Search Results 1-20 of 1374

  • Methylation deficiency disrupts biological rhythms from bacteria to humans

    Fustin Jean-Michel , Ye Shiqi , Rakers Christin , Kaneko Kensuke , Fukumoto Kazuki , Yamano Mayu , Versteven Marijke , Grünewald Ellen , Cargill Samantha J. , Tamai T. Katherine , Xu Yao , Jabbur Maria Luísa , Kojima Rika , Lamberti Melisa L. , Yoshioka-Kobayashi Kumiko , Whitmore David , Tammam Stephanie , Howell P. Lynne , Kageyama Ryoichiro , Matsuo Takuya , Stanewsky Ralf , Golombek Diego A. , Johnson Carl Hirschie , Kakeya Hideaki , van Ooijen Gerben , Okamura Hitoshi

    … We have previously shown that methyl cycle inhibition in mammals strongly affects circadian rhythms. … Since the methyl cycle and circadian clocks have evolved early during evolution and operate in organisms across the tree of life, we sought to determine whether the link between the two is also conserved. …

    Communications Biology (3), 2020-05-06


  • Visually Comfortable Supplementary Lighting for the Elderly : Effects on Elderly People's Circadian Rhythms : Two cases with different degrees of dementia  [in Japanese]

    上野 早織 , 川瀬 由布 , 山村 泰典 , 藤野 雅史 , 野口 公喜

    パナソニック技報 = Panasonic technical journal 66(1), 74-79, 2020-05

  • Identification and functional characterisation of N-linked glycosylation of the orphan G protein-coupled receptor Gpr176

    Wang Tianyu , Nakagawa Shumpei , Miyake Takahito , Setsu Genzui , Kunisue Sumihiro , Goto Kaoru , Hirasawa Akira , Okamura Hitoshi , Yamaguchi Yoshiaki , Doi Masao

    … Gpr176 encodes a class-A orphan GPCR that has a role in circadian clock regulation in mouse hypothalamus and is also implicated in human breast cancer transcriptional response. …

    Scientific Reports (10), 2020-03-10


  • Urinary Bile Acid Shows Diurnal Fluctuation and Phase Shift with Daytime-Restricted Feeding in Rats

    河合 洋 , 黒川 愛 , 石橋 拓也 , 岩舘 怜子 , 工藤 なをみ , 川嶋 洋一 , 光本 篤史

    … To investigate the relationship between biological rhythms and disorders, an efficient monitoring method of the biological clock is necessary. … In this study, we analyzed the circadian rhythmicity profile of bile acids in urine and investigated whether urinary bile acid (UBA) could reflect the circadian rhythm in liver physiology. … Since bile acids are synthesized in the liver, we propose that UBA might reflect the circadian fluctuation in liver physiology. …

    BPB Reports 3(3), 60-64, 2020-03


  • Chronic circadian misalignment accelerates immune senescence and abbreviates lifespan in mice

    Inokawa Hitoshi , Umemura Yasuhiro , Shimba Akihiro , Kawakami Eiryo , Koike Nobuya , Tsuchiya Yoshiki , Ohashi Munehiro , Minami Yoichi , Cui Guangwei , Asahi Takuma , Ono Ryutaro , Sasawaki Yuh , Konishi Eiichi , Yoo Seung-Hee , Chen Zheng , Teramukai Satoshi , Ikuta Koichi , Yagita Kazuhiro

    … Modern society characterized by a 24/7 lifestyle leads to misalignment between environmental cycles and endogenous circadian rhythms. … Persisting circadian misalignment leads to deleterious effects on health and healthspan. … Here, we subjected adult, wild-type mice to distinct chronic jet-lag paradigms, which showed that long-term circadian misalignment induced significant early mortality. …

    Scientific Reports (10), 2020-02-13


  • Feasibility of the duration of actigraphy data to illustrate circadian rhythm among cognitively intact older people in nursing home : cosinor analysis

    Dolu Ilknur , Nahcivan Nursen O.

    Sleep and biological rhythms : official journal of the Japanese Society of Sleep Research 18(1), 59-64, 2020

  • Chrono-nutrition  [in Japanese]

    Kim Hyeon-Ki , Shibata Shigenobu

    … <p>In mammals, the circadian rhythms have been shown to regulate several physiological functions, including body temperature, sleep-wake behavior, physical activity, hormonal secretions, and metabolism. … These processes are controlled by circadian clock genes, and abnormal circadian rhythms are associated with the development of obesity, diabetes, and lifestyle-related diseases. …

    Japanese Journal of Physical Fitness and Sports Medicine 69(5), 401-411, 2020


  • Mechanisms of cisplatin-induced chronotoxicity in mice  [in Japanese]

    TOMINAGA Sarah , YOSHIOKA Hiroki , SAKANASHI Mayuko , MAEDA Tohru , YOSHIKAWA Masae , PARK Sang Jun , MIURA Nobuhiko

    … <p>【Purpose】Living organisms are controlled by the circadian rhythms. … It has become clear that these circadian differences affect the frequency of diseases. … In this study, we investigated the circadian variations in CDDP-induced toxicity focused on toxicity and its mechanism using mouse model.</p><p> …

    Annual Meeting of the Japanese Society of Toxicology 47.1(0), P-7S, 2020


  • Effects of Chronic Glucocorticoid Receptor Stimulation on Circadian Locomotor Activity and Serotonergic Neurotransmission in the Basolateral Amygdala of Rats

    Shimizu Norifumi , Hara Chiaki

    … To further investigate the relationship between GR activation and depression, we used the synthetic glucocorticoid dexamethasone (DEX) and the GR antagonist mifepristone to examine the effects of chronic GR stimulation on the circadian rhythms of locomotor activity and serotonergic neurotransmission in the basolateral amygdala (BLA) of rats. …

    Biological and Pharmaceutical Bulletin 43(8), 1279-1282, 2020


  • Control of the Daily Rhythms by Photoperiods in Protomont Detachment and Theront Excystment of the Parasitic Ciliate <i>Cryptocaryon irritans</i>

    Watanabe Yuho , How Kah Hui , Zenke Kosuke , Itoh Naoki , Yoshinaga Tomoyoshi

    … has clear daily rhythms in protomont detachment from fish and theront excystment from tomonts. … ​While the rhythms seem to be regulated by photoperiods, it has not been confirmed. … ​We investigated whether the daily rhythms of the parasite would be controlled by giving different photoperiods of 12 h light and 12 h dark (06:00–18:00 L and 18:00–06:00 D; …

    Fish Pathology 55(2), 38-41, 2020


  • Chronobiology: Human circadian pacemaker and circadian rhythms  [in Japanese]

    Yamanaka Yujiro

    Japanese Journal of Physical Fitness and Sports Medicine 69(4), 343-350, 2020


  • Circadian rhythms and exercise/physical activity  [in Japanese]

    Takahashi Masaki , Aoyama Shinya

    … <p>Circadian rhythms have been shown to regulate several physiological functions including body temperature, sleep/wake cycle, physical activity, and cognition. … These functions are controlled by circadian clock genes, and the circadian clock system in the body is classified into two clocks which are the central clock in the suprachiasmatic nucleus (SCN) of the hypothalamus and peripheral clocks in peripheral tissues such as the liver and skeletal muscle. …

    Japanese Journal of Physical Fitness and Sports Medicine 69(4), 351-358, 2020


  • Cacao polyphenols regulate the circadian clock gene expression and through glucagon-like peptide-1 secretion

    Hironao Ken-yu , Mitsuhashi Yuji , Huang Shujiao , Oike Hideaki , Ashida Hitoshi , Yamashita Yoko

    … <p>Energy metabolism and circadian rhythms are closely related together, i.e., the timing of nutrient intake affects metabolism under the regulation of circadian rhythms. … In this study, we investigated whether the administration timing of CLPr affected clock gene expression and found that CLPr regulated the circadian clock gene expression through the glucagon-like peptide-1 (GLP-1) signaling pathway. …

    Journal of Clinical Biochemistry and Nutrition 67(1), 53-60, 2020


  • Mutation of alanine-422 in KaiC leads to a low amplitude of rhythm in the reconstituted cyanobacterial circadian clock

    Nagata Kazuki , Oyama Katsuaki , Ota Atsushi , Azai Chihiro , Terauchi Kazuki

    … <p>The cyanobacterial circadian oscillator can be reconstituted by mixing the purified clock proteins KaiA, KaiB, and KaiC with ATP <i>in vitro</i>, leading to a 24-h oscillation of KaiC phosphorylation. … carrying valine instead of alanine at position 422 of KaiC (KaiC-A422V) lost the ability to shift the phase of the circadian rhythm. …

    The Journal of General and Applied Microbiology 66(2), 140-146, 2020


  • Shift work and migraine: A systematic review

    Leso Veruscka , Gervetti Paola , Mauro Sara , Macrini Maria C. , Ercolano Maria L. , Iavicoli Ivo

    … In this perspective, it is possible that shift and night work, affecting circadian rhythms, may play a key function in the disease pathogenesis. …

    Journal of Occupational Health 62(1), n/a, 2020


  • Implications of the circadian clock in implant dentistry

    OKAWA Hiroko , EGUSA Hiroshi , NISHIMURA Ichiro

    … <p>Circadian rhythms are approximately 24-h cell-autonomous cycles driven by transcription and translation feedback loops of a set of core circadian clock genes, such as <i>circadian locomoter output cycles kaput</i> … The genetic clockwork of these genes produces circadian rhythms in cells throughout the body, including the craniofacial region. …

    Dental Materials Journal 39(2), 173-180, 2020


  • Message to women scientists: Success in research comes when you refuse to give up  [in Japanese]

    Honma Sato

    … In the recent special issue on Circadian Rhythms at Eur. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-S36-3, 2020


  • Histamine H1 receptor on neurons and astrocytes plays different roles in mouse behavior  [in Japanese]

    Yoshikawa Takeo , Karpati Aniko , Naganuma Fumito , Matsuzawa Takuro , Yanai Kazuhiko

    … Astrocytic H1R contributed to the regulation of aggressive behavior, circadian rhythms and quality of wakefulness. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-O-033, 2020


  • Small molecule modulators of the circadian clock function  [in Japanese]

    Hirota Tsuyoshi

    … <p>In mammals, circadian rhythms are generated through transcriptional regulatory networks of the clock genes. … From hundreds of thousands of small molecules with diverse structure, we identified a number of compounds that potently change the period of the circadian clock in human cells. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-S12-3, 2020


  • A Catalog of GAL4 Drivers for Labeling and Manipulating Circadian Clock Neurons in Drosophila melanogaster

    Sekiguchi Manabu , Inoue Kotaro , Yang Tian , Luo Dong-Gen , Yoshii Taishi

    … Daily rhythms of physiology, metabolism, and behavior are orchestrated by a central circadian clock. … Together with existing driver lines, these newly identified ones are versatile tools that will facilitate a better understanding of the Drosophila central circadian clock. …

    Journal of Biological Rhythms, 2019-12-19


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