Search Results 1-20 of 293

  • Development of a novel immune checkpoint inhibitor suppressing both PD-1 and CTLA4 signals

    Nagase Hiroki

    <p>免疫チェックポイント阻害剤は,成人だけでなく小児のがんでも注目されている.我々は,PD-1とCTLA-4の両パスウェイを特異的に阻害できるアルキル化転写阻害剤CCC07-01を開発した.CCC07-01はPD-1,PD-L1およびCTLA-4遺伝子の発現を抑制し,がん細胞に細胞死を誘導するが,正常細胞には誘導しないことを確認し,PBMCの移植により免疫系をヒト化した担癌NGSマウ …

    The Japanese Journal of Pediatric Hematology / Oncology 56(3), 331-333, 2019

    J-STAGE 

  • A case of therapy-related myeloid neoplasm resulting in acute promyelocytic leukemia in a patient following breast cancer therapy  [in Japanese]

    HIRAO Mamiko , KOUCHI Yoshiko , TAKAHARA Rie , TAKAHASHI Tsukasa , TASAKA Fumie

    <p>乳がん治療後に急性前骨髄性白血病(acute promyelocytic leukemia; APL)として発症した治療関連骨髄性腫瘍(therapy-related myeloid neoplasms; t-MN)の症例を経験した。本症例は染色体検査で15;17転座は検出されなかったが,FISH法およびPCR法にて<i>PML/RARA</i>融合遺伝子 …

    Japanese Journal of Medical Technology 68(1), 180-185, 2019

    J-STAGE  Ichushi Web 

  • Evaluation of alkylating pyrrole-imidazole polyamide conjugates by a novel method for high-throughput sequencer

    Kashiwazaki Gengo , Maeda Rina , Kawase Takashi , Hashiya Kaori , Bando Toshikazu , Sugiyama Hiroshi

    … DNA-alkylating PI polyamide conjugates are attractive candidates as anticancer drugs acting through DNA damage and its subsequent inhibition of cell proliferation. … Herein, we apply another DNA-alkylating agent, seco-CBI, to target the consensus sequence of the RUNX family. … This is the first report to employ the MR method on alkylating PI polyamide conjugates. …

    Bioorganic and Medicinal Chemistry 26(1), 1-7, 2018-01-01

    IR 

  • ALC1/CHD1L, chromatin-remodeling enzyme, is required for efficient base excision repair

    Tsuda Masataka , Cho Kosai , Ooka Masato , Shimizu Naoto , Watanabe Reiko , Yasui Akira , Nakazawa Yuka , Ogi Tomoo , Harada Hiroshi , Agama Keli , Nakamura Jun , Asada Ryuta , Fujiike Haruna , Sakuma Tetsushi , Yamamoto Takashi , Murai Junko , Hiraoka Masahiro , Koike Kaoru , Pommier Yves , Takeda Shunichi , Hirota Kouji

    … The resulting ALC1-/- and ALC1-/E165Q cells displayed an indistinguishable hypersensitivity to methylmethane sulfonate (MMS), an alkylating agent, and to H2O2, indicating that ATPase plays an essential role in the DNA-damage response. …

    PLoS ONE 12(11), e0188320, 2017-11-17

    IR 

  • ALC1/CHD1L, a chromatin-remodeling enzyme, is required for efficient base excision repair

    Tsuda Masataka , Cho Kosai , Ooka Masato , Shimizu Naoto , Watanabe Reiko , Yasui Akira , Nakazawa Yuka , Ogi Tomoo , Harada Hiroshi , Agama Keli , Nakamura Jun , Asada Ryuta , Fujiike Haruna , Sakuma Tetsushi , Yamamoto Takashi , Murai Junko , Hiraoka Masahiro , Koike Kaoru , Pommier Yves , Takeda Shunichi , Hirota Kouji

    … The resulting ALC1⁻/⁻ and ALC1⁻/E165Q cells displayed an indistinguishable hypersensitivity to methylmethane sulfonate (MMS), an alkylating agent, and to H₂O₂, indicating that ATPase plays an essential role in the DNA-damage response. …

    PloS one 12(11), 2017-11-17

    IR 

  • Synthesis of CZTS Nano Particles in Liquid System and its Application for Solar Cells  [in Japanese]

    森 康維 , 平井 暁人 , 岡本 耕太郎 , 山本 琢真 , 土屋 活美 , モリ ヤスシゲ , ヒライ アキト , オカオト コウタロウ , ヤマモト タクマ , ツチヤ カツミ , Mori Yasushige , Hirai Akito , Okamoto Kotaro , Yamamoto Takuma , Tsuchiya Katsumi

    次世代太陽電池としてCZTSなどの半導体ナノ粒子を基本とした溶液プロセスで作製される装置が注目されている。CZTSは直接遷移型の光吸収率の高いp型半導体で,地球上に多く存在し毒性の低い物質から作製される。本研究では,CZTSナノ粒子を用いてカドミウムを使用しないCZTS/PCBMヘテロ接合型の有機/無機ハイブリッド型太陽電池を作製した。CZTSナノ粒子は水熱合成法の一つであるホットインジェクション …

    同志社大学ハリス理化学研究報告 = The Harris science review of Doshisha University 58(1), 25-30, 2017-04

    IR  DOI 

  • Antineoplastic Drugs Induce Morphological Changes During Dental Root Development in Young Mice  [in Japanese]

    KAWAKAMI Tomomi

    <p>近年,小児がんの治療法が改善され,長期生存するがん治療経験者は増加している。小児がんの治療には,化学療法,放射線療法,幹細胞移植などがあり,これらの治療法を組み合わせることでさらに治癒率が向上している。その一方で,小児がん治療経験者の晩期合併症が注目されるようになってきた。小児がん治療の口腔領域の晩期合併症としては,石灰化障害,矮小歯,欠如歯,歯根の短根化などが報告されている。こ …

    The Japanese Journal of Pediatric Dentistry 55(3), 345-351, 2017

    J-STAGE 

  • Identification of Binding Targets of a Pyrrole-Imidazole Polyamide KR12 in the LS180 Colorectal Cancer Genome

    Lin Jason , Hiraoka Kiriko , Watanabe Takayoshi , Kuo Tony , Shinozaki Yoshinao , Takatori Atsushi , Koshikawa Nobuko , Chandran Anandhakumar , Otsuki Joe , Sugiyama Hiroshi , Horton Paul , Nagase Hiroki

    … Pyrrole-imidazole polyamides are versatile DNA minor groove binders and attractive therapeutic options against oncological targets, especially upon functionalization with an alkylating agent such as seco-CBI. … Here we propose a next-generation sequencing-based workflow combined with whole genome expression arrays to address such issue using a candidate anti-cancer alkylating agent, KR12, against codon 12 mutant KRAS. …

    PLOS ONE 11(10), 2016-10-31

    IR 

  • Use of a Catalytic Chiral Leaving Group for Asymmetric Substitutions at sp3‐Hybridized Carbon Atoms : Kinetic Resolution of β‐Amino Alcohols by p‐Methoxybenzylation

    Kuroda Yusuke , Harada Shingo , Oonishi Akinori , Kiyama Hiroki , Yamaoka Yousuke , Yamada Ken-ichi , Takasu Kiyosei

    … We developed a catalytic strategy for asymmetric substitution reactions at sp3-hybridized carbon atoms using a chiral alkylating agent generated in situ from trichloroacetimidate and a chiral phosphoric acid. …

    Angewandte Chemie International Edition 55(42), 13137-13141, 2016-10-06

    IR 

  • Cell fate of müller cells during photoreceptor regeneration in an N-methyl-N-nitrosourea- induced retinal degeneration model of zebrafish

    Ogai Kazuhiro , Hisano Suguru , Sugitani Kayo , Koriyama Yoshiki , Kato Satoru

    … Very recently, a study has demonstrated the photoreceptor regeneration in the alkylating agent N-methyl-N-nitrosourea (MNU)- induced retinal degeneration (RD) zebrafish model, in which whole photoreceptors are lost within a week after MNU treatment and then regenerated within a month. …

    Advances in Experimental Medicine and Biology (854), 685-692, 2016-10-01

    IR 

  • Nucleosome Assembly Alters the Accessibility of the Antitumor Agent Duocarmycin B2 to Duplex DNA

    Zou Tingting , Kizaki Seiichiro , Pandian Ganesh N. , Sugiyama Hiroshi

    … Our results suggested that the alkylating efficiencies of duocarmycin B2 were significantly decreased in core DNA and increased at the histone-free linker DNA sites when compared with naked DNA conditions. … Our finding that nucleosome assembly alters the accessibility of duocarmycin B2 to duplex DNA could advance its design as an antitumor agent. …

    Chemistry - A European Journal 22(26), 8756-8758, 2016-06-20

    IR 

  • Hepatoprotective effect of kampo formula "Juzen-taiho-to" on bromobenzene-induced toxicity in mice

    Yoshioka Hiroki , Fukaya Shiori , Miura Nobuhiko , Nagatsu Akito , Nonogaki Tsunemasa

    … Carbon tetrachloride (CCl<sub>4</sub>), a well-known hepatic toxicant, was selected as a model of alkylating agents that do not induce glutathione depletion. … In contrast, bromobenzene (BB) is a known glutathione-depleting agent. …

    Fundamental Toxicological Sciences 3(5), 233-236, 2016

    J-STAGE  Ichushi Web 

  • Mutation assay using single-molecule real-time (SMRT™) sequencing technology

    Matsuda Tomonari , Matsuda Shun , Yamada Masami

    … Salmonella typhimurium YG7108 was treated with the alkylating agent N-ethyl-N-nitrosourea (ENU) and grown though several generations to fix the induced mutations, the DNA was extracted and the mutations were analyzed by using the SMRT DNA sequencer. …

    Genes and Environment (37), 2015-09-01

    IR 

  • Inhibition of KRAS codon 12 mutants using a novel DNA-alkylating pyrrole–imidazole polyamide conjugate

    Hiraoka Kiriko , Inoue Takahiro , Taylor Rhys Dylan , Watanabe Takayoshi , Koshikawa Nobuko , Yoda Hiroyuki , Shinohara Ken-ichi , Takatori Atsushi , Sugimoto Hirokazu , Maru Yoshiaki , Denda Tadamichi , Fujiwara Kyoko , Balmain Allan , Ozaki Toshinori , Bando Toshikazu , Sugiyama Hiroshi , Nagase Hiroki

    KRAS遺伝子変異を持ったがんを標的とした新規のアルキル化剤の開発について. 京都大学プレスリリース. 2015-05-01.

    Nature Communications (6), 2015-04-27

    IR 

  • Wrn knockdown enhanced apoptosis induced by oxidative stress  [in Japanese]

    ISHIBASHI Kazunari , HAYASHI Michio , UMEZU Keiko

    … The same phenomenon was observed with menadione, another oxidative stress-inducing agent, but not with UV and MNU (an alkylating agent) not observed. …

    The Journal of Fukuoka Dental College 40(4), 103-111, 2015-03-20

    Ichushi Web 

  • Nuclear Blebs Assay for Genome Instability in <i>Phaseolus vulgaris</i> L.

    Kumar Girjesh , Chaudhary Nitu

    … The present study has been undertaken to evaluate the mutagenic effect of the alkylating agent EMS on the meiotic behavior of pollen mother cells of <i>Phaseolus vulgaris</i> …

    CYTOLOGIA 80(4), 505-512, 2015

    J-STAGE 

  • Serum ALP elevation early after treatment is a predictor for response in myeloma patients treated with bortezomib  [in Japanese]

    MINAUCHI Koichiro , IMAI Kiyotoshi , HIRANO Teiichi , KIYAMA Yoshio , OGASAWARA Masahiro , KOBAYASHI Naoki , IMAMURA Masahiro , SHIMA Kanako , HASHIGUCHI Junichi , ARA Takahide , YASUMOTO Atsushi , FUJINO Kenji , OBARA Masato , NAKATA Masanobu , OTA Shuichi

    Bortezomib (BTZ)使用後に血清alkaline phosphatase値(ALP)上昇を来す症例が認められるが,BTZ使用後のALP上昇と奏効率の関係は不明である。【対象と方法】2007年10月から2012年10月まで当院でBTZを含む治療薬にて加療された多発性骨髄腫30例を対象とし,治療開始後早期のALP上昇の有無と治療反応性について後方視的に評価した。【結果】治療開始後21日目, …

    Rinsho Ketsueki 56(8), 1064-1068, 2015

    J-STAGE  Ichushi Web 

  • Novel Strategies in Chemotherapy for Gliomas  [in Japanese]

    Natsume Atsushi , Chalise Lushun , Wakabayashi Toshihiko

     原発性脳腫瘍は腫瘍の形態学, 細胞学, 分子遺伝学, 免疫組織学的特徴を併せて評価するWHOのgradingが広く普及し, 疾患予後を表す指標となっている. 神経膠腫の遺伝子診断は, 病理診断の補助的な役割をするばかりではなく, 新しい腫瘍分類を構築し, それに基づいた治療体系を提示する可能性を秘めている. いくつもの遺伝子異常が重なる必要があるという多段階発癌説が現在の共通認識であり …

    Japanese Journal of Neurosurgery 24(6), 386-398, 2015

    J-STAGE  Ichushi Web 

  • Dose-dense Temozolomide: Is It Still Promising?

    NAGANE Motoo

    … Since TMZ is the most active cytotoxic agent against GBM, and the standard dosing of TMZ has shown favorable safety profile in clinical trials, re-challenge with TMZ in increased dose density schedules for recurrent tumors that have evaded from prior standard TMZ therapy appears to be a rational approach and has been intensively exploited. …

    Neurologia medico-chirurgica 55(1), 38-49, 2015

    J-STAGE  Ichushi Web 

  • Chemotherapy for Malignant Glioma; Beyond the Temozolomide Era

    Wakabayashi Toshihiko

    … (WHO grades III and IV) malignant gliomas, especially glioblastoma (GBM), the most common glioma in adults, kills patients within a median time span of a year after diagnosis despite treatment with aggressive surgical resection, chemotherapy, and radiotherapy.In Japan, alkylating agents such as 1- (4-amino-2-methyl-5-pyridiminyl) methyl-3- (2-chloroethyl) -3-nitrosourea (ACNU) and methyl-6-[3- (2-chloroethyl) -3-nitrosoureido] -6-deoxy-alpha-D-glucopyranoside (MCNU) have been used to treatmalignant gliomas for a long time, however, this treatment …

    Progress in Neuro-Oncology 21(3), 45-50, 2014

    J-STAGE  Ichushi Web 

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