Search Results 1-20 of 85

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  • Effects of the expectorant drug ambroxol hydrochloride on chemically induced lung inflammatory and neoplastic lesions in rodents

    Yoshida Shota , Yokohira Masanao , Yamakawa Keiko , Nakano-Narusawa Yuko , Kanie Shohei , Hashimoto Nozomi , Imaida Katsumi

    … We also analyzed the modulatory effects of AH on neoplastic lung lesions induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mice and by N-nitrosobis (2-hydroxypropyl) amine (DHPN) in F344/DuCrlCrj (F344) rats. … In the NNK and DHPN experiments, no significant differences in body weight, hematology, plasma biochemistry, and histopathological changes were associated with AH concentration. …

    Journal of Toxicologic Pathology 31(4), 255-265, 2018

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  • γH2AX is immunohistochemically detectable until 7 days after exposure of N-bis (2-hydroxypropyl) nitrosamine (DHPN) in rat lung carcinogenesis

    Ying Jane Tey Xin , Yokohira Masanao , Nakano-Narusawa Yuko , Yamakawa Keiko , Hashimoto Nozomi , Imaida Katsumi

    … In this experiment, the time-course manner of the expression of γH2AX in the lung was examined in the early phase after treatment with a lung carcinogen, N-bis (2-hydroxypropyl) nitrosamine (DHPN). … The DHPN groups were administered 0.1% DHPN in drinking tap water for two weeks, while the control group received drinking tap water. …

    Journal of Toxicologic Pathology 31(3), 163-168, 2018

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  • Early prediction of bladder carcinogenicity by γ-H2AX - a validation study using additional chemicals -  [in Japanese]

    YAMADA Takanori , TOYODA Takeshi , SONE Mizuki , SUZUKI Shugo , MATSUSHITA Kohei , MORIKAWA Tomomi , OGAWA Kumiko

    … 【方法】各群5匹の6週齢,雄性F344ラットに,7種の膀胱発がん物質(ANP・DB1・DHPN・EHBN・CPA・COP・NTA)及び11種の非膀胱発がん物質(ENU・DEN等)を28日間反復経口投与した。 … Ki67陽性細胞数の有意な増加は,膀胱発がん物質4種(DHPN・EHBN・CPA・COP)の投与群でのみ認められた。 …

    Annual Meeting of the Japanese Society of Toxicology 45.1(0), P-5, 2018

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  • Effects of the expectorant drug ambroxol hydrochloride on chemically induced lung inflammatory and neoplastic lesions in rodents

    YOSHIDA Shota , YOKOHIRA Masanao , YAMAKAWA Keiko , NAKANO-NARUSAWA Yuko , KANIE Shohei , HASHIMOTO Nozomi , IMAIDA Katsumi

    … We also analyzed the modulatory effects of AH on neoplastic lung lesions induced by 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) in A/J mice and by N-nitrosobis (2-hydroxypropyl) amine (DHPN) in F344/DuCrlCrj (F344) rats. … In the NNK and DHPN experiments, no significant differences in body weight, hematology, plasma biochemistry, and histopathological changes were associated with AH concentration. …

    Journal of Toxicologic Pathology, 2018

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  • γH2AX is immunohistochemically detectable until 7 days after exposure of N-bis (2-hydroxypropyl) nitrosamine (DHPN) in rat lung carcinogenesis

    YING Jane Tey Xin , YOKOHIRA Masanao , NAKANO-NARUSAWA Yuko , YAMAKAWA Keiko , HASHIMOTO Nozomi , IMAIDA Katsumi

    … In this experiment, the time-course manner of the expression of γH2AX in the lung was examined in the early phase after treatment with a lung carcinogen, N-bis (2-hydroxypropyl) nitrosamine (DHPN). … The DHPN groups were administered 0.1% DHPN in drinking tap water for two weeks, while the control group received drinking tap water. …

    Journal of Toxicologic Pathology, 2018

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  • A dose range finding study of initiator (DMH) in the medium-term multi-organ carcinogenesis bioassay  [in Japanese]

    IMAI Norio , NUMANO Takamasa , DOI Yuko , SUGURO Mayuko , KAWABE Mayumi , HAGIWARA Akihiro , FURUKAWA Fumio

    … 【目的】中期多臓器発がん性試験法では<i>N</i>-nitrosodiethylamine (DEN)、<i>N</i>-nitroso-<i>N</i>-methylurea (MNU)、<i>N</i>-butyl-<i>N</i>-(4-hydroxybutyl)nitrosamine (BBN)、1,2-dimethylhydrazine dihydrochloride (DMH)、diisopropanolnitrosamine (DHPN)でイニシエーション処置を行う。 …

    Annual Meeting of the Japanese Society of Toxicology 41.1(0), P-231, 2014

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  • Alveolar hyperplasia like lesions associated with intra tracheal spray of multi walled carbon nanotube or carbon black particles  [in Japanese]

    FUTAKUCHI Mitsuru , XU Jegou , INOUE Yoshiyuki , TAKATSUKI Mineo , TSUDA Hiroyuki , SUZUI Masumi

    … 6週齢の雄F344ラットに N-nitrosobis (2-hydroxypropyl) amine (DHPN)を2週間0.2%の用量で飲水投与した。 … DHPNにより誘発された肺の腫瘍性病変(過形成、腺腫および腺癌)が観察され、これとは別の部位にCNT-Mを貪食したマクロファージが集族像が多数観察され、マクロファージを取り囲むように肺胞過形成様の病変が観察された。 …

    Annual Meeting of the Japanese Society of Toxicology 41.1(0), O-37, 2014

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  • Immunohistochemical Characteristics of Surfactant Proteins A, B, C and D in Inflammatory and Tumorigenic Lung Lesions of F344 Rats

    Yokohira Masanao , Saoo Kousuke , Imaida Katsumi , Yamakawa Keiko , Nakano Yuko , Numano Takamasa , Furukawa Fumio , Kishi Sosuke , Ninomiya Fumiko , Kanie Shohei , Hitotsumachi Hiroko

    … In this experiment, the expressions of SP-A, SP-B, SP-C and SP-D in lung neoplastic lesions induced by N-bis (2-hydroxypropyl) nitrosamine (DHPN) and inflammatory lesions due to quartz instillation were examined and compared immunohistochemically. … Formalin fixed paraffin embedded (FFPE) lung samples featuring inflammation were obtained with a rat quartz instillation model, and neoplastic lesions, hyperplasias and adenomas, were obtained with the rat DHPN-induced lung carcinogenesis model. …

    Journal of Toxicologic Pathology 27(3+4), 175-182, 2014

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  • Reactive pulmonary hyperplasia induced by intra pulmonary spray of nano-sized carbon black particles  [in Japanese]

    FUTAKUCHI Mitsuru , XU Jegou , INOUE Yoshiyuki , TAKATSUKI Mineo , TSUDA Hiroyuki , SUZUI Masumi

    … Male and female F344 rats were treated first with DHPN in the drinking water for 2 weeks. … This alveolar hyperplasia like lesions (AHLL) were observed in the rats treated with CB regardless of DHPN treatment and these AHLL were located independently of DHPN-induced lesions such as alveolar hyperplasias, adenomas and adenocarcinomas. … The average numbers of AHLL in the lung were higher than that of DHPN-induced lesions. …

    Annual Meeting of the Japanese Society of Toxicology 39.2(0), AP-158, 2012

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  • Effects of rat lung carcinogenesis of fullerene (C60) administered by intra-pulmonary spraying  [in Japanese]

    FUKAMACHI Katsumi , XU Jiegou , FUTAKUCHI Mitsuru , HASHIZUME Naoki , INOUE Yoshiyuki , TAKATSUKI Mineo , TSUDA Hiroyuki , SUZUI Masumi

    … 6週齢の雌雄F344ラットにそれぞれ0.2%DHPNを2週間飲水投与した後、氷砂糖溶液に分散させたC60を第4週から第24週まで1週間に1回の割合で、250 µg/mlまたは500 µg/mlの用量で、それぞれ0.5 mlを肺内に噴霧した。 …

    Annual Meeting of the Japanese Society of Toxicology 39.1(0), O-33, 2012

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  • Reactive hyperplasia induced by intra tracheal spray of nano-sized carbon black particles  [in Japanese]

    FUTAKUCHI Mitsuru , XU Jiegou , INOUE Yoshiyuki , TAKATSUKI Mineo , TSUDA Hiroyuki , SUZUI Masumi

    … 6週齢の雌雄のF344ラットにそれぞれ0.2%DHPNを2週間飲水投与した後、氷砂糖溶液に分散させたカーボンブラックを第4週から第24週まで1週間に1回の割合で肺内に噴霧した。 … この病変は、DHPNで誘発された肺胞過形成、肺腺腫および肺腺がんとは別の部位に観察された。 … DHPNで誘発された病変の平均発生個数は、カーボンブラックの肺内噴霧により有意に上昇しなかった。 …

    Annual Meeting of the Japanese Society of Toxicology 39.1(0), O-31, 2012

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  • Induction of interstitial pneumonia by intra tracheal spray of nano size ZnO  [in Japanese]

    Futakuchi Mitsuru , Xu Jiegou , Fukamachi Katsumi , Suzui Masumi , Tsuda Hiroyuki

    … 【方法と結果】6週齢の雌のc-Ha-ras TGラットに肺発がん物質DHPNを2週間飲水投与し、nZnOを250ppm、500ppmの濃度で第4から16週まで計7回気管内噴霧し屠殺剖検した。 …

    Annual Meeting of the Japanese Society of Toxicology 38(0), 10011-10011, 2011

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  • Modifying effects of lac color and cochineal extract on the development of thyroid capsular carcinomas induced by promotion with sulfadimethoxine in a rat two-stage carcinogenesis model  [in Japanese]

    KEMMOCHI Sayaka , KAWAI Masaomi , SAEGUSA Yukie , SHIMAMOTO Keisuke , HASUMI Keiji , MITSUMORI Kunitoshi , SHIBUTANI Makoto

    … 【方法】6週齢の雄性F344ラットにDHPNのイニシエーション処置をし,その1週後から1500 ppm SDMを13週間飲水投与し,同時に5%ラック色素(ラッカイン酸76.6%)ないし3%コチニール色素(カルミン酸35.6%)を混餌投与した。 …

    Annual Meeting of the Japanese Society of Toxicology 37(0), 307-307, 2010

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  • Lung Carcinogenic Bioassay of CuO and TiO_2 Nanoparticles with Intratracheal Instillation Using F344 Male Rats

    YOKOHIRA Masanao , HASHIMOTO Nozomi , YAMAKAWA Keiko , SUZUKI Satoshi , SAOO Kousuke , KUNO Toshiya , IMAIDA Katsumi

    Journal of toxicologic pathology 22(1), 71-78, 2009-03-01

    References (27)

  • Promotion of Nano-size Titanium Dioxide on Rat Lung and Mammary Carcinogenesis; Involvement of Macrophage Inflammation Protein 1 alfa (MIP1alfa)  [in Japanese]

    Tsuda Hiroyuki , Hirose Akihiko , Kanno Jun , Xu Jiegou , Futakuchi Mitsuru , Iigou Masaaki , Fukamachi Katsumi , Alexander B. David , Uchino Tadashi , Nishimura Tetsuji , Tokunaga Hiroshi

    … 【方法と結果】乳腺発がん高感受性雌ヒトプロト型c-Ha-ras遺伝子トランスジェニックラット(Tg)に0.2% DHPNを2週間飲水投与して発がんイニシエーション処置をした。 …

    Annual Meeting of the Japanese Society of Toxicology 36(0), 1804-1804, 2009

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  • Lung Carcinogenic Bioassay of CuO and TiO2 Nanoparticles with Intratracheal Instillation Using F344 Male Rats

    Yokohira Masanao , Hashimoto Nozomi , Yamakawa Keiko , Suzuki Satoshi , Saoo Kousuke , Kuno Toshiya , Imaida Katsumi

    … In experiment 1, a sequential pilot study, the effectiveness of a carcinogenic bioassay featuring intraperitoneal injection (i.p.) of 20 mg 4-(methylnitrosamino)-1-(3-pyridyl)-1-butanone (NNK) or 0.1 % <i>N</i>-bis(2-hydroxypropyl)nitrosamine (DHPN) in drinking water for 2 weeks was examined. … Based on the results, DHPN, as the lung carcinogen, and evaluation at week 30 were selected as the most appropriate for our purposes in Experiment 1. …

    Journal of Toxicologic Pathology 22(1), 71-78, 2009

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  • Inhibitory effects of prepubertal administration of decabromodiphenyl ether on susceptibility to thyroid and renal carcinogenesis in rats exposed to DHPN and DMBA during adolescence  [in Japanese]

    Takami Shigeaki , Imai Toshio , Cho Young-Man , Hirose Masao , Nishikawa Akiyoshi

    【目的】臭素化難燃剤であるdecabromodiphenyl ether (DBDE)は、雌雄ラットの肝臓、雄マウスの肝臓及び甲状腺に発がん性を示すことが報告されている。今回、乳幼児期にDBDEを投与した際の発がん感受性に及ぼす影響を明らかにする目的で、多臓器に発がん標的性を示す発がん物質の組み合わせ投与を応用したラット中期発がん性試験を行った。【方法】実験1: 25匹の妊娠F344ラットを5群に …

    Annual Meeting of the Japanese Society of Toxicology 35(0), 196-196, 2008

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  • Rat medium-term multi-organ carcinogenesis bioassay of Agaricus blazei Murrill fruit-body extract  [in Japanese]

    Suguro Mayuko , Doi Yuko , Nakashima Hironao , Nanbu Tomomi , Kobayashi Hitoshi , Kinugasa Satomi , Inatomi Satoshi

    … また第1~2週に飲料水中に0.05% BBNを混じ毎日投与し、更に第3~4週には飲料水中に0.1%DHPNを混じ毎日投与した。 …

    Annual Meeting of the Japanese Society of Toxicology 35(0), 213-213, 2008

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  • Proposal of a medium-term assay system for evaluation of the carcinogenicity of nanoparticles  [in Japanese]

    Tsuda Hiroyuki , Kanno Jun , Xu Jiegou , Fukamachi Katsumi , Inoue Yoshiyuki , Takatsuki Mineo , Tokunaga Hiroshi , Uchino Tadashi , Nishimura Tetsuji , Hirose Akihiko

    … 1)肺・乳腺発がんプロモーション試験:乳腺発がん高感受性雌ヒト正常型Ha-ras遺伝子トランスジェニックラット(Tg)を用い、ニトロサミンのDHPN飲水投与(イニシエーション)後にTiO2(ルチル型、500および250ppm/生食懸濁)を2週に1度肺内に噴霧投与して16週で終了した。 …

    Annual Meeting of the Japanese Society of Toxicology 35(0), 31-31, 2008

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  • Combined Chemopreventive Effects of Perilla or Corn Oil and Indomethacin in a Rat Medium-Term Multiorgan Carcinogenesis Model

    FUTAKUCHI Mitsuru , HIROSE Masao , KAWABE Mayumi , YAMAGUCHI Tsuyoshi , SATO Shinya , SHIRAI Tomoyuki

    … Male F344 rats were given N-diethylnitrosamine (DEN), N-methyl-nitrosourea (MNU), N-butyl- N-(4-hydroxybutyl) nitrosamine (BBN), N-nitrosobis (2-hydroxypropyl) amine (DHPN) and 1,2- dimethylhydrazine (DMH) during the initial 4 weeks as initiators. …

    Journal of Toxicologic Pathology 20(4), 245-252, 2007-12-25

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