Search Results 1-20 of 470

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The Differential Selectivity of Aryl Hydrocarbon Receptor (AHR) Agonists towards AHR-Dependent Suppression of Mammosphere Formation and Gene Transcription in Human Breast Cancer Cells

Saito Nao , Kanno Yuichiro , Yamashita Naoya , Degawa Masakuni , Yoshinari Kouichi , Nemoto Kiyomitsu

Biological & pharmaceutical bulletin 44(4), 571-578, 2021-04
2

Chronic low-dose exposure to imidacloprid potentiates high fat diet-mediated liver steatosis in C57BL/6J male mice

NIMAKO Collins , NAKAYAMA Shouta M. M. , ISHIZUKA Mayumi , IKENAKA Yoshinori , OKAMATSU-OGURA Yuko , BARIUAN Jussiaea V. , KOBAYASHI Atsushi , YAMAZAKI Ryo , TAIRA Kumiko , HOSHI Nobuhiko , HIRANO Tetsushi

… Imidacloprid also induced hepatic expression of the gene encoding pregnane X receptor; … but had no significant effect on hepatic expressions of liver X receptor and aryl hydrocarbon receptor. …

Journal of Veterinary Medical Science 83(3), 487-500, 2021

J-STAGE
3

The Differential Selectivity of Aryl Hydrocarbon Receptor (AHR) Agonists towards AHR-Dependent Suppression of Mammosphere Formation and Gene Transcription in Human Breast Cancer Cells

Saito Nao , Kanno Yuichiro , Yamashita Naoya , Degawa Masakuni , Yoshinari Kouichi , Nemoto Kiyomitsu

… We had previously reported that treatment with the aryl hydrocarbon receptor (AHR) agonist β-naphthoflavone (βNF) suppressed mammosphere formation derived from cancer stem cells in human breast cancer MCF-7 cells (Cancer Lett., 317, 2012, Zhao et al.). …

Biological and Pharmaceutical Bulletin 44(4), 571-578, 2021

J-STAGE
4

An Indigo Naturalis constituent indigo ameliorates colitis by accelerating wound closure [in Japanese]

Shimizu Takaaki , Takagi Chisa , Sawano Toshinori , Nakatani Jin , Tanaka Hidekazu

… INDG is an aryl hydrocarbon receptor (AhR) ligand. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 1-O-G2-2, 2021

J-STAGE
5

Anti-colitis effect of a new component isolated from Qing-dai (Sei-tai) [in Japanese]

Imai Saki , Miyashita Moe , Tsuboi Tae , Isohama Yoichiro

… In our previous pharmacological experiments, Sei-tai considerably inhibited LPS-induced cytokine expression in cultured gastric epithelial cells and inhibited DSS-induced UC in mice. Indigo, a major component of this medicine, is known to activate a nuclear receptor Aryl hydrocarbon receptor (AhR) and have anti-inflammatory effect. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 1-O-G2-1, 2021

J-STAGE
6

Polycyclic aromatic hydrocarbons induce CYP3A5 gene expression via aryl hydrocarbon receptor in HepG2 cells

Yamashita Naoya , Kanno Yuichiro , Yoshikawa Minami , Ozawa Moeno , Sanada Noriko , Nemoto Kiyomitsu , Kizu Ryoichi

… The aryl hydrocarbon receptor (AhR) regulates expression of genes encoding drug/xenobiotic metabolizing enzymes. …

The Journal of Toxicological Sciences 46(1), 25-29, 2021

J-STAGE
7

Lack of association between multiple polymorphisms in aryl hydrocarbon receptor (AhR) gene and cancer susceptibility

Li He , Luo Li , Wang Dan , Duan Jun , Zhang Rui

Environmental Health and Preventive Medicine 25(1), 2020-12-05

DOI
8

Anti-pollution effects via activation of Nrf2 anti-oxidation system in skin cells [in Japanese]

仁木洋子 , 小寺啓貴 , 小野内裕美

Fragrance journal : Research & development for cosmetics, toiletries & allied industries = フレグランスジャーナル : 香粧品科学研究開発専門誌 48(10), 26-32, 2020-10

Ichushi Web
9

Pathogenesis of Chloracne and Hyperpigmentation in Yusho : Role of Aryl Hydrocarbon Receptor [in Japanese]

古江増隆

… Dioxins exert their major toxicity by binding and activating aryl hydrocarbon receptor (AHR) and subsequent generation of reactive oxygen species (ROS). …

福岡医学雑誌 = Fukuoka acta medica 111(3), 124-136, 2020-09-25

IR DOI
10

Biochemical properties of human full-length aryl hydrocarbon receptor (AhR)

Uemura Seiya , Nakajima Yasutomo , Yoshida Yuhki , Furuya Moeko , Matsutani Shun , Kawate Shinya , Ikeda Shun-ichi , Tsuji Noriko , Grave Ewa , Wakui Hideki , Itoh Hideaki

The journal of biochemistry 168(3), 285-294, 2020-09
11

Controlling Hepatitis C Virus and Drug-resistant Viruses by Isoflavones [in Japanese]

渡士幸一

大豆たん白質研究 22(40), 15-20, 2020-06
12

Significant Benefits of AIP Testing and Clinical Screening in Familial Isolated and Young-onset Pituitary Tumors

Marques Pedro , Caimari Francisca , Hernández-Ramírez Laura C. , Collier David , Iacovazzo Donato , Ronaldson Amy , Magid Kesson , Lim Chung Thong , Stals Karen , Ellard Sian , Grossman Ashley B. , Korbonits Márta , Iwata Takeo , Yoshimoto Katsuhiko

… Germline mutations in the aryl hydrocarbon receptor-interacting protein (AIP) gene are responsible for a subset of familial isolated pituitary adenoma (FIPA) cases and sporadic pituitary neuroendocrine tumors (PitNETs).Objective: To compare prospectively diagnosed AIP mutation-positive (AIPmut) PitNET patients with clinically presenting patients and to compare the clinical characteristics of AIPmut and AIPneg PitNET patients.Design: 12-year prospective, observational study.Participants & …

The Journal of Clinical Endocrinology & Metabolism 105(6), dgaa040, 2020-01-30

IR
13

Pathogenesis of atopic dermatitis; Competitive Regulatory Mechanisms of Skin Barrier Function by AHR Axis versus IL-13/IL-4-JAK-STAT6/STAT3 Axis [in Japanese]

Furue Masutaka

… デュピルマブ療法がアトピー性皮膚炎に奏功することから，その病態にIL-13/IL-4が深く関与することが明らかとなった．本稿では皮膚バリア機能がaryl hydrocarbon receptor（AHR）軸（バリアを強める）とIL-13/IL-4-JAK-STAT6/STAT3軸（バリアを弱める）による競合的調節を受けていることを概説し，現在の薬物治療に加え，AHR軸を亢進させる薬物治療（coal tarやglyteer）の作用機序と将来 …

The Japanese Journal of Dermatology 130(13), 2705-2723, 2020

J-STAGE
14

Role of aryl-hydrocarbon receptor in malignant transformation of human epidermal growth factor receptor 2-overexpressing breast cancer [in Japanese]

SAITO Nao , YAMASHITA Naoya , KANNO Yuichiro , DEGAWA Masakuni , NEMOTO Kiyomitsu

芳香族炭化水素受容体（AhR）は、ダイオキシンなど種々化学物質の毒性発現に関与する受容体型転写因子として知られている。AhRは通常、細胞質に存在しており、リガンドの結合により活性化し核に移行する。当教室の菅野らは、ヒト乳がん由来細胞株MCF-7より樹立したヒト上皮成長因子受容体2（HER2）安定発現細胞株（HER2-5細胞）において、AhRの発現量増加及び恒常的な核局在化が認めら …

Annual Meeting of the Japanese Society of Toxicology 47.1(0), P-76S, 2020

J-STAGE
15

喫煙による肺がん細胞増殖亢進リスク [in Japanese]

TERASHIMA Jun , ONODERA Ryo , MIURA Toshitaka

喫煙と肺がんの関係は、多くの場合発がんを基本に語られる事が多い。がんの予防は重要であり、がんにならないため、周囲にがんのリスクを与えないための禁煙運動は将来的に効果が出てくると考えられる。では、肺がんになってしまった場合、喫煙はどのような影響をがんに与えるのだろうか？本稿では、たばこの煙に含まれる発がん物質が肺がん細胞に与える影響を分子的に解析した研究結果を紹介する。

Farumashia 56(8), 736-738, 2020

J-STAGE Ichushi Web
16

Enzymatically synthesized glycogen protects inflammation induced by urban particulate matter in normal human epidermal keratinocytes

Kitakaze Tomoya , Yoshioka Yasukiyo , Furuyashiki Takashi , Ashida Hitoshi

… PM contains polycyclic aromatic hydrocarbons, and they act as the agonists of aryl hydrocarbon receptor (AhR). …

Journal of Clinical Biochemistry and Nutrition 67(1), 29-35, 2020

J-STAGE
17

Impact of maternal dietary gut microbial metabolites on an offspring's systemic immune response in mouse models

NAKAJIMA Akihito , WATANABE Sumio , NAGAHARA Akihito , HABU Sonoko , KASAI Masataka , OKUMURA Ko , ISHIKAWA Dai , SHIBUYA Tomoyoshi , KOBAYASHI Osamu , OSADA Taro , OHKUSA Toshifumi

… Previous studies have also revealed that metabolites such as short-chain fatty acids (SCFAs) and the aryl hydrocarbon receptor (AhR) ligands are involved in host health and diseases. …

Bioscience of Microbiota, Food and Health 39(2), 33-38, 2020

J-STAGE Ichushi Web
18

Proton pump inhibitors block iron absorption through direct regulation of hepcidin via the aryl hydrocarbon receptor-mediated pathway

Hamano Hirofumi , Niimura Takahiro , Horinouchi Yuya , Zamami Yoshito , Takechi Kenshi , Goda Mitsuhiro , Imanishi Masaki , Chuma Masayuki , Izawa-Ishizawa Yuki , Miyamoto Licht , Fukushima Keijo , Fujino Hiromichi , Tsuchiya Koichiro , Ishizawa Keisuke , Tamaki Toshiaki , Ikeda Yasumasa

… In fact, the PPI omeprazole increased hepcidin secretion, and omeprazole-induced hepcidin upregulation was inhibited by gene silencing or the pharmacological inhibition of the aryl hydrocarbon receptor. …

Toxicology Letters (318), 86-91, 2019-10-24

IR
19

The effect of 2,3,7,8-Tetrafluorodibenzo-p-dioxin on Dioxin Toxicity [in Japanese]

武田知起 , 人見将也 , 山田英之 , 石井祐次

… Our previous studies have found that the toxic effects induced by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD), a highly toxic congener of dioxins, are due to a reduction in the pituitary expression of growth hormone (GH) and luteinizing hormone (LH) during the fetal period, via activation of the aryl hydrocarbon receptor (AHR). …

福岡医学雑誌 = Fukuoka acta medica 110(2), 122-127, 2019-06-25

IR DOI
20

Aryl Hydrocarbon Receptor Activation Induced by Epidermal Growth Factor Receptor Inhibitors in Human Keratinocytes and Sebocytes: A Possible Mechanism of Acneiform Eruption

辻学 , 竹村正規 , 八谷顕子 , 古江増隆 , 中原剛士

上皮成長因子受容体阻害薬は進行期の癌に対して有効であるが，しばしば，副作用としてざ瘡様発疹症を生じる．これには脂腺の活動性が増加することが関連することが示唆されているが，その機序はほとんど知られていない．我々は，1）芳香族炭化水素受容体が毛包上皮細胞や表皮細胞の細胞分化を制御し，脂腺の活動性も制御すること，2）上皮成長因子受容体シグナルと芳香族炭化水素受容体シグナルはp300 タンパクを共有してお …

福岡医学雑誌 = Fukuoka acta medica 110(2), 113-121, 2019-06-25

IR DOI Ichushi Web

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