Search Results 1-20 of 139

  • Annexin A2 is involved in activation of ERK upon endothelin-1 stimulation  [in Japanese]

    Mazaki Yuichi , Higashi Tsunehito , Horinouchi Takahiro , Miwa Soichi

    … <p>Endothelin receptors (ETRs) is one of G protein coupled receptors, and consist of ET type A receptor (ET<sub>A</sub>R) and ET type B receptor (ET<sub>B</sub>R). … The overexpression of endothelin (ET)-1 or ETRs is related to malignancy of human cancer, although ET-1 was originally identified as an endothelium-derived vasocontractile peptide. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-P-361, 2020

    J-STAGE 

  • Current Treatment Strategies and Nanoparticle-Mediated Drug Delivery Systems for Pulmonary Arterial Hypertension

    Nakamura Kazufumi , Akagi Satoshi , Ejiri Kentaro , Yoshida Masashi , Miyoshi Toru , Toh Norihisa , Nakagawa Koji , Takaya Yoichi , Matsubara Hiromi , Ito Hiroshi

    … There are three critical pathways for the pathogenesis and progression of pulmonary arterial hypertension (PAH): the prostacyclin (prostaglandin I-2) (PGI(2)), nitric oxide (NO), and endothelin pathways. …

    International Journal of Molecular Sciences 20(23), 5885, 2019-11-23

    IR 

  • Progress in pulmonary hypertension guidelines according to historical changes  [in Japanese]

    巽 浩一郎

    日本臨床 = Japanese journal of clinical medicine 77(7), 1067-1074, 2019-07

    Ichushi Web 

  • Pulmonary Hypertension: Diagnosis, Management, and Treatment

    Kondo Takahisa , Okumura Naoki , Adachi Shiro , Murohara Toyoaki

    … Drugs available for the specific treatment of PAH include endothelin-receptor antagonists, phosphodiesterase type 5 inhibitors, soluble guanylate cyclase stimulators, prostacyclin analogs, and prostacyclin-receptor agonists. …

    Nagoya Journal of Medical Science 81(1), 19-30, 2019-02

    IR  DOI  Ichushi Web 

  • Improvement by a phosphodiesterase type 5 inhibitor in the vascular impairment prevents oxaliplatin-induced peripheral neuropathy  [in Japanese]

    Ogihara Takashi , Hayashi Maho , Nakagawa Takayuki , Imai Satoshi , Matsubara Kazuo

    … A single injection of vasodilators (PDE5 inhibitor, endothelin receptor antagonist and prostaglandin analog) 1 h before tests improved the decreased skin blood flow and cold hypersensitivity induced by oxaliplatin, while it had no effect on mechanical hypersensitivity. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 2-O-44, 2019

    J-STAGE 

  • GRP78 promotes ERK activation through endothelin type B receptor  [in Japanese]

    Mazaki Yuichi , Higashi Tsunehito , Onodera Yasuhito , Nam Jin-Min , Hashimoto Ari , Hashimoto Shigeru , Horinouchi Takahiro , Miwa Soichi

    … <p>Endothelin (ET)-1 is involved in various diseases, including cancer, hypertension, atherosclerosis, diabetes, and fibrotic diseases, although ET-1 is originally identified as endothelium-derived vasocontractile peptide. … ET receptors belong to the class A of G protein-coupled receptor, and consist of ET type A receptor (ET<sub>A</sub>R) and ET type B receptor (ET<sub>B</sub>R). …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 1-P-110, 2019

    J-STAGE 

  • Isoflavone Ameliorated Oxidative Stress and Vascular Damages in Nicotine-Administrated Mice

    Sukketsiri Wanida , Hoshino Kiyoto , Kugo Hirona , Nakamura Tomomi , Sasoh Tsukasa , Moriyama Tatsuya , Zaima Nobuhiro

    … Nicotine reportedly increases the occurrence of abdominal aortic aneurysms by activating endothelin-1 (ET-1), angiotensinogen and the angiotensin II type 1 (AT<sub>1</sub>) receptor, leading to an increase in neutrophil elastase, oxidative stress, and matrix metalloproteinase (MMP)-2 expression, which causes vascular wall weakness and damage. … receptor in nicotine-administered mice. …

    Journal of Oleo Science 68(12), 1241-1249, 2019

    J-STAGE 

  • Molecular mechanism for ET-1-induced insulin resistance in skeletal muscle cells  [in Japanese]

    Horinouchi Takahiro , Mazaki Yuichi , Terada Koji , Miwa Soichi

    … <p>Insulin resistance is a condition where the sensitivity to insulin of the tissues expressing insulin receptor (InsR) is decreased due to a functional disturbance of InsR-mediated intracellular signaling. … Endothelin-1 (ET-1), a potent vasoconstrictor and pro-inflammatory peptide, induces insulin resistance through a direct action on skeletal muscle. …

    Folia Pharmacologica Japonica 151(4), 140-147, 2018

    J-STAGE  Ichushi Web 

  • Glial Endothelin-1 Regulates Retinal Blood Flow During Hyperoxia in Cats

    宋 勇錫 , 長岡 泰司 , 善岡 尊文 , 大野 晋治 , 和田 剛成 , 中林 征吾 , 谷 智文 , 吉田 晃敏

    … This work is licensed under a Creative Commons Attribution 4.0 International License.Purpose:To investigate the role of endothelin-1 (ET-1) in retinal glial cells in regulating retinal blood flow (RBF) during hyperoxia in cats.Methods:We measured the vessel diameter (D), blood velocity (V), and blood flow (F) simultaneously in first-order retinal arterioles using a laser Doppler velocimetry system. …

    Investigative Ophthalmology and Visual Science 57(11), 4962-4969, 2016-09

    IR 

  • Knockout of endothelin type B receptor signaling attenuates bleomycin-induced skin sclerosis in mice

    Akashi Kengo , Saegusa Jun , Sendo Sho , Nishimura Keisuke , Okano Takuya , Yagi Keiko , Yanagisawa Masashi , Emoto Noriaki , Morinobu Akio

    Arthritis Research & Therapy (18), 113, 2016-05-21

    IR 

  • Knockout of endothelin type B receptor signaling attenuates bleomycin-induced skin sclerosis in mice

    Akashi Kengo , Saegusa Jun , Sendo Sho , Nishimura Keisuke , Okano Takuya , Yagi Keiko , Yanagisawa Masashi , Emoto Noriaki , Morinobu Akio , 柳沢 正史

    … ET-1 binds two receptors, endothelin type A (ETA) and endothelin type B (ETB). … Dual ETA/ETB receptor antagonists and a selective ETA receptor antagonist are used clinically to treat SSc, and the effect of these antagonists on fibroblast activation has been described. … However, the role of ETB receptor signaling in fibrogenesis is less clear. …

    Arthritis research & therapy (18), 113, 2016-05

    IR 

  • Developmental Endothelial Locus-1 (Del-1) Inhibits Oxidized Low-Density Lipoprotein Activity by Direct Binding, and Its Overexpression Attenuates Atherogenesis in Mice

    Kakino Akemi , Fujita Yoshiko , Nakano Atsushi , Horiuchi Sayaka , Sawamura Tatsuya

    … Del-1 also inhibited DiI-labeled oxLDL uptake by scavenger receptors irrespective of the receptor type (LOX-1, SR-AI, CD36, or SR-BI) expressed in COS-7 cells, and independent of cell type (human coronary artery endothelial cells (HCAECs) or THP-1-derived macrophages). … Furthermore, Del-1 suppressed oxLDL-induced<i>MCP-1</i>and<i>ICAM-1</i>expression and endothelin-1 secretion in HCAECs. …

    Circulation Journal 80(12), 2541-2549, 2016

    J-STAGE  Ichushi Web 

  • Efficacy and Safety of Inhaled Iloprost in Japanese Patients With Pulmonary Arterial Hypertension – Insights From the IBUKI and AIR Studies –

    Saji Tsutomu , Satoh Toru , Myoishi Masafumi , Sugimura Koichiro , Tahara Nobuhiro , Takeda Yutaka , Fukuda Keiichi , Olschewski Horst , Matsuda Yoshimi , Nikkho Sylvia

    … IBUKI was a phase III, non-randomized, open-label study of the efficacy and safety of inhaled iloprost in Japanese patients with PAH.<b><i>Methods and Results:</i></b>Adults with PAH who were treatment-naïve or administered endothelin receptor antagonists (ERAs) and/or phosphodiesterase type 5 inhibitors (PDE5-Is) and in NYHA/WHO functional class (FC) III/IV had inhaled iloprost (2.5 µg, increased to 5.0 µg if tolerated) 6–9 times daily for 12 weeks. …

    Circulation Journal 80(4), 835-842, 2016

    J-STAGE  Ichushi Web 

  • Involvement of endothelin B receptor in peripheral nerve regeneration using sciatic nerve transection-regeneration model

    Huu Tu Nguyen , Katano Tayo , Matsumura Shinji , Ito Seiji

       Whereas the central nervous system usually cannot regenerate, axons within the peripheral nervous system regenerate spontaneously and rapidly after injury. To study molecular mechanisms o …

    PAIN RESEARCH 30(3), 167-172, 2015

    J-STAGE  Ichushi Web 

  • Losartan and Sodium Nitroprusside Effectively Protect against Renal Impairments after Ischemia and Reperfusion in Rats

    Srisawat Umarat , Kongrat Surachai , Muanprasat Chatchai , Chatsudthipong Varanuj

    … Different degrees of preventive effects were observed in rats treated with captopril, BQ-123 (endothelin type A receptor antagonist), sodium nitroprusside (SNP, a nitric oxide donor), and losartan (angiotensin II type 1 receptor antagonist). …

    Biological and Pharmaceutical Bulletin 38(5), 753-762, 2015

    J-STAGE  Ichushi Web 

  • Ubiquitination-regulated receptor trafficking of endothelin type A and type B receptors  [in Japanese]

    Terada Koji , Horinouchi Takahiro , Higashi Tsunehito , Nepal Prabha , Miwa Soichi

    エンドセリン-1(ET-1)の受容体(ETR)はA型(ET<sub>A</sub>R)とB型(ET<sub>B</sub>R)の2種類が存在する.両受容体は相同性が高いにも関わらず,ET-1による刺激後の運命が大きく異なる.すなわち,両受容体とも細胞膜上でET-1により刺激されると細胞内移行するが,その後ET<sub>A</sub& …

    Folia Pharmacologica Japonica 145(1), 4-9, 2015

    J-STAGE  Ichushi Web 

  • Piebald mutation on a C57BL/6J background

    FUKUSHIMA Sanae , NIIMI Kimie , TAKAHASHI Eiki

    … The classic piebald mutation in the endothelin receptor type B (<i>Ednrb</i>) gene was found on <i>rolling</i> …

    Journal of Veterinary Medical Science 77(2), 161-166, 2015

    J-STAGE 

  • Agonist-promoted Ubiquitination Differentially Regulates Receptor Trafficking of Endothelin Type A and Type B Receptors

    Terada Koji , Horinouchi Takahiro , Fujioka Yoichiro , Higashi Tsunehito , Nepal Prabha , Horiguchi Mika , Karki Sarita , Hatate Chizuru , Hoshi Akimasa , Harada Takuya , Mai Yosuke , Ohba Yusuke , Miwa Soichi

    Journal of biological chemistry 289(51), 35283-35295, 2014-12-19

    IR 

  • Rolling Nagoya Mouse Strain (PROD-<i>rol</i>/<i>rol</i>) with Classic Piebald Mutation

    YOSHIMOTO Takuro , AOYAMA Yo , KIM Tae Yeon , NIIMI Kimie , TAKAHASHI Eiki , ITAKURA Chitoshi

    … locus encoding the endothelin receptor type B (<i>Ednrb</i>) gene in PROD-<i>rol</i>/<i>rol</i> … and wild-type <i>rolling</i> … Nagoya-type Ca<sub>v</sub>2.1 channel dysfunctions. …

    Journal of Veterinary Medical Science 76(8), 1093-1098, 2014

    J-STAGE  Ichushi Web 

  • Pathological function of Ca<sup>2+</sup>-sensing receptor in pulmonary arterial hypertension

    Yamamura Aya

    … channel blockers (nifedipine, diltiazem), three categories of drug have been developed for the treatment of PAH based on the pathological mechanisms: prostacyclin and its analogues (epoprostenol, treprostinil, iloprost), endothelin receptor antagonists (bosentan, ambrisentan), and phosphodiesterase type 5 inhibitors (sildenafil, tadalafil). …

    Journal of Smooth Muscle Research 50(0), 8-17, 2014

    J-STAGE  Ichushi Web 

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