Search Results 1-20 of 44

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  • Proteinase-activated receptor 1 (PAR<sub>1</sub>)-mediated cellular effects of coagulation factor XI in vascular smooth muscle cells  [in Japanese]

    Hirano Katsuya , Liu Wenhua , Hiashimoto Takeshi , Yamashita Tetsuo

    … influx in the fura-2-loaded A7r5 cells, rat embryonic aorta smooth muscle cells. … signal in embryonic fibroblasts derived from PAR<sub>1</sub>-knockout mice. … FXIa accelerated cell migration of A7r5 cells in a wound healing assay. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 2-O-30, 2019

    J-STAGE 

  • Septin-dependent remodeling of cortical microtubule drives cell reshaping during epithelial wound healing

    Shindo Asako , Audrey Anastasia , Takagishi Maki , Takahashi Masahide , Wallingford John B. , Kinoshita Makoto

    ファイル公開:2019-06-28

    Journal of Cell Science 131(12), jcs212647, 2018-11

    IR 

  • Wnt inhibition promotes vascular specification of embryonic cardiac progenitors

    Reichman David E. , Park Laura , Man Limor , Redmond David , Chao Kenny , Harvey Richard P. , Taketo Makoto M. , Rosenwaks Zev , James Daylon

    … Several studies have demonstrated a multiphasic role for Wnt signaling during embryonic cardiogenesis and developed protocols that enrich for cardiac derivatives during in vitro differentiation of human pluripotent stem cells (hPSCs). … Wnt5a, which has been shown to exert an inhibitory influence on Wnt signaling during cardiac development, was dynamically expressed during vascular commitment of hPSC-derived CPCs, and ectopic Wnt5a promoted vascular specification of hPSC-derived and mouse embryonic CPCs. …

    Development 145(1), 2018-01

    IR 

  • Growth inhibitory effect of beta-eudesmol on cholangiocarcinoma cells is associated with suppression of heme oxygenase-1 production and STAT3 phosphorylation

    NA-BANGCHANG KESARA , Mathema Vivek Bhakta , Chailaroenkul Wanna

    … Human cholangiocarcinoma (CL-6) and normal human embryonic fibroblast (OUMS) cells were used in this study. … Cell migration was studied using wound healing assay. … The compound pretreatment significantly decreased wound healing ability of CL-6 cells in the presence or absence of interlukin-6 stimulation. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO3-7-6, 2018

    J-STAGE 

  • Using single-cell tracing technique to elucidate SLK-ROCK interaction in endothelial and cancer cell migration

    Fan Cheng-Yu , Chia-Jung Tsai , Hsuan-Chao Lin , Ling-Yea Yu , Yung-Jen Hsiao , Ching-Cheng Chang , Feng-Chiao Tsai

    … <p>Cell migration is a fundamental process in embryonic development, tissue repair and cancer metastasis. … screen using shRNAs combined with small molecule inhibitors and scratch wound healing assays in endothelial cells, to identify potential synergistic or antagonistic effects among signaling molecules during cell migration. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO1-6-12, 2018

    J-STAGE 

  • Untangling STK40-MAPK interactions in endothelial and cancer cell migration

    Yu Ling-Yea , Tseng Ting-Jen , Xiao Yung-Jen , Tsai Chia-Jung , Lin Hsuan-Chao , Tsai Feng-Chiao

    … <p>Cell migration is important for embryonic development, tissue regeneration and cancer metastasis. … We thus aim at elucidating the molecular mechanisms of STK40 and MAPK signalling during cell migration.</p><p>We started our exploration by tracing the migration of individual STK40-manipulated cells in monolayers or in scratch-wound healing assays. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), OR12-1, 2018

    J-STAGE 

  • Investigation of cell migration mechanism by using microchannel device  [in Japanese]

    MA Ming , MAZALAN Mazlee , OHASHI Toshiro

    … <p>Cell migration of mechanically coupled cell layers is essential for a variety of biological and pathological processes such as embryonic development, wound healing, inflammation and tumor metastasis. …

    The Proceedings of the Symposium on Micro-Nano Science and Technology 2018.9(0), 01pm1PN157, 2018

    J-STAGE 

  • Use of animal models for the imaging and quantification of angiogenesis

    Liu Min , Xie Songbo , Zhou Jun

    … it is necessary for normal physiological processes, such as embryonic development and wound healing. …

    Experimental Animals 67(1), 1-6, 2018

    J-STAGE  Ichushi Web 

  • (2) Neovascularization  [in Japanese]

    UTSUGISAWA Taiju , KANNO Hitoshi

    … <p>Neovascularization consists of three processes, namely angiogenesis, arteriogenesis, and vasculogenesis, which are involved in the development and progression of diseases such as cancer growth/metastasis, proliferative retinopathy, and atherosclerosis, and in the process of normal physiological phenomena such as embryonic development, wound healing, corpus luteum, and placenta formation process. …

    Journal of Tokyo Women's Medical University 87(1-2), 5-12, 2017

    IR  J-STAGE  Ichushi Web 

  • Hepatocyte specific expression of an oncogenic variant of β-catenin results in cholestatic liver disease

    Lemberger Ursula J. , Fuchs Claudia D. , Karer Matthias , Haas Stefanie , Stojakovic Tatjana , Schöfer Christian , Marschall Hanns-Ulrich , Wrba Fritz , Taketo Makoto M. , Egger Gerda , Trauner Michael , Österreicher Christoph H.

    … [Background] The Wnt/β-catenin signaling pathway plays a crucial role in embryonic development, tissue homeostasis, wound healing and malignant transformation in different organs including the liver. …

    Oncotarget 7(52), 86985-86998, 2016-12-27

    IR 

  • Distribution of Focal Adhesion in Fibrosarcoma Cells by Laser Confocal Microscopy  [in Japanese]

    SUGAWARA Michiko , WATANABE Kentaro , LIU Hao , TAKEI Masahiro

    … Cell movement plays an essential role in embryonic development, wound healing in multicellular organisms and cancer metastatis. …

    Journal of the Japanese Society for Experimental Mechanics 16(2), 154-161, 2016

    J-STAGE 

  • Exercise-induced Capillary Growth in Skeletal Muscle

    SUZUKI Junichi

    … Angiogenesis, the formation of new blood vessels from a preexisting capillary network, is an essential process that improves endurance capability and also plays a critical role in embryonic development, wound healing, and cardiovascular diseases. …

    Advances in exercise and sports physiology 21(1), 1-6, 2015-04

    NDL Digital Collections  Ichushi Web 

  • Mathematical model for collective cell migration regulated by external molecular signal  [in Japanese]

    MURASE Akio , Honda NAOKI , ISHII Shin

    発生過程において、神経や臓器は細胞が集団として移動することで形作られる。したがって、多細胞が協働的に移動するメカニズムを解明することは重要な課題である。本研究では創傷治癒において見られる細胞集団移動に着目し、外部から与えられる分子シグナルがどのように協働的な細胞集団移動に寄与しているのか調べるため、数理モデルを構築した。その結果、傷周辺部位から生成するトラベリングウェーブ状の分子シグナルが効率的な …

    IEICE technical report. Neurocomputing 114(515), 245-248, 2015-03-16

  • Mathematical model for collective cell migration regulated by external molecular signal  [in Japanese]

    MURASE Akio , Honda NAOKI , ISHII Shin

    発生過程において、神経や臓器は細胞が集団として移動することで形作られる。したがって、多細胞が協働的に移動するメカニズムを解明することは重要な課題である。本研究では創傷治癒において見られる細胞集団移動に着目し、外部から与えられる分子シグナルがどのように協働的な細胞集団移動に寄与しているのか調べるため、数理モデルを構築した。その結果、傷周辺部位から生成するトラベリングウェーブ状の分子シグナルが効率的な …

    IEICE technical report. ME and bio cybernetics 114(514), 245-248, 2015-03-16

    Ichushi Web 

  • The Synergistic Effect of Basic Fibroblast Growth Factor and Growth Factors  [in Japanese]

    YAGI Yosuke , KITOH Akihiko , NAKAMIZO Satoshi , KABASHIMA Kenji , MIYACHI Yoshiki

    塩基性線維芽細胞増殖因子(bFGF: basic fibroblast growth factor)は線維芽細胞および血管内皮細胞の増殖を促すことにより,新生血管に富む良性肉芽の形成を促進することが知られている。血管新生については,他の成長因子との併用でさらに効果を発揮する事が報告されている。bFGF と他の成長因子との相乗効果について,過去の報告と我々の研究結果をもとに総括する。(皮膚の科学,増 …

    Hifu no kagaku 13(Suppl.22), 25-27, 2014

    J-STAGE  Ichushi Web 

  • Retraction: Inflammatory Cytokine-induced MMP-3 Regulates Proliferation of Odontoblast-like Cells Derived from Induced Pluripotent Stem Cells  [in Japanese]

    Nobuaki OZEKI , Hideyuki YAMAGUCHI , Taiki HIYAMA , Naoko HASE , Rie KAWAI , Makio MOGI , Kazuhiko NAKATA

    …  目的: これまでにわれわれは, マトリックスメタロプロテアーゼ (Matrix metalloproteinase: MMP) -3がラットの歯髄創傷治癒に関与すること, さらに, 純化したマウス胚性幹細胞 (ES細胞: Embryonic stem cell) 由来象牙芽細胞において, 炎症性サイトカイン誘導MMP-3が象牙芽細胞の増殖を制御することを報告した. …

    The Japanese Journal of Conservative Dentistry 57(4), 358-368, 2014

    J-STAGE  Ichushi Web 

  • 4AAQB inhibits vascular endothelial growth factor-induced angiogenesis in in vitro and in vivo model  [in Japanese]

    CHUNG Ching-Hu

    … Angiogenesis, the formation of new capillaries from preexisting blood vessels, plays an important role in physiologic and pathologic processes, such as the embryonic development, wound healing, tumor growth, metastasis, and various inflammatory disorders. …

    Annual Meeting of the Japanese Society of Toxicology 39.2(0), AP-169, 2012

    J-STAGE 

  • Stirred Suspension Culture Improves Embryoid Body Formation and Cardiogenic Differentiation of Genetically Modified Embryonic Stem Cells

    He Wenjun , Ye Lingling , Li Shichong , Liu Hong , Wang Qiwei , Fu Xiaobing , Han Weidong , Chen Zhaolie

    Embryonic stem cells (ESCs) can propagate unlimitedly <i>in vitro</i> …

    Biological and Pharmaceutical Bulletin 35(3), 308-316, 2012

    J-STAGE  Ichushi Web 

  • Tenascin-C in Cardiovascular Tissue Remodeling:– From Development to Inflammation and Repair –

    Imanaka-Yoshida Kyoko

    … Tenascin-C (TN-C) is a matricellular protein expressed during embryonic development, as well as in wound healing and cancer invasion in various tissues, and may regulate cell behavior and matrix organization during tissue remodeling. … In the cardiovascular system, TN-C is transiently expressed at several important steps of embryonic development, playing important roles in the differentiation of cardiomyocytes and in coronary vasculo/angiogenesis. …

    Circulation Journal 76(11), 2513-2520, 2012

    J-STAGE 

  • Regenerative medicine for epidermolysis bullosa  [in Japanese]

    Tamai Katsuto

    表皮水疱症は,皮膚基底膜領域における接着構造制御蛋白の遺伝子異常により,日常生活の軽微な外力で表皮が剥離して全身熱傷様の水疱,潰瘍を形成する遺伝性水疱性皮膚難病である.近年の再生医学研究の進展により,骨髄移植,骨髄幹細胞移植による表皮水疱症の再生医療が探索されつつある.表皮水疱症の病態:表皮水疱症は表皮・基底膜間および基底膜・真皮間を連結しているタンパク分子群の遺伝子異常により発症し,外力で表皮基 …

    Journal of the National Institute of Public Health 60(2), 118-124, 2011-04

    Ichushi Web 

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