Search Results 1-20 of 1399

  • IL-33-induced pathogenic Th2 cells in allergic diseases  [in Japanese]

    遠藤 裕介

    臨床免疫・アレルギー科 = Clinical immunology & allergology 74(5), 462-469, 2020-11

  • REGULATORY MECHANISMS OF ALLERGIC AIRWAY INFLAMMATION  [in Japanese]

    中島 裕史

    アレルギー = Japanese journal of allergology 69(8), 644-651, 2020-09

  • Group 2 Innate Lymphoid Cells and the House Dust Mite-Induced Asthma Mouse Model

    Yasuda Yuichiro , Nagano Tatsuya , Kobayashi Kazuyuki , Nishimura Yoshihiro

    … Among innate immune cells, group 2 innate lymphoid cells (ILC2s) have been considered to be crucial for eosinophilic airway inflammation by releasing T helper 2 cytokines. … Moreover, house dust mites (HDMs) belonging to group 1 act on airway epithelial cells not only as allergens but also as cysteine proteases. … The production of interleukin-25 (IL-25), IL-33, and thymic stromal lymphopoietin (TSLP) from airway epithelial cells was induced by the protease activity of HDMs. …

    Cells 9(5), 1178, 2020-05

    IR 

  • Impact of fractional exhaled nitric oxide on the outcomes of lung resection surgery: a prospective study.

    OKAMOTO Keigo , HAYASHI Kazuki , KAKU Ryosuke , KAWAGUCHI You , OSHIO Yasuhiko , HANAOKA Jun , 岡本 圭伍 , 林 一喜 , 賀来 良輔 , 川口 庸 , 大塩 恭彦 , 花岡 淳

    Methods: We measured FeNO using NIOX VERO® once before and on days 1, 3, 5–7 after surgery in participants who were candidates for lung cancer surgery. The primary endpoint was the relationship betwee …

    Journal of thoracic disease 12(5), 2663-2671, 2020-05

    IR 

  • Group 2 innate lymphoid cells and allergic inflammation  [in Japanese]

    久保 允人

    臨床免疫・アレルギー科 = Clinical immunology & allergology 73(2), 175-179, 2020-02

    Ichushi Web 

  • Roles of C-type lectin receptors in allergic airway inflammation  [in Japanese]

    廣瀬 晃一 , 伊藤 崇 , 中島 裕史

    臨床免疫・アレルギー科 = Clinical immunology & allergology 73(2), 168-174, 2020-02

    Ichushi Web 

  • A new mechanism of bronchial hyperresponsiveness revealed by murine Th9 cell-transferred asthma model  [in Japanese]

    Saeki Mayumi , Kaminuma Osamu , Hiroi Takachika

    <p>気管支喘息の病態形成には,さまざまな炎症細胞や組織構成細胞が複雑に関与している.吸入ステロイド薬の普及は,喘息を制御可能な疾病へと変えつつあるが,それでもコントロールできない難治性患者の存在は,喘息の発症および重症化に関わる新たなメカニズムの存在を示唆する.臨床的にも,各患者の病態像および分子機構の相違に基づいたフェノタイプおよびエンドタイプ分類など,疾患理解の細分化が進みつつあ …

    Folia Pharmacologica Japonica 155(6), 375-380, 2020

    J-STAGE 

  • The role of neuropeptide Y for the development of allergic airway responses  [in Japanese]

    Miyahara Nobuaki

    <p>気管支喘息は気道過敏性の亢進,気道狭窄を特徴とする慢性の気道炎症性疾患であり,その病態形成には極めて多様な因子が関与しており,未だ不明な点が多い.ストレスと喘息の発症や増悪の関連が以前から知られているが,神経ペプチドの一種であるneuropeptide Y(NPY)は,交感神経系を介してストレスに大きく関与しており,また免疫系にも深く関わっており,T細胞やマクロファージなどからの …

    Folia Pharmacologica Japonica 155(6), 360-363, 2020

    J-STAGE 

  • Japanese guidelines for adult asthma 2020

    Nakamura Yoichi , Nagata Makoto , Yokoyama Akihito , Tohda Yuji , The Japanese Society of Allergology , Tamaoki Jun , Nagase Hiroyuki , Yamaguchi Masao , Horiguchi Takahiko , Hozawa Soichiro , Ichinose Masakazu , Iwanaga Takashi , Kondo Rieko

    … <p>Bronchial asthma is characterized by chronic airway inflammation, which manifests clinically as variable airway narrowing (wheezes and dyspnea) and cough. … Long-standing asthma may induce airway remodeling and become intractable. …

    Allergology International 69(4), 519-548, 2020

    J-STAGE 

  • REGULATORY MECHANISMS OF ALLERGIC AIRWAY INFLAMMATION  [in Japanese]

    Nakajima Hiroshi

    Japanese Journal of Allergology 69(8), 644-650, 2020

    J-STAGE 

  • Inhibitory Effects of Dabigatran on Airway Inflammation Induced by Lipopolysaccharide in Mice  [in Japanese]

    Kimura Genki , Takahashi Risa , Nagamoto Ayaka , Yoshino Kotomi , Ueda Keitaro , Nishimoto Yuki , Kizawa Yasuo

    … <p>Asthma and chronic obstructive pulmonary disease are characterised by chronic inflammation in the lung that is associated with airway obstruction. … In this study, we investigated the effects of anti-coagulants on lipopolysaccharide (LPS)-induced airway inflammation in mice. … LPS exposure induced airway neutrophilia and accumulation of TNF-α, CXCL1, and osteopontin in BALF. …

    YAKUGAKU ZASSHI, 2020

    J-STAGE 

  • Inflammatory Disease (3) Role of Airway Mucins in Inflammatory Lung Diseases  [in Japanese]

    Takeyama Kiyoshi

    … However, in airway inflammation, mucin gene expression in mucus-producing cells is stimulated by various inflammatory mediators, cytokines, growth factors, and reactive oxygen species that are produced by recruited inflammatory cells, such as neutrophils and eosinophils, thereby increasing the production and secretion of airway mucus. …

    Journal of Tokyo Women's Medical University 90(4), 71-78, 2020

    IR  J-STAGE 

  • Latest Information on the Diagnosis and Treatment of Allergic Rhinitis and Eosinophilic Chronic Rhinosinusitis  [in Japanese]

    Nagata Yoshiyuki , Nomura Yasuyuki

    … Research on the pathophysiology of airway mucosal disease has been dramatically advanced by recent progressin immunology in the past few decades. …

    Journal of Nihon University Medical Association 79(2), 87-92, 2020

    J-STAGE  Ichushi Web 

  • Improvement of prognosis with anti-inflammatory therapy in childhood-onset asthma  [in Japanese]

    Ikeda Masanori

    <p>小児期発症喘息の治療目標は,基本病態である気道炎症を抑制し,最終的には寛解・治癒を目指すことである.抗炎症療法は薬物治療の中心であり,その普及のもとに2017年には小児の喘息死ゼロが達成され,入院患者数は最近20年間で約1/5に低下,有症率も減少に転じるなど疫学的予後は改善を示した.しかし,喘息コントロールについては,喘息児の17~25%は毎週,42~65%で毎月喘息増悪がみられ …

    Nihon Shoni Arerugi Gakkaishi. The Japanese Journal of Pediatric Allergy and Clinical Immunology 34(2), 186-197, 2020

    J-STAGE 

  • Cellular Physiology in Airway Epithelium Under Allergic Inflammation  [in Japanese]

    Cho Hyung-Ju

    Nihon Bika Gakkai Kaishi (Japanese Journal of Rhinology) 59(1), 108-108, 2020

    J-STAGE 

  • Patency Capsule Aspiration

    Takeda Keita , Tashimo Hiroyuki , Miyakawa Kazuko , Shimada Masahiro , Ohshima Nobuharu , Tamura Atsuhisa , Nagai Hideaki , Matsui Hirotoshi

    … In cases of patency capsule aspiration, the capsule must be removed without deformity, before it causes inflammation by releasing barium into the airway. …

    Internal Medicine 59(8), 1071-1073, 2020

    IR  J-STAGE 

  • Involvement of stress resilience in the pathogenesis of psychosomatic respiratory diseases  [in Japanese]

    Maruoka Shuichiro

    <p>気管支喘息(以下,喘息)は,遺伝的要因と環境要因の相互作用で誘導される免疫応答により繰り返される気道狭窄をきたす慢性炎症性疾患である.環境要因の1つである心理社会的ストレス(以下,ストレス)により増悪することから,心身相関の病態を有する呼吸器心身症の代表的疾患である.ストレスは,内分泌系,免疫系,自律神経系を介して喘息の病態形成に関与しているが,その分子病態についてはいまだに不明 …

    The Autonomic Nervous System 57(1), 36-38, 2020

    J-STAGE 

  • Azithromycin Inhibits Constitutive Airway Epithelial Sodium Channel Activation <i>in Vitro</i> and Modulates Downstream Pathogenesis <i>in Vivo</i>

    Fujikawa Haruka , Nakagata Naomi , Suico Mary Ann , Kai Hirofumi , Shuto Tsuyoshi , Kawakami Taise , Nakashima Ryunosuke , Nasu Aoi , Kamei Shunsuke , Nohara Hirofumi , Eto Yuka , Ueno-Shuto Keiko , Takeo Toru

    … ENaC overexpression and/or hyperactivation in airway epithelial cells cause sodium over-absorption and dysregulated ciliary movement for mucus clearance; … however, the agents that suppress constitutive airway ENaC activation are yet to be clinically available. … studies, mice harboring airway specific βENaC overexpression (C57BL/6J-βENaC-transgenic mice) were treated orally with azithromycin, a well-established antimicrobial agent that has been widely prescribed. …

    Biological and Pharmaceutical Bulletin 43(4), 725-730, 2020

    J-STAGE 

  • Requirement for neuropeptide Y in the development of allergen-induced airway hyperresponsiveness and inflammation  [in Japanese]

    Miyahara Nobuaki

    … however, involvement of NPY in the pathophysiology of bronchial asthma, particularly airway hyperresponsiveness (AHR), has not been defined. … NPY-deficient and wild-type mice were intranasally sensitized and challenged to house dust mite (HDM) extract, and airway responses were monitored. … Treatment with a NPY receptor antagonist, significantly suppressed development of HDM-induced AHR and inflammation in wild-type mice. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-S35-1, 2020

    J-STAGE 

  • Effects of topical dosed anti-coagulant on LPS-induced exacerbation in asthma model mice  [in Japanese]

    Kimura Genki , Ueda Keitaro , Nishimoto Yuki , Kizawa Yasuo

    … <p>RNA virus and bacterial infections induce exacerbation and steroid insensitive airway inflammation in patients with asthma. … We have previously demonstrated that dabigatran inhibited steroid insensitive airway inflammation. … The aim of this study is to evaluate the effects of anti-coagulant on LPS-induced steroid insensitive airway inflammation in asthma model mice. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-P-309, 2020

    J-STAGE 

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