Search Results 1-20 of 133

  • The role of Ca<sup>2+</sup> impermeable AMPA receptor in the bed nucleus of stria terminalis in the lipopolysaccharide-induced behavioral despair  [in Japanese]

    Fukuwada Nao , Kanno Miki , Seki Kenjiro

    … impermeable AMPA receptor by RNA editing of GluR2, we investigated whether Ca<sup>2+</sup> … To mimic the GluR2 RNA editing, we bilaterally injected 1-Naphthylacetyl spermine (Naspm), a Ca<sup>2+</sup> … We suggest that the GluR2 RNA-editing in BNST contribute to the LPS-induced behavioral despair in mice.</p> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), 3-P-028, 2019

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  • Alterations of NMDA and AMPA receptors and their signaling apparatus in the hippocampus of mouse offspring induced by developmental arsenite exposure

    Zhao Fenghong , Wang Zijiang , Liao Yingjun , Wang Gaoyang , Jin Yaping

    … The effect of arsenite in the expressions of different components of NMDAR (NR1, NR2A, NR2B) and AMPAR (GluR1, GluR2, GluR3), including calcium/calmodulin-dependent protein kinase II (CaMKII) and phosphorylated-CaMKII (p-CaMKII), at PND 7, 14, 21 and 35 was estimated and analyzed from the hippocampus of mice. … Down regulation of GluR2 and GluR3 both at mRNA and protein levels was observed in mice exposed to 50 mg/L arsenite till PND 14. …

    The Journal of Toxicological Sciences 44(11), 777-788, 2019

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  • Molecular mechanisms of the sedation and analgesia induced by xylazine on Wistar rats and PC12 cell

    Zhao Jinghua , Gao Li , Zhang Yiming , Liu Wenhan , Chen Yu , Chang Daiyue , Zhang Xintong , Chang Tian , Wang Qi , Liu Tao

    … However, xylazine did not significantly affect the expression of GluR2 and protein kinase C (PKC). …

    Experimental Animals 68(3), 351-360, 2019

    J-STAGE  Ichushi Web 

  • Neurotoxicity Mechanism of Environmental Chemicals and Its Evaluation System  [in Japanese]

    Kotake Yaichiro

    … We clarified that low concentrations of tributyltin decrease α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor subunit GluA2 (GluR2) expression, leading to the vulnerability of cultured neurons. …

    YAKUGAKU ZASSHI 138(10), 1227-1233, 2018

    J-STAGE  Ichushi Web 

  • Comprehensive genetic manifested fluctuation result from decrease in nuclear respiratory factor-1  [in Japanese]

    SAIKI Takashi , ISHIDA Keishi , OHTA Shigeru , KOTAKE Yaichiro

    … <p>【目的】我々は現在までに低濃度の有機スズが核呼吸因子-1(nuclear respiratory factor-1;NRF-1)の転写活性を低下させ、AMPA受容体サブユニットGluR2の発現量を低下させることで神経細胞を脆弱化することを明らかにしてきた。 …

    Annual Meeting of the Japanese Society of Toxicology 45.1(0), P-83, 2018

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  • Neurotoxic mechanism of methylmercury through GluA2 decrease  [in Japanese]

    TAKEDA Kazuki , ISHIDA Keishi , TAKEHARA Yuki , OHTA Shigeru , KOTAKE Yaichiro

    … 流入を調節している GluR2 / GluA2 (GluA2) の発現変動について検討した。 …

    Annual Meeting of the Japanese Society of Toxicology 45.1(0), P-65, 2018

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  • Roles of 5-HT1A receptor in the expression of AMPA receptor and BDNF in developing mouse cortical neurons

    Yoshimura Yuko , Ishikawa Chihiro , Kasegai Haruki , Masuda Tomoyuki , Yoshikawa Masaaki , Shiga Takashi , 増田 知之 , 志賀 隆

    … We now investigated roles of 5-HT1A receptor in the mRNA expression of AMPA receptor subunits (GluR1 and GluR2) and brain-derived neurotrophic factor (BDNF) using primary culture of cerebral cortex of mouse embryos. … In neurons cultured for 3 days, 8-OH-DPAT treatment for both 3 h and 24 h increased the mRNA levels of BDNF and GluR1, but not GluR2. …

    Neuroscience research (115), 13-20, 2017-02

    IR  Ichushi Web 

  • Prenatal Exposure to Tributyltin Decreases GluR2 Expression in the Mouse Brain

    Ishida Keishi , Saiki Takashi , Umeda Kanae , Miyara Masatsugu , Sanoh Seigo , Ohta Shigeru , Kotake Yaichiro

    … We previously reported that exposure of primary cortical neurons to TBT in vitro decreased the α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor subunit glutamate receptor 2 (GluR2) expression and subsequently increased neuronal vulnerability to glutamate. …

    Biological and Pharmaceutical Bulletin 40(7), 1121-1124, 2017

    IR  J-STAGE  Ichushi Web 

  • Developmental exposure to PFOS enhances neuronal vulnerability to glutamate excitotoxicity  [in Japanese]

    ISHIDA Keishi , KOTAKE Yaichiro , TSUYAMA Yumi , SANOH Seigo , OHTA Shigeru

    … また、2 mg/kg PFOS曝露により大脳皮質のGluR2タンパク質発現量の低下が認められた。 … GluR2サブユニットはAMPA受容体のCa<sup>2+</sup>透過性決定因子であり、GluR2の発現減少は神経細胞のCa<sup>2+</sup>透過性を上昇させることが知られている。 …

    Annual Meeting of the Japanese Society of Toxicology 44.1(0), P-227, 2017

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  • 学術振興賞受賞 古武弥一郎氏の業績  [in Japanese]

    KUMAGAI Yoshito

    … 日常的な曝露濃度あるいは病態に即した現象を反映させる条件下において、脳神経系に有害性を示す外因性および内因性化学物質に注目した分子毒性学的な研究成果やGluR2減少を指標とした毒性評価系の構築が認められた。 …

    Farumashia 53(5), 478-478, 2017

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  • Lead-Induced ERK Activation Is Mediated by GluR2 Non-containing AMPA Receptor in Cortical Neurons

    Ishida Keishi , Kotake Yaichiro , Sanoh Seigo , Ohta Shigeru

    … The α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor that is devoid of the glutamate receptor 2 (GluR2) subunit is Ca<sup>2+</sup>-permeable, which increases the neuronal vulnerability to excitotoxicity. … We have previously reported that long-term exposure of rat cortical neurons to lead acetate induces decrease of GluR2 expression. … However, it is not clarified whether lead-induced GluR2 decrease is involved in neurotoxicity. …

    Biological and Pharmaceutical Bulletin 40(3), 303-309, 2017

    IR  J-STAGE  Ichushi Web 

  • Isoflurane postconditioning induces concentration- and timing-dependent neuroprotection partly mediated by the GluR2 AMPA receptor in neonatal rats after brain hypoxia-ischemia

    Xu Ying , Xue Hang , Zhao Ping , Yang Yating , Ji Guoyu , Yu Weiwei , Han Guang , Ding Mengmeng , Wang Feifei

    Journal of anesthesia 30(3), 427-436, 2016

  • 脳出血後のスキルトレーニングが大脳皮質および線条体のAMPA受容体サブユニットに与える影響  [in Japanese]

    玉越 敬悟 , 大西 秀明 , 高松 泰行 , 石田 和人

    … リアルタイムPCR(ABI 7300 PCR system)を用いて,AMPA受容体サブユニットであるGluR1,GluR2,GluR3,GluR4のmRNA発現量を解析した。 …

    Congress of the Japanese Physical Therapy Association 2015(0), 0469, 2016

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  • Neurotoxicity through GluR2 reducting action of carbofuran  [in Japanese]

    UMEDA Kanae , KOTAKE Yaichiro , SUGIYAMA Chihiro , MIYARA Masatsugu , ISHIDA Keishi , SANOH Seigo , OHTA Shigeru

    … 【目的】当研究室では、AMPA受容体を構成するサブユニットのうち、Ca<sup>2+</sup>透過性を決定するGluR2が数種類の化学物質曝露により減少し、これにより神経細胞脆弱化が引き起こされることを明らかにした。 … さらにAlphaLISA<sup>®</sup>を応用してin vitro GluR2発現簡便評価系を構築した。 …

    Annual Meeting of the Japanese Society of Toxicology 43.1(0), O-19, 2016

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  • Methoxychlor and fenvalerate induce neuronal death by reducing GluR2 expression

    Umeda Kanae , Kotake Yaichiro , Miyara Masatsugu , Ishida Keishi , Sanoh Seigo , Ohta Shigeru

    GluR2, an α-amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA) receptor subunit, plays important roles in neuronal survival. … We previously showed that exposure of cultured rat cortical neurons to several chemicals decreases GluR2 protein expression, leading to neuronal toxicity. … Treatment of cultured rat cortical neurons with 1 or 10 µM methoxychlor and fenvalerate for 9 days selectively decreased GluR2 protein expression; …

    The Journal of Toxicological Sciences 41(2), 255-264, 2016

    J-STAGE  Ichushi Web 

  • Mechanism of nuclear respiratory factor-1 inhibition involved in organotin induced neurotoxicity  [in Japanese]

    ISHIDA Keishi , KOTAKE Yaichiro , AOKI Kaori , TAKISHITA Tomoko , KIMURA Tomoki , KANDA Yasunari , OHTA Shigeru

    … 我々は現在までに 20 nM TBT が AMPA 型グルタミン酸受容体 GluR2 サブユニットの発現を特異的に低下させ、神経細胞を脆弱にすることを報告している。 … そこで本研究では、TBT が GluR2 発現に関与する転写因子に与える影響について検討した。 …

    Annual Meeting of the Japanese Society of Toxicology 42.1(0), P-62, 2015

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  • 脳出血後のスキルトレーニングがAMPA受容体サブユニットと興奮性および抑制性ニューロンに与える影響  [in Japanese]

    玉越 敬悟 , 川中 健太郎 , 大西 秀明 , 高松 泰行 , 石田 和人

    … リアルタイムPCR(ABI 7300 PCR system)を用いて,AMPA受容体サブユニットであるGluR1,GluR2,GluR3,GluR4のmRNA発現量を解析した。 …

    Congress of the Japanese Physical Therapy Association 2014(0), 0516, 2015

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  • Environmental chemicals-induced GluR2 decrease and its neurotoxicological evaluation  [in Japanese]

    KOTAKE Yaichiro

    … 我々は、脳に常在する濃度付近の20 nM有機スズを大脳皮質初代培養神経細胞に培養2日目から9日間曝露することにより、GluR2 mRNAおよびタンパク質が持続的に減少することを報告した。 … GluR2はグルタミン酸受容体の1種であるAMPA受容体を構成するサブユニットであり、平常時に細胞内へのカルシウム流入を阻止する役割を担う。 …

    Annual Meeting of the Japanese Society of Toxicology 41.1(0), S9-3, 2014

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  • Involvement of decreased glutamate receptor subunit GluR2 expression in lead-induced neuronal cell death

    ISHIDA Keishi , KOTAKE Yaichiro , MIYARA Masatsugu , AOKI Kaori , SANOH Seigo , KANDA Yasunari , OHTA Shigeru

    … Lead is known to induce neurotoxicity, particularly in young children, and GluR2, an AMPA-type glutamate receptor subunit, plays an important role in neuronal cell survival. … Therefore, we hypothesized that altered GluR2 expression plays a role in lead-induced neuronal cell death. … To test this idea, we investigated the effect of exposure to 5 and 20 µM lead for 1-9 days on the viability and GluR2 expression of primary-cultured rat cortical neurons. …

    The Journal of Toxicological Sciences 38(3), 513-521, 2013-06-01

    J-STAGE  Ichushi Web  References (39)

  • Reduction of AMPA-type glutamate receptor GluR2 subunit expression by lead  [in Japanese]

    ISHIDA Keishi , KOTAKE Yaichiro , AOKI Kaori , OHTA Shigeru

    … そこで本研究では、平常時のカルシウムイオン透過性を決定する AMPA 型グルタミン酸受容体の GluR2 サブユニット発現に鉛が影響を与えている可能性を考え、検討を行った。 … GluR2 タンパク質の発現変動は特異的抗体を用いた western blotting により評価した。 … <br>【結果及び考察】<br>5 uM より濃度依存的に GluR2 の発現減少が認められた。 …

    Annual Meeting of the Japanese Society of Toxicology 39.1(0), P-97, 2012

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