Search Results 1-20 of 3352

  • Clinical Manifestations of Allergic Bronchopulmonary Aspergillosis without Major Features of Asthma Diagnosed by the New Criteria in Japan

    Kurihara Yuki , Tashiro Hiroki , Takahashi Koichiro , Komiya Natsuko , Sadamatsu Hironori , Kimura Shinya , Sueoka-Aragane Naoko

    … A 25-year-old man without any major features of asthma had lung infiltration with dilatation of the central bronchus, high-attenuation mucus with histological eosinophilic invasion, fungi detected on cultures, and positive <i>Aspergillus</i>-specific immunoglobulin E (IgE) and precipitating antibody of <i>Aspergillus</i>, with a significant elevation of blood eosinophils and slightly increased total IgE. …

    Internal Medicine, 2021

    J-STAGE 

  • Clinical Features of Esophageal Eosinophilia According to Endoscopic Phenotypes

    Kon Takashi , Onozato Yusuke , Mizumoto Naoko , Ueno Yoshiyuki , Abe Yasuhiko , Sasaki Yu , Kikuchi Ryosuke , Uchiyama Shiho , Kusaka Gen , Yaoita Takao , Yagi Makoto , Shoji Masakuni

    … EE was histologically defined as ≥15 eosinophils per high-power field. …

    Internal Medicine, 2021

    J-STAGE 

  • Group 2 Innate Lymphoid Cells Exacerbate Amebic Liver Abscess in Mice

    Nakamura Risa , Yoshizawa Akihiro , Moriyasu Taeko , Deloer Sharmina , Senba Masachika , Kikuchi Mihoko , Koyasu Shigeo , Moro Kazuyo , Hamano Shinjiro

    … These results suggest that ILC2s contribute to exacerbating the pathogenesis of ALA by producing early type 2 cytokines and promoting the accumulation of eosinophils and neutrophils in the liver. …

    iScience 23(9), 101544, 2020-09-25

    IR 

  • Chronic spontaneous urticaria and PAF  [in Japanese]

    齋藤 怜 , 秀 道広

    臨床免疫・アレルギー科 = Clinical immunology & allergology 73(6), 602-606, 2020-06

    Ichushi Web 

  • Eosinophils and PAF  [in Japanese]

    加藤 政彦

    臨床免疫・アレルギー科 = Clinical immunology & allergology 73(6), 581-585, 2020-06

    Ichushi Web 

  • Clinical Significance of Cytoplasmic IgE-Positive Mast Cells in Eosinophilic Chronic Rhinosinusitis

    Gion Yuka , Okano Mitsuhiro , Koyama Takahisa , Oura Tokie , Nishikori Asami , Orita Yorihisa , Tachibana Tomoyasu , Marunaka Hidenori , Makino Takuma , Nishizaki Kazunori , Sato Yasuharu

    … A positive correlation was found between the membrane IgE-positive cells and the radiological severity score, the ratio of eosinophils, and the total serum IgE level. … A positive correlation was observed between the cytoplasmic IgE-positive cells and the radiological severity score, the ratio of eosinophils in the blood, and the total IgE level. …

    International Journal of Molecular Sciences 21(5), 1843, 2020-03-07

    IR 

  • Serum IgG4 as a biomarker reflecting pathophysiology and post-operative recurrence in chronic rhinosinusitis

    Oka Aiko , Ninomiya Takahiro , Fujiwara Tazuko , Takao Soshi , Sato Yasuharu , Gion Yuka , Minoura Akira , Haruna Shin-ichi , Yoshida Naohiro , Sakuma Yasunori , Izuhara Kenji , Ono Junya , Taniguchi Masami , Haruna Takenori , Higaki Takaya , Kariya Shin , Koyama Takahisa , Takabayashi Tetsuji , Imoto Yoshimasa , Sakashita Masafumi , Kidoguchi Masanori , Nishizaki Kazunori , Fujieda Shigeharu , Okano Mitsuhiro

    Background: Type 2 chronic rhinosinusitis (CRS), especially eosinophilic CRS (ECRS), is an intractable upper airway inflammatory disease. Establishment of serum biomarkers reflecting the pathophysiolo …

    Allergology International, 2020-01-14

    IR 

  • Eosinophils in disease and treating strategies  [in Japanese]

    本間 哲也 , 秋本 佳穂 , 平井 邦朗 , 相良 博典

    臨床免疫・アレルギー科 = Clinical immunology & allergology 73(1), 14-22, 2020-01

    Ichushi Web 

  • A Low Serum CCL4/MIP-1β Level May Predict a Severe Asthmatic Responsiveness to Mepolizumab

    Suzukawa Maho , Ohshima Nobuharu , Tashimo Hiroyuki , Asari Isao , Kobayashi Nobuyuki , Shoji Shunsuke , Tohma Shigeto , Ohta Ken

    <p><b>Objective </b>Mepolizumab, a humanized anti-interleukin-5 monoclonal antibody, is effective for treating eosinophilic severe asthma. However, there is a need for more biomarker …

    Internal Medicine 59(22), 2849-2855, 2020

    J-STAGE 

  • Eosinophilic esophagitis and asymptomatic esophageal eosinophilia display similar immunohistological profiles

    Kitamura Hiroyuki , Fukumoto Shinya , Watanabe Toshio , Kawada Norifumi , Fujiwara Yasuhiro , Tanaka Fumio , Nadatani Yuji , Otani Koji , Hosomi Shuhei , Kamata Noriko , Taira Koichi , Nagami Yasuaki , Tanigawa Tetsuya

    <p>Patients with asymptomatic esophageal eosinophilia (aEE) do not exhibit clinical symptoms because of esophageal dysfunction, although they have endoscopic and histological findings similar to …

    Journal of Clinical Biochemistry and Nutrition, 2020

    J-STAGE 

  • Reactions of kynurenic acid with hypobromous acid and hypochlorous acid

    Suzuki Toshinori , Morishita Hiroyuki , Fukuhara Kosumo

    … Hypobromous acid (HOBr) and hypochlorous acid (HOCl) are generated by eosinophils and neutrophils. …

    Journal of Clinical Biochemistry and Nutrition, 2020

    J-STAGE 

  • A case of post-surgical inflammatory neuropathy with lower-extremity weakness after surgery for anorectal malignant melanoma that showed the effectiveness of immunotherapy  [in Japanese]

    M.D. Asano Rei , M.D. Kitazaki Yuki , M.D. Ph.D. Ikawa Masamichi , M.D. Ph.D. Kurebayasi Hidetaka , M.D. Ph.D. Koike Haruki , M.D. Ph.D. Hamano Tadanori

    <p>症例は59歳男性.直腸肛門部悪性黒色腫に対し経肛門直腸腫瘍摘出術を受けた後,3日目より右優位の両下肢筋力低下と感覚鈍麻が出現した.神経伝導検査で脛骨・腓骨神経の複合筋活動電位の低下がみられ,軸索障害による多発ニューロパチーが示唆された.腓腹神経生検では神経上膜の血管周囲にリンパ球主体の炎症性細胞浸潤をみとめ,発症の経緯からpost-surgical inflammatory ne …

    Rinsho Shinkeigaku, 2020

    J-STAGE 

  • Mechanisms of allergen-specific immunotherapy and allergen tolerance

    Kucuksezer Umut C. , Ozdemir Cevdet , Cevhertas Lacin , Ogulur Ismail , Akdis Mubeccel , Akdis Cezmi A.

    … Modified T- and B-cell responses and antibody isotypes, increased activity thresholds for eosinophils, basophils and mast cells and consequent limitation of inflammatory cascades altogether induce and maintain a state of sustained allergen-specific unresponsiveness. …

    Allergology International 69(4), 549-560, 2020

    J-STAGE 

  • Dupilumab efficacy and safety in Japanese patients with uncontrolled, moderate-to-severe asthma in the phase 3 LIBERTY ASTHMA QUEST study

    Tohda Yuji , Rowe Paul , Patel Naimish , Graham Neil M.H. , Teper Ariel , Nakamura Yoichi , Fujisawa Takao , Ebisawa Motohiro , Arima Kazuhiko , Miyata Masanori , Takahashi Yoshinori , Rice Megan S. , Deniz Yamo

    … For each endpoint, greater efficacy was observed in patients with elevated baseline levels of type 2 inflammatory biomarkers (blood eosinophils or FeNO). … Dupilumab treatment significantly reduced levels of FeNO and total IgE, but not blood eosinophils.</p><p><i>Conclusions:</i> …

    Allergology International 69(4), 578-587, 2020

    J-STAGE 

  • Differential Diagnosis of COVID-19: Importance of Measuring Blood Lymphocytes, Serum Electrolytes, and Olfactory and Taste Functions

    Nakanishi Hiroki , Suzuki Motohiko , Maeda Hiroyoshi , Nakamura Yoshitaka , Ikegami Yosuke , Takenaka Yuya , Mori Yusuke , Hasuo Takahiro , Hasegawa Chihiro

    … The counts of leucocytes, neutrophils, lymphocytes, eosinophils, monocytes, and basophils and the levels of chloride and calcium in blood of COVID-19 patients were significantly lower than those of non-COVID-19 patients. …

    The Tohoku Journal of Experimental Medicine 252(2), 109-119, 2020

    J-STAGE 

  • Endosonographic features in patients with non-alcoholic early chronic pancreatitis improved with treatment at one year follow up

    Higuchi Kazutoshi , Ueki Nobue , Kaneko Keiko , Gudis Katya , Ohashi Ryuji , Iwakiri Katsuhiko , Futagami Seiji , Yamawaki Hiroshi , Murakami Makoto , Kirita Kumiko , Agawa Shuhei , Ikeda Go , Noda Hiroto , Kodaka Yasuhiro

    … Duodenal degranulated eosinophils and glucagon-like peptide 1 producing cells were estimated by immunostaining. … The extent of migration of duodenal degranulated eosinophils in FD-P patients was significantly higher compared to that in ECP patients. …

    Journal of Clinical Biochemistry and Nutrition, 2020

    J-STAGE 

  • Eosinophilic Gastroenteritis-associated Duodenal Ulcer Successfully Treated with Crushed Budesonide

    Kubo Kimitoshi , Kimura Noriko , Mabe Katsuhiro , Matsuda Soichiro , Tsuda Momoko , Kato Mototsugu

    … A biopsy revealed marked infiltration of eosinophils, suggestive of EGE-associated duodenal ulcers. …

    Internal Medicine 59(18), 2249-2254, 2020

    J-STAGE 

  • Influence of exposure to inorganic arsenic compounds on allergic asthma development  [in Japanese]

    OGATA Yuri , IWASITA Naoki , KURATA Keigo , TAKAGI Yoshiichi , FUKUYAMA Tomoki

    <p>無機ヒ素化合物の汚染は発展途上国を中心として深刻な問題となっている。また、最近の疫学研究では、血中無機ヒ素濃度の上昇が皮膚炎や喘息等のアレルギー疾患の発症に関連していることが報告されている。昨年度の本学会では、マウスモデルおよび培養細胞を用いて無機ヒ素曝露が皮膚アレルギー疾患発症に及ぼす影響について報告した。本研究では、ダニ抗原誘発マウスアレルギー性喘息モデルを用い、無機ヒ素曝露 …

    Annual Meeting of the Japanese Society of Toxicology 47.1(0), P-63S, 2020

    J-STAGE 

  • A case of eosinophilic inflammatory mass of the liver associated with eosinophilic gastroenteritis  [in Japanese]

    Taniguchi Leo , Iwasaki Akito , Takeuchi Yuriko , Shiba Tadahiko , Atsukawa Kazuhiro , Nagai Kouki , Chida Akihiko , Suzuki Kou , Takahashi Kouta , Kawamura Nobuyoshi , Tamura Tetsuya , Tomonari Hisakuni , Goto Shungo

    <p>症例は58歳男性.黄疸,肝機能障害,腹痛にて近医より紹介受診.採血では,黄疸,肝機能障害,好酸球の増多を伴う白血球上昇を認めた.CTでは,肝臓両葉に多発する不整形の低吸収域,十二指腸球部の浮腫性の肥厚を認めた.上部消化管内視鏡では,球部にびらんや粘膜炎症所見を認めた.内視鏡による生検,肝低吸収域の生検を実施したところ,双方共に悪性所見はなく,著明な好酸球の浸潤を認めた.好酸球性胃 …

    Kanzo 61(9), 470-477, 2020

    J-STAGE 

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