Search Results 1-20 of 21

LU Kuiqing , LI Yun , BAO Qilin , WANG Dan , NING Yanhua , XIE Xuejian , ZHOU Mingming , ZHOU Linhua , ZENG Xiang , SHAN Jingyan

… In the ATRA-experiment, ATRA suppressed the expression of IL-6, TNF-α, NO, a disintegrin and metalloprotease with thrombospondin motifs-4 (ADAMTS-4), MMP-3, and MMP-9. …

Journal of Nutritional Science and Vitaminology 65(1), 8-18, 2019

J-STAGE  Ichushi Web 

UNNO Hironori , 長谷川 正裕 , 鈴木 慶亮 , 松井 佑梨世 , 湏藤 啓広 , 今中（吉田） 恭子 , 吉田 利通

… The control group had injection of phosphate buffered saline (PBS) (group Ⅱ).</p><p> Mice were sacrificed at 4 days, 2 weeks, and 4 weeks postoperatively. … We evaluated the expression of TNC, inflammatory cytokines [TNF-α, IL-1β, NFκB], anabolic factors [TGFβ, TIMP3, bFGF], and catabolic factors [ADAMTS-4, -5, and MMP-3, -13].</p><p><b>Results</b>: With the <i>in vivo</i> …

Japanese Journal of Joint Diseases 35(2), 131-136, 2016

J-STAGE  Ichushi Web 

Kondo Mayo , Nakata Ken , Kakudo Kenji

… We found that mechanical stress to the human synovial cells in 3D culture induced PGE2 production and up-regulated ADAMTS-4 and MMP-1, -3 gene expression. … Celecoxib down-regulated mechanically induced ADAMTS-4 gene expression at a lower concentration than indomethacin. …

Journal of Osaka Dental University 48(1), 55-59, 2014

J-STAGE  Ichushi Web 

Tauchi Ryoji , Imagama Shiro , Natori Takamitsu , Ohgomori Tomohiro , Muramoto Akio , Shinjo Ryuichi , Matsuyama Yukihiro , Ishiguro Naoki , Kadomatsu Kenji

… Methods: The degradation activity of ADAMTS-4 was estimated for the core proteins of chondroitin sulfate proteoglycans, that is, brevican, neurocan and phosphacan. … To evaluate the biological significance of ADMATS-4 activity, an in vitro neurite growth assay and an in vivo neuronal injury model, spinal cord contusion injury, were employed. … Results: ADAMTS-4 digested proteoglycans, and reversed their inhibition of neurite outgrowth. …

Journal of Neuroinflammation (9), 53-53, 2012-03-15

IR 

Imada Keisuke , Oka Hideki , Kawasaki Daisuke , Miura Naoyoshi , Sato Takashi , Ito Akira

… To clarify the exact anti-arthritic action mechanisms of chondroitin sulfate (CS), we evaluated the effects of CS derived from shark cartilage (CS-SC) composed mainly of chondroitin-6-sulfate and porcine trachea cartilage (CS-PC) composed mostly of chondrotin-4-sulfate on the functions of human articular chondrocytes and synovial fibroblasts. …

Biological and Pharmaceutical Bulletin 33(3), 410-414, 2010

J-STAGE  Ichushi Web  Cited by (1)

HUH Jeong-Eun , BAEK Yong-Hyeon , LEE Jae-Dong , CHOI Do-Young , PARK Dong-Suk

… The expression level of ADAMTS-4, ADAMTS-5, MMP-1, MMP-3, and MMP-13 were dose-dependently decreased in the <i>S. …

Journal of Pharmacological Sciences 107(3), 317-328, 2008-07-20

J-STAGE  Ichushi Web  References (48)

HATANO Eiju , FUJITA Takuya , UEDA Yoshimichi , OKUDA Tetsuhito , KATSUDA Shogo , OKADA Yasunori , MATSUMOTO Tadami

Spine 31(13), 1426-1432, 2006-06-01

References (41) Cited by (1)

Demircan Kadir , Hirohata Satoshi , Nishida Keiichiro , Hatipoglu Omer F. , Oohashi Toshitaka , Yonezawa Tomoko , Apte Suneel S. , Ninomiya Yoshifumi

… <p><b>Objective</b><br />To compare induction of the aggrecanases (ADAMTS-1, ADAMTS-4, ADAMTS-5, ADAMTS-8, ADAMTS-9, and ADAMTS-15) by interleukin-1 (IL-1) and tumor necrosis factor (TNF) in chondrocyte-like OUMS-27 cells and human chondrocytes, and to determine the mechanism of induction of the most responsive aggrecanase gene.</p><p><b>Methods</b>< …

Arthritis & Rheumatism 52(5), 1451-1460, 2005-05

IR  Cited by (2)

HASHIMOTO G.

J. Biol. Chem. 279(31), 32483-32491, 2004

DOI  Cited by (3)

SANDY JD

J. Biol. Chem. 276, 13372-13378, 2001

DOI  Cited by (11)