Search Results 1-20 of 2295

  • Interleukin-21 reduces Listeria monocytogenes secondary infection via CD8+ effector memory T cells

    Md. Yeashin Gazi , 武田 裕司 , 奈良 英利 , 荒木 明美 , 根本 信仁 , 浅尾 裕信

    … IL-21isoTg possess high amount of CD8+ T cells in normal physiological condition. … The purpose of this study is to determine whether CD8+ T cells in the IL-21isoTg work against intracellular bacteria infection.Methods: Wild type mice (WT) and IL-21isoTg are orally inoculated Listeria monocytogenes (L. … Bacterial load in each organs, and T cell responses are analyzed.Results: IL-21isoTg and WT had similar bacterial load after primary infection. …

    山形大学紀要. 医学 : 山形医学 = Bulletin of the Yamagata University. Medical science : Yamagata medical journal 39(1), 45-51, 2021-02-15

    IR  DOI 

  • Toxic shock syndrome with a cytokine storm caused by Staphylococcus simulans: a case report

    Goda Ken , Kenzaka Tsuneaki , Hoshijima Masahiko , Yachie Akihiro , Akita Hozuka

    CD8+ T cells were activated in peripheral blood. … Vβ2+ population activation, which is characteristic for TSST-1, was not observed in the Vβ usage of CD8+ T cells in T cell receptor Vβ repertoire distribution analysis. …

    BMC Infectious Diseases 21(1), 19, 2021-01-06

    IR 

  • Pathological Findings of the Host Immune Reaction in the Tumor Microenvironment of Gastroenteropancreatic Neuroendocrine Neoplasms

    Hasegawa Sho , Nakajima Atsushi , Ichikawa Yasushi , Kobayashi Noritoshi , Okubo Naoki , Tokuhisa Motohiko , Goto Ayumu , Kurita Yusuke , Sato Takamitsu , Hosono Kunihiro , Endo Itaru

    … We additionally assessed the expression of programmed death (PD)-1, PD-L1, and the tumor-infiltrating lymphocyte (TIL) markers CD8 and family of transcription factor P3 (FOXP3). … PD-1-, CD8-, and FOXP3-positive TILs were more frequently associated with PD-L1-positive tumors than with PD-L1 negative tumors (PD-1: 19.5 vs. 7.3, CD8: 18.1 vs. 7.1, FOXP3: 13.2 vs. 3.2, p=0.438, p=0.419, P=0.603, respectively). …

    Internal Medicine 60(7), 977-983, 2021

    J-STAGE 

  • Systemic Epstein-Barr virus-positive T-cell lymphoma in an adult patient with chronic myeloid leukemia receiving a tyrosine kinase inhibitor

    Tanaka Yuka , Anan Tomoe , Tabayashi Takayuki , Tokuhira Michihide , Momose Shuji , Tamaru Jun-ichi , Kizaki Masahiro

    … T-cell lymphoma(TCL)は小児期に多いが,稀に成人でも発症する.今回,成人慢性白血病(CML)に対しチロシンキナーゼ阻害薬(TKI)で加療中の患者に発症したEBV-positive TCLを経験した.CMLに対しニロチニブ(TKI)で2年間加療が行われ,分子生物学的寛解の状態であった.入院2ヶ月前より頸部リンパ節腫脹,感冒様症状がみられ,末梢血の単核球中にEBVの高い増殖を認めた.リンパ節生検で,CD8陽性 …

    Journal of Saitama Medical University 47(2), 91-95, 2021

    J-STAGE 

  • The role of tumor endothelial cells in cancer progression  [in Japanese]

    Hida Kyoko

    … For example, TECs in highly metastatic tumors aberrantly express angiocrine factors which stimulates cancer cell intravasation, in turn they instigate tumor cells to metastasize. … Biglycan knockout mouse tumor showed more CD8 cells, suggesting tumor immunity is activated by biglycan inhibition. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 3-S26-4, 2021

    J-STAGE 

  • Chimeric Antigen receptor-T (CAR-T) cells targeting Epithelial cell adhesion molecule (EpCAM) can inhibit tumor growth in ovarian cancer mouse model

    FU Juan , SHANG Yuhong , QIAN Zhang , HOU Jinping , YAN Feng , LIU Guodi , DEHUA Li , TIAN Xiaoli

    … In 2017, two chimeric antigen receptor-T (CAR-T) cell drugs were approved by the U.S. Food and Drug Administration (FDA), and continuously optimized CAR-T cells therapy might be the novel hope for OC patient. …

    Journal of Veterinary Medical Science 83(2), 241-247, 2021

    J-STAGE 

  • Pulse steroid therapy to treat liver injury with risk of liver failure due to immune-related adverse events:a case report  [in Japanese]

    HASHIGUCHI Masafumi , IDO Akio , TAMAI Tsutomu , NAKAZAWA Junichi , IWASHITA Yuji , NASU Yuichiro , FUNAKAWA Keita , HORI Takeshi , SUEYOSHI Kazuhiro , TSUBOUCHI Hirohito

    … <p>症例は75歳女性.肺癌に対して放射線・化学療法後,durvalumabが投与された.Grade 3の肝障害が出現し,当科へ紹介された.肝組織は自己免疫性肝炎に類似した所見で,免疫染色ではCD8陽性リンパ球の浸潤が特徴的であった.ステロイドパルス療法にて肝障害は改善した.免疫チェックポイント阻害薬はさまざまな臓器で免疫関連有害事象を惹起するため,各診療科とも対応に慣れておく必要がある.</p> …

    Nippon Shokakibyo Gakkai Zasshi 118(2), 175-182, 2021

    J-STAGE 

  • Characterization of an interdigitating dendritic cell hyperplasia case in a lymph node of a control C57BL/6 mouse

    Rouillé Elodie , Bilbault Héloïse , Levin Clément , Lezmi Stéphane

    … <p>Interdigitating dendritic cell (IDC) hyperplasia is considered a benign spontaneous condition occasionally observed in the lymph nodes of mice. … The spindle cell population was positive for F4/80, partially positive for S100 calcium-binding protein A4 (S100A4), slightly positive for E-cadherin, and negative for α-Smooth muscle actin (SMA) and cytokeratin. … Lymphocytes were positive for CD3, CD4, CD20 and negative for CD8. …

    Journal of Toxicologic Pathology 34(1), 101-106, 2021

    J-STAGE 

  • Effect of asbestos exposure on differentiation and function of cytotoxic T lymphocytes

    Kumagai-Takei Naoko , Nishimura Yasumitsu , Maeda Megumi , Hayashi Hiroaki , Matsuzaki Hidenori , Lee Suni , Yoshitome Kei , Ito Tatsuo , Otsuki Takemi

    Environmental Health and Preventive Medicine 25(1), 2020-10-08

    DOI 

  • Effect of steroid treatment in immune checkpoint inhibitor  [in Japanese]

    杉山 大介

    血液内科 = Hematology 81(4), 562-567, 2020-10

    Ichushi Web 

  • Kinetics of CD4+ T Helper and CD8+ Effector T Cell Responses in Acute Dengue Patients

    Manh Dao Huy , Weiss Lan Nguyen , Thuong Nguyen Van , Mizukami Shusaku , Dumre Shyam Prakash , Luong Quang Chan , Thanh Le Chi , Thang Cao Minh , Huu Pham Thanh , Phuc Le Hong , Nhung Cao Thi Hong , Mai Nguyen Thi , Truong Nguyen Quang , Ngu Vu Thien Thu , Quoc Do Kien , Ha Tran Thi Ngoc , Ton Tran , An Tran Van , Halhouli Oday , Quynh Le Nhat , Kamel Mohamed Gomaa , Karbwang Juntra , Huong Vu Thi Que , Huy Nguyen Tien , Hirayama Kenji

    … They were investigated and monitored for T cell subsets and a panel of clinical and laboratory parameters every day until discharged and at post-discharge from the hospital. … Results: We described for the first time the kinetics of T cell response during the clinical course of DENV infection. … Severe cases showed significantly lower levels of effector CD8+ T cells compared to mild cases at day ?1 (p = 0.017) and day 0 (p = 0.033) of defervescence. …

    Frontiers in Immunology (11), art.no.1980, 2020-09-24

    IR 

  • Kinetics of CD4+ T Helper and CD8+ Effector T Cell Responses in Acute Dengue Patients

    Manh Dao Huy , Weiss Lan Nguyen , Thuong Nguyen Van , Mizukami Shusaku , Dumre Shyam Prakash , Luong Quang Chan , Thanh Le Chi , Thang Cao Minh , Huu Pham Thanh , Phuc Le Hong , Nhung Cao Thi Hong , Mai Nguyen Thi , Truong Nguyen Quang , Ngu Vu Thien Thu , Quoc Do Kien , Ha Tran Thi Ngoc , Ton Tran , An Tran Van , Halhouli Oday , Quynh Le Nhat , Kamel Mohamed Gomaa , Karbwang Juntra , Huong Vu Thi Que , Huy Nguyen Tien , Hirayama Kenji

    … They were investigated and monitored for T cell subsets and a panel of clinical and laboratory parameters every day until discharged and at post-discharge from the hospital. … Results: We described for the first time the kinetics of T cell response during the clinical course of DENV infection. … Severe cases showed significantly lower levels of effector CD8+ T cells compared to mild cases at day ?1 (p = 0.017) and day 0 (p = 0.033) of defervescence. …

    Frontiers in Immunology (11), art.no.1980, 2020-09-24

    IR 

  • Characterization of tumour-infiltrating lymphocytes in a tumour rejection cynomolgus macaque model.

    SATOOKA Hiroki , ISHIGAKI Hirohito , TODO Kagefumi , TERADA Koji , AGATA Yasutoshi , ITOH Yasushi , OGASAWARA Kazumasa , HIRATA Takako , 里岡 大樹 , 石垣 宏仁 , 藤堂 景史 , 寺田 晃士 , 縣 保年 , 伊藤 靖 , 小笠原 一誠 , 平田 多佳子

    … Better understanding of tumour-infiltrating lymphocytes (TILs) from nonhuman primate tumours could provide insights into improving effector cell accumulation in tumour tissues during immunotherapy. … Here, we characterize TILs in a cynomolgus macaque tumour model in which the tumours were infiltrated with CD4+ and CD8+ T cells and were eventually rejected. …

    Scientific Reports 10(1), 8414, 2020-05-21

    IR 

  • Feed-forward regulation of CD8T cell activation by glycolysis and glutaminolysis  [in Japanese]

    桑原 誠 , 山下 政克

    臨床免疫・アレルギー科 = Clinical immunology & allergology 73(5), 461-466, 2020-05

  • Intestinal epithelial cell-derived IL-15 determines local maintenance and maturation of intraepithelial lymphocytes in the intestine

    Zhu Yuanbo , Cui Guangwei , Miyauchi Eiji , Nakanishi Yuki , Mukohira Hisa , Shimba Akihiro , Abe Shinya , Tani-Ichi Shizue , Hara Takahiro , Nakase Hiroshi , Chiba Tsutomu , Sehara-Fujisawa Atsuko , Seno Hiroshi , Ohno Hiroshi , Ikuta Koichi

    … Interleukin-15 (IL-15) is a cytokine critical for maintenance of intestinal intraepithelial lymphocytes (IELs), especially CD8αα+ IELs (CD8αα IELs). … The cell number and frequency of CD8αα IELs and NK IELs were significantly reduced in Vil-Cre IL-15cKO mice. …

    International immunology 32(5), 307-319, 2020-05

    IR 

  • IL-15 Improves Aging-Induced Persistent T Cell Exhaustion in Mouse Models of Repeated Sepsis

    Saito Masafumi , Inoue Shigeaki , Yamashita Kimihiro , Kakeji Yoshihiro , Fukumoto Takumi , Kotani Joji

    … Aging is a grave problem in sepsis, and T cell exhaustion is the main cause of sepsis-induced immunosuppression. … Sepsis- and aging-induced T cell exhaustion is related to secondary infection with a poor long-term outcome in the elderly. … However, the trend, impact, and mechanism of T cell exhaustion are still unclear. … however, it is still unclear how IL-15 reverses prolonged T cell exhaustion in aged septic mice. …

    Shock 53(2), 228-235, 2020-02

    IR 

  • Combination of host immune metabolic biomarkers for the PD-1 blockade cancer immunotherapy

    Hatae Ryusuke , Chamoto Kenji , Kim Young Hak , Sonomura Kazuhiro , Taneishi Kei , Kawaguchi Shuji , Yoshida Hironori , Ozasa Hiroaki , Sakamori Yuichi , Akrami Maryam , Fagarasan Sidonia , Masuda Izuru , Okuno Yasushi , Matsuda Fumihiko , Hirai Toyohiro , Honjo Tasuku

    PD-1抗体がん免疫治療の有効性を判別するバイオマーカーを同定 --血液検査のみで有効性の診断が可能に--. 京都大学プレスリリース. 2020-01-31.

    JCI Insight 5(2), 2020-01-30

    IR 

  • Immune Modulation by Telomerase-Specific Oncolytic Adenovirus Synergistically Enhances Antitumor Efficacy with Anti-PD1 Antibody

    Kanaya Nobuhiko , Kuroda Shinji , Kakiuchi Yoshihiko , Kumon Kento , Tsumura Tomoko , Hashimoto Masashi , Morihiro Toshiaki , Kubota Tetsushi , Aoyama Katsuyuki , Kikuchi Satoru , Nishizaki Masahiko , Kagawa Shunsuke , Tazawa Hiroshi , Mizuguchi Hiroyuki , Urata Yasuo , Fujiwara Toshiyoshi

    … Here, we examined the potential of OBP-502, an OBP-301 variant, as an agent for inducing immunogenic cell death (ICD) and synergistically enhancing the efficacy of OBP-502 with PD-1 Ab using CT26 murine colon cancer and PAN02 murine pancreatic cancer cell lines. …

    Molecular Therapy 28(3), 794-804, 2020-01-10

    IR 

  • Blockade of EGFR improves responsiveness to PD-1 blockade in EGFR-mutated non–small cell lung cancer

    Sugiyama Eri , Togashi Yosuke , Takeuchi Yoshiko , Shinya Sayoko , Tada Yasuko , Kataoka Keisuke , Tane Kenta , Sato Eiichi , Ishii Genichiro , Goto Koichi , Shintani Yasushi , Okumura Meinoshin , Tsuboi Masahiro , Nishikawa Hiroyoshi

    … The clinical efficacy of anti–PD-1 (programmed cell death–1) monoclonal antibody (mAb) against cancers with oncogenic driver gene mutations, which often harbor a low tumor mutation burden, is variable, suggesting different contributions of each driver mutation to immune responses. … the former increased CCL22, which recruits CD4^+ regulatory T cells, and the latter decreased CXCL10 and CCL5, which induce CD8^+ T cell infiltration. …

    Science Immunology 5(43), eaav3937, 2020-01

    IR 

  • RENAL CANCER TISSUE AFTER NIVOLUMAB/IPILIMUMAB COMBINATION THERAPY FOR METASTATIC RENAL CELL CARCINOMA  [in Japanese]

    奥野 佑美子 , 田中 亮 , 三上 耕治 , 武内 巧

    … The histopathological diagnosis was clear cell carcinoma pT1bN0, grade 2. … In the specimens from 2 patients treated using pazopanib, a tyrosine kinase inhibitor, prior to renal cell cancer removal, there were fewer CD8- and CD4-positive cells infiltrating the renal cancer than after the combination therapy. …

    泌尿器科紀要 = Acta urologica Japonica 66(1), 13-17, 2020-01

    IR  DOI  Ichushi Web 

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