Search Results 1-6 of 6

  • Genetic Analysis and Direction of Basic Research in Glioma(<Special Issue>Current Status and Perspectives of Treatment for Glioma)  [in Japanese]

    Nakamura Hideo , Kuratsu Jun-ichi

    … ている遺伝子の解析もTCGAのサンプルを用いて行われ,臨床的な治療反応性との関連性が示唆された.今回,代表的なグリオーマの遺伝子,染色体異常として1p/19q LOH, IDH1/2 mutation, BRAFの異常などが選択された.1p/19q LOHは,oligodendroglioma系の腫瘍で頻度が高く,この染色体異常が存在するとgenotoxicな治療に対する反応性がよいと言われている.IDH1は,grade 2/3のグリオーマに …

    Japanese Journal of Neurosurgery 21(3), 216-223, 2012

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  • Histopathological diagnosis and genetic analysis for malignant glioma treatment

    Nakamura Mitsutoshi , Yamada Shuichi , Matsuda Ryosuke , Sugimoto Tadashi , Nakase Hiroyuki

    … The current practice of relying solely on microscopic examinations for histological classification of gliomas and, consequentially, determination of optimal treatment, appears to be insufficient. … As a result of the increasing use of molecular markers in tumor classification, there is an emerging emphasis in the genetic profiles of distinct subtypes of glioma. …

    Progress in Neuro-Oncology 19(1), 12-18, 2010

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  • Clinicopathological diagnosis of gliomas by genotype analysis  [in Japanese]

    中村 光利 , 島田 啓司 , 中瀬 裕之 [他]

    Brain and nerve 61(7), 773-780, 2009-07

    Ichushi Web 

  • Analysis of the specific proteins in gliomas using fully automated two-dimensional gel electrophoresis system.  [in Japanese]

    Tsubota Nobuyuki , Sasaki Noriko , Yano Kazuyoshi , Sakairi Koji , Ueyama Kosuke , Nakamura Makoto , Yokayama Kenji , Nakamura Hideo , Kuratsu Junichi , Araki Norie , Morikawa Takashi , Kobayashi Daiki , Kinoshita Hideki , Sakaguchi Nao , Hiratsuka Atsunori , Maruo Yuji , Midorikawa Uichi , Unuma Yutaka

    … We have developed a fully automated two-dimensional gel electrophoresis system (auto-2D system) which makes tissue/cellular protein analysis by 2D-PAGE and 2D-western blotting more simple, quick, sensitive, and reproducible with a small volume of sample within 2 hrs, thus, being expected as a convenient clinical analysis tool for the personal diagnosis. … In this study, we utilized this system for the analysis of brain tumor specific proteins. …

    Abstracts for Annual Meeting of Japanese Proteomics Society 2008(0), 28-28, 2008

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  • Efficacy of Temozolomide Is Correlated With 1p Loss and Methylation of the Deoxyribonucleic Acid Repair Gene MGMT in Malignant Gliomas

    ISHII Dai , NATSUME Atsushi , WAKABAYASHI Toshihiko , HATANO Hisashi , ASANO Yoshio , TAKEUCHI Hiroki , SHIMATO Shinji , ITO Motokazu , FUJII Masazumi , YOSHIDA Jun

    … Promoter methylation of the deoxyribonucleic acid (DNA) repair gene, O<sup>6</sup>-methylguanine-DNA methyltransferase (MGMT), is associated with improved outcome of patients with glioblastoma multiforme and anaplastic astrocytoma treated with temozolomide (TMZ). …

    Neurologia medico-chirurgica 47(8), 341-349, 2007-08-15

    J-STAGE  Ichushi Web  References (36)

  • Genetic Analysis in Intracranial Tumors and Its Clinical Significance  [in Japanese]

    MARUKAWA Kohei

    … p53遺伝子変異を解析した.又,それらのデータを基に,形態学的に確定できなかった大脳実質腫瘍2例に対し,遺伝学的解析を行った.OL,OAでは,LOH 1p,19qが高頻度に認められたが,p53遺伝子変異は比較的稀であった.CN,DNTでは,LOH 1p,19q,p53遺伝子変異はどれも検出されず,遺伝学的にはOL,OAとは異なる腫瘍と考えられた.病理組織学的に鑑別が困難であった症例の確定診断に,遺 …

    Journal of the Juzen Medical Society 111(1), 44-53, 2002-02-20

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