Search Results 1-20 of 517

  • Fluorescence analysis of optical trapping and manipulation dynamics of cell surface molecules  [in Japanese]

    岸本 龍典 , 工藤 卓 , 田口 隆久 , 細川 千絵

    電気学会研究会資料. OQD = The papers of technical meeting on optical and quantum devices, IEE Japan 2020(1-8), 25-28, 2020-01-08

  • Assessment to anti-epilepsy drugs in human iPSC-derived neural network  [in Japanese]

    Yokoi Remi , Ishibashi Yuto , Odawara Aoi , Suzuki Ikuro

    … For example, the old generation AEDs are mainly Na+ channel inhibitory and GABA receptor agonists. … On the other hand, a new generation of AEDs has a mechanism of action different from that of the previous generation, such as those that act on AMPA-type glutamate receptors and act on multiple channels and receptors. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-P-265, 2020

    J-STAGE 

  • Brain nitric oxide can induce frequent urination via brain glutamatergic receptors in rats  [in Japanese]

    Ono Hideaki , Hamada Tomoya , Nagao Yoshiki , Saito Motoaki , Shimizu Takahiro , Zou Suo , Yamamoto Masaki , Shimizu Yohei , Hata Yurika , Shimizu Shogo , Higashi Youichirou , Aratake Takaaki

    … Effects of icv pretreated carboxy-PTIO (PTIO, NO scavenger, 750 μg/rat), MK-801 [N-methyl-D-aspartate (NMDA) receptor antagonist, 10 or 30 nmol/rat] or DNQX (AMPA receptor antagonist, 3 nmol/rat) on the SIN-1-induced responses were also investigated. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-P-197, 2020

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  • Intranasal administration of resolvin E1 attenuates lipopolysaccharide-induced depression-like behaviors via BDNF/VEGF release and mTORC1 activation in the medial prefrontal cortex  [in Japanese]

    Aoki Shun , Deyama Satoshi , Ishimura Kohei , Fukuda Hayato , Shuto Satoshi , Minami Masabumi , Kaneda Katsuyuki

    … RvE1 are completely blocked by intraperitoneal injection of an AMPA receptor antagonist NBQX or an L-type voltage-dependent Ca<sup>2+</sup> … RvE1 are mediated by BDNF/VEGF release which is probably caused by activation of AMPA receptors and L-VDCCs, and subsequent activation of mTORC1 in the mPFC.</p> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-P-178, 2020

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  • CRMP2 Binding Compound Accelerates Recovery from Central Nervous System damage  [in Japanese]

    Susumu Jitsuki , Takahashi Takuya

    … Restoration of motor impairment after CNS damage is considered to be the result of compensative neural plasticity in spared neural circuit, and the Experience-dependent synaptic AMPA (α-amino-3-hydroxy-5-methyl-4-isoxazole-propionic-acid) receptor (AMPAR) delivery underlies behaviors that require neural plasticity such as learning. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-S08-4, 2020

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  • NMDA receptor-dependent molecular plasticity in dendritic spines of the cerebral cortex after somatosensory stimulation  [in Japanese]

    Kuboyama Kazuya , Miyazawa Tohru , Gusain Pooja , Tawata Masakiyo , Kano Masanobu , Yamada Maki , Inoue Takafumi , Hashimotodani Yuki , Itoh Takuya , Suzuki Tohsuke , Tetsuzawa Aya , Kinoshita Ryo , Ohtsuka Yosuke , Takara Ren

    … That difference was abolished by an NMDA receptor blocker, MK801. … Immunolabeling of α-actinin, a PSD-95 binding protein that can recruit AMPA receptors to postsynaptic sites, showed that α-actinin localization was more frequent/more accumulated in the brightest EGFP-CapZ spines (top 100) than in less bright spines (top 1000). …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-P-006, 2020

    J-STAGE 

  • Oxytocin recovers Aβ-induced impairment of hippocampal synaptic plasticity in mice  [in Japanese]

    Junpei Takahshi , Yamada Daisuke , Ueta Yudai , Iwai Takashi , Koga Eri , Tanabe Mitsuo , Oka Jun-Ichiro , Saitoh Akiyoshi

    … These effects were blocked by the pretreatment with a selective OXT receptor antagonist L-368,899. … Further, the pretreatment with an ERK inhibitor U0126 and a selective Ca<sup>2+</sup>-permeable AMPA receptor antagonist NASPM were completely antagonized the effects of OXT, respectively. … We proposed that ERK phosphorylation and Ca<sup>2+</sup>-permeable AMPA receptors are involved in these effects of OXT.</p> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-LBS-06, 2020

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  • The development of novel anti-depressant targeting AMPA receptor  [in Japanese]

    Megumi Hara

    … Postmortem human brain analysis indicated that the number of AMPA receptors (AMPARs), major molecule controlling synaptic functions, varied among depression patients compared to healthy subjects and these results were not consistent. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-LBS-04, 2020

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  • Mechanisms underlying the development of mental disorders revealed using novel PET tracer recognizing AMPA receptors  [in Japanese]

    Miyazaki Tomoyuki

    … <p>Glutamate AMPA (alfa-amino-3-hydroxy-5-methyl-4-isoxazole propionic acid) receptors (AMPARs) play central roles in neuronal functions. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-JS2-4, 2020

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  • Chronic stress causes excessive aggression by altering synaptic actin dynamics in the mPFC.  [in Japanese]

    Tada Hirobumi , Takahashi Takuya

    … Here, we show that chronic stress environment changes spines in the mPFC by reducing actin dynamics, leading to the decrease of synaptic AMPA receptor delivery and altered social cognition and aggressive behavior. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-JS2-3, 2020

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  • Perampanel for Sporadic Amyotrophic Lateral Sclerosis  [in Japanese]

    相澤 仁志 , 郭 伸

    Brain and nerve 71(11), 1270-1278, 2019-11

    Ichushi Web 

  • Evaluation of adjunctive perampanel therapy in 1,641 Japanese patients with epilepsy aged over 18 years  [in Japanese]

    井上 有史 , 西田 拓司 , 福多 真史 , 加藤 昌明 , 渡邉 雅子 , 岡本 暁彦 , 松谷 一弘 , 住友 健太

    臨床精神薬理 = Japanese journal of clinical psychopharmacology 22(7), 733-747, 2019-07

    Ichushi Web 

  • PIP3-Phldb2 is crucial for LTP regulating synaptic NMDA and AMPA receptor density and PSD95 turnover

    Min-Jue Xie , Yasuyuki Ishikawa , Hideshi Yagi , Tokuichi Iguchi , Yuichiro Oka , Kazuki Kuroda , Keiko Iwata , Hiroshi Kiyonari , Shinji Matsuda , Hideo Matsuzaki , Michisuke Yuzaki , Yugo Fukazawa , Makoto Sato

    … Phldb2 was indispensable for the interaction between NMDA receptors and CaMKII, and the synaptic density of AMPA receptors. …

    Scientific Reports 9(1), 4305, 2019-03-13

    IR 

  • optical technology for inactivation of protein function  [in Japanese]

    竹本 研

    個々の分子活性の単純なON・OFFだけでなく,その時空間的な変動パターンにも細胞機能の制御メカニズムが内包すると示唆される.ところがこうした分子活性の時空間ダイナミクスがもつ生理的意義や個体レベルへの寄与の程度は,未だ多くが謎に包まれている.分子の時空間ダイナミクスにアプローチする手法として,生きた細胞の中で分子活性を光で可視化・操作する手法がある.光を用いることで,神経スパインなどのわずか数マイ …

    横浜医学 = Yokohama Medical Journal 70(1), 67-74, 2019-01-30

    IR  Ichushi Web 

  • Axonal transport through signaling endosome and its roles in neurodegenerative disorders  [in Japanese]

    Yamashita Naoya

    … <p>Long-distance axonal transport of ligand-receptor complexes from the site of endocytosis in the axon to somatodendrite acts as a signaling platform in neurons. … I discovered that retrograde axonal transport of semaphorin3A and its receptors by signaling endosomes regulates dendritic development, specifically enhances AMPA receptor GluA2 localization in dendrites. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 3-YAL-2, 2019

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  • Involvement of glutamate receptors in the impairment of social behaviors induced by social defeat stress exposure as juveniles  [in Japanese]

    Yoshida Mikio , Nabeshima Toshitaka , Noda Yukihiro , Hasegawa Sho , Yoshimi Akira , Mouri Akihiro , Uchida Yoji , Hida Hirotake , Mishina Masayoshi , Yamada Kiyofumi , Ozaki Norio

    … Acute administration of ketamine, a non-competitive NMDA receptor antagonist and subsequent AMPA receptor stimulation attenuated the impairment of social behaviors in adolescent mice exposed to social defeat stress as juveniles. … NBQX, a selective AMPA receptor antagonist prevented the attenuating effect of ketamine on the impairment of social behaviors. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 3-P-029, 2019

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  • The role of Ca<sup>2+</sup> impermeable AMPA receptor in the bed nucleus of stria terminalis in the lipopolysaccharide-induced behavioral despair  [in Japanese]

    Fukuwada Nao , Kanno Miki , Seki Kenjiro

    … <p>We previously reported that the lipopolysaccharide (LPS)-induced depressive-like behavior is associated with α<sub>1</sub>-adrenoceptor dependent membrane AMPA receptor GluR1 subunit downregulation in the reward system. … impermeable AMPA receptor by RNA editing of GluR2, we investigated whether Ca<sup>2+</sup> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 3-P-028, 2019

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  • Regulation of maternal aggression and care via glutamatergic signals in the dorsal raphe nucleus in mice  [in Japanese]

    Muroi Yoshikage , Ishii Toshiaki

    … Injections of N-methyl-D-aspartic acid (NMDA) receptor antagonists or α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)/kainate receptor antagonists into the DRN inhibited biting behavior but not nurturing behavior. … In contrast, injections of NMDA or AMPA into the DRN inhibited nurturing behavior. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 3-P-052, 2019

    J-STAGE 

  • Contribution of GRP-GRPR system in the spinal dorsal horn to pathological itch  [in Japanese]

    Kiguchi Norikazu , Uta Daisuke , Uchida Hitoshi , Saika Fumihiro , Kishioka Shiroh

    … <p>Gastrin-releasing peptide (GRP) receptor (GRPR)<sup>+</sup> … neurons through AMPA receptors (AMPAR), and those transmitters play fundamental roles in the spinal transmission of physiological itch. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 2-O-41, 2019

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  • The development of novel anti-depressant targetting AMPA receptor  [in Japanese]

    Miyazaki Tomoyuki , Nakajima Waki , Arisawa Tetsu , Takahashi Takuya

    … Postmortem human brain analysis indicated that the number of AMPA receptors (AMPARs), major molecule controlling synaptic functions, varied among depression patients and the results of these analysis were not consistent. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 1-YIA-02, 2019

    J-STAGE 

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