Search Results 1-20 of 952

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The Chemokine CXCL14-like Immunoreactivity Co-exists with Somatostatin, but not NPY in the Rat Dorsal Horn and Has Intimate Association with GABAergic Neurons in the Lateral Spinal Nucleus

Yamamoto Toshiharu , Sasaguri Kenichi , Mizumoto Natsuki , Suzuki Hirohumi

… CXCL14 immunoreactive fibers and puncta were observed in lamina II, which modulates somatosensation including nociception, and the lateral spinal nucleus of the spinal dorsal horn at cervical, thoracic, and lumber spinal cord levels. …

ACTA HISTOCHEMICA ET CYTOCHEMICA 53(5), 121-129, 2020

J-STAGE
2

Transporters LAT-1 and MRP-2 as a key factor of methylmercury cytotoxicity specific in rat dorsal root ganglion cells in culture [in Japanese]

AOKI Kazuhiro , YOSHIDA Eiko , SHINODA Yo , FUJIWARA Yasuyuki , KAJI Toshiyuki

… In this study, we found that the dorsal root ganglion (DRG) were much more sensitive to than anterior horn cells and Schwann cells. …

Annual Meeting of the Japanese Society of Toxicology 47.1(0), P-13S, 2020

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3

MRI evaluation of myelopathic pain after spinal cord injury or spinal cord tumor surgery [in Japanese]

Tsuji Osahiko , Matsubayashi Kohei , Horiuchi Yosuke , Komaki Yuji , Hata Junichi , Konomi Tsunehiko , Fujiyoshi Kanehiro , Kosugi Shizuko , Nakamura Masaya

… Regarding the mechanism, various theories such as functional changes in the brain, disorders within the spinal dorsal horn and/or spinothalamic tract have been proposed. …

PAIN RESEARCH 35(1), 34-44, 2020

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4

Right–side predominance of the central amygdala activation in trigeminal inflammatory pain model [in Japanese]

Takahashi Yukari , Miyazawa Yuta , Arimura Daigo , Sugimura Yae K , Kato Fusao

… The central amygdala (CeA), especially the capsular part (CeC), receives nociceptive information from the superficial layer of the spinal dorsal horn and the caudal subnucleus of the trigeminal nucleus via the lateral parabrachial nucleus (LPB). …

PAIN RESEARCH 35(1), 10-16, 2020

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5

Ethenzamide Exerts Analgesic Effect at the Spinal Cord via Multiple Mechanisms of Action Including the 5HT2B Receptor Blockade in the Rat Formalin Test

Nikaido Takato , Maruyama Chikashi , Hamanaka Minako , Yamaguchi Chiharu , Fujimaru Yukiko , Nakanishi Yutaka , Asano Toshiki , Takaoka Akiko

… In the rat formalin test, oral administration of ETZ significantly reduced the nociceptive responses of the second phase and also the number of c-Fos-expressing cells in the spinal dorsal horn, in a dose-dependent manner. …

Biological and Pharmaceutical Bulletin 43(5), 839-847, 2020

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6

Anatomical aspects of corticotrigeminal projections to the medullary dorsal horn

Kobayashi Masayuki , Nakaya Yuka

… Corticofugal projections to neurons in the medullary dorsal horn, i.e., the trigeminal spinal subnucleus caudalis (Sp5C), are thought to play a critical role in regulating nociceptive information processing in the trigeminal nervous system. …

Journal of Oral Science 62(2), 144-146, 2020

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7

A new mechanism for somatosensory information processing by descending noradrenergic pathway via spinal dorsal horn astrocytes [in Japanese]

Yoshihara Kohei , Kohro Yuta , Matsuda Tsuyoshi , Tozaki-Saitoh Hidetoshi , Inoue Kazuhide , Tsuda Makoto

… The spinal dorsal horn (SDH) receives somatosensory inputs from the periphery and descending pain modulatory inputs from several brain regions including the locus coeruleus (LC). …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-YIA-31, 2020

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8

Neuropathic and inflammatory pain increases glutamatergic excitatory postsynaptic current on adult rat spinal dorsal horn neurons. [in Japanese]

Uta Daisuke , Andoh Tsugunobu , Kume Toshiaki , Yoshimura Megumu , Koga Kohei

Background; Chronic pain is characterized by abnormal sensitivity to normal stimulation coupled with a feeling of unpleasantness. This condition afflicts people worldwide and severely impacts …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-P-152, 2020

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9

Discovery of a new MrgprA3 agonist and evaluation of its effect for itch sensation [in Japanese]

Tomohiro Yamashita , Ito Mayu , Kawanami Yuka , Keisuke Koga , Kanehisa Kensho , Fujii Shiori , Shiratori-Hayashi Miho , Tsuda Makoto

… The G-protein-coupled receptor MrgprA3 (MAS-related GPR family member A3) is expressed specifically in a subpopulation of dorsal root ganglion (DRG) sensory neurons. … We further found that intradermal papaverine caused phosphorylation of extracellular signal-regulated kinases (ERK) in the superficial dorsal horn. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-P-019, 2020

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10

Activation of microglia cells in spinal dorsal horn in rats at an early stage of inactivation [in Japanese]

肥田朋子 , 中川達貴

慢性痛の発症には種々の原因が考えられているが，その一つとしてミクログリアやアストロサイトなどのグリア細胞を含む中枢神経系の活性化が関与していることが明らかにされてきている。我々は，慢性痛モデルの一つとしてラット後肢をギプス固定することで不活動状態を作製し，これまでに末梢組織の変化について検討を行ってきた。しかし，本モデルにおける中枢神経系の変化についてはまだ調べられていない。そこで，ラット不活動モ …

名古屋学院大学論集. 医学・健康科学・スポーツ科学篇 = Journal of Nagoya Gakuin University 8(2), 25-31, 2020

IR DOI Ichushi Web
11

Mechanisms of pain reception and modification in primary afferent and dorsal horn of spinal cord [in Japanese]

山中博樹 , 野口光一

日本臨床 = Japanese journal of clinical medicine 77(12), 1890-1897, 2019-12

Ichushi Web
12

Stimulation of nuclear receptor REV-ERBs suppresses production of pronociceptive molecules in cultured spinal astrocytes and ameliorates mechanical hypersensitivity of inflammatory and neuropathic pain of mice

Morioka Norimitsu , Kodama Keitaro , Tomori Mizuki , Yoshikawa Kanade , Saeki Munenori , Nakamura Yoki , Zhang Fang Fang , Hisaoka-Nakashima Kazue , Nakata Yoshihiro

… Spinal dorsal horn astrocytes contribute to the maintenance of chronic pain. … Intrathecal LPS treatment in male mice induces hind paw mechanical hypersensitivity, and upregulation of IL-1β mRNA, IL-6 mRNA and glial fibrillary acidic protein (GFAP) expression in spinal dorsal horn. …

Brain, Behavior, and Immunity (78), 116-130, 2019-05

IR
13

NMDA NR2B Subunit Antagonist May Attenuate Mechanical Allodynia by Increasing the Release of Enkephalin in the Spinal Dorsal Horn

Shunsaku Kobayashi , Shiho Tanaka , Eiko Kato

… Background：Neurons containing enkephalin（ENK）are distributed at high concentrations in the superficial dorsal horn（SDH）of the spinal cord, where they play an important role in the modulation of nociceptive information. …

Dokkyo Journal of Medical Sciences 46(1), 1-7, 2019-03-25

IR Ichushi Web
14

Effects of naftopidil on inhibitory transmission in substantia gelatinosa neurons of the adult rat spinal dorsal horn. [in Japanese]

Uta Daisuke , Hattori Tsuyoshi , Andoh Tsugunobu , Kume Toshiaki , Yoshimura Megumu

… studies in which naftopidil was applied intrathecally abolished rhythmic bladder contraction, suggesting that naftopidil might inhibit a voiding reflex through interaction with spinal dorsal horn neurons. … In this study, we aimed to clarify the mechanism of action of naftopidil on spinal dorsal horn neurons by using patch-clamp recording of rat spinal cord slices. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 3-P-044, 2019

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15

Enhancement of excitatory synaptic inputs to GRPR+ dorsal horn neurons in a mouse model of atopic dermatitis [in Japanese]

Kanehisa Kensho , Koga Keisuke , Fujii Shiori , Shiratori-Hayashi Miho , Tsuda Makoto

… Recent studies have identified an interneuron subpopulation expressing gastrin-releasing peptide receptors (GRPR) in the spinal dorsal horn (SDH) that is crucial for itch transmission. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 3-P-043, 2019

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16

Involvement of astrocyte-neuron-lactate shuttle in neuropathic pain [in Japanese]

Ohsawa Masahiro , Miyamoto Keisuke , Ishikura Kei-ichiro , Ueda Rina , Uta Daisuke , Kume Kazuhiko

… We revealed that the selective activation of spinal dorsal horn astrocytes causes mechanical hyperalgesia through the excessive L-lactate supply to neurons via monocarboxylate transporters (MCTs). … In addition, application of L-lactate enhanced the excitatory neurotransmission evoked by mechanical stimulation in the dorsal horn of spinal cord. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 2-S20-2, 2019

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17

Specific contribution of monocarboxylate transpoter-dependent energetic supply in the brain network underlying nociception-emotion link [in Japanese]

Kato Fusao , Nagase Masashi , Eguchi Ryota

… The lateral parabrachial nucleus (LPB) is the site where the nociceptive information arising from the spinal dorsal horn and trigeminal nerve converges and functions as a relay of these signals to the pain-associated networks. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 2-S20-3, 2019

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18

Contribution of GRP-GRPR system in the spinal dorsal horn to pathological itch [in Japanese]

Kiguchi Norikazu , Uta Daisuke , Uchida Hitoshi , Saika Fumihiro , Kishioka Shiroh

… neurons in the spinal dorsal horn (SDH) are itch-responsive, but their regulatory mechanisms are not yet clarified. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 2-O-41, 2019

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19

Inhibitory effect of etidronate on partial sciatic nerve ligation-induced hyperalgesia in mice [in Japanese]

Nemoto Wataru , Yamagata Ryota , Nakagawasai Osamu , Hung Wan-Yi , Shima Kazuhiro , Endo Yasuo , Tan-No Koichi

… Indeed, we detected several members of the SLC17 family in the mouse dorsal lumbar spinal cord. … In mice subjected to PSNL, SLC17A9 was present in neurons and microglia of the superficial dorsal horn. … Collectively, our results suggest that Eti produces its anti-hyperalgesic effects by inhibiting SLC17A9-dependent exocytotic ATP release from the dorsal horn in mice subjected to PSNL. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 2-P-035, 2019

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20

Spinal dorsal horn astrogliosis facilitates itch transmission in a mouse model of contact dermatitis. [in Japanese]

Koga Keisuke , Yamagata Ryo , Shiratori-Hayashi Miho , Tsuda Makoto

… We have previously shown that spinal dorsal horn (SDH) astrocytes become activated in mouse models of chronic itch and that astrocyte-derived lipocalin-2 (LCN2) is crucial for maintaining chronic itching. …

Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 1-YIA-05, 2019

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