Search Results 1-20 of 3551

  • Impaired plasmalogen synthesis dysregulates liver X receptor-dependent transcription in cerebellum

    Honsho Masanori , Dorninger Fabian , Abe Yuichi , Setoyama Daiki , Ohgi Ryohei , Uchiumi Takeshi , Kang Dongchon , Berger Johannes , Fujiki Yukio

    The journal of biochemistry 166(4), 353-361, 2019-10

  • Microglia-Triggered Plasticity of Intrinsic Excitability Modulates Psychomotor Behaviors in Acute Cerebellar Inflammation

    Yamamoto Masamichi , Kim Minsoo , Imai Hirohiko , Itakura Yamato , Ohtsuki Gen

    … 2019-09-11.An overactive cerebellum causes issues across the brain. …

    Cell Reports 28(11), 2923-2938.e8, 2019-09-10

    IR 

  • Widespread and lateralized social brain activity for processing dynamic facial expressions

    Sato Wataru , Kochiyama Takanori , Uono Shota , Sawada Reiko , Kubota Yasutaka , Yoshimura Sayaka , Toichi Motomi

    … In the same manner, activation was found in the right inferior frontal gyrus (IFG) and left cerebellum. … Laterality analyses comparing original and flipped images revealed right hemispheric dominance in the superior temporal sulcus and IFG and left hemispheric dominance in the cerebellum. …

    Human Brain Mapping 40(13), 3753-3768, 2019-09

    IR 

  • Artificial Intelligence and Cerebellar Motor Learning  [in Japanese]

    永雄 総一 , 本多 武尊

    Brain and nerve 71(7), 665-680, 2019-07

    Ichushi Web 

  • Similar and Differing Distributions Between 18F-FDG-PET and Arterial Spin Labeling Imaging in Temporal Lobe Epilepsy

    太田 深秀 , Daichi Sone , Norihide Maikusa , Noriko Sato , Yukio Kimura , Miho OTA , Hiroshi Matsuda

    … These images were spatially normalized using Statistical Parametric Mapping 12, and the regional values in both ASL and FDG-PET were calculated using PMOD software within 20 volumes of interest (VOIs), including the temporal lobe, adjacent cortices, subcortical structures, and cerebellum. …

    Frontiers in Neurology (10), 318, 2019-04

    IR 

  • Region-Dependent Differences in Morphological Changes Induced by Mercury Compounds and Lysophosphatidic Acid in Cultured Rat Astrocytes

    ADACHI Tatsumi , KATAMOTO Yusuke , IWATATE Tomomi , YANAGISAWA Yasuhide , YASUDA Ichiro

    … Region-dependent differences in morphological changes induced by an increment of cAMP, and an exposure with either mercury compounds or lysophosphatidic acid (LPA), a Rho activator, were examined in cultured astrocytes from the cerebral hemisphere and cerebellum of newborn rats. …

    千葉科学大学紀要 (12), 1-10, 2019-02

    IR 

  • Neural Evidence of the Cerebellum as a State Predictor

    Tanaka Hirokazu , Ishikawa Takahiro , Kakei Shinji

    … Recent computational studies hypothesize that the cerebellum performs state prediction known as a forward model. … To test the forward-model hypothesis, we analyzed activities of 94 mossy fibers (inputs to the cerebellar cortex), 83 Purkinje cells (output from the cerebellar cortex to dentate nucleus), and 73 dentate nucleus cells (cerebellar output) in the cerebro-cerebellum, all recorded from a monkey performing step-tracking movements of the right wrist. …

    The Cerebellum 18(3), 349-371, 2019-01-09

    IR 

  • Exploration of preventive drugs for spinocerebellar ataxia using cultured cerebellar Purkinje cells  [in Japanese]

    Seki Takahiro

    <p>アルツハイマー病などの神経変性疾患は加齢とともに発症頻度が増大するため，現在の超高齢化社会ではその克服が喫緊の課題である．神経変性疾患の多くでは疾患が診断された段階では神経変性がかなり進んでおり，その状況からの改善は困難である．特に遺伝性神経変性疾患の場合，原因遺伝子を保有していることが分かった場合は発症予防が望まれるが，現状では発症を予防する方法はなく，ただただ発症を待つことし …

    Folia Pharmacologica Japonica 154(6), 310-314, 2019

    J-STAGE 

  • A case of ruptured micro AVM diagnosed by superselective angiography  [in Japanese]

    Miki Kenji , Noguchi Naoki , Mori Megumu , Yamada Tetsuhisa , Arimura Koichi , Kai Yasutoshi , Natori Yoshihiro

    <p>要旨：急性期に診断がつかなかった破裂micro arteriovenous malformation（AVM）の1 例を報告する．症例は19 歳女性，小脳出血を認め，造影検査を施行するも出血源は認めなかった．時期をおいた血管造影検査で瘤状構造物を認め，術中のマイクロカテーテル造影で静脈の早期描出を認めたため，静脈瘤を伴う破裂micro AVM と診断した．同病変に対して栄養動脈塞 …

    Japanese Journal of Stroke, 2019

    J-STAGE 

  • Two neonates with characteristic MRI findings of neurocutaneous melanosis  [in Japanese]

    Aoki Ryo , Hara Hiroko , Yamada Yosuke , Tsuruta Shio , Hasegawa Hisaya

    <p>神経皮膚黒色症は，先天性巨大色素性母斑と中枢神経系のメラノサイト増殖からなる稀な先天性疾患である．我々は先天性巨大色素性母斑と多発する衛星色素性細胞を有し，頭部MRIで神経皮膚黒色症として特徴的な画像所見を認めた新生児2例を経験したので報告する．2例ともにT1強調画像で高信号，T2強調画像で低信号を示す脳実質病変が，特に側頭葉扁桃体と脳幹，小脳に多発して認められた．MRIでの信号 …

    Journal of Japanese Society of Pediatric Radiology 35(2), 143-147, 2019

    J-STAGE 

  • Inflammatory Cerebellar PML with a CD4/CD8 Ratio of 2.9 Showed a Favorable Prognosis in a Patient with Rheumatoid Arthritis

    Nishigori Ryusei , Warabi Yoko , Shishido-Hara Yukiko , Nakamichi Kazuo , Nakata Yasuhiro , Komori Takashi , Isozaki Eiji

    <p>The patient was a 74-year-old woman with rheumatoid arthritis who developed ataxia. MRI revealed T2-hyperintense lesions predominantly in the left middle cerebellar peduncle. Punctate or line …

    Internal Medicine 58(22), 3323-3329, 2019

    J-STAGE 

  • Effects of ascorbic acid treatment on developmental alterations in calcium-binding proteins and gamma-aminobutyric acid transporter 1 in the cerebellum of lead-exposed rats during pregnancy and lactation

    Nam Sung Min , Seo Jin Seok , Nahm Sang-Soep , Chang Byung-Joon

    … The chemical administration was stopped on postnatal day 21 when the morphology of the offspring's cerebellum is similar to that of the adult brain. … Nissl staining demonstrated that the number of Purkinje cells was significantly reduced following Pb exposure, while ascorbic acid ameliorated this effect in the cerebellum of the offspring. …

    The Journal of Toxicological Sciences 44(11), 799-809, 2019

    J-STAGE 

  • Cerebellar Stroke-like Lesions?

    Finsterer Josef

    Internal Medicine 58(21), 3205-3205, 2019

    J-STAGE 

  • Supplemental study on 2', 3'-Cyclic Nucleotide 3'-Phosphodiesterase (CNPase) activity in developing rat spinal cord lesions induced by hexachlorophene and cuprizone

    KANNO Takeshi , KUROTAKI Tetsuro , YAMADA Naoaki , TOMONARI Yuki , SATO Junko , TSUCHITANI Minoru , KOBAYASHI Yoshiyasu

    … <p>In a previous study, we showed that 2', 3'-Cyclic Nucleotide 3'-Phosphodiesterase (CNPase) expression is induced in different temporal patterns in the cerebrum, cerebellum and medulla oblongata of hexachlorophene (HCP) and cuprizone (CPZ) treated rats. …

    Journal of Veterinary Medical Science 81(9), 1368-1372, 2019

    J-STAGE 

  • Plasma cell myeloma positive for t(14;20) with relapse in the central nervous system

    Murase Takayuki , Inagaki Atsushi , Masaki Ayako , Fujii Keiichiro , Narita Tomoko , Ri Masaki , Hanamura Ichiro , Iida Shinsuke , Inagaki Hiroshi

    … Six months after remission, tumor relapse was noted in the left cerebellum and the right frontal lobe of the cerebrum. …

    Journal of Clinical and Experimental Hematopathology 59(3), 135-139, 2019

    J-STAGE 

  • Availability of D-cysteine as a protectant for cerebellar neurons  [in Japanese]

    Seki Takahiro

    <p>硫化水素はタンパク質の機能変化や抗酸化能増大を引き起こすシグナル分子として最近注目を集めている．また，神経保護作用を有するため，神経保護薬としての応用も期待されている．硫化水素は生体内でL-システインを原料に生合成されるが，L-システイン神経障害性を有するため，神経保護薬としての応用は困難である．一方，2013年に新たにD-システインから硫化水素を生合成する経路が同定された．この …

    Folia Pharmacologica Japonica 154(3), 133-137, 2019

    J-STAGE  Ichushi Web 

  • Risk Factors for the Onset of Aspiration Pneumonia among Stroke Patients in the Recovery Stage in a Rehabilitation Hospital  [in Japanese]

    MIYAGAMI Mitsusuke , HOSHI Tatsuya , HUKUOKA Hiroyuki , TOHARA Haruka , ABE Kimiko

    <p>【目的】脳血管障害はしばしば嚥下障害を合併し誤嚥性肺炎を発生するが，その頻度については脳卒中の急性期に多く，回復期リハビリテーション病院入院中の経管栄養例の報告は少ない．誤嚥性肺炎の発症要因についても，いまだ十分解明されていない．今回，これらの発生率と発生要因を明らかにすることを目的とした．</p><p>【方法】発症後1～2 カ月後に回復期リハビリテーショ …

    The Japanese Journal of Dysphagia Rehabilitation 23(1), 8-18, 2019

    J-STAGE  Ichushi Web 

  • Does the cerebellum contribute to unconscious affective processing?  [in Japanese]

    INAGAKI Kyota , ONODA Keiichi , YAMAGUCHI Shuhei

    <p>小脳が運動機能に関連することは広く知られているが，近年の研究は非運動機能にも小脳が関与することを実証してきた．小脳の寄与は運動の場合，無意識的な処理にまで及ぶが，非運動機能の無意識的処理に小脳が関わるかは明らかではない．そこで本研究では，閾下呈示された感情表情に対する処理において小脳が関与するかどうか，機能的MRIを用いた実験によって検証した．右小脳皮質の第Ⅵ小葉は，閾上呈示され …

    Japanese Journal of Physiological Psychology and Psychophysiology, 2019

    J-STAGE 

  • Surgical Indications and Strategies for Hemangioblastoma  [in Japanese]

    Nakatomi Hirofumi , Takayanagi Shunsaku , Kin Taichi , Saito Nobuhito

    <p> 【目的】血管芽腫の手術適応と手術戦略を総括する. 【方法】対象は, 1996～2017年に手術を施行した血管芽腫連続79例である. 延髄11例, 内リンパ囊5例, 脊髄13例, 小脳50例であった. Von Hippel Lindau (VHL) 病患者は, 24例 (31%) であった. 2010年より術前三次元融合画像 (3DCG) による血管芽腫のフィーダー・ドレーナーの …

    Japanese Journal of Neurosurgery 28(8), 480-490, 2019

    J-STAGE 

  • Lamotrigine Induces Tremor among Epilepsy Patients Probably via Cerebellar Pathways

    Kovács Andrea , Farkas Zsuzsanna , Kelemen Anna , Juhos Vera , Szűcs Anna , Kamondi Anita

    … Quantitative characteristics suggest the involvement of the cerebellum in the pathomechanism of lamotrigine-induced tremor. …

    The Tohoku Journal of Experimental Medicine 248(4), 273-284, 2019

    J-STAGE 

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