Search Results 1-20 of 7126

  • Plasma Xanthine Oxidoreductase (XOR) Activity in Cardiovascular Disease Outpatients

    Matsushita Masato , Murase Takayo , Nakamura Takashi , Takayasu Tsutomu , Asano Miwako , Okajima Fumitaka , Kobayashi Nobuaki , Hata Noritake , Asai Kuniya , Shimizu Wataru , Shirakabe Akihiro , Okazaki Hirotake , Shibata Yusaku , Goda Hiroki , Shigihara Shota , Asano Kazuhiro , Tani Kenichi , Kiuchi Kazutaka

    Blood samples were collected from patients who visited a daily cardiovascular outpatient clinic. …

    Circulation Reports, 2020

    J-STAGE 

  • A Puncturing Device that Mimics the Mechanism of Mosquito's Proboscis and Labium - Verification of the Effect of Skin Deformation / Needle Buckling Prevention Mechanism and Puncture Experiment on Artificial Skin and Experimental Animals –

    Yamamoto Shunki , Hosomi Ryota , Fukunaga Kenji , Uta Daisuke , Takazawa Tomonori , Hikitsuchi Tomoyuki , Kawajiri Yumi , Nakayama Koji , Aoyagi Seiji , Yamada Masahiro , Takahashi Tomokazu , Suzuki Masato , Nagashima Toshio , Kunugi Atsushi , Chiyonobu Makoto , Kuroiwa Takeshi

    … The study successfully samples blood from the mouse without stagnation of blood flow.</p> …

    International Journal of Automation Technology 14(1), 117-127, 2020

    J-STAGE 

  • Serum Pepsinogen Values in Japanese Junior High School Students With Reference to <i>Helicobacter Pylori</i> Infection

    Okuda Masumi , Lin Yingsong , Mabe Katsuhiro , Kato Mototsugu , Osaki Takako , Miyamoto Ryosuke , Okumura Akihisa , Kamiya Shigeru , Kikuchi Shogo

    … All junior high school students (1,225 in total) in Sasayama city, who were basically healthy, were asked to provide urine and serum samples, which were used to measure urine and serum <i>H. … Of the 187 subjects who provided urine and blood samples, 8 were infected, 4 had discrepant results, 4 had negative serum antibody titers no less than 3.0 U/ml, and 171 were non-infected. …

    Journal of Epidemiology 30(1), 30-36, 2020

    J-STAGE 

  • The Japan Public Health Center-based Prospective Study for the Next Generation (JPHC-NEXT): Study Design and Participants

    Sawada Norie , Iso Hiroyasu , Yasuda Nobufumi , Kato Tadahiro , Saito Isao , Hasegawa Maiko , Aoyagi Kiyoshi , Tsugane Shoichiro , Iwasaki Motoki , Yamaji Taiki , Goto Atsushi , Shimazu Taichi , Inoue Manami , Tanno Kozo , Sakata Kiyomi , Yamagishi Kazumasa

    … We obtained informed consent from each participant to participate in this long follow-up study of at least 20 years, including consent to the potential use of their residence registry, medical records, medical fee receipts, care insurance etc., and to the provision of biospecimens (blood and urine), including genomic analysis.</p><p><b>Results:</b> …

    Journal of Epidemiology 30(1), 46-54, 2020

    J-STAGE 

  • A case of liver abscess caused by <i>Edwardsiella tarda</i> with rapid increase and bacteremia  [in Japanese]

    Suehiro Tomoyuki , Komori Atsumasa , Yatsuhashi Hiroshi , Beppu Asami , Kugiyama Yuki , Bekki Shigemune , Hashimoto Satoru , Saeki Akira , Nagaoka Shinya , Abiru Seigo , Yamasaki Kazumi

    <p>Edwardsiella tarda(以下E. tarda)による肝膿瘍は稀であるが,基礎疾患がある場合は重症化する場合もあり注意を要する.症例は79歳女性,C型慢性肝炎治癒後および肝内結石に対し肝左葉切除術の既往がある.悪寒と発熱を主訴に来院し,腹部CTでS5/8に50 mm大の膿瘍を認め入院となった.入院6日前に施行した腹部超音波検査では,肝膿瘍は指摘できなかった.入院時の血 …

    Kanzo 61(1), 18-23, 2020

    J-STAGE 

  • Anti-Hexokinase 1 Antibody as a Novel Serum Biomarker of a Subgroup of Diabetic Macular Edema

    Yoshitake Tatsuya , Murakami Tomoaki , Yoshitake Shin , Suzuma Kiyoshi , Dodo Yoko , Fujimoto Masahiro , Ito Shinji , Tsujikawa Akitaka

    … Diabetic retinopathy (DR) induces the breakdown of the blood-retinal barrier and promotes neuroinflammation, although autoimmune responses to sequestered retinal antigens remain poorly understood. … Screening by immunoblotting demonstrated that IgG from 7 of 10 DME sera samples reacted to an ~102-kDa autoantigen from porcine retinas. …

    Scientific Reports (9), 2019-12-01

    IR 

  • Use of the ¹³C breath test to assess late dumping after esophagectomy and subsequent gastric tube reconstruction for esophageal cancer

    Tairo Ryotokuji , Akinori Miura , Masaki Sanaka , Takatsugu Yamamoto , Kazuya Yamaguchi , Toshihiro Matsui , Takuya Okada , Akihiro Hoshino , Yutaka Tokairin , Kenro Kawada , Yasuaki Nakajima , Yusuke Kinugasa , Tatsuyuki Kawano

    … Breath samples for the ¹³C gas analysis and blood samples were collected. …

    Journal of Medical and Dental Sciences 66(4), 65-73, 2019-12

    IR 

  • Discovery of a new Theileria sp. closely related to Theileria annulata in cattle from Sri Lanka

    Sivakumar Thillaiampalam , Fujita Shiori , Tuvshintulga Bumduuren , Kothalawala Hemal , Silva Seekkuge Susil Priyantha , Yokoyama Naoaki

    … annulata in Sri Lanka, we observed that merozoite-piroplasm surface antigen (tams1) and surface protein (tasp)-like gene sequences obtained from bovine blood DNA samples, which were PCR-positive for T. … Moreover, the 18S rRNA sequences from the Sri Lankan samples contained ten unique single-nucleotide polymorphisms compared with all known T. …

    Scientific Reports 9(1), 16132, 2019-12

    IR 

  • Initial periodontal treatment affects nucleotide-binding domain leucine-rich repeat-containing protein 3 inflammasome priming in peripheral blood mononuclear cells

    Higuchi Kanako , SM Ziauddin , Yamashita Yasunori , Ozaki Yukio , Yoshimura Atsutoshi

    … We investigated the effect of initial periodontal treatment on the inflammasome priming of peripheral blood mononuclear cells (PBMCs). … Peripheral blood samples were collected at baseline and re-evaluation (41.1 ± 29.1 d after the treatment), and the relative expression of IL-1β, and three inflammasome components, ASC, NLRP3 and Caspase-1, mRNA was determined using quantitative reverse transcription PCR. …

    Archives of Oral Biology (110), 104625, 2019-11-29

    IR 

  • Genomic landscape of epithelium with low-grade atypia on gastric cancer after Helicobacter pylori eradiation therapy

    Masuda Kazuhiko , Urabe Yuji , Itou Masanori , Ono Atsushi , Nelson Hayes Clair , Nakamura Koki , Kotachi Takahiro , Boda Tomoyuki , Tanaka Shinji , Chayama Kazuaki

    … However, whether ELA originates from cancer after re-differentiation or from the non-cancerous surrounding mucosa is unknown.Methods We isolated ELA regions from 10 early gastric cancer patients and analyzed the nucleotide sequences for 90 oncogenes and 35 fusion oncogenes, comparing them with counterpart cancer tissue, normal gastric mucosa, and blood cell-derived DNA. …

    Journal of Gastroenterology 54(10), 907-915, 2019-10

    IR 

  • IL-17A, a possible biomarker for the evaluation of treatment response in Trypanosoma cruzi infected children: A 12-months follow-up study in Bolivia

    Vásquez Velásquez Clara , Russomando Graciela , Espínola Emilio E. , Sanchez Zunilda , Mochizuki Kota , Roca Yelin , Revollo Jimmy , Guzman Angelica , Quiroga Benjamín , Rios Morgan Susana , Vargas Ortiz Roberto , Zambrana Ortega Alberto , Espinoza Eida , Nishizawa Juan Eiki , Kamel Mohamed Gomaa , Kikuchi Mihoko , Mizukami Shusaku , Na-Bangchang Kesara , Tien Huy Nguyen , Hirayama Kenji

    … METHODS AND FINDINGS: We conducted a 12-month follow-up study and seven blood samples were taken during and after the treatment. …

    PLOS Neglected Tropical Diseases 13(9), e0007715, 2019-09-25

    IR 

  • Development of a novel transport system for emergency blood samples using unmanned aerial vehicles in medical depopulated areas(Phase 2 study)  [in Japanese]

    儀賀 普嗣 , 貞森 拓磨 , 島谷 竜俊 , 住吉 泰士 , 宮内 英樹 , 小林 博幸 , 大下 慎一郎 , 志馬 伸朗

    日本遠隔医療学会雑誌 = Japanese journal of telemedicine and telecare 15(2), 96-99, 2019-09

  • Pilot study on serum C-reactive protein in pet rabbits: Clinical usefulness

    Oohashi Eiji , Kimura Yuki , Matsumoto Kotaro

    … Methods The CRP level using a rabbit CRP ELISA and white blood cell (WBC) count in pet rabbits (30 healthy controls and 62 with various diseases) were measured in the clinical practice setting. … Serum samples were collected from two rabbits before and after ovariohysterectomy. …

    Veterinary Record Open 6(1), e000272, 2019-09

    IR 

  • Epidemiological survey of hemoprotozoan parasites in cattle from low-country wet zone in Sri Lanka

    Gunasekara Erandi , Sivakumar Thillaiampalam , Kothalawala Hemal , Abeysekera Thuduwege Sanath , Weerasingha Amitha Sampath , Vimalakumar Singarayar Caniciyas , Kanagaratnam Ratnam , Yapa Palitha Rohana , Zhyldyz Atambekova , Igarashi Ikuo , Silva Seekkuge Susil Priyantha , Yokoyama Naoaki

    … In this study, DNA samples were prepared from the blood of 121 cattle in Galle, a coastal district located in low-country wet zone in Sri Lanka, and were PCR-screened for Babesia bovis, Babesia bigemina, T. …

    Parasitology International (71), 5-10, 2019-08

    IR 

  • Bovine leukemia virus genotype 1 and 6 are circulating among dairy and beef cattle of small and medium holding farms in northern Vietnam

    Dao Tung Duy , Nguyen Hoa Thanh , Than Son The , Bui Vuong Nghia , Ogawa Haruko , Imai Kunitoshi

    … Ninety-three blood samples (45 dairy and 48 beef cattle) were randomly collected from 464 cattle from 22 farms in four districts in northern Vietnam. … The samples were tested for the presence of BLV by using two realtime PCR detection systems that targeted the BLV pol gene and tax gene. … The samples were also tested for BLV antibody, using an ELISA kit. …

    Japanese Journal of Veterinary Research 67(1), 83-92, 2019-07

    IR  Ichushi Web 

  • Enantiomeric Analysis of 2,2',3,4,4',5',6-Heptachlorobiphenyl in the Blood of Examinees Collected during Medical Check-up for Yusho  [in Japanese]

    酒谷 圭一 , 安武 大輔 , 高橋 浩司 , 堀 就英 , 梶原 淳睦 , 香月 進 , 中野 武 , 三苫 千景 , 古江 増隆

    … In this study, we analyzed 2,2ʼ,3,4,4ʼ,5ʼ,6-Heptachlorobiphenyl (PCB183) in the human blood enantioselectively, and quantified the enantiomer-specific accumulation. … The samples were collected during medical check-up for Yusho from 2015 through 2017. … The average enantiomeric fraction (EF) of PCB183 in samples were 0.718. …

    福岡医学雑誌 = Fukuoka acta medica 110(2), 91-96, 2019-06-25

    IR 

  • Blood Dioxin Concentrations and their Tendencies Examined in 2001-2017 Annual Inspections for Yusho  [in Japanese]

    堀 就英 , 安武 大輔 , 平川 博仙 , 戸髙 尊 , 広瀬 勇気 , 新谷 依子 , 梶原 淳睦 , 香月 進 , 三苫 千景 , 古江 増隆

    … We performed congener specific analysis of dioxins using HRGC/HRMS and determined their concentrations in blood samples collected from approx. 1,700 persons during annual Yusho examinations between 2001 and 2017. …

    福岡医学雑誌 = Fukuoka acta medica 110(2), 61-66, 2019-06-25

    IR 

  • Dynamics of Minimal Residual Disease in Neuroblastoma Patients

    Uemura Suguru , Ishida Toshiaki , Thwin Khin Kyae Mon , Yamamoto Nobuyuki , Tamura Akihiro , Kishimoto Kenji , Hasegawa Daiichiro , Kosaka Yoshiyuki , Nino Nanako , Lin Kyaw San , Takafuji Satoru , Mori Takeshi , Iijima Kazumoto , Nishimura Noriyuki

    … MRD is composed of drug-resistant tumor cells and dynamically presented as cancer stem cells (CSCs) in residual tumors, circulating tumor cells (CTCs) in peripheral blood (PB), and disseminated tumor cells (DTCs) in bone marrow (BM) and other metastatic sites. … Because MRD can be detected by tumor-specific antigens, genetic or epigenetic changes, and mRNAs, numerous assays using different methods and samples have been reported to detect MRD in cancer patients. …

    Frontiers in Oncology (9), 455, 2019-06-04

    IR 

  • Detection of Transgenes in Gene Delivery Model Mice by Adenoviral Vector Using ddPCR

    川上 康 , Takehito Sugasawa , Kai Aoki , Koichi Watanabe , Koki Yanazawa , Tohru Natsume , Tohru Takemasa , Kaori Yamaguchi , Yoshinori Takeuchi , Yuichi Aita , Naoya Yahagi , Yasuko Yoshida , Katsuyuki Tokinoya , Nanami Sekine , Kaoru Takeuchi , Haruna Ueda , Yasushi KAWAKAMI , Satoshi Shimizu , Kazuhiro Takekoshi

    … After five days, stool and whole blood samples were collected, and total DNA was extracted. … As additional experiments, whole blood was also collected from the mouse tail tip until 15 days from injection of the rAdv vector. … Transgene fragments from different DNA samples were analyzed using semi-quantitative PCR (sqPCR), quantitative PCR (qPCR), and droplet digital PCR (ddPCR). …

    Genes 10(6), 436, 2019-06

    IR 

  • Pharmacokinetic study of the oral fluorouracil antitumor agent S-1 in patients with impaired renal function

    Goto Keiko , Fujiwara Yutaka , Isobe Takeshi , Chayahara Naoko , Kiyota Naomi , Mukohara Toru , Tsubata Yukari , Hotta Takamasa , Tamura Kenji , Yamamoto Noboru , Minami Hironobu

    Blood samples were collected for pharmacokinetic analysis. …

    Cancer Science 110(6), 1987-1994, 2019-06

    IR 

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