Search Results 1-20 of 1447

  • Identification and functional characterisation of N-linked glycosylation of the orphan G protein-coupled receptor Gpr176

    Wang Tianyu , Nakagawa Shumpei , Miyake Takahito , Setsu Genzui , Kunisue Sumihiro , Goto Kaoru , Hirasawa Akira , Okamura Hitoshi , Yamaguchi Yoshiaki , Doi Masao

    … Gpr176 encodes a class-A orphan GPCR that has a role in circadian clock regulation in mouse hypothalamus and is also implicated in human breast cancer transcriptional response. …

    Scientific Reports (10), 2020-03-10

    IR 

  • Expressions of circadian clock genes represent disease activities of RA patients treated with biological DMARDs

    Kaneshiro Kenta , Yoshida Kohsuke , Morii Kanta , Oketani Yuto , Uchida Koto , Yaekura Arisa , Okumura Ikumi , Hashimoto Teppei , Kawasaki Yoshiko , Shibanuma Nao , Sakai Yoshitada , Hashiramoto Akira

    … Objectives: Rheumatoid Arthritis (RA) is the autoimmune disease representing the circadian variations of symptoms such as morning stiffness of joints or increased production of cytokines around midnight. … Clock genes have been reported to affect on the pathogenesis of RA, however, the detailed relation between clock genes and disease activities of RA has remained unclear. … Total RNA was extracted from leukocytes to examine the expressions of the clock genes. …

    Modern Rheumatology 30(2), 293-300, 2020-03-03

    IR 

  • Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice

    Inokawa Hitoshi , Umemura Yasuhiro , Shimba Akihiro , Kawakami Eiryo , Koike Nobuya , Tsuchiya Yoshiki , Ohashi Munehiro , Minami Yoichi , Cui Guangwei , Asahi Takuma , Ono Ryutaro , Sasawaki Yuh , Konishi Eiichi , Yoo Seung-Hee , Chen Zheng , Teramukai Satoshi , Ikuta Koichi , Yagita Kazuhiro

    … Modern society characterized by a 24/7 lifestyle leads to misalignment between environmental cycles and endogenous circadian rhythms. … Persisting circadian misalignment leads to deleterious effects on health and healthspan. … Here, we subjected adult, wild-type mice to distinct chronic jet-lag paradigms, which showed that long-term circadian misalignment induced significant early mortality. …

    Scientific Reports (10), 2020-02-13

    IR 

  • Implications of the circadian clock in implant dentistry

    OKAWA Hiroko , EGUSA Hiroshi , NISHIMURA Ichiro

    … <p>Circadian rhythms are approximately 24-h cell-autonomous cycles driven by transcription and translation feedback loops of a set of core circadian clock genes, such as <i>circadian locomoter output cycles kaput</i> … (<i>Clock</i>), <i>brain and muscle arnt-like protein-1</i> …

    Dental Materials Journal 39(2), 173-180, 2020

    J-STAGE 

  • Mutation of alanine-422 in KaiC leads to a low amplitude of rhythm in the reconstituted cyanobacterial circadian clock

    Nagata Kazuki , Oyama Katsuaki , Ota Atsushi , Azai Chihiro , Terauchi Kazuki

    … <p>The cyanobacterial circadian oscillator can be reconstituted by mixing the purified clock proteins KaiA, KaiB, and KaiC with ATP <i>in vitro</i>, leading to a 24-h oscillation of KaiC phosphorylation. … carrying valine instead of alanine at position 422 of KaiC (KaiC-A422V) lost the ability to shift the phase of the circadian rhythm. …

    The Journal of General and Applied Microbiology, 2020

    J-STAGE 

  • Allergic rhinitis and clock gene  [in Japanese]

    Honma Aya

    Journal of Japan Society of Immunology & Allergology in Otolaryngology 38(1), 13-16, 2020

    J-STAGE 

  • Small molecule modulators of the circadian clock function  [in Japanese]

    Hirota Tsuyoshi

    … <p>In mammals, circadian rhythms are generated through transcriptional regulatory networks of the clock genes. … To search for novel clock modifiers, we applied chemical biology approaches. … From hundreds of thousands of small molecules with diverse structure, we identified a number of compounds that potently change the period of the circadian clock in human cells. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-S12-3, 2020

    J-STAGE 

  • CaMKII-dependent control of sleep duration in mammals  [in Japanese]

    Ode Koji , Ueda Hiroki

    … <p>The sleep-wake cycle is regulated through circadian clocks that drive the near-24 hrs rhythmicity of many physiological processes and sleep homeostasis that determines the sleep duration required per day. … The discovery of core circadian clock components was initiated by the finding of <i>period</i> … gene that controls the clock speed bidirectionally. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-S12-2, 2020

    J-STAGE 

  • Study of time-dependent pharmacokinetics of mouse embryonic stem cell-derived cardiomyocytes for drug screening

    Qi Zhen , KAMOSHIDA Misato , TAMAI Miho , HIROSE Masamichi , TAGAWA Yoh-ichi

    … <p>Core clock proteins play a significant role in maintaining physiological functions, including the metabolism in organisms in a circadian pattern. … Metabolism is critical for drug efficiency and pharmacokinetics, which depend on circadian rhythm in animals and humans. … Although alternative results are expected in animal experiments, there are limited reports on the influence of circadian rhythm on drug metabolism in culture. …

    Translational and Regulatory Sciences 2(1), 7-13, 2020

    J-STAGE 

  • Forward genetic approach for behavioral neuroscience using animal models

    FUNATO Hiromasa

    … Fruit flies were the first animal to which this genetic approach was applied systematically and have provided major discoveries on behaviors including sexual, learning, circadian, and sleep-like behaviors. … The unprecedented success of forward genetic approaches was the identification of the transcription–translation negative feedback loop composed of clock genes as a fundamental and conserved mechanism of circadian rhythm. …

    Proceedings of the Japan Academy, Series B 96(1), 10-31, 2020

    J-STAGE 

  • A Catalog of GAL4 Drivers for Labeling and Manipulating Circadian Clock Neurons in Drosophila melanogaster

    Sekiguchi Manabu , Inoue Kotaro , Yang Tian , Luo Dong-Gen , Yoshii Taishi

    … Daily rhythms of physiology, metabolism, and behavior are orchestrated by a central circadian clock. … In mice, this clock is coordinated by the suprachiasmatic nucleus, which consists of 20,000 neurons, making it challenging to characterize individual neurons. … In Drosophila, the clock is controlled by only 150 clock neurons that distribute across the fly's brain. …

    Journal of Biological Rhythms, 2019-12-19

    IR 

  • Aging and circadian clock  [in Japanese]

    柴田 重信

    Anti-aging medicine 15(6), 666-670, 2019-12

    Ichushi Web 

  • Clock-driven neural activity patterns determine sleep quality  [in Japanese]

    田渕 理史

    臨床免疫・アレルギー科 = Clinical immunology & allergology 72(5), 541-546, 2019-11

    Ichushi Web 

  • Hypotheses of circadian rhythm dysfunction in bipolar disorder : Current perspectives  [in Japanese]

    金野 倫子

    精神科治療学 34(10), 1107-1114, 2019-10

    Ichushi Web 

  • 2017, the discoveries of molecular mechanisms controlling the circadian rhythm  [in Japanese]

    海老澤 尚

    精神科 = Psychiatry 35(4), 379-385, 2019-10

  • Interconnection between circadian clocks and thyroid function

    Ikegami Keisuke , Refetoff Samuel , Van Cauter Eve , Yoshimura Takashi

    Circadian rhythmicity is an approximately 24-h cell-autonomous period driven by transcription–translation feedback loops of specific genes, which are referred to as 'circadian clock genes'. … In mammals, the central circadian pacemaker, which is located in the hypothalamic suprachiasmatic nucleus, controls peripheral circadian clocks. …

    Nature Reviews Endocrinology 15(10), 590-600, 2019-10

    IR 

  • 6. Life Science and Medical Science

    … (30008) [203]CO6-4 Structural Characterization of Circadian Clock Potein Complexes /H. …

    KURNS Progress Report (2018), 201-217, 2019-08

    IR 

  • Non-coding cis-element of Period2 is essential for maintaining organismal circadian behaviour and body temperature rhythmicity

    Doi Masao , Shimatani Hiroyuki , Atobe Yuta , Murai Iori , Hayashi Hida , Takahashi Yukari , Fustin Jean-Michel , Yamaguchi Yoshiaki , Kiyonari Hiroshi , Koike Nobuya , Yagita Kazuhiro , Lee Choogon , Abe Manabu , Sakimura Kenji , Okamura Hitoshi

    体内リズムの発現に必要なDNAのスイッチを発見 --蛋白質をコードしないノンコーディング領域のDNA配列が活躍--. 京都大学プレスリリース. 2019-06-12.

    Nature Communications (10), 2019-06-12

    IR 

  • The Kidney Clock Contributes to Timekeeping by the Master Circadian Clock

    Jihwan Myung , Mei-Yi Wu , Chun-Ya Lee , Amalia Ridla Rahim , Vuong Hung Truong , Dean Wu , Hugh David Piggins , Mai-Szu Wu

    … The kidney harbors one of the strongest circadian clocks in the body. … Kidney failure has long been known to cause circadian sleep disturbances. … Using an adenine-induced model of chronic kidney disease (CKD) in mice, we probe the possibility that such sleep disturbances originate from aberrant circadian rhythms in kidney. … Under the CKD condition, mice developed unstable behavioral circadian rhythms. …

    International Journal of Molecular Sciences 20(11), 2765, 2019-06-05

    IR 

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