Search Results 1-20 of 41

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  • A clinical study on levofloxacin concentration in the skin on antibiotic prophylaxis for outpatient surgery.  [in Japanese]

    Nakatani Yoshihiro , Uchiyama Kazuhisa , Tanimura Hiroshi

    The growing use of outpatient surgery has necessitated antibiotic agents having good tissue penetration after oral administration. We studied the skin penetration of levofloxacin, an oral fluoroquinol …

    Japanese Journal of Chemotherapy 50(4), 223-226, 2002

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  • Clinical study of pazufloxacin mesilate, a new quinolone antibacterial agent, in burn infections and tissue concentrations.  [in Japanese]

    Sugihara Tsuneki , Takeno Naokazu , Kimura Chu , Tsutsumida Arata , Yoshida Tetsunori , Minagawa Hidehiko , Kawashima Kunihiro , Horiuchi Katsumi , Honda Kouichi , Takeuchi Akiteru , Homma Kenichi , Maeda Kazuhiko

    To evaluate the efficacy, safety, and utility of pazufloxacin mesilate (PZFX, injectable), an injectable new quinolone antibiotic, a phase III clinical study was conducted in patients with burn infect …

    Japanese Journal of Chemotherapy 48(6), 401-416, 2000-06-25

    J-STAGE  Ichushi Web  References (15) Cited by (2)

  • Basic and clinical evaluations of NM441, a prodrug new quinolone, in dermatology  [in Japanese]

    ARATA Jiro

    We studied NM441, the prodrug of active form NM394, and obtained the following results.<BR>1) Skin penetration of NM441 was examined using exudates from skin lesions and skin samples from skin s …

    Japanese Journal of Chemotherapy 44, 509-517, 1996-03-01

    J-STAGE  Ichushi Web  References (16) Cited by (2)

  • Basic study on pazufloxacin in the field of dermatology  [in Japanese]

    AKIYAMA Hisanori , TORIGOE Rikako , KANZAKI Hiroko , ARATA Jiro

    1. Minimum inhibitory concentrations (MICs)(inoculum size 10<SUP>4</SUP> CFU/well) of pazufloxacin (PZFX), ofloxacin (OFLX), and tosufloxacin (TFLX) were determined against 62 isolates of …

    Japanese Journal of Chemotherapy 43, 126-127, 1995-09-25

    J-STAGE  Ichushi Web  References (3)

  • Skin pentetration of grepafloxacin and its clinical use in the treatment of skin and skin struture infections  [in Japanese]

    ARATA Jiro , MATSUURA Yoshiko , AKIYAMA Hisanori , OGAWARA Akira , KOIZUMI Hiroko , ISHIBASHI Yasumasa , IOZUMI Ken , TAMAKI Takeshi , NAKAMURA Koichiro , TAKEHARA Kazuhiko , TAKAHASHI Hisashi , WATANABE Shin-ichi , OHNISHI Takamitsu , NIIMURA Michihito , KAMIDE Ryoichi , YAGINUMA Taketoshi , SAWADA Shunichi , YOKOI Kiyoshi , NOMURA Nakao , URUSHIBATA Osamu , MAKINO Sagae , SAITO Ryuzo , HARADA Shotaro , NAKANISHI Hiroshi , KOMINE Mayumi , ABE Masanori , TOMIZAWA Takanori , YAMADA Kouji , WATABE Yoshihiro , MORI Shunji , NANBA Tadashi , HORIGUCHI Yuji , TACHIBANA Takao , TANAKA Toshihiro , FURUKAWA Fukumi , DANNO Kiichiro , IKAI Koichi , IMAMURA Sadao , OKUDA Yoshiharu , YASUNO Hirokazu , ASADA Yasuo , HORIO Takeshi , NISHIJIMA Setsuko , ISEI Taiki , KUROKAWA Ichiro , UOI Miyuki , URANO Yoshio , SASAKI Shiro , KANNO Yoshiyuki , ARASE Seiji , KODAMA Hajime , IKEDA Masami , HORI Yoshiaki , NAKAYAMA Juichiro , YASUMOTO Shinichiro , NAGAE Shonosuke , TASHIRO Masaaki , SETOYAMA Mitsuru , HAMADA Tetsu , KANZAKI Tamotsu

    日本化学療法学会雜誌 = Japanese journal of chemotherapy 43, 468-480, 1995-07-31

    Ichushi Web  References (20) Cited by (1)

  • Dermatological evaluation of pazufloxacin, a new fluoroquinolone, in a multicenter clinical trial  [in Japanese]

    Arata Jiro

    Pazufloxacin (PZFX), a new fluoroquinolone antimicrobial agent, was examined in the field of dermatology in terms of its efficacy, safety, and usefulness in a multicenter clinical trial. Patients with …

    Japanese Journal of Chemotherapy 43(Supplement2), 459-472, 1995

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  • Skin penetration of grepafloxacin and its clinical use in the treatment of skin and skin structure infections  [in Japanese]

    Arata Jiro

    In a multicenter clinical trial, grepafloxacin (GPFX), a new fluoroquinolone, was examined in terms of its skin penetration and its clinical efficacy in the treatment of skin and skin structure infect …

    Japanese Journal of Chemotherapy 43(Supplement1), 468-480, 1995

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  • STUDIES ON ASPDXICILLIN FOR ITS TRANSFER TO THE SKIN  [in Japanese]

    KUROKAWA MASATO , NAITO MOTOKO , SAWABE KAZUMA , YONEMURA NOBUYOSHI , SUZUKI SHIGEHIKO , MATSUDA KAZUYA , NAKAMURA AKITO , MATSUSHITA YOJI , KITAHARA KIYOSHI , AOKI HISANAO , OTA MASAYOSHI , TAKABA KIYOAKI

    To evaluate the usefulness of aspoxicillin (ASPC) in the field of plastic ana reconstructive surgery, we examined its transfer to the skin.<BR>1. After intravenous drip infusion of ASPC for 1 ho …

    The Japanese Journal of Antibiotics 47(2), 215-218, 1994

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  • Biapenem in the field of dermatology

    Arata Jiro

    The minimum inhibitory concentrations (MICs)(10<SUP>6</SUP>CFU/ml) of biapenem (BIPM), imipenem (IPM) and flomoxef (FMOX) were determined against 113 strains of <I>Staphylococcus aur …

    CHEMOTHERAPY 42(Supplement4), 620-625, 1994

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  • Evaluation of FK037 in dermatology

    Arata Jiro

    FK037, a new parenteral cephalosporin, was evaluated from the dermatological aspects.<BR>1) Minimum inhibitory concentrations (MICs) of FK037, imipenem (IPM) and flomoxef (FMOX) were determined …

    CHEMOTHERAPY 42(Supplement3), 375-382, 1994

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  • Tazobactam/piperacillin in the field of dermatology

    Kanzaki Hiroko , Asada Yasuo , Torigoe Rikako , Arata Jiro , Suzuki Taku , Ohsumi Masayoshi , Inoue Chiyuki , Takahashi Hisashi , Uoi Miyuki , Nose Kyoko

    1. The minimum inhibitory concentrations (MICs) (10<SUP>4</SUP> CFU/ml) of tazobactam/piperacillin (TAZ/PIPC) and piperacillin (PIPC) were determined against 79 strains of <I>Staphyl …

    CHEMOTHERAPY 42(Supplement2), 666-670, 1994

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  • Loracarbef in superficial skin infections

    Tomizawa Takanori , Yamada Koji , Watabe Yoshihiro

    The results of clinical trials and laboratory examination of loracarbef (LCBF) are summarized as follows:<BR>1. The skin and plasma concentrations of LCBF were 0.24-3.70 μg/g and 1.27-9.97 &m …

    CHEMOTHERAPY 41(Supplement3), 371-379, 1993

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  • Clinical trial of S-1108 in the dermatological field

    Watanabe Shinichi , Kashima Masato , Okuda Masaru , Takahashi Hisashi

    1) Serum and skin concentrations of S-1006 after a single oral dose of S-1108 (75mg or 150 mg) were determined in patients undergoing skin surgery. The skin/serum concentration ratios were 0.27-2.33 ( …

    CHEMOTHERAPY 41(Supplement1), 866-869, 1993

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  • Laboratory and clinical studies on S-1108 in bacterial skin infection

    Tomizawa Takanori , Kondou Sigeo , Yamada Kouji , Washizaki Kumiko

    We studied S-1108, a new oral cephem, for its clinical efficacy and safety, of thirty-five patients with bacterial skin infection were given S-1108 orally in a daily dose of 225mg-450mg for 5-1 days a …

    CHEMOTHERAPY 41(Supplement1), 499-505, 1993

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  • Tissue Penetration of Ofloxacin to Cutaneous Ulcer Lesion.  [in Japanese]

    NAKAGAWA Koichi , HAMADA Toshio

    Skin tissue and serum concentration of ofloxacin (OFLX) in five patients associated with cutaneous ulcer lesion was studied. The concentration of OFLX was determined by high-performance liquid chromat …

    Skin research 35(4), 527-532, 1993

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  • Study of therapy effects on a skin infectious disease of Banan tablet.  [in Japanese]

    西嶋 攝子 , 赤井 容子 , 増田 理恵 , 為政 大機 , 朝田 康夫 , 杉山 徹 , 尾高 達男 , 白井 教文 , 松村 比呂江 , 伊庭 仁樹 , 中川 裕美

    … またバナン<SUP>®</SUP>錠単回投与120分後, 180分後に血清中および皮膚組織内濃度の測定を行った。 … 血中濃度と皮膚組織内濃度比は, 平均で18.4%と良好であり, 本剤の皮膚組織内移行も良好と考えられた。 …

    Nishi Nihon Hifuka 54(1), 125-128, 1992

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  • MEROPENEM IN THE FIELD OF DERMATOLOGY

    Kanzaki Hiroko , Miyoshi Kaoru , Katayama Haruko , Nakakita Takashi , Umemura Shigeo , Akagi Osamu , Torigoe Rikako , Yamada Taku , Abe Yoshiko , Shimoe Keisei , Akiyama Hisanori , Arata Jiro , Masuda Toshiki , Nishihara Osami

    The minimum inhibitory concentrations (MICs)(10<SUP>6</SUP> CPU/ml) of meropenem (MEPM) and imipenem (IPM) were determined against 123 strains of <I>Staphylococcus aureus</I> i …

    CHEMOTHERAPY 40(Supplement1), 751-754, 1992

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  • SKIN TISSUE CONCENTRATION AND CLINICAL EVALUATION OF MEROPENEM

    Nakanishi Hiroshi , Tamaki Takeshi , Minami Haruo , Komine Mayumi , Harada Shotaro

    We performed fundamental and clinical studies on meropenem (MEPM), a new carbapenem derivative, with the following results.<BR>The plasma concentration of MEPM was 1.16-13.1 μg/ml, and the co …

    CHEMOTHERAPY 40(Supplement1), 746-750, 1992

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  • Fundamental and Clinical Studies of Fleroxacin(FLRX)in the Field of Dermatology.  [in Japanese]

    TAKAHASHI Hisashi , IMAKADO Sumihisa , SAITO Ryuzo , URUSHIBATA Osamu , HORIE Koji , ANZAI Takashi , JITSUKAWA Kumiko , OHARA Kuniaki , ONISHI Takamitsu , HARADA Shotaro , MINAMI Haruo , TAKAHAMA Hideto , TAMAKI Tsuyoshi , NAKANISHI Hiroshi , TOMIZAWA Takanori , MUKAI Hideki , YAMADA Koji , NAKAJIMA Hiroshi , ICHIYAMA Shinichi , BABA Naoko , KODAMA Hajime , YAMAMOTO Yasuo , ARATA Jiro , IKEDA Masami , AKIYAMA Hisanori , ISHIBASHI Akira , HIRUMA Seitaro , ISHIBASHI Yasumasa , NAKAGAWA Hidemi , SHIMOZUMA Michiro

    Fundamental and clinical studies on Fleroxacin (FLRX), a new quinolone derivative, were conducted in relation to its application to the field of dermatology. The skin concentrations of FLRX in 12 case …

    Nishi Nihon Hifuka 53(3), 571-582, 1991

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  • SKIN TISSUE TRANSFER OF FLEROXACIN AND ITS CLINICAL EFFICACY IN DERMATOLOGY

    TOMIZAWA TAKANORI , MUKAI HIDEKI , YAMADA KOJI

    The results of laboratory examination and clinical trials of fleroxacin are summarized as follows:<BR>1. Skin, intra-blister and serum concentrations 3-4 h a ter a single oral administration of …

    CHEMOTHERAPY 38(Supplement2), 614-621, 1990

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