

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  • Genotoxicity and Cytotoxicity of Multi-wall Carbon Nanotubes in Cultured Chinese Hamster Lung Cells in Comparison with Chrysotile A Fibers

    ASAKURA Masumi , SASAKI Toshiaki , SUGIYAMA Toshie , TAKAYA Mitsutoshi , KODA Shigeki , NAGANO Kasuke , ARITO Heihachiro , FUKUSHIMA Shoji

    … The present study was designed to examine the <i>in vitro</i> … Cytotoxicity using both colony formation and lactate dehydrogenase (LDH) assays and genotoxicity including chromosome aberration, micronucleus induction and <i>hgprt</i> …

    Journal of Occupational Health 52(3), 155-166, 2010-05-01

    J-STAGE  Ichushi Web  References (36)

  • In vitro and in vivo evaluation of mutagenicity of fucoxanthin (FX) and its metabolite fucoxanthinol (FXOH)

    BEPPU Fumiaki , NIWANO Yoshimi , SATO Emiko , KOHNO Masahiro , TSUKUI Takayuki , HOSOKAWA Masashi , MIYASHITA Kazuo

    … Mutagenicity of fucoxanthinol (FXOH), the major compound after oral ingestion of fucoxanthin (FX), was evaluated by <i>in vitro</i> … Ames test, and of FX by <i>in vivo</i> … micronucleus test. … In<i> …

    The Journal of Toxicological Sciences 34(6), 693-698, 2009-12-01

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  • Multi-endpoint genotoxic assay using L5178Y (Tk^<+/->-3.7.2c) cells

    OGAWA Izumi , FURUKAWA Satoshi , ABE Masayoshi , TANAKA Yoshinori , HAYASHI Seigo , USUDA Koji

    … When the mouse lymphoma <i>Tk</i> … assay<i> … </i>(MLA) provides a positive result, its cause can be roughly estimated by examining colony sizes. … An increase in the number of large colonies means that the compound tested has point mutational potential, while an increase in small colonies indicates the potential for chromosome aberration. …

    The Journal of Toxicological Sciences 34(5), 547-553, 2009-10-01

    J-STAGE  Ichushi Web  References (18)

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