CiNii Articles - Ergosterol

1

Study on the Inhibitory Activity and Possible Mechanism of Myriocin on Clinically Relevant Drug-Resistant Candida albicans and Its Biofilms

Yang Xin , Pei Zejun , Hu Renjing , Zhang Zhehao , Lou Zaixiang , Sun Xin

… The effect of myriocin on fungal cell wall or membrane was evaluated by adding sorbitol, ergosterol or phytosphingosine (PHS). …

Biological and Pharmaceutical Bulletin 44(3), 305-315, 2021

J-STAGE
2

ERG3-encoding sterol C5,6-DESATURASE in Candida albicans Is required for virulence in an enterically infected invasive candidiasis mouse model

Hirayama Tatsuro , Miyazaki Taiga , Sumiyoshi Makoto , Ashizawa Nobuyuki , Takazono Takahiro , Yamamoto Kazuko , Imamura Yoshifumi , Izumikawa Koichi , Yanagihara Katsunori , Kohno Shigeru , Mukae Hiroshi

… The ERG3 gene in Candida albicans encodes a sterol C5,6-desaturase, which is essential for ergosterol biosynthesis. … These results establish that the ergosterol biosynthetic pathway may be associated with C. …

Pathogens 10(1), 23, 2020-12-31

IR
3

The search for new compounds using ergosterol modified silica (ES silica) [in Japanese]

松尾洋孝 , 中島琢自

Research communications = 発酵研究所研究報告 (34), 111-120, 2020
4

Inhibitory effect of ergosterol on bladder carcinogenesis is due to androgen signaling inhibition by brassicasterol, a metabolite of ergosterol

Yazawa Yasuharu , Ikarashi Nobutomo , Hoshino Motohiro , Kikkawa Hironori , Sakuma Fumiyo , Sugiyama Kiyoshi

Journal of natural medicines 74(4), 680-688, 2020
5

New Synthetic Method for Efficient Synthesis of Bioactive Natural Products —Biomimetic Synthesis of Chaxines— [in Japanese]

Nishikawa Toshio

… This paper describes our proposed biosynthetic routes of chaxines and an eight-step synthesis of chaxines from ergosterol, on the basis of our biosynthetic proposal, which includes photo-induced 6-π-electrocyclic reaction of ergosterol, site and regioselective Baeyer-Villiger oxidation of 2-ene-1,4-dione, and acyloxy migration of epoxide of the resulting enol ester as key steps. …

Journal of Synthetic Organic Chemistry, Japan 78(6), 566-574, 2020

J-STAGE
6

Development of new synthetic methods for collective synthesis of biologically active natural products [in Japanese]

Nishikawa Toshio

… キノコ由来のステロイド系天然物chaxine類は、独自に推定したergosterolを前駆体とする生合成仮説に従って、光電子環状反応によって得られるtachysterolから6工程での効率的合成法を開発した。 …

MEDCHEM NEWS 29(4), 193-197, 2019

J-STAGE
7

Non-cyp51A Azole-Resistant Aspergillus fumigatus Isolates with Mutation in HMG-CoA Reductase

萩原大祐 , Daisuke Hagiwara , Teppei Arai , Hiroki Takahashi , Yoko Kusuya , Akira Watanabe , Katsuhiko Kamei

… We compared the genomic sequences of susceptible and resistant isolates without mutations in cyp51A (non-cyp51A) and found mutations in hmg1 and erg6 involved in ergosterol biosynthesis. … The resistant isolates with mutations in hmg1 showed increased intracellular ergosterol levels compared with susceptible isolates. … This finding supports the concept that the ergosterol level is a determinant for resistance to any class of azoles. …

Emerging Infectious Diseases 24(10), 1889-1897, 2018-10

IR
8

A Synthetic Approach to the Channel Complex Structure of Antibiotic in a Membrane: Backbone 19F-Labeled Amphotericin B for Solid-State NMR Analysis

Tsuchikawa Hiroshi , Umegawa Yuichi , Murata Michio , Oishi Tohru

… Over 40 years have passed since a well-known hypothesis of a channel-like amphotericin B (AmB) assembly with ergosterol (Erg) was proposed as the mode of action accounting for its selective fungal toxicity. …

Journal of Synthetic Organic Chemistry, Japan 76(11), 1197-1205, 2018

J-STAGE
9

Blood and Lung Concentrations of Itraconazole and its Active Metabolite in Patients with Pulmonary Aspergillosis [in Japanese]

松元加奈 , 仲村弥栄子 , 佐藤敦夫 , 朝倉庄志 , 森田邦彦 , Matsumoto Kana , Nakamura Yaeko , Sato Atsuo , Asakura Shoji , Morita Kunihiko

研究ノート

同志社女子大學學術研究年報 = Doshisha Women's College of Liberal Arts annual reports of studies (68), 127-132, 2017-12-26

IR DOI
10

Increased metabolite production by deletion of an HDA1-type histone deacetylase in the phytopathogenic fungi, Magnaporthe oryzae (Pyricularia oryzae) and Fusarium asiaticum

Maeda K. , Izawa M. , Nakajima Y. , Jin Q. , Hirose T. , Nakamura T. , Koshino H. , Kanamaru K. , Ohsato S. , Kamakura T. , Kobayashi T. , Yoshida M. , Kimura M.

ファイル公開：2018-11-01

Letters in Applied Microbiology 65(5), 446-452, 2017-11

IR
11

P-13 Synthesis of Strophasterols A and B with a Rearranged Ergostane Skeleton [in Japanese]

Sato Shuntaro , Fukuda Yuki , Ogura Yusuke , Kwon Eunsang , Kuwahara Shigefumi

… The former epimer 22 was elaborated into strophasterol A (1) byutilizing, as the key steps, regio- and diastereoselective hydroiodination (25 → 33) andmCPBA oxidation of protected iodohydrin 33 to deliver epoxide 39 in one pot, thuscompleting the synthesis of 1 in 1.8% overall yield from ergosterol (3) through 17 steps. …

Symposium on the Chemistry of Natural Products, symposium papers 59(0), 315-320, 2017

J-STAGE
12

【Rapid communications】 Applying Amphotericin B–Ergosterol in Forward Osmosis : a simulation study

Wu Hao-Chen , Yoshioka Tomohisa , Nakagawa Keizo , Shintani Takuji , Tsuru Toshinori , Saeki Daisuke , Matsuyama Hideto

… In this study, water–molecule transport properties of an Amphotericin B–Ergosterol (AmBEr) channel were examinedon a molecular level via simulation of the forward osmosis (FO) filtration phenomena. …

MEMBRANE 42(6), 250-254, 2017

J-STAGE Ichushi Web
13

Development of the novel fungicide fenpyrazamine

Kimura Norio , Hashizume Masaya , Kusaba Tomoyuki , Tanaka Soichi

… The target enzyme of fenpyrazamine is 3-keto reductase in the ergosterol biosynthetic pathway. …

Journal of Pesticide Science 42(3), 137-143, 2017

J-STAGE
14

Trialkylamine Derivatives Containing a Triazole Moiety as Promising Ergosterol Biosynthesis Inhibitor: Design, Synthesis, and Antifungal Activity

Sui Guoqing , Zhang Wen , Zhou Kun , Li Yulin , Zhang Bingyu , Xu Dan , Zou Yong , Zhou Wenming

As a part of our continuing research on amine derivative antifungal agents, 19 novel target compounds containing 1,2,4-triazole and tertiary amine moieties were designed and synthesized, and …

Chemical and Pharmaceutical Bulletin 65(1), 82-89, 2017

J-STAGE
15

Development of a control method for Bakanae disease (2) -Effect of seed disinfection using EBI chemical fungicides on the invasion of Fusarium fujikuroi during the sprouting period- [in Japanese]

藤晋一 , 工藤学

秋田県立大学ウェブジャーナルB（研究成果部門） (3), 200-205, 2016-09-30

IR
16

Commensal relation between Bursaphelenchus xylophilus (Nematoda: Aphelenchoididae) and Monochamus alternatus (Coleoptera: Cerambycidae) within pine trees

Togashi Katsumi , Miyauchi Osamu , Kusumoto Dai [他]

Applied entomology and zoology 51(1), 53-62, 2016-02
17

Development of a method to control bakanae disease (1) : Effect of seed disinfection using EBI chemical fungicides and hot water treatment, and monitoring of F. fujikuroi contamination in farmer facilities [in Japanese]

藤晋一 , 工藤学 , 佐々木南海

秋田県立大学ウェブジャーナルB（研究成果部門） = Akita prefectural University Web Journal B(Results of research) (2), 181-186, 2015-09-30

IR
18

Amphotericin B-ergosterol interaction analysis based on intermolecular distance information [in Japanese]

Umegawa Yuichi , Nakagawa Yasuo , Matsushita Naohiro , Tsuchikawa Hiroshi , Hanashima Shinya , Oishi Tohru , Matsumori Nobuaki , Murata Michio

　アンフォテリシンB(AmB, 図1a)は放線菌Streptomyces nodosusの生産するポリエンマクロライド化合物であり、その強力な抗カビ活性と耐性のできにくい性質から、現在でも抗真菌薬として広く用いられている。AmBの活性は細胞膜中に形成されるイオン透過性チャネル(図1-b)に起因するとされており1)、また選択毒性はチャネ …

Symposium on the Chemistry of Natural Products, symposium papers 57(0), Oral9, 2015

J-STAGE
19

DA 5505: A Novel Topical Formulation of Terbinafine That Enhances Skin Penetration and Retention

Thapa Raj Kumar , Han Sang-Duk , Park Hyoung Geun , Son Miwon , Jun Joon Ho , Kim Jong Oh

… Terbinafine is a fungicidal agent that inhibits ergosterol, an essential fungal component. …

Chemical and Pharmaceutical Bulletin 63(7), 525-530, 2015

J-STAGE Ichushi Web
20

Characterization of Tamoxifen as an Antifungal Agent Using the Yeast Schizosaccharomyces Pombe Model Organism

Zhang Xibo , Fang Yue , Jaiseng Wurentuya , Hu Lingling , Lu Yabin , Ma Yan , Furuyashiki Tomoyuki

… Since terbinafine and azoles inhibit enzymes for ergosterol biosynthesis, Erg1 and Erg11, for their antifungal actions, we also examined involvement of these molecules. … Overexpression of Erg1 and Erg11 reduced the sensitivity to terbinafine and azoles, respectively, but increased tamoxifen sensitivity, suggesting that ergosterol biosynthesis is differently related to the action of tamoxifen and those of terbinafine and azoles. …

The Kobe journal of the medical sciences 61(2), 54-63, 2015

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