Search Results 1-20 of 117

  • Investigating the maladaptive cortical reorganization in the human auditory cortex using magnetoencephalography

    Okamoto Hidehiko

    … The cortical reorganization is usually beneficial such as an increased auditory cortical representation in professional musicians. … On the other hand, maladaptive cortical reorganization in the auditory cortex can lead to hearing disorders such as tinnitus and hyperacusis. …

    Acoustical Science and Technology 41(1), 196-200, 2020

    J-STAGE 

  • Functional and structural brain changes in patients with phantom limb pain  [in Japanese]

    Kan Shigeyuki

    … Now, this model is known as the maladaptive reorganization model. … They demonstrated that cortical representation of a missing hand had been preserved and activation evoked by phantom limb movement had been related to the severity of phantom limb pain. … After that, the maladaptive reorganization model has been revisited, and recent studies have suggested that functional alterations in the primary motor cortex rather than the primary sensory cortex are associated with phantom limb pain. …

    PAIN RESEARCH 34(1), 1-9, 2019

    J-STAGE  Ichushi Web 

  • Septin-dependent remodeling of cortical microtubule drives cell reshaping during epithelial wound healing

    Shindo Asako , Audrey Anastasia , Takagishi Maki , Takahashi Masahide , Wallingford John B. , Kinoshita Makoto

    ファイル公開:2019-06-28

    Journal of Cell Science 131(12), jcs212647, 2018-11

    IR 

  • Axonal outgrowth and functional recovery after stroke  [in Japanese]

    Ueno Yuji , Tanaka Ryota , Urabe Takao , Hattori Nobutaka

    <p>脳梗塞後の軸索再生は,損傷後の組織再構築において重要な役割を担い,機能回復とも関連する.筆者は,ラット中大脳動脈閉塞モデルのperi-infarct area において,7 日後の急性期に脱落した軸索や樹状突起は56 日後の慢性期では再生していることを確認した.In vitro では,虚血後軸索の再生にはphosphatase tensin homolog deleted on …

    Cerebral Blood Flow and Metabolism (Japanese journal of cerebral blood flow and metabolism) 30(1), 65-69, 2018

    J-STAGE 

  • MEG–BMI to Control Phantom Limb Pain

    YANAGISAWA Takufumi , KAMITANI Yukiyasu , SAITOH Youichi , FUKUMA Ryohei , SEYMOUR Ben , HOSOMI Koichi , KISHIMA Haruhiko , SHIMIZU Takeshi , YOKOI Hiroshi , HIRATA Masayuki , YOSHIMINE Toshiki

    … However, there is little evidence to demonstrate the causal links between the pain and the cortical representation, and how much cortical factors affect the pain. … These results strongly suggested that pain after the BPRA was partly attributable to cortical representation of phantom hand movements and that the BMI training controlled the pain by inducing appropriate cortical reorganization. …

    Neurologia medico-chirurgica 58(8), 327-333, 2018

    J-STAGE  Ichushi Web 

  • MEG–BMI to Control Phantom Limb Pain

    YANAGISAWA Takufumi , KAMITANI Yukiyasu , SAITOH Youichi , FUKUMA Ryohei , SEYMOUR Ben , HOSOMI Koichi , KISHIMA Haruhiko , SHIMIZU Takeshi , YOKOI Hiroshi , HIRATA Masayuki , YOSHIMINE Toshiki

    … However, there is little evidence to demonstrate the causal links between the pain and the cortical representation, and how much cortical factors affect the pain. … These results strongly suggested that pain after the BPRA was partly attributable to cortical representation of phantom hand movements and that the BMI training controlled the pain by inducing appropriate cortical reorganization. …

    Neurologia medico-chirurgica, 2018

    J-STAGE 

  • Induction of cortical plasticity reveals the mechanism of the phantom limb pain and develops novel treatment  [in Japanese]

    Yanagisawa Takufumi , Kamitani Yukiyasu , Saitoh Yoichi , Fukuma Ryohei , Ben Seymour , Hosomi Koichi , Shimizu Takeshi , Kishima Haruhiko , Hirata Masayuki , Yokoi Hiroshi , Yoshimine Toshiki

    … It has been suggested that experimental reorganization would affect pain. … Here, we tested the hypothesis that a training to use brain–machine interface (BMI) based on magnetoencephalographic (MEG) signals will induce some cortical plasticity in the sensorimotor cortex and modulate the phantom limb pain.</p><p><i>Methods.</i> … The sensorimotor cortical plasticity might induce pain.</p> …

    PAIN RESEARCH 33(1), 26-31, 2018

    J-STAGE  Ichushi Web 

  • Microtubule array observed in the posterior-vegetal cortex during cytoplasmic and cortical reorganization of the ascidian egg

    Ishii Hirokazu , Goto Toshiyuki , Nishikata Takahito

    Development, Growth & Differentiation / Development Growth & Differentiation 59(8), 648-656, 2017-10

  • Induced sensorimotor brain plasticity controls pain in phantom limb patients

    Yanagisawa Takufumi , Fukuma Ryohei , Seymour Ben , Hosomi Koichi , Kishima Haruhiko , Shimizu Takeshi , Yokoi Hiroshi , Hirata Masayuki , Yoshimine Toshiki , Kamitani Yukiyasu , Saitoh Youichi

    … A popular but increasingly controversial theory is that it results from maladaptive reorganization of the sensorimotor cortex, suggesting that experimental induction of further reorganization should affect the pain, especially if it results in functional restoration. … These results reveal a functional relevance between sensorimotor cortical plasticity and pain, and may provide a novel treatment with BMI neurofeedback. …

    Nature Communications (7), 2016-10-27

    IR 

  • Associative-memory representations emerge as shared spatial patterns of theta activity spanning the primate temporal cortex

    Nakahara Kiyoshi , Adachi Ken , Kawasaki Keisuke , Matsuo Takeshi , Sawahata Hirohito , Majima Kei , Takeda Masaki , Sugiyama Sayaka , Nakata Ryota , Iijima Atsuhiko , Tanigawa Hisashi , Suzuki Takafumi , Kamitani Yukiyasu , Hasegawa Isao

    … however, whether memory formation involves area-wide reorganization of ensemble activity, which often accompanies rhythmicity, or just local microcircuit-level plasticity, remains elusive. … Our results suggest that the formation and sharing of widespread cortical theta patterns via learning-induced reorganization are involved in the mechanisms of associative memory representation. …

    Nature communications (7), 2016-06-10

    IR 

  • <b>Voxel-based lesion mapping on central poststroke pain </b>  [in Japanese]

    Hosomi Koichi , Shimizu Takeshi , Goto Yuko , Mano Tomoo , Kadono Yoshinori , Oshino Satoru , Kishima Haruhiko , Yoshimine Toshiki , Saitoh Youichi

    … Although central poststroke pain (CPSP)might be understood as a network reorganization disorder that leads to a maladaptive central state, the mechanisms of CPSP are poorly understood. … cortical ⁄ subcortical lesion, <i>n</i>=3). …

    PAIN RESEARCH 31(4), 228-237, 2016

    J-STAGE 

  • Dentate Circuitry as a Model to Study Epileptogenesis

    Koyama Ryuta

    … Epileptogenic changes include induction of immediate early genes, post-translational modification of ion-channel functions, neuronal death, gliosis, and reorganization of neural circuits. … Each of these changes alone or in combination can contribute to an epileptogenic focus, which is defined by the minimal cortical region that is necessary and sufficient to induce synchronized epileptic bursting activity in neurons. …

    Biological and Pharmaceutical Bulletin 39(6), 891-896, 2016

    J-STAGE  Ichushi Web 

  • Abscisic acid induces ectopic outgrowth in epidermal cells through cortical microtubule reorganization in Arabidopsis thaliana

    Takatani Shogo , Hirayama Takashi , Hashimoto Takashi , Takahashi Taku , Motose Hiroyasu

    … Furthermore, cortical microtubules were disorganized and depolymerized by the ABA treatment. … These results suggest that ABA signaling induces ectopic outgrowth in epidermal cells through microtubule reorganization. …

    Scientific Reports (5), 11364, 2015-06-12

    IR 

  • A short splicing isoform of afadin suppresses the cortical axon branching in a dominant-negative manner

    Umeda Kentaro , Iwasawa Nariaki , Negishi Manabu , Oinuma Izumi

    … We recently identified afadin, an F-actin-binding protein, as an effector of R-Ras mediating axon branching through F-actin reorganization. … Here we identify s-afadin as an endogenous inhibitor of cortical axon branching. … In contrast to the abundant and constant expression of l-afadin throughout neuronal development, the expression of s-afadin is relatively low when cortical axons branch actively. …

    Molecular Biology of the Cell 26(10), 1957-1970, 2015-05-15

    IR 

  • Dynamics of cortical neuronal activity during long-term motor learning and short-term operant conditioning  [in Japanese]

    MATSUZAKI MASANORI

    … Motor performance improves with repetitive training, and it has been proposed that this is mediated by functional and structural reorganization of the motor cortex. …

    Transactions of Japanese Society for Medical and Biological Engineering 53(Supplement), S130_03-S130_03, 2015

    J-STAGE 

  • The relationships between the distorted body image of neck and clinical profile in patients with chronic nonspecific neck pain  [in Japanese]

    Mibu Akira , Nishigami Tomohiko , Kishishita Syuzou , Son Kouki , Yamamoto Syougo , Tanaka Katsuyoshi , Kajiwara Saori , Tanabe Akihito

    … This result suggested that pathological condition of CNSNP was associated with cortical dysfunction as well as CRPS, chronic non–specific lower back pain and phantom limb pain. …

    PAIN RESEARCH 30(1), 30-36, 2015

    J-STAGE  Ichushi Web 

  • Brain Plasticity and Rehabilitation in Stroke Patients

    Hara Yukihiro

    Reorganization of surviving central nervous system elements supports behavioral recovery, for example, through changes in interhemispheric lateralization, activity of association cortices linked to injured zones, and organization of cortical representational maps. … Evidence from animal models suggests that both motor learning and cortical stimulation alter intracortical inhibitory circuits and can facilitate long-term potentiation and cortical remodeling. …

    Journal of Nippon Medical School 82(1), 4-13, 2015

    J-STAGE  Ichushi Web 

  • Mitochondrial inhibitor sodium azide inhibits the reorganization of mitochondria-rich cytoplasm and the establishment of the anteroposterior axis in ascidian embryo

    Ishii Hirokazu , Shirai Takuma , Makino Chisato [他]

    Development, growth & differentiation 56(2), 175-188, 2014-02

  • Functional Near Infrared Spectroscopy in Neurorehabilitation  [in Japanese]

    MIHARA Masahito

    … Functional Near-Infrared Spectroscopy (fNIRS) is a characteristically functional neuroimaging technique which enables us to measure the daily tasks related to cortical activation including gait and postural task. … In addition, it was also revealed that the individual balance ability was correlated with the cortical activation in the supplementary motor area during the postural task. …

    The Japanese Journal of Rehabilitation Medicine 51(10), 645-649, 2014

    J-STAGE  Ichushi Web 

  • ING3 Is Essential for Asymmetric Cell Division during Mouse Oocyte Maturation.

    Suzuki Shinnosuke , Nozawa Yusuke , Tsukamoto Satoshi , Kaneko Takehito , Imai Hiroshi , Minami Naojiro

    … Here, we show that loss of ING3 function led to the failure of asymmetric cell division and cortical reorganization in the mouse oocyte. … In those oocytes, oocyte polarization was not established due to the failure to form an actin cap or a cortical granule-free domain (CGFD), the lack of which inhibited spindle migration. …

    PloS one 8(9), 2013-09-16

    IR 

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