Search Results 1-20 of 1713

  • A Vaspin-HSPA1L complex protects proximal tubular cells from organelle stress in diabetic kidney disease

    Nakatsuka Atsuko , Yamaguchi Satoshi , Eguchi Jun , Kakuta Shigeru , Iwakura Yoichiro , Sugiyama Hitoshi , Wada Jun

    … Proximal tubular cells (PTCs) are crucial for maintaining renal homeostasis, and tubular injuries contribute to progression of diabetic kidney disease (DKD). … Vaspin-/- obese mice showed enlarged and leaky lysosomes in PTCs associated with increased apoptosis, and these abnormalities were also observed in the patients with DKD. …

    Communications Biology 4(1), 373, 2021-03-19


  • Immunohistochemical study for the expression of leukocyte adhesion molecules, and FGF23 and ACE2 in P. gingivalis LPS-induced diabetic nephropathy

    Kajiwara Koichiro , Sawa Yoshihiko , Fujita Takahiro , Tamaoki Sachio

    … Objective</br>The present study aims to examine the expression of leukocyte adhesion molecules and renal metabolic factors in diabetic mouse kidneys with periodontal pathogen Pg-LPS-induced nephropathy.</br>Background</br>We recently reported that the glomerular endothelium expresses toll-like receptor (TLR)2 and TLR4 in diabetic environments and TLR2/4 ligand Porphyromonas (P.) gingivalis lipopolysaccharides (Pg-LPS) induce nephropathy in diabetic mice. …

    BMC Nephrology 22(1), 3, 2021-01-06


  • Pemafibrate, A Novel Selective Peroxisome Proliferator-Activated Receptor α Modulator, Reduces Plasma Eicosanoid Levels and Ameliorates Endothelial Dysfunction in Diabetic Mice

    Suto Kumiko , Sata Masataka , Fukuda Daiju , Shinohara Masakazu , Ganbaatar Byambasuren , Yagi Shusuke , Kusunose Kenya , Yamada Hirotsugu , Soeki Takeshi , Hirata Ken-ichi

    … Here we examined the effects of pemafibrate, a selective peroxisome proliferator-activated receptor α modulator, on plasma eicosanoid levels and endothelial function in diabetic mice.<b> … </b></p><p><b>Methods: </b>Diabetes was induced in 7-week-old male wild-type mice by a single injection of streptozotocin (150 mg/kg). … Untreated mice received vehicle. …

    Journal of Atherosclerosis and Thrombosis, 2021


  • Arginase 1 is involved in lacrimal hyposecretion in male NOD mice.  [in Japanese]

    Ohno Yuta , Satoh Keitaro , Shitara Akiko , Nagase Haruna , Kashimata Masanori

    … To elucidate such a factor, we conducted transcriptome analysis of the lacrimal glands in male non-obese diabetic (NOD) mice as a SS model. … The result revealed that only four genes, including arginase 1, were downregulated in the lacrimal glands of male NOD mice after onset of lacrimal hyposecretion and dacryoadenitis. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 3-Y-G3-1, 2021


  • Implicated in spinal cholecystokinin-8 and hemokinin-1 in type 1 diabetes allodynia in mice  [in Japanese]

    Hayashi Takafumi , Watanabe Chizuko , Kanno Syu-ichi , Yoshizumi Masaru , Agatsuma Yasuyuki , Hara Akiyoshi , Sakurada Shinobu

    … The sulfated octapeptide cholecystokinin (CCK-8) is present in the dorsal spinal cord in mice, which is involved in modulating afferent nociceptive information. … Our study was designed to determine a potential involvement of spinal CCK-8 and hemokinin-1 in mediating streptozotocin (STZ)-induced type 1 diabetes allodynia in mice. … The level of CCK receptors mRNA in the dorsal root ganglia and spinal dorsal hone of the STZ-induced type 1 diabetes mice was measured by real time PCR. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 3-P1-05, 2021


  • Transcription factor ATF4 maintains pancreatic β-cell identity during ER stress  [in Japanese]

    Kitakaze Keisuke , Oyadomari Miho , Zhang Jun , Hamada Yoshimasa , Takenouchi Yasuhiro , Tsuboi Kazuhito , Fujitani Yoshio , Okamoto Yasuo , Oyadomari Seiichi

    … First, we investigated the therapeutic effect of ISR enhancer Sephin1 on an animal model of diabetes using Akita mice. … Sephin1 improved glucose metabolism and increased ATF4 expression in Akita mice. … Next, we established β-cell-specific ATF4 knockout (β<i>Atf4</i>-KO) mice, which were then crossed with Akita mice. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 2-Y-E2-1, 2021


  • Evaluation of cognitive function in diabetic germ-free mice  [in Japanese]

    Kobayashi Hiroyuki , Shimato Nozomu , Nonomura Hiroko , Nishiyama Ryusei , Mizuki Takuji , Hirasawa Yasushi , Murasawa Hiroyasu , Pawlak Akiko , Katayama Kazutaka , Kishigai Daisuke , Shimato Saki , Sugiyama Miki , Okuyama Masae , Imaizumi Takahito

    … It has been reported that the cognitive function is impaired in the streptozotocin (STZ)-induced diabetic mouse model. … One of the reasons is that germ-free mice, which have no intestinal flora, need to be housed in a germ-free environment. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 2-P1-12, 2021


  • Generation of novel hypertension-diabetic nephropathy mice model and ameliorative effect of PDE 4 and 5 inhibitors.  [in Japanese]

    Nio Yasunori

    … <p>Diabetic nephropathy (DN) is a leading cause of end-stage renal disease (ESRD). …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 1-Y-E1-3, 2021


  • Involvement of amygdalar NPY and glutamatergic functions in impaired social behavior in diabetic mice  [in Japanese]

    Yonemochi Naomi , Ueda Daiki , Kamata Tomohiro , Kamei Junzo , Ikeda Hiroko

    … In the present study, we investigated the role of neuropeptide Y (NPY) and glutamatergic functions in impairment of social interaction in streptozotocin (STZ)-induced diabetic mice. … In social interaction test, interaction time with the stranger mouse was decreased in STZ-induced diabetic mice. … NPY mRNA level in the hypothalamus was increased in STZ-induced diabetic mice. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 94(0), 1-Y-F3-1, 2021


  • Glucosyl Hesperidin Has an Anti-diabetic Effect in High-Fat Diet-Induced Obese Mice

    Yoshida Hiroki , Tsuhako Rika , Sugita Chihiro , Kurokawa Masahiko

    … In the present study, we evaluated the effects of long- and short-term intake of GH on hyperglycemia and macrophage infiltration into the adipose tissue of high-fat diet (HFD)-fed mice. … Long-term (11-week) consumption of GH tended to reduce body weight and the fasting blood glucose concentration of the HFD-fed mice, and ameliorated glucose intolerance and insulin resistance, according to glucose and insulin tolerance tests. …

    Biological and Pharmaceutical Bulletin 44(3), 422-430, 2021


  • Triptolide reduces salivary gland damage in a non-obese diabetic mice model of Sjögren's syndrome via JAK/STAT and NF-κB signaling pathways

    Guo Yunke , Ji Wei , Lu Yueyang , Wang Yue

    … In this paper, we studied the effects of triptolide on non-obese diabetes mice model of SS. …

    Journal of Clinical Biochemistry and Nutrition 68(2), 131-138, 2021


  • Administration of metrnl delays the onset of diabetes in non-obese diabetic mice

    Yao Zhina , Lin Peng , Wang Chuan , Wang Kexin , Sun Yu

    … In this experiment, we asked whether intravenous administration of metrnl could delay the onset of diabetes in non-obese diabetic (NOD) mice. … 4-week-old NOD mice were injected intravenously with metrnl. … The results showed that intravenous administration of metrnl delayed the onset of diabetes in NOD mice. …

    Endocrine Journal 68(2), 179-188, 2021


  • Preventive and Therapeutic Efficacy of ONO-4641, a Selective Agonist for Sphingosine 1-Phosphate Receptor 1 and 5, in Preclinical Models of Type 1 Diabetes Mellitus

    Shioya Hiroki , Inagaki Yuichi , Hiraizumi Kenji , Hoshino Tomohiro , Kurata Haruto , Habashita Hiromu , Sato Kazutoyo , Nakade Shinji

    … ONO-4641 was tested in non-obese diabetic (NOD) mice, an animal model of spontaneous type 1 diabetes mellitus, an autoimmune disease with unmet medical needs. … ONO-4641 at a dose of 0.1 mg/kg prevented the onset of diabetes mellitus in NOD mice. … Furthermore, ONO-4641 at doses of 0.03 and 0.1 mg/kg decreased diabetic prevalence in NOD mice after the onset of diabetes mellitus in a dose-dependent manner. …

    Biological and Pharmaceutical Bulletin 44(2), 188-196, 2021


  • The Functions of SGLT2 and the Recent Advances in the Studies of SGLT2 Inhibitors  [in Japanese]

    Nakatsu Yusuke , Asano Tomoichiro

    … Importantly, human SGLT2 deficiency or SGLT2 knockout mice show no remarkable phenotypes except renal glycosuria, supporting that SGLT2 inhibitors could be relatively safe. … In addition, recent studies reveal that treatment with SGLT2 inhibitors improves a variety of metabolic syndromes, such as nonalcoholic steatosis, atherosclerosis and diabetic nephropathy. …

    MEMBRANE 46(1), 38-43, 2021


  • Application of Partial Hydrogenation for the Generation of Minor Tocochromanol Homologs and Functional Evaluation of Hydrogenated Tocotrienol-rich Vitamin E Oil in Diabetic Obese Mice

    Beppu Fumiaki , Sakuma Aimi , Kasatani Satoshi , Aoki Yoshinori , Gotoh Naohiro

    … To investigate the beneficial effects of the hydrogenated product, we fed diabetic obese KK-<i>A</i> … mice with a hydrogenated T3 mixture (HT3). …

    Journal of Oleo Science 70(1), 103-112, 2021


  • Comprehensive analysis of gene expression of isolated pancreatic islets during pretransplant culture

    Haga Junichiro , Sato Naoya , Anazawa Takayuki , Kimura Takashi , Kenjo Akira , Gotoh Mitsukazu , Marubashi Shigeru

    … Methods: The survival of islets from Wistar rats, transplanted to diabetic C57BL/B6 mice, was compared between fresh islets and cultured islets. …

    Fukushima Journal of Medical Science 67(1), 17-26, 2021


  • Long-term preoperative glycemic control restored the perioperative neutrophilic phagocytosis activity in diabetic mice

    Fujimoto Daichi , Nomura Yuki , Egi Moritoki , Obata Norihiko , Mizobuchi Satoshi

    … Therefore, we investigated the effects of preoperative long-term insulin therapy and short-term insulin therapy on perioperative neutrophil functions in diabetic mice with chronic hyperglycemia. … Methods Five-week-old male C57BL/6 J mice were divided into four groups (No insulin (Diabetes Mellitus: DM), Short-term insulin (DM), Long-term insulin (DM), and Non-diabetic groups). …

    BMC Endocrine Disorders 20(1), 146, 2020-09-29


  • Loss of β-cell identity and diabetic phenotype in mice caused by disruption of CNOT3-dependent mRNA deadenylation

    Dina Mostafa , Akiko Yanagiya , Eleni Georgiadou , Yibo Wu , Theodoros Stylianides , Guy A. Rutter , Toru Suzuki , Tadashi Yamamoto

    … Here, we show that CNOT3, a CCR4-NOT deadenylase complex subunit, is dysregulated in islets in diabetic db/db mice, and that it is essential for murine β cell maturation and identity. … Mice with β cell-specific Cnot3 deletion (Cnot3βKO) exhibit impaired glucose tolerance, decreased β cell mass, and they gradually develop diabetes. …

    Communications Biology 3(1), 476, 2020-08-28


  • Human cultured epidermis accelerates wound healing regardless of its viability in a diabetic mouse model

    Sakamoto Michiharu , Ogino Shuichi , Shimizu Yoshihiro , Inoie Masukazu , Lee Sunghee , Yamanaka Hiroki , Tsuge Itaru , Saito Susumu , Morimoto Naoki

    … The four CEs were applied on the full-thickness skin defect of diabetic mice (BKS.Cg-Dock 7m +/+ Leprdb/Jcl), and the wound area and neoepithelium length were evaluated on days 4, 7, and 14. …

    PLOS ONE 15(8), 2020-08-21


  • Hydrocolloid dressing improves wound healing by increasing M2 macrophage polarization in mice with diabetes

    Takeuchi Tamaki , Ito Morihiro , Yamaguchi Seiji , Watanabe Saki , Honda Masashi , Imahashi Takuya , Yamada Tsuyoshi , Kokubo Tadashi

    … The present study sought to clarify the effects of wound dressing material for moist healing of diabetic wounds, in terms of the dynamics of angiogenic factors and macrophages, using a mouse model of naturally occurring diabetes. … Wounds with full-thickness skin defects were inflicted on the backs of mice and covered with dressing materials of hydrogel or gauze (control), which were retained for 3, 5, 7, 10, or 14 days following wound generation. …

    Nagoya Journal of Medical Science 82(3), 487-498, 2020-08

    IR  DOI 

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