Search Results 1-20 of 1073

  • Nasal Extracts from Patients with Alzheimer's Disease Induce Tau Aggregates in a Cellular Model of Tau Propagation.

    PAHRUDIN ARROZI Aslina , YANAGISAWA Daijiro , KATO Tomoko , AKATSU Hiroyasu , HASHIZUME Yoshio , KANEDA Daita , TOOYAMA Ikuo , 柳沢 大治郎 , 加藤 智子 , 遠山 育夫

    … prion activity has been typically studied in brain extracts of patients with Alzheimer's disease (AD), but not in the olfactory region that can be a potential biomarker in AD.Objective:To investigate the prion seeding activity of tau in nasal mucosa tissues using a cell culture model of tau propagation.Methods:Brain and nasal mucosa homogenates were added to HEK293T cells expressing three repeat or four-repeat domains of tau with the L266V, V337M …

    Journal of Alzheimer's Disease Reports 5(1), 263-274, 2021-04-06

    IR 

  • Extracellular Release of ILEI/FAM3C and Amyloid-β Is Associated with the Activation of Distinct Synapse Subpopulations.

    NAKANO Masaki , MITSUISHI Yachiyo , LIU Lei , WATANABE Naoki , HIBINO Emi , HATA Saori , SAITO Takashi , SAIDO Takaomi C , MURAYAMA Shigeo , KASUGA Kensaku , IKEUCHI Takeshi , SUZUKI Toshiharu , NISHIMURA Masaki , 中野 将希 , 三ツ石 弥千代 , 渡邊 直希 , 日比野 絵美 , 西村 正樹

    … Background:Brain amyloid-β (Aβ) peptide is released into the interstitial fluid (ISF) in a neuronal activity-dependent manner, and Aβ deposition in Alzheimer's disease (AD) is linked to baseline neuronal activity. … Brain ILEI levels were selectively decreased in AD. …

    Journal of Alzheimer's disease : JAD 80(1), 159-174, 2021-03-09

    IR 

  • Fluorine-19 Magnetic Resonance Imaging for Detection of Amyloid β Oligomers Using a Keto Form of Curcumin Derivative in a Mouse Model of Alzheimer's Disease.

    YANAGISAWA Daijiro , IBRAHIM Nor Faeizah , TAGUCHI Hiroyasu , MORIKAWA Shigehiro , TOMIYAMA Takami , TOOYAMA Ikuo , 柳沢 大治郎 , 田口 弘康 , 森川 茂廣 , 遠山 育夫

    … Recent evidence suggests that the formation of soluble amyloid β (Aβ) aggregates with high toxicity, such as oligomers and protofibrils, is a key event that causes Alzheimer's disease (AD). … In this study, we investigated the in vivo detection of Aβ oligomers by fluorine-19 (19F) magnetic resonance imaging (MRI) using Shiga-Y51 in an APP/PS1 double transgenic mouse model of AD. …

    Molecules 26(5), 1362, 2021-03-04

    IR 

  • Machine Learning for Diagnosis of AD and Prediction of MCI Progression From Brain MRI Using Brain Anatomical Analysis Using Diffeomorphic Deformation.

    SYAIFULLAH Ali Haidar , SHIINO Akihiko , KITAHARA Hitoshi , ITOH Ryuta , ISHIDA Manabu , TANIGAKI Kenji , 椎野 顯彦 , 北原 均 , 井藤 隆太

    … We have developed a software named BAAD, which uses ML algorithms for the diagnosis of Alzheimer's disease (AD) and prediction of mild cognitive impairment (MCI) progression.Methods:We constructed an algorithm by combining a support vector machine (SVM) to classify and a voxel-based morphometry (VBM) to reduce concerned variables. …

    Frontiers in Neurology (11), 2021-02-05

    IR 

  • Reappraisal of the Cerebral Blood Flow Measured Using 123I-I-iodoamphetamine Single-photon Emission Computed Tomography in Normal Subjects and Patients with Alzheimer's Disease and Dementia with Lewy Bodies

    Seto Makiko , Fukushima Naomi , Yuasa Takayuki , Nakao Yoko , Ichinose Katsuhiro , Tomita Itsuro , Satoh Hideyo , Satoh Akira , Ochi Makoto , Tsujihata Mitsuhiro

    … Purpose: Our aim was to re-evaluate the usefulness of perfusion single-photon emission computed tomography (SPECT) for the diagnosis of AD and DLB.Methods: A total of 1,232 patients, including 180 cognitively normal subjects (NSs), 148 patients with amnestic mild cognitive impairment (aMCI), 802 patients with AD and 102 patients with dementia with Lewy bodies (DLB) were enrolled. …

    Acta medica Nagasakiensia 64(3), 91-100, 2021-02

    IR 

  • Keto form of curcumin derivatives strongly binds to Aβ oligomers but not fibrils.

    YANAGISAWA Daijiro , KATO Tomoko , TAGUCHI Hiroyasu , SHIRAI Nobuaki , HIRAO Koichi , SOGABE Takayuki , TOMIYAMA Takami , GAMO Keizo , HIRAHARA Yukie , KITADA Masaaki , TOOYAMA Ikuo , 柳沢 大治郎 , 加藤 智子 , 田口 弘康 , 遠山 育夫

    … The accumulation of β-amyloid (Aβ) aggregates in the brain occurs early in the progression of Alzheimer's disease (AD), and non-fibrillar soluble Aβ oligomers are particularly neurotoxic. … Furthermore, with imaging mass spectrometry we revealed the blood-brain barrier permeability of Shiga-Y51 and its accumulation in the cerebral cortex and the hippocampus, where Aβ oligomers were mainly localized, in a mouse model of AD. …

    Biomaterials (270), 120686, 2021-01-23

    IR 

  • Correlation between levels of medial temporal atrophy and scores of Rivermead Behavioural Memory Test in patients with early Alzheimer disease  [in Japanese]

    Nagayama Tomiko , Nakayama Takuya , Sato Kenshiro , Yang Sunghoon , Yamaguchi Shuhei , Nagayama Masao

    … <p>【要旨】 VSRAD(voxel-based specific regional analysis system for Alzheimer's disease)は頭部MRIを用いた、嗅内皮質、扁桃、海馬を含む側頭葉内側部の萎縮からアルツハイマー病(Alzheimer's disease:AD)を早期診断するための補助ツールである。 …

    Japanese Journal of Cognitive Neuroscience 22(2), 98-104, 2021

    J-STAGE 

  • Female dominance of both spatial cognitive dysfunction and neuropsychiatric symptoms in a mouse model of Alzheimer's disease

    MURAYAMA Masanori A. , SUZUKI Tomoko , SUZUKI Noboru , ARIMITSU Nagisa , SHIMIZU Jun , FUJIWARA Naruyoshi , TAKAI Kenji , IKEDA Yoshiki , OKADA Yoko , HIROTSU Chieko , TAKADA Erika

    … <p>Alzheimer's disease (AD) is a prevalent neurological disorder affecting memory function in elderly persons. … Indeed, AD exhibits abnormality in cognitive behaviors and higher susceptibility to neuropsychiatric symptoms (NPS). … Various factors including aging, sex difference and NPS severity, are implicated during in development of AD. …

    Experimental Animals, 2021

    J-STAGE 

  • Dementia model mice exhibited improvements of neuropsychiatric symptoms as well as cognitive dysfunction with neural cell transplantation

    MURAYAMA Masanori A. , SUZUKI Noboru , ARIMITSU Nagisa , SHIMIZU Jun , FUJIWARA Naruyoshi , TAKAI Kenji , OKADA Yoko , HIROTSU Chieko , TAKADA Erika , SUZUKI Tomoko

    Alzheimer's disease (AD) is a form of age-related dementia, and loss of cholinergic neurons is intimately associated with development of AD symptoms. … We and others have reported that neural cell transplantation ameliorated cognitive dysfunction in AD model mice. … It remains largely unclear whether neural cell transplantation ameliorates the NPS of AD. …

    Experimental Animals, 2021

    J-STAGE 

  • The effects of Ninjinyoeto on spatial memory impairment in a rat model with cerebral ischemia and β-amyloid injection  [in Japanese]

    Nagao Masaki , Katsurabayashi Shutaro , Iwasaki Katsunori , Hatae Akinobu , Mine Kazuma , Tsutsumi Soichiro , Hiarata Marika , Matsui Kazuma , Omori Hiroya , Watanabe Takuya , Kubota Kaori

    … Recently, NYT ameliorated a cognitive dysfunction in patients with Alzheimer's disease (AD), however the mechanisms have been still unclear. … Our results suggest that NYT is a useful treatment for AD patients.</p> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 3-Y-F1-2, 2021

    J-STAGE 

  • Animal model for donepezil-induced nausea and vomiting using pica behavior in mice  [in Japanese]

    Yamamoto Kouichi , Sato Yuhki , Kirikihira Kyosuke , Jotaki Akito , Michihara Ayana , Miyake Yumi

    … <p>Alzheimer's disease (AD) is a neurodegenerative disorder that affects over 50 million people worldwide. … Since it is known that the hypofunction of cholinergic system is one of pathologies associated with AD, acetylcholinesterase inhibitors (AChIs) such as donepezil are used for symptomatic treatment of AD; …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 3-O-E5-5, 2021

    J-STAGE 

  • Axonal targeting of TrkA-APP complex via transcytosis  [in Japanese]

    Yamashita Naoya , Sakurai Takashi

    … Since APP and its proteolytic products play an important role in pathogenesis of Alzheimer's disease (AD), our data further implicate that the deficit of TrkA-APP transcytosis is related to the onset of AD.</p> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 3-O-G5-2, 2021

    J-STAGE 

  • Characterization of β-sheet ligand positive astrocytosis found in Frontotemporal lobar degeneration TDP-43 type-A  [in Japanese]

    Yuka Yokoyama , Harada Ryuichi , Ohira Akihiro , Du Yiqing , Morito Takahiro , Kudo Yukitsuka , Okamura Nobuyuki , Arai Hiroyuki , Yanai Kazuhiko

    … <p>Misfolded proteins such as amyloid and tau found in Alzheimer's disease (AD), β-sheet ligands bind, is one of the therapeutic targets in neurodegenerative diseases. … Frontotemporal lobar degeneration (FTLD) is clinically, pathologically, and genetically heterogenous neurodegenerative disease that affects the frontal and temporal lobes of the brain. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 2-O-B2-2, 2021

    J-STAGE 

  • Restoration of CLSP activity rescues Alzheimer disease  [in Japanese]

    Matsuoka Masaaki , Hashimoto Yuichi , Kusakari Shinya , Nawa Mikiro , Toyama Yuka

    … <p>Calmodulin-like skin protein (CLSP), a secreted peptide, inhibits neuronal death in cell-based Alzheimer's disease (AD) models and transgenic overexpression of the <i>CLSP</i> gene suppresses synaptic loss and memory impairment in AD model mice, <i>APPswe/PS1dE7</i> double transgenic mice (APP/PS1 mice). …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 2-P1-LB46, 2021

    J-STAGE 

  • Effect of forest bioresources for amyloid-β protein and working memory performance  [in Japanese]

    Kensuke Iwasa , Maruyama Kei , Asai Masashi , Shimizu Kuniyoshi , Yoshikawa Keisuke

    … <p>The progressive deposition of amyloid-β protein (Aβ) in the brain is a pathologic feature of Alzheimer's disease (AD). … We evaluated forest bioresources whether to have an efficacy for AD. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 1-P1-31, 2021

    J-STAGE 

  • Establishment of a new tri-culture system for elucidating crosstalk mechanisms between brain microvascular endothelial system and central nervous system in Alzheimer's disease brains  [in Japanese]

    Sasahara Tomoya , Hoshi Minako

    … <p>Data have accumulated suggesting that angiopathy accelerates brain damage in Alzheimer's disease (AD), but its molecular mechanism remains unclear. … We hypothesize that amyloid-beta (Ab) assemblies, termed <u>a</u>mylo<u>sp</u>heroi<u>d</u>s (ASPD), purified from AD patient brains (Noguchi <i>et al</i>. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 1-P1-36, 2021

    J-STAGE 

  • Effect of Gpnmb gene on memory deficits in 9 month-old 5xFAD mice  [in Japanese]

    Kawahara Koichi , Kojima Yukina , Kumakura Natsuki , Sano Masaaki , Hosokai Kota , Yamada Takumi , Hasegawa Takuya , Maeda Takehiko

    … <p>The onset and progression of Alzheimer's disease (AD) correlate with neuroinflammatory processes, and inflammatory microglia (MG) are associated with AD-like pathology in a transgenic mouse model. … However, the function of GPNMB+ type 1 MG in AD brain are largely unknown. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 1-P1-15, 2021

    J-STAGE 

  • Effects of the Alzheimer's disease drug rivastigmine on nerve growth factor via sigma receptor  [in Japanese]

    Yukari Matsushima , Terada Kazuki , Umehara Kaoru , Sakakibara Iwao

    … <p>Currently, acetylcholinesterase (AChE) inhibitors, such as donepezil, are considered the main therapeutic agents for Alzheimer's disease (AD). … We reported previously that treating AD with rivastigmine (Riv) enhanced nerve growth factor (NGF)-induced neurite outgrowth; …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 1-P1-30, 2021

    J-STAGE 

  • The role of nicotinic acetylcholine receptors on differentiation of iPSC-derived macrophages and dopaminergic neurons  [in Japanese]

    Harada Koki , Kato Takeshi , Nishimura Kaneyasu , Hirao Masahiro , Shimohama Shun , Takata Kazuyuki

    … <p>Involvement of nicotinic acetylcholine receptors (nAChRs) in differentiation and maturation of microglia and/or dopaminergic (DA) has not been elucidated, and its clarification may greatly contribute to development of cell therapy against brain diseases, such as Alzheimer's disease (AD) and Parkinson's disease (PD). …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 1-P1-22, 2021

    J-STAGE 

  • Three-dimensional co-culture model using human iPSC derived brain organoid and microglia-like cells  [in Japanese]

    Takata Mayuko , Nishimura Kaneyasu , Takata Kazuyuki

    … <p>Alzheimer's disease (AD) is an age-related neurodegenerative disease that is characterized by formation of amyloid-β (Aβ) plaque and neurofibrillary tangle. These pathological events cause neural cell death and progressive cognitive impairment. While, microglia are the resident macrophages of central nervous system and have the function of Aβ phagocytosis. Although AD animal models have been used to …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 1-P1-21, 2021

    J-STAGE 

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