Search Results 1-20 of 241

  • DNA damage responses in aging  [in Japanese]

    本山 昇

    医学のあゆみ 272(13), 1299-1306, 2020-03-28

    Ichushi Web 

  • Eupalinolide J induces apoptosis, cell cycle arrest, mitochondrial membrane potential disruption and DNA damage in human prostate cancer cells

    Wu Zeqi , Xu Xintong , Dai Lingjie , Wang Yiqi , Yang Bo , Zhao Huajun , Lou Chenghua

    … Furthermore, our results demonstrated that the expression levels of γH2AX, p-Chk1 and p-Chk2 were significantly up-regulated, suggesting the induction of DNA damage responses in EJ-treated prostate cancer cells. …

    The Journal of Toxicological Sciences 45(1), 15-23, 2020


  • The Role of High Mobility Group Box-1 in Epileptogenesis

    Fu Li , Nishibori Masahiro

    … High mobility group box-1 (HMGB1) is a non-histone, DNA-binding nuclear protein belonging to the family of damage-associated molecular patterns (DAMPs). … Many hypotheses have been suggested especially about the relationship between HMGB1 and inflammation responses and blood-brain barrier disruption during epileptogenesis. …

    Acta Medica Okayama 73(5), 383-386, 2019-10

    IR  DOI 

  • High LET Radiation Overcomes In Vitro Resistance to X-Rays of Chondrosarcoma Cell Lines

    Francois Chevalier , Dounia Houria Hamdi , Charlotte Lepleux , Mihaela Temelie , Anaïs Nicol , Jean Baptiste Austry , Paul Lesueur , Guillaume Vares , Diana Savu , Tetsuo Nakajima , Yannick Saintigny

    … In addition, biomarkers of DNA damage responses were analyzed in the SW1353 cell line. … Persistent unrepaired DNA damage was also higher following C-ions irradiation. …

    Technology in Cancer Research & Treatment (18), 1-11, 2019-09-08


  • Nucleolar protein nucleolin functions in replication stress–induced DNA damage responses

    Kawamura Kasumi , Qi Fei , Meng Qingmei , Hayashi Ikue , Kobayashi Junya

    … The nucleolus contains multiple copies of ribosomal (r)DNA, which indicate sites of frequent replication stress and suggest the existence of a mechanism to prevent replication stress–related rDNA instability and the possibility that such a mechanism contributes to the whole genomic stability against replication stress. …

    Journal of Radiation Research 60(3), 281-288, 2019-05


  • Vascular endothelial cells, inflammation and HMGB1  [in Japanese]

    Nishibori Masahiro

    … <p>High mobility group box-1 (HMGB1) was originally identified as an intranuclear chromatin DNA binding protein. … Intravenous injection of anti-HMGB1 mAb protected BBB and ameliorated brain damage by reducing inflammatory responses including cytokine expression. … In the epileptic animal model, we found that therapeutic anti-HMGB1 mAb administered systemically accumulated on vascular endothelial cells while protecting brain inflammation and neural damage. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 2-JS3-2, 2019


  • Participation of UV-regulated Genes in the Response to Helix-distorting DNA Damage in the Thermoacidophilic Crenarchaeon <i>Sulfolobus acidocaldarius</i>

    Suzuki Shoji , Kurosawa Norio

    … To date, the transcriptional responses of genes involved in the initiation of DNA replication, transcriptional regulation, protein phosphorylation, and hypothetical function have been observed in <i>Sulfolobales</i> … The knockout strains exhibited significant sensitivities to UV-B irradiation, indicating that the five UV-regulated genes play an important role in responses to UV irradiation <i>in vivo</i>. …

    Microbes and Environments 34(4), 363-373, 2019


  • Quantification of Ultraviolet-B Stress-Induced Changes in Nuclear and Cellular Sizes of Tobacco Bright Yellow-2 Cells

    Takahashi Shinya , Kojo Kei H. , Hasezawa Seiichiro

    … <p>In higher plants, ultraviolet (UV)-B irradiation induces DNA damage and inhibits DNA replication, and this subsequently inhibits plant growth. … However, the specific responses of plant cells to UV-B stress remain largely unknown. …

    CYTOLOGIA 84(4), 347-351, 2019


  • Reactive Oxygen Species (ROS) Signaling: Regulatory Mechanisms and Pathophysiological Roles  [in Japanese]

    Hirata Yusuke

    … <p>Reactive oxygen species (ROS) are highly reactive molecules generated during mitochondrial respiration and under various environmental stresses, and cause damage to DNA, proteins, and lipids, which is linked to a wide variety of pathologies. … According to the extent and duration of ROS generation, ROS-mediated oxidation-reduction (redox) signaling (ROS signaling) is tightly regulated by various molecules and post-translational modifications (PTMs), for inducing appropriate cellular responses. …

    YAKUGAKU ZASSHI 139(10), 1235-1241, 2019

    J-STAGE  Ichushi Web 

  • Cell-cycle dependent response to DNA damage in mouse zygotes  [in Japanese]

    WANG Yuan , AOKI Fugaku

    … <p>Mammalian zygotes were found hypersensitive to radiation exposure, which may be ascribed to unusual DNA damage responses. … Zygotes were irradiated in G1 and G2 phases and their cellular responses were assessed by examining the entry into mitosis, micronucleus formation and development to the blastocyst stage. …

    The Journal of Reproduction and Development Supplement 112(0), P-60-P-60, 2019


  • The role of tumor suppressor p53 in metabolism and energy regulation, and its implication in cancer and lifestyle-related diseases

    Hashimoto Naoko , Nagano Hidekazu , Tanaka Tomoaki

    … When the cells receives stimuli such as DNA damage, oncogene activation, oxidative stress or undernutrition, p53 gives rise to a number of cellular responses, including cell cycle arrest, apoptosis, cellular senescence and metabolic adaptation. …

    Endocrine Journal 66(6), 485-496, 2019


  • Polyhexamethylene guanidine phosphate-induced ROS-mediated DNA damage caused cell cycle arrest and apoptosis in lung epithelial cells

    Park Ji Soo , Park Yong Joo , Kim Ha Ryong , Chung Kyu Hyuck

    … Current evidence indicates that pulmonary fibrosis is initiated as a result of epithelial damage, which can lead to an inflammatory response and fibrotic cell infiltration; … In this study, the toxic response of PHMG-p on human lung epithelial cells was evaluated, and its mechanisms associated with reactive oxygen species (ROS), DNA damage, and its relationship with p53 activation were investigated. …

    The Journal of Toxicological Sciences 44(6), 415-424, 2019

    J-STAGE  Ichushi Web 

  • Autophagy in the Heart

    Yamaguchi Osamu

    … Hemodynamic stress and aging induce mitochondrial damage, leading to increased oxidative stress and decreased ATP production. … Complete digestion of mitochondrial DNA through mitophagy is important to avoid inflammatory responses that can induce heart failure. …

    Circulation Journal 83(4), 697-704, 2019


  • Inflammation Due to Voriconazole-induced Photosensitivity Enhanced Skin Phototumorigenesis in Xpa-knockout Mice

    Kunisada Makoto , Yamano Nozomi , Hosaka Chieko , Takemori Chihiro , Nishigori Chikako

    … To assess the effects of photosensitizing drugs voriconazole and hydrochlorothiazide (HCTZ) on the enhancement of UV-induced inflammatory responses and UV-induced tumorigenesis, we utilized Xpa-knockout mice, which is DNA repair-deficient and more susceptible to UV-induced inflammation and tumor development than wild-type mice. …

    Photochemistry and Photobiology 94(5), 1077-1081, 2018-09


  • Potential relationship between the biological effects of low-dose irradiation and mitochondrial ROS production

    Kawamura Kasumi , Qi Fei , Kobayashi Junya

    … Exposure to ionizing radiation (IR) induces various types of DNA damage, of which DNA double-strand breaks are the most severe, leading to genomic instability, tumorigenesis, and cell death. … Hence, cells have developed DNA damage responses and repair mechanisms. …

    Journal of Radiation Research 59(suppl_2), ii91-ii97, 2018-04


  • A Chemical Modulator of p53 Transactivation that Acts as a Radioprotective Agonist

    Morita Akinori , Takahashi Ippei , Sasatani Megumi , Aoki Shin , Wang Bing , Ariyasu Shinya , Tanaka Kaoru , Yamaguchi Tetsuji , Sawa Akiko , Nishi Yurie , Teraoka Tatsuro , Ujita Shohei , Kawate Yosuke , Yanagawa Chihiro , Tanimoto Keiji , Enomoto Atsushi , Nenoi Mitsuru , Kamiya Kenji , Nagata Yasushi , Hosoi Yoshio , Inaba Toshiya

    … Inhibiting p53-dependent apoptosis by inhibitors of p53 is an effective strategy for preventing radiation-induced damage in hematopoietic lineages, while p53 and p21 also play radioprotective roles in the gastrointestinal epithelium. … We found that 5-chloro-8-quinolinol (5CHQ) has a unique p53-modulating activity that shifts its transactivation from proapoptotic to protective responses including enhancing p21 induction and suppressing PUMA induction. …

    Molecular Cancer Therapeutics 17(2), 432-442, 2018-02


  • Effect of antimicrobial cathelicidin peptide LL-37 on septic mouse model via the modulation host cell death  [in Japanese]

    Nagaoka Isao , Hosoda Hiroshi , Nakamura Kaho , Hu Zhongshuang , Murakami Taisuke , Suzuki Kaori , Tamura Hiroshi

    … The results indicated that the intravenous administration of LL-37 suppressed the increase of damage-associated molecular patterns, DAMPs (such as histone-DNA complex and HMGB1) as well as IL-1β, TNF-α and soluble triggering receptor expressed on myeloid cells (TREM-1) in plasma and peritoneal fluids. … Notably, LL-37 increased the level of NETs (myeloperoxidase-DNA complex) in plasma and peritoneal fluids. …

    Endotoxin and Innate Immunity 21(0), 56-61, 2018

    J-STAGE  Ichushi Web 

  • Role of oxidative stress in the chemical structure-related genotoxicity of nitrofurantoin in <i>Nrf2</i>-deficient <i>gpt</i> delta mice

    Tsuchiya Takuma , Kijima Aki , Ishii Yuji , Takasu Shinji , Yokoo Yuh , Nishikawa Akiyoshi , Yanai Tokuma , Umemura Takashi

    … This is supported by our recent results indicating that the structure of the nitrofuran plays a key role in NFT-induced genotoxicity, and oxidative DNA damage is involved in renal carcinogenesis. … Nuclear factor erythroid 2-related factor 2 (NRF2) regulates cellular responses to oxidative stress. …

    Journal of Toxicologic Pathology 31(3), 169-178, 2018

    J-STAGE  Ichushi Web 

  • NBS1 is regulated by two kind of mechanisms: ATM-dependent complex formation with MRE11 and RAD50, and cell cycle–dependent degradation of protein

    Zhou Hui , Kawamura Kasumi , Yanagihara Hiromi , Kobayashi Junya , Zhang-Akiyama Qiu-Mei

    … Nijmegen breakage syndrome (NBS), a condition similar to Ataxia-Telangiectasia (A-T), is a radiation-hypersensitive genetic disorder showing chromosomal instability, radio-resistant DNA synthesis, immunodeficiency, and predisposition to malignances. … The MRN complex is necessary for the DNA damage–induced activation of ATM. …

    Journal of Radiation Research 58(4), 487-494, 2017-07

    IR  Ichushi Web 

  • DNA repair, DNA damage responses, mutations, and environmental adaptation : the important findings in the recent studies of eukaryotic microbes  [in Japanese]

    原島 小夜子 , 山本 幸希 , 八木 孝司

    放射線生物研究 = Radiation biology research communications : 放射線生物研究会機関誌 52(1), 48-67, 2017-03

    Ichushi Web 

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