Search Results 1-20 of 303

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A Chondroitin Sulfate Chain of Urinary Trypsin Inhibitor Enhances Protease Inhibitory Activity of the Core Protein

Teshigahara Yu , Kakizaki Ikuko , Hirao Wataru , Tanaka Kanji , Takahashi Ryoki

… Human urinary trypsin inhibitor (UTI) is a proteoglycan composed of one core protein covalently linked to one glycosaminoglycan, which is a low sulfated chondroitin 4-sulfate. … However, functions of the chondroitin sulfate have not been clarified. …

Journal of Applied Glycoscience 67(2), 63-66, 2020

J-STAGE
2

Development of a Capillary Zone Electrophoresis Method for the Analysis of Four Extracellular Matrices Commonly Found in Foods with Functional Claims

ESAKA Yukihiro , TOKORO Eriko , KUNISHIMA Saki , YAMAMOTO Takuhei , KOJIMA Hiroyuki , TAKAHASHI Tatsuji , MURAKAMI Hiroya , UNO Bunji

… The four polymeric compounds, namely, proteoglycan, chondroitin sulfate, hyaluronic acid, and collagen, were separated with 100 mM borate buffer (pH 10.0) using capillaries coated with poly-N,N-dimethylacrylamide on the inner wall, which almost completely suppressed the electroosmotic flow to give reproducible migration times for the analytes. …

CHROMATOGRAPHY 41(1), 45-49, 2020

J-STAGE
3

Arsenite inhibits gene expression of perlecan, syndecan-1, -2, -3 and biglycan in cultured vascular endothelial cells

Wu Dong-pan , Nakano Tsuyoshi , Tsuneoka Yayoi , Takahashi Tsutomu , Shinoda Yo , Kaji Toshiyuki , Fujiwara Yasuyuki

… We previously demonstrated that arsenite, but not arsenate, decreases the synthesis of both heparan sulfate proteoglycans (HSPGs) and chondroitin/dermatan sulfate proteoglycans (CS/DSPGs) in cultured vascular endothelial cells. …

Fundamental Toxicological Sciences 7(2), 77-83, 2020

J-STAGE
4

Recent Advances in the Pathophysiology of Musculocontractural Ehlers-Danlos Syndrome

Kosho Tomoki , Mizumoto Shuji , Watanabe Takafumi , Yoshizawa Takahiro , Miyake Noriko , Yamada Shuhei

… Musculocontractural Ehlers–Danlos Syndome (mcEDS) is a type of EDS caused by biallelic pathogenic variants in the gene for carbohydrate sulfotransferase 14/dermatan 4-O-sulfotransferase 1 (CHST14/D4ST1, mcEDS-CHST14), or in the gene for dermatan sulfate epimerase (DSE, mcEDS-DSE). … Pathogenic variants in CHST14 or DSE lead to reduced activities of relevant enzymes, resulting in a negligible amount of dermatan sulfate (DS) and an excessive amount of chondroitin sulfate. …

Genes 11(1), 43-1-43-14, 2019-12

IR
5

Induction of Versican V0 Variant Synthesis by A Thrombin Receptor Agonist Peptide in Cultured Human Coronary Smooth Muscle Cells

Hara Takato , Wakata Takako , Fujiwara Yasuyuki , Yamamoto Chika , Kaji Toshiyuki

… Versican is a large aggregating chondroitin sulfate proteoglycan that accumulates in vascular wall during atherosclerosis. … This proteoglycan is particularly synthesized by arterial smooth muscle cells and contributes to atherosclerosis progression by enhancing the retention of low density lipoproteins and inducing the proliferation and migration of the cells in atherosclerotic plaques. …

BPB Reports 2(6), 106-112, 2019

J-STAGE
6

Polymer brush in articular cartilage lubrication: Nanoscale modelling and simulation

Kajinami Nobuhiko , Matsumoto Mitsuhiro

… It is suggested that a part of proteoglycan forms aggregate on the cartilage surface, making a polymer brush, which has an important role in lubrication. … We use chondroitin 6-sulfate molecules grafted on resilient surface as the polymer brush and water with sodium ions as the synovial liquid. …

Biophysics and Physicobiology 16(0), 466-472, 2019

J-STAGE
7

Development of New Therapies for Neurodegenerative Diseases via Axonal Growth [in Japanese]

Kuboyama Tomoharu

… models of AD and SCI were developed by culturing neurons in the presence of amyloid β (Aβ) and chondroitin sulfate proteoglycan, respectively. …

YAKUGAKU ZASSHI 139(11), 1385-1390, 2019

J-STAGE Ichushi Web
8

Mast cell-mediated oxygen-induced retinopathy [in Japanese]

Matsuda Kenshiro , Tanaka Akane , Matsuda Hiroshi

… The mast cell is one of the hematopoietic cells containing cytoplasmic granules that contain various kinds of cytokines, chemokines, and chondroitin sulfate proteoglycan, and these factors induce allergy and inflammation through degranulation process. …

Functional Food Research 14(0), 4-9, 2018

J-STAGE Ichushi Web
9

Defects in Biosynthesis of Glycosaminoglycans Cause Hereditary Bone, Skin, Heart, Immune, and Neurological Disorders

Mizumoto Shuji

… The indispensable roles of glycosaminoglycans (GAGs), including chondroitin sulfate, dermatan sulfate, and heparan sulfate, have been demonstrated in various biological events such as construction of the extracellular matrix, tissue development, and cell signaling through interactions with extracellular matrix components, morphogens, and growth factors by analyses using the following model organisms: nematodes, fruit flies, frogs, zebrafish, and mice. …

Trends in Glycoscience and Glycotechnology 30(174), E67-E89, 2018

J-STAGE
10

Defects in Biosynthesis of Glycosaminoglycans Cause Hereditary Bone, Skin, Heart, Immune, and Neurological Disorders [in Japanese]

Mizumoto Shuji

… The indispensable roles of glycosaminoglycans (GAGs), including chondroitin sulfate, dermatan sulfate, and heparan sulfate, have been demonstrated in various biological events such as construction of the extracellular matrix, tissue development, and cell signaling through interactions with extracellular matrix components, morphogens, and growth factors by analyses using the following model organisms: nematodes, fruit flies, frogs, zebrafish, and mice. …

Trends in Glycoscience and Glycotechnology 30(174), J43-J64, 2018

J-STAGE Ichushi Web
11

Postnatal lethality and chondrodysplasia in mice lacking both chondroitin sulfate N-acetylgalactosaminyltransferase-1 and -2

Shimbo Miki , Suzuki Riku , Fuseya Sayaka , Sato Takashi , Kiyohara Katsue , Hagiwara Kozue , Okada Risa , Wakui Hiromasa , Tsunakawa Yuki , Watanabe Hideto , Kimata Koji , Narimatsu Hisashi , Kudo Takashi , Takahashi Satoru , 高橋智 , 岡田理沙 , 工藤崇

… Chondroitin sulfate (CS) is a sulfated glycosaminoglycan (GAG) chain. … In cartilage, CS plays important roles as the main component of the extracellular matrix (ECM), existing as side chains of the major cartilage proteoglycan, aggrecan. …

PLOS ONE 12(12), e0190333, 2017-12

IR
12

Pathophysiological Significance of Dermatan Sulfate Proteoglycans Revealed by Human Genetic Disorders

Mizumoto Shuji , Kosho Tomoki , Yamada Shuhei , Sugahara Kazuyuki

Pharmaceuticals 10(2), 34, 2017-06

IR
13

Characterization of Proteoglycan and Hyaluronan in Hot Water Extract from Salmon Cartilage

Kakizaki Ikuko , Miura Ayako , Mineta Takashi , Hong Jinseo , Kato Yoji

… Salmon cartilage proteoglycan fractions have recently gained favor as ingredients of functional food and cosmetics. … An optimal hot water method to extract proteoglycan from salmon cartilage has recently been developed. … The extracted cartilage includes hyaluronan and collagen in addition to proteoglycan as counterparts that interact with each other. …

Journal of Applied Glycoscience 64(4), 83-90, 2017

J-STAGE
14

Sushi repeat-containing protein X-linked 2 promotes angiogenesis through the urokinase-type plasminogen activator receptor dependent integrin αvβ3/focal adhesion kinase pathways

Liu Kuiliang , Fan Jianghao , Wu Jing

… Sushi repeat-containing protein X-linked 2 (SRPX2) is a newly identified chondroitin sulfate proteoglycan that is markedly elevated in multiple solid tumors. …

Drug Discoveries & Therapeutics 11(4), 212-217, 2017

J-STAGE Ichushi Web
15

Reduced molecular size and altered disaccharide composition of cerebral chondroitin sulfate upon Alzheimer's pathogenesis in mice

Zhang Zui , Ohtake-Niimi Shiori , Kadomatsu Kenji , Uchimura Kenji

… Chondroitin sulfate (CS) is an extracellular component abundant in the brain. … CS is a sulfated glycosaminoglycan covalently attached to a core protein, forming chondroitin sulfate proteoglycan. …

Nagoya Journal of Medical Science 78(3), 293-301, 2016-08

IR DOI Ichushi Web
16

Transition and future of research in cartilage metabolism : Translational research severity and its evaluation [in Japanese]

岩田久

日本整形外科学会雑誌 89(11), 943-958, 2015-11

Ichushi Web
17

Regarding the utility of the neural-glial antigen 2 (NG2) in MLL-related ALL [in Japanese]

TAKENOSHITA Tomohisa , MASAMOTO Izumi , TANIGUCHI Mayumi , TABATA Hitomi , TAKAMI Satoko , HASHIGUCHI Teruto , NISHIKAWA Takuro , KAWANO Yoshifumi

… However, positive results for CD79a, CD19 and negative results for CD66c led us to use chondroitin sulfate proteoglycan-type neural-glial antigen 2 antibody (NG2 antibody), with a focus on negative CD10, positive CD15 and partially positive CD34 findings. …

Cytometry Research 25(2), 21-26, 2015

J-STAGE Ichushi Web
18

Characterization of Proteoglycan and Hyaluronan in Water-based Delipidated Powder of Salmon Cartilage

Kakizaki Ikuko , Miura Ayako , Ito Seiko , Mineta Takashi , Jin Seo Hong , Kato Yoji

… Salmon cartilage proteoglycan fractions have attracted attention as new ingredients of functional food and cosmetics. … In this study, global molecular images of proteoglycan in the water-based delipidated powder were analyzed by biochemical techniques and atomic force microscopy. … Analytical data presented here provides assurance of the quality of the proteoglycan powder obtained using these methods. …

Journal of Applied Glycoscience 62(3), 115-120, 2015

J-STAGE
19

A Novel Eliminase from a Marine Bacterium That Degrades Hyaluronan and Chondroitin Sulfate

Han Wenjun , Wang Wenshuang , Zhao Mei , Sugahara Kazuyuki , Li Fuchuan

Journal of Biological Chemistry 289(40), 27886-27898, 2014-10-03

IR
20

Effects of sesamin on the biosynthesis of chondroitin sulfate proteoglycans in human articular chondrocytes in primary culture

Pothacharoen Peraphan , Najarus Sumet , Settakorn Jongkolnee , Mizumoto Shuji , Sugahara Kazuyuki , Kongtawelert Prachya

Glycoconjugate Journal 31(3), 221-230, 2014-04-01

IR

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