Search Results 1-20 of 157

  • Critical moieties of aromatic amino acid probes causing renal accumulation in tumor imaging  [in Japanese]

    Jin Chunhuan , Wei Ling , Ohgaki Ryuichi , Okuda Suguru , Nagamori Shushi , Kanai Yoshikatsu

    … Here, we examined a series of aromatic amino acid derivatives with the altered positions for hydroxyl groups and halogen groups on the aromatic ring. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-YIA-17, 2020


  • Development of New Neurotrophic Compounds Based on Talaumidin  [in Japanese]

    Harada Kenichi

    … Using the same synthetic route, several talaumidin derivatives were synthesized to optimize the oxy-functionality on aromatic rings. … indicated that the 2,5-diphenyl structure was crucial moiety, and the two methyl groups on the tetrahydrofuran (THF) ring could enhance the neurotrophic activity. …

    YAKUGAKU ZASSHI 140(2), 129-137, 2020


  • Synthesis of Polycyclic Spirocarbocycles via Acid-Promoted Ring-Contraction/Dearomative Ring-Closure Cascade of Oxapropellanes

    Ogawa Naoki , Yamaoka Yousuke , Takikawa Hiroshi , Takasu Kiyosei

    … DFT calculations suggest that the reaction pathway involves generation of a cyclobutyl cation, ring contraction to the cyclopropylcarbinyl cation, and dearomative ring closure by an internal 2-naphthol moiety. … The resulting spirocarbocycles are synthetically valuable, as they could be transformed into two different polycyclic aromatic hydrocarbons via skeletal rearrangement. …

    Organic letters 21(18), 7563-7567, 2019-09


  • Critical moieties of aromatic amino acids for the interaction with organic anion transporter OAT1: Implications for reducing the renal background in tumor imaging  [in Japanese]

    Jin Chunhuan , Wei Ling , Ohgaki Ryuichi , Tominaga Hideyuki , Okuda Suguru , Nagamori Shushi , Kanai Youshikatsu

    … To reveal the critical moieties responsible for the interaction with OAT1, we performed a structure-activity relationship analysis of aromatic amino acid derivatives <i>in vitro</i>. … We revealed that both halogen and hydroxyl groups on the benzene ring are critical for the interaction with OAT1. … Their positions on the benzene ring also affected the interaction. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 1-SS-02, 2019


  • Study on Synthesis and Biological Evaluation of 3-Aryl Substituted Xanthone Derivatives as Novel and Potent Tyrosinase Inhibitors

    Yu Lihong , Chen Liandi , Luo Guolin , Liu Licai , Zhu Wenqi , Yan Pengke , Zhang Peiquan , Zhang Chao , Wu Wenhao

    … In this study, we targeted a series of structure-based 3-aryl substituted xanthone derivatives in which diverse functional groups were respectively attached on 3-aromatic ring moiety as new tyrosinase inhibitors. … value of 11.3 µM, uncovering that the introduction of the proper hydroxyl group in the 3-aromatic ring was beneficial for enhancing the inhibitory potency against tyrosinase. …

    Chemical and Pharmaceutical Bulletin 67(11), 1232-1241, 2019

    J-STAGE  Ichushi Web 

  • Structure activity relations of aromatic amino acid derivatives to interact with organic anion transporter OAT1 reveal critical moieties for renal accumulation of tumor imaging probes

    Jin Chunhuan , Ohgaki Ryuichi , Tominaga Hideyuki , Okuda Suguru , Nagamori Shushi , Kanai Yoshikatsu

    … Therefore, we speculate that OAT1 plays a pivotal role in the accumulation of FAMT and IMT in the kidney.</p><p>Method: We used a series of aromatic amino acid derivatives with the altered positions for hydroxyl groups and halogen groups on the aromatic rings. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO1-8-40, 2018


  • Facile Synthesis of Polycyclic Aromatic Hydrocarbons: Brønsted Acid Catalyzed Dehydrative Cycloaromatization of Carbonyl Compounds in 1,1,1,3,3,3-Hexafluoropropan-2-ol

    Fujita Takeshi , Takahashi Ikko , Hayashi Masaki , Wang Jingchen , Fuchibe Kohei , Ichikawa Junji , 市川 淳士 , 藤田 健志 , 渕辺 耕平

    … The cycloaromatization of aromatic aldehydes and ketones was readily achieved by using a Brønsted acid catalyst in 1,1,1,3,3,3-hexafluoropropan-2-ol (HFIP). … Furthermore, biaryl-2-ylacetaldehydes bearing a cyclopentene moiety at the α-position underwent unprecedented cycloaromatization including ring expansion to afford triphenylenes. …

    European journal of organic chemistry 2017(2), 262-265, 2017-01


  • A Novel Probe with a Chlorinated α-Cyanoacetophenone Acceptor Moiety Shows Near-Infrared Fluorescence Specific for Tau Fibrils

    Park Kwang-su , Yoo Kyungha , Kim Mi Kyoung , Jung Woong , Choi Yoon Kyung , Chong Youhoon

    … <p>Development of a novel, tau-selective near-infrared fluorescence (NIRF) probe was attempted by combining the 3,5-dimethoxy-<i>N</i>,<i>N</i>-dimethylaniline-4-yl moiety with an α-cyanoacetophenone <i>via</i> … In particular, for structure–activity relationship study of the α-cyanoacetophenones, a chlorine substituent was introduced to the aromatic ring to give a series of compounds (<b>2a</b>–<b>2d</b>). …

    Chemical and Pharmaceutical Bulletin 65(12), 1113-1116, 2017

    J-STAGE  Ichushi Web 

  • Synthesis of Silicone Rubber using Polysilarylenesiloxane Derivatives  [in Japanese]

    ICHIKAWA Tsukasa , HARUKI Mitsuru , NEMOTO Nobukatsu

    … We consider the introduction of an aromatic ring with sulfobetaine substituents into the main chain of PDMS to solve the problems. … Poly(tetramethylsilphenylenesiloxane)(PTMS) is the representative polymer where an aromatic moiety is incorporated into the polysiloxane backbone, which would presumably improve the good properties of polysiloxane, especially the thermostability. …

    NIPPON GOMU KYOKAISHI 90(7), 354-358, 2017


  • Asymmetric Total Synthesis of Hinckdentine A  [in Japanese]

    Douki Kazuya , Ono Hiroyuki , Shimokawa Jun , Fukuyama Tohru , Kitamura Masato

    … Unprecedented structural features of 1 include the highly brominated indolo[1,2-c]quinazoline core structure connected to azepanone moiety through the tetrasubstituted carbon center, as well as the characteristic cyclic amidine moiety. … The intermediate 2 could be deemed the dearomatized indole with an aromatic moiety wedging into the indole 2-position. …

    Symposium on the Chemistry of Natural Products, symposium papers 58(0), Oral2, 2016


  • Asymmetric Total Syntheses of Antibiotic Tetracenomycins  [in Japanese]

    Sato Shogo , Sakata Keiichiro , Hashimoto Yoshimitsu , Takikawa Hiroshi , Suzuki Keisuke

    … Tetracenomycins constitute an intriguing class of naturally occurring aromatic polyketides, sharing a characteristic tetracyclic structure with dense oxygen functionalities. … The structure of 1 and 2 features a highly functionalized tetracyclic core with three contiguous stereogenic centers located at the A-ring, including the characteristic angular cis-diol. …

    Symposium on the Chemistry of Natural Products, symposium papers 58(0), Oral24, 2016


  • Anti-osteoporotic effects of 5,6-dehydrokawain and it's synthetic analogs  [in Japanese]

    Kumagai Momochika , Mishima Takashi , Yoshida Izumi , Ide Masahiro , Koizumi Keiko , Watai Masatoshi , Nishikawa Keisuke , Morimoto Yoshiki

    … Moreover, we found that the analogs having hydrophobic groups at the para position on the aromatic ring indicated the strong activity. … This result is important for the probe design because the direct substitution of a functional moiety onto the aromatic ring resulted in loss of the activity. …

    Symposium on the Chemistry of Natural Products, symposium papers 58(0), Poster38, 2016


  • Differentiation of the Isomers of <i>N</i>-Alkylated Cathinones by GC-EI-MS-MS and LC-PDA

    KOHYAMA Erina , CHIKUMOTO Takao , TADA Hiroyuki , KITAICHI Kiyoyuki , HORIUCHI Tadashi , ITO Tetsuro

    … Product ion spectrometry of iminium ions allows for an univocal differentiation of the studied cathinones with the same aminoalkyl moiety. … Furthermore, the product ion spectrometry of acylium ions and ultraviolet spectra obtained by LC-PDA enabled differentiation of regioisomers resulting from different substitution patterns on the aromatic ring. …

    Analytical Sciences 32(8), 831-837, 2016


  • Enhanced Structural Variety of Nonplanar <i>N</i>-Oxyl Radical Catalysts and Their Application to the Aerobic Oxidation of Benzylic C–H Bonds

    Kadoh Yoichi , Oisaki Kounosuke , Kanai Motomu

    moiety, and investigated their utility in the aerobic oxidation of benzylic C–H bonds. … The introduction of substituents at the aromatic ring was also effective, as evident from the performance of 7-CF<sub>3</sub> …

    Chemical and Pharmaceutical Bulletin 64(7), 737-753, 2016


  • Effects of humic acids on the sorption and bioavailability of pyrene and 1,2-dihydroxynaphthalene

    Kobayashi Takayuki , Sumida Hiroaki

    … Sorption of organic contaminants such as polycyclic aromatic hydrocarbons (PAHs) is an important process that controls their mobility and toxicity in soil. … The relationship between the chemical properties of various types of humic acids (HAs) and their pyrene (4-ring PAH) sorption ability was investigated in batch experiments. … Furthermore, the detoxification effect tended to increase with increasing aromatic carbon content of HA (r = 0.94). …

    Soil Science and Plant Nutrition 61(sup1), 113-122, 2015-04-27


  • Replacement of Tyr50 stacked on the si-face of the isoalloxazine ring of the flavin adenine dinucleotide prosthetic group modulates Bacillus subtilis ferredoxin-NADP+ oxidoreductase activity toward NADPH

    Seo Daisuke , Naito Hiroshi , Nishimura Erika , Sakurai Takeshi

    … These FNRs contain two unique aromatic residues stacked on the si- and re-face of the isoalloxazine ring moiety of the FAD prosthetic group whose configurations are often found among other types of flavoproteins including plant-type FNR and flavodoxin, but not in bacterial NADPH-thioredoxin reductase. …

    Photosynthesis Research 125(1-2), 321-328, 2015-02-20


  • Synthesis of all stereoisomers of spectomycin A1 and their inhibitory activity against protein SUMOylation  [in Japanese]

    Nomura Yusaku , Sodeoka Mikiko , Thuaud F. , Sekine Daisuke , Hirai Go , Maeda Satoko , Ito Akihiro , Ichikawa Satoshi , Matsuda Akira , Yoshida Minoru

    … </p><p>Structural features of SMAs are represented as an aromatizable β-hydroxy tetralone moiety and a non-conjugated β-methoxy acrylate with aromatic ring. … Palladium-catalyzed reductive cyclization of the common intermediate successfully constructed the all possible stereoisomers at C4 and C5 of the precursors of SMA1 with the β-methoxy acrylate moiety. …

    Symposium on the Chemistry of Natural Products, symposium papers 57(0), Oral24, 2015


  • Catalytic Reactions with (π-Arene) chromium Complexes  [in Japanese]

    Arae Sachie

    … Complexation of an arene to a low-valent metal carbonyl, such as Cr(CO)<sub>3</sub>, transfers electron density from the aromatic ring to the metal tricarbonyl moiety. … As a result, the acidity of the aromatic ring as well as of the benzylic position is enhanced. …

    Journal of Synthetic Organic Chemistry, Japan 73(8), 844-845, 2015


  • Unique and Specific Reaction Behavior and Characteristic Spatial Organization of Non-coplanarly Aromatic-ring-accumulated Molecular Compounds  [in Japanese]

    Okamoto Akiko , Yonezawa Noriyuki

    … The polyaromatic ketone compounds having non-coplanarly aromatic-ring-accumulated structure have been studied from the viewpoint of uniqueness and specificity in reaction behavior and characteristics in spatial organization. … By the separate reaction of the isolated aryl-aryl ketones, the acid-mediated retro-aroylation of aromatic ketone molecules is confirmed. …

    Journal of Synthetic Organic Chemistry, Japan 73(4), 339-360, 2015


  • Syntheses of rigid-rod but degradable biopolyamides from itaconic acid with aromatic diamines

    Ali Mohammad Asif , Tateyama Seiji , Kaneko Tatsuo

    … Highly-thermostable but degradable polyamides have been synthesized by a polycondensation of bio-derived itaconic acid salts with aromatic diamines to form heterocyclic pyrrolidone ring in the polymer backbone. … We then incorporated an appropriate amount of aliphatic moiety into the aromatic backbones to prepare the high-performance and processable polyamides with T_g over 115 °C and T_<10> …

    Polymer Degradation and Stability 109, 367-372, 2014-06-11

    IR  DOI 

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