Search Results 1-20 of 70

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  • Autocrine HGF/c-Met signaling pathway confers aggressiveness in lymph node adult T-cell leukemia/lymphoma

    Totani Haruhito , Shinjo Keiko , Suzuki Miho , Katsushima Keisuke , Mase Shoko , Masaki Ayako , Ito Asahi , Ri Masaki , Kusumoto Shigeru , Komatsu Hirokazu , Ishida Takashi , Inagaki Hiroshi , Iida Shinsuke , Kondo Yutaka

    … While ATL cells in peripheral blood (PB-ATL) are sensitive to anti-CC chemokine receptor 4 treatment, non–PB-ATLs, including lymph node ATLs (LN-ATLs), are more aggressive and resistant. … Protein array analysis revealed hepatocyte growth factor (HGF) and C-C motif chemokine 2 (CCL2) were significantly upregulated in non–PB-ATLs compared with PB-ATLs. …

    Oncogene 39(35), 5782-5794, 2020-02-27

    IR 

  • Atheroprotective Roles of Adiponectin via CCL2 Inhibition

    Fujita Makoto , Yamamoto Hiroyasu , Yoshida Nao , Ono Runa , Matsuoka Tetsuro , Kihara Shinji

    … In the present study, we aimed to identify a novel atheroprotective mechanism of APN via C-C motif chemokine 2 (CCL2).<b> … The plaque characteristics were determined where "plaque burden" [(EEM CSA − lumen CSA)/(EEM CSA)×100 (%)] >50%, and their correlation with serum CCL2 and APN levels was analyzed. …

    Journal of Atherosclerosis and Thrombosis, 2020

    J-STAGE 

  • Expression of C–C motif chemokines and their receptors in bovine placentomes at spontaneous and induced parturition

    HIRAYAMA Hiroki , KAGEYAMA Soichi , SAKUMOTO Ryosuke , KOYAMA Keisuke , YASUHARA Taichi , HASEGAWA Taito , INABA Ryo , FUJII Takashi , NAITO Akira , MORIYASU Satoru

    … Polymerase chain reaction (PCR) array analysis indicated that 9/13 C–C motif chemokine ligands (<i>CCLs</i>) were upregulated > … two-fold in spontaneous parturition, with <i>CCL2</i> … The expressions of <i>CCL2</i>, <i>CCL8,</i> … C–C motif chemokine receptor 1 (<i>CCR1</i>), and <i>CCR5</i> …

    Journal of Reproduction and Development 66(1), 49-55, 2020

    J-STAGE  Ichushi Web 

  • Cancer Cell-Derived Granulocyte-Macrophage Colony-Stimulating Factor Is Dispensable for the Progression of 4T1 Murine Breast Cancer

    Yoshimura Teizo , Nakamura Kaoru , Li Chunning , Fujisawa Masayoshi , Shiina Tsuyoshi , Imamura Mayu , Li Tiantian , Mukaida Naofumi , Matsukawa Akihiro

    … We previously reported that 4T1 murine breast cancer cells produce GM-CSF that up-regulates macrophage expression of several cancer promoting genes, including Mcp-1/Ccl2, Ccl17 and Rankl, suggesting a critical role of cancer cell-derived GM-CSF in cancer progression. … By contrast, GM-CSF-deficiency did not affect tumor growth, lung metastasis or the expression of these chemokine and cytokine genes in tumor tissues. …

    International Journal of Molecular Sciences 20(24), 2019-12-16

    IR 

  • Influences of prenatal nicotine exposure on behavioral functions of the offspring: Involvement of chemokine levels in the brain.  [in Japanese]

    Kimata Ryoko , Mamiya Takayoshi , Takekawa Riho , Ito Ai , Ibi Daisuke , Nabeshima Toshitaka , Hiramatsu Masayuki

    … The prenatal nicotine exposure increased the expression levels of CXCL1 and CCL2, but decreased those of CCL3, CCL4, CCL11 and CCL5 compared to those in the control on P1. It is suggested that prenatal nicotine exposure may influence the chemokine balance in the brain of offspring.</p> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 3-P-048, 2019

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  • The anti-metastasis effects of oroxylin-a on oral squamous cell carcinoma cells  [in Japanese]

    Ku Wei-Ting , Lee Tony Jer-Fu , Lai Kuo-Chu

    … In present study, we found that the migration abilities of the oral cancer cells long-term oro-A treatment may increased by chemokine ligand 2 (CCL2). … It seems that CCL2 plays a critical role in anti-migration of long-term oro-A exposure. … The CCL2 treatment was demonstrated to activate the protein levels of the p-ERK, p-JNK, NF-κB, MMP-2&9 signaling pathway. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 3-P-115, 2019

    J-STAGE 

  • Leptin enhances cytokine/chemokine production by normal lung fibroblasts by binding to leptin receptor

    Watanabe Kaoru , Ohta Ken , Suzukawa Maho , Arakawa Sayaka , Kobayashi Koichi , Igarashi Sayaka , Tashimo Hiroyuki , Nagai Hideaki , Tohma Shigeto , Nagase Takahide

    … Leptin enhanced production of CCL11/Eotaxin, monocyte chemoattractant protein-1 (CCL2/MCP-1), CXCL8/IL-8, interferon gamma-induced protein 10 (CXCL10/IP-10) and IL-6 by NHLFs at both the protein and messenger ribonucleic acid (mRNA) levels. …

    Allergology International 68(Supplement.1), S3-S8, 2019

    J-STAGE 

  • Neospora caninum dense granule protein 7 regulates the pathogenesis of neosporosis by modulating host immune response  [in Japanese]

    Nishikawa Yoshifumi , Shimoda Naomi , Fereig Ragab M. , Moritaka Tomoya , Umeda Kousuke , Nishimura Maki , Ihara Fumiaki , Kobayashi Kaoru , Himori Yuu , Suzuki Yutaka , Furuoka Hidefumi

    … An RNA sequencing analysis of infected macrophage cultures showed that NcGRA7 mainly regulates the host cytokine and chemokine production. … The levels of gamma interferon in the ascites fluid, CXCL10 expression in the peritoneal cells, and CCL2 expression in the spleen were lower 5 days after infection with the NcGRA7-deficient parasite than after infection with the parental strain. …

    Applied and Environmental Microbiology 84(18), e01350-18, 2018-09-01

    IR 

  • PACAP-induced pain responses are mediated by spinal Cyr61-chemokine signaling pathway

    Ogata Tomoki , Maeda Tatsunori , Yokai Masafumi , Miyata Atsuro , Kurihara Takashi , Takasaki Ichiro

    … Next we examined the expression of CC chemokine mRNA in the spinal cord after i.t. … As a results, CCL2, CCL7, and CCL22 mRNA expression was significantly elevated after i.t. … rCyr61 also significantly increased the expression of CCL2, CCL7, and CCL22 mRNA in cultured primary astrocyte and KT-5 cells (the mouse astrocyte cell line). … Finally, we examined the effects of antagonist of chemokine receptors on rCyr61-induced mechanical allodynia. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO3-2-33, 2018

    J-STAGE 

  • Differential effects of heavy metals on CCL2 release from human astrocytes

    Rungreangplangkool Norapat , Phuagkhaopong Suttinee , Kasemsuk Thitima , Yubolphan Ruedeemars , Vivithanaporn Pornpun

    … C-C motif ligand 2 (CCL2), also known as monocyte chemoattractant protein 1 (MCP1), is a major chemokine released by astrocytes. … CCL2 plays a role in the pathogenesis of Alzheimer's disease, HIV-associated dementia, multiple sclerosis, and ischemic brain injury. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO3-13-7, 2018

    J-STAGE 

  • Red ginseng extracts attenuate skin inflammation in atopic dermatitis through p70 ribosomal protein S6 kinase activation

    Osada-Oka Mayuko , Izumi Yasukatsu , Samukawa Keiichi , Iwao Hiroshi

    … RGE also decreased p-p70S6K levels in IFN-γ-stimulated human keratinocytes, suppressing the IFN-γ induced increase in levels of C-C chemokine ligand 2 (CCL2) mRNA. … These results suggested that RGE suppressed the increase in CCL2 mRNA levels by IFN-γ via inhibition of p70S6K phosphorylation. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO3-10-14, 2018

    J-STAGE 

  • Sphingosine kinase 1 promotes liver fibrosis by preventing miR-19b-mediated inhibition of CCR2

    Lan Tian , Guo Jiao , Li Changzheng , Yang Guizhi , Sun Yue

    … Secretion of CCL2 in SphK1<sup>-/-</sup> … mice decreased compared with WT mice by Chemokine array. … mice increased compared with WT mice and microRNA-19b-3p downregulated CCR2 (CCL2 receptor) in HSCs. … Moreover, SphK1 knockout in KC reduced the secretion of CCL2; … SphK1 knockout in HSCs inhibited the activation of HSCs through the CCL2-CCR2 axis. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO2-6-12, 2018

    J-STAGE 

  • <b>Gnetin C suppresses double-stranded RNA-induced C-C motif chemokine ligand 2 (CCL2) and CCL5 production by inhibiting Toll-like receptor 3 signaling </b><b>pathway </b>

    YOSHIDA Hidemi , IMAIZUMI Tadaatsu , MATSUMIYA Tomoh , SEYA Kazuhiko , KAWAGUCHI Shogo , TANAKA Hiroshi

    … To determine a safe method of controlling inflammatory reactions in the brain, we examined the effects of gnetin C, a natural resveratrol dimer, on C-C motif chemokine ligand 2 (CCL2) and CCL5 (pro-inflammatory chemokines) production observed after treatment with polyinosinic–polycytidylic acid [poly IC; … The addition of gnetin C (10 μM) to the media moderately reduced the CCL2 production and markedly suppressed CCL5 production in both cells. …

    Biomedical Research 39(5), 231-240, 2018

    J-STAGE  Ichushi Web 

  • Micro-computed tomography for evaluating alveolar bone resorption induced by hyperocclusion

    Tsutsumi Takashi , Kajiya Hiroshi , Tsuzuki Takashi , Goto Kazuko T. , Okabe Koji , Takahashi Yutaka

    … Previously, we showed that C--C chemokine ligand (CCL) 2/CCR2 receptor axis plays a crucial role in MS-dependent osteoclastogenesis. … Under anesthesia, a stainless steel wire was attached to the molars of 5-week-old C57/BL6 wildtype (WT) mice, CCL2<sup>-/-</sup> … Similarly, significant alveolar bone resorption was observed in the CCL2<sup>-/-</sup> …

    Journal of Prosthodontic Research 62(3), 298-302, 2018

    J-STAGE  Ichushi Web 

  • The effect of mesenchymal stem cells on chemotaxis of osteoclast precursor cells

    Sumi Keisuke , Abe Takaharu , Kunimatsu Ryo , Oki Nanae , Tsuka Yuji , Awada Tetsuya , Nakajima Kengo , Ando Kazuyo , Tanimoto Kotaro

    … In this study, we investigated the effect of MSCs on chemotaxis of RAW264 cells via C-C motif chemokine ligand 2 (CCL2). … The gene expression of CCL2 in MSCs and CC-chemokine receptor 2 (CCR2) in RAW264 cells was determined using quantitative real-time PCR. …

    Journal of Oral Science 60(2), 221-225, 2018

    J-STAGE  Ichushi Web 

  • CCL2 as a potential therapeutic target for clear cell renal cell carcinoma

    Arakaki Ryuichiro , Yamasaki Toshinari , Kanno Toru , Shibasaki Noboru , Sakamoto Hiromasa , Utsunomiya Noriaki , Sumiyoshi Takayuki , Shibuya Shinsuke , Tsuruyama Tatsuaki , Nakamura Eijiro , Ogawa Osamu , Kamba Tomomi

    … We previously reported that the pVHL-atypical PKC-JunB pathway contributed to promotion of cell invasiveness and angiogenesis in clear cell renal cell carcinoma (ccRCC), and we detected chemokine (C-C motif) ligand-2 (CCL2) as one of downstream effectors of JunB. … CCL2 plays a critical role in tumorigenesis in other types of cancer, but its role in ccRCC remains unclear. … In this study, we investigated the roles and therapeutic potential of CCL2 in ccRCC. …

    Cancer Medicine 5(10), 2920-2933, 2016-09-26

    IR 

  • Serum chemokine (CC motif) ligand 2 level as a diagnostic, predictive, and prognostic biomarker for prostate cancer

    Izumi Kouji , Mizokami Atsushi , Lin Hsiu-Ping , Ho Hui-Min , Iwamoto Hiroaki , Maolake Aerken , Natsagdorj Ariunbold , Kitagawa Yasuhide , Kadono Yoshifumi , Miyamoto Hiroshi , Huang Chiung-Kuei , Namiki Mikio , Lin Wen-Jye

    … Although androgen/androgen receptor (AR) signaling promotes prostate cancer progression, suppression of AR signaling induces chemokine (CC motif) ligand 2 (CCL2), which enables prostate cancer cells to gain metastatic potential. … Therefore, we investigated the validity of CCL2 as a complementary biomarker to PSA for prostate cancer. … Our in vitro approach of enriching for prostate cancer cells with higher migration potential showed that CCL2 activated cellular migration. …

    Oncotarget 7(7), 8389-8398, 2016-01-01

    IR 

  • The cell wall component lipoteichoic acid of <i>Staphylococcus aureus</i> induces chemokine gene expression in bovine mammary epithelial cells

    KIKU Yoshio , HAYASHI Tomohito , NAGASAWA Yuya , TANABE Fuyuko , SUGAWARA Kazue , WATANABE Atsushi , HATA Eiji , OZAWA Tomomi , NAKAJIMA Kei-ichi , ARAI Toshiro

    … Three of these genes encode chemokines (IL-8, CXCL6 and CCL2) functioning as chemoattractant molecules for neutrophils and macrophages. … These results suggest that the initial inflammatory response of SA infection in mammary gland may be related with LTA induced chemokine genes.</p> …

    Journal of Veterinary Medical Science 78(9), 1505-1510, 2016

    J-STAGE  Ichushi Web 

  • CCL2 level is elevated with metabolic syndrome and CXCL10 level is correlated with visceral fat area in obese children

    Ishii Masahiro , Araki Shunsuke , Goto Motohide , Yamamoto Yukiyo , Kusuhara Koichi

    … The aim of this study was to investigate the relationship between circulating chemokine levels and both MS and VAT accumulation in obese children. … Blood samples were drawn after overnight fasting, and serum chemokine levels (CCL2, CCL5 and CXCL10) were quantitated. … Eighteen were diagnosed with MS. CCL2 was significantly increased in MS subjects compared with non-MS subjects (<i>p</i><0.05). …

    Endocrine Journal 63(9), 795-804, 2016

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  • 組織球症の病態解明と治療の進歩  [in Japanese]

    森本 哲

    … V600Eを代表とする活性化変異がある.病変部位にはLCH細胞以外に好酸球やリンパ球,マクロファージ,破骨細胞様巨細胞などの炎症細胞浸潤があり,これらが互いに活性化し合い,オステオポンチンやIL-18, CCL2を代表とする炎症性サイトカイン/ケモカインが多量に分泌され,組織破壊が生じる.リスク臓器病変陽性多臓器型LCHの生命予後はシタラビン/ビンクリスチンの導入により著しく改善したが,再発と非可逆的病 …

    The Japanese Journal of Pediatric Hematology / Oncology 53(5), 428-435, 2016

    J-STAGE  Ichushi Web 

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