Search Results 1-20 of 5659

  • Analysis of Risk Factors for Proteinuria Associated with Ramucirumab  [in Japanese]

    佐久間 晶基 , 近藤 有 , 一木 万奈美 , 杉本 智哉 , 髙橋 智洋 , 荒川 裕貴 , 牛膓 沙織 , 間瀬 広樹 , 宮崎 雅之 , 佐藤 由美子 , 築山 郁人 , 久田 達也 , 板倉 由縁

    日本病院薬剤師会雑誌 = Journal of Japanese Society of Hospital Pharmacists 56(2), 191-197, 2020-02

  • Pathogenesis of primary biliary cholangitis : a mechanistic insight  [in Japanese]

    小森 敦正

    日本臨床 = Japanese journal of clinical medicine 78(1), 71-77, 2020-01

    Ichushi Web 

  • Novel mode of antidepressant action based on exercise-induced beneficial effects  [in Japanese]

    Kondo Makoto , Shimada Shoichi

    … It has been known that physical exercise provides neurogenic and antidepressant effects, and we recently demonstrated that the serotonin type 3 (5HT3) receptor is essential for exercise-induced hippocampal neurogenesis and antidepressant effects. … In this study, we examined the 5HT3 receptor-mediated mechanism underlying hippocampal neurogenesis and antidepressant effects, and tried to establish novel prevention and treatment for depression, which is based on mechanisms of exercise-induced beneficial effects. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-S30-2, 2020

    J-STAGE 

  • Role of prefrontal VEGF signaling in the rapid antidepressant actions of ketamine  [in Japanese]

    Deyama Satoshi

    … <p>Previous studies have shown that the NMDA receptor antagonist ketamine produces rapid and sustained antidepressant effects in treatment-resistant depressed patients, and that brain-derived neurotrophic factor (BDNF) signaling in the medial prefrontal cortex (mPFC) mediates the antidepressant actions of ketamine. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-S30-3, 2020

    J-STAGE 

  • TRPM2 channel regulates tumor angiogenesis via interacting with Stat3  [in Japanese]

    Ryuhei Kurogi , Ueda Yoshifumi , Yamada Yuji , Hasegawa Yoshiaki , Mori Yasuo

    … Especially, tumor-associated macrophages (TAMs) are one of the major components of tumor tissues, and they play pivotal roles in prompting the various tumor growths by producing growth factors. … Previously, we have reported that Transient receptor potential melastatin 2 (TRPM2), a ROS-sensitive Ca<sup>2+</sup> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-P-356, 2020

    J-STAGE 

  • Impaired endothelium-dependent vasodilator responses of retinal blood vessels in adult rats with a history of retinopathy of prematurity  [in Japanese]

    Mori Asami , Nakano Ayuki , Sumida Daiki , Kondo Rho , Asano Daiki , Morita Akane , Sakamoto Kenji , Nakahara Tsutomu

    … We reported that short-term interruption of retinal vascular development with blockade of vascular endothelial growth factor (VEGF) signaling pathway in neonatal rats induces ROP-like retinal blood vessels, such as aggressive angiogenesis and tortuous arteries. … ROP was induced in rats by the subcutaneous injection of the VEGF receptor tyrosine kinase inhibitor KRN633 on postnatal day (P) 7 and P8. … receptor agonist, were unaltered. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-P-322, 2020

    J-STAGE 

  • The mechanism of serotonin-induced increase in intracellular Ca<sup>2+</sup> and constriction via Rho kinase in rat thoracic aortas  [in Japanese]

    Terada Yuka , Kishimoto Minami , Torii Karin , Yayama Katsutoshi

    … in rat thoracic aortas is mediated by Rho kinase activation through Src, epidermal growth factor receptor (EGFR), and extracellular signal-regulated kinase (Erk).</p><p>5-HT induced a biphasic [Ca<sup>2+</sup>]i response, and the initial [Ca<sup>2+</sup>]i increase was attenuated by inositol triphosphate (IP<sub>3</sub>) receptor blocker, and inhibitors of Src and phosphoinositide 3-kinase (PI3K), but not L-type …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-O-096, 2020

    J-STAGE 

  • VEGFR1 signaling plays a critical role in endometriosis through increasing lymphangiogenesis  [in Japanese]

    Kyoko Hattori , Ito Yoshiya , Honda Masako , Sekiguchi Kazuki , Unno Nobuya , Majima Masataka

    … <p>Lymphangiogenesis is associated with the growth of endometriosis. … In this study, we examined the role of vascular endothelial growth factor (VEGF) receptor 1 (VEGFR1) signaling in lymphangiogenesis and tissue growth in an endometriosis model. … Endometrial tissue growth and lymphangiogenesis as indicated by lymphatic vessel density were determined. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-YIA-57, 2020

    J-STAGE 

  • TP signaling in immune cells promotes lymphangiogenesis in the diaphragm during peritonitis  [in Japanese]

    Tsuru Seri , Ito Yoshiya , Matsuda Hiromi , Hosono Kanako , Okamoto Hirotsugu , Majima Masataka

    receptor (TP) signaling in inflammation-associated formation of newly lymphatic vessels. … Compared with WT, LPS-induced lymphangiogenesis in TPKO was suppressed, which was accompanied by reduced expression of vascular endothelial growth factor (VEGF)-C and VEGF-D in CD11b+ and CD4+ cells in diaphragm tissue. … As compared with controls, mice with macrophage TP receptor deletion showed attenuation of lymphangiogenesis with reduced expression of VEGF-C and VEGF-D. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-YIA-58, 2020

    J-STAGE 

  • Fibroblast growth factor 2 modulates purine metabolic enzymes through MAPK pathway in rat spinal cord astrocytes  [in Japanese]

    Eguchi Ryota , Otsuguro Ken-ichi

    … In the previous study, we showed that fibroblast growth factor 2 (FGF2) upregulates purine metabolic enzymes, ecto-5'-nucleotidase (CD73) and adenosine deaminase (ADA), in rat spinal cord astrocytes. … An FGF receptor inhibitor, SU5402 (5 μM), inhibited the increase in the expression and activity of CD73 and ADA by FGF2. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 3-P-278, 2020

    J-STAGE 

  • Dedifferentiation of Schwann cells by taxanes participates in the chemotherapy-induced peripheral neuropathy pathogenesis  [in Japanese]

    Imai Satoshi

    … Furthermore, the novelty of our study lies in the finding that paclitaxel induces dedifferentiation of myelin-forming Schwann cells characterized by increased expression of low affinity nerve growth factor receptor p75 (immature Schwann cell marker) and decreased expression of myelin-associated molecule (MBP, mature Schwann cell marker).</p><p>In this presentation, I will talk about our research on the mechanisms underlying CIPN pathogenesis, focusing on Schwann cells.</p> …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-S25-2, 2020

    J-STAGE 

  • The role of Prostaglandin D<sub>2 </sub>synthase in retinal angiogenesis  [in Japanese]

    Erika Sekihachi , Omori Keisuke , Kobayashi Koji , Nagata Nanae , Nakamura Tatsuro , Kurata Kaori , Uemura Akiyoshi , Murata Takahisa

    … Gene deficiency of L-PGDS impaired the physiological angiogenesis of retina, accompanied with increased mRNA expression of pro-angiogenic factor VEGF. … Gene deficiency of H-PGDS or PGD receptor DP accelerated the angiogenesis. … This phenomenon was accompanied with increased mRNA expression of one of the chemokines, Stromal derived factor 1α. … In isolated macrophage, hypoxia increased the expression of cytokines, wich was inhibited by adding receptor inhibitor. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-YIA-35, 2020

    J-STAGE 

  • Vascular remodeling in pulmonary arterial hypertension: roles of CaSR and PDGF  [in Japanese]

    Yamamura Aya

    … We previous found that the Ca<sup>2+</sup>-sensing receptor (CaSR) is upregulated in PASMCs from idiopathic pulmonary arterial hypertension (IPAH) patients, and contributes to enhanced Ca<sup>2+</sup> … In normal-PASMCs, expression of CaSR was increased by platelet-derived growth factor (PDGF), which is known as an endogenous signal associated with IPAH. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-S22-4, 2020

    J-STAGE 

  • Intranasal administration of resolvin E1 attenuates lipopolysaccharide-induced depression-like behaviors via BDNF/VEGF release and mTORC1 activation in the medial prefrontal cortex  [in Japanese]

    Aoki Shun , Deyama Satoshi , Ishimura Kohei , Fukuda Hayato , Shuto Satoshi , Minami Masabumi , Kaneda Katsuyuki

    … <p>We have recently demonstrated that infusion of eicosapentaenoic acid-derived resolvin E1 (RvE1) into the medial prefrontal cortex (mPFC) exerts antidepressant effects via brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF) release and subsequent activation of mechanistic target of rapamycin complex 1 (mTORC1) in a murine lipopolysaccharide (LPS)-induced depression model. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 2-P-178, 2020

    J-STAGE 

  • Hypoxia stimulates CXCR4, an EMT-related factor expression in endometrial epithelial cells  [in Japanese]

    Tsubata Naoya , Kusama Kazuya , Tamura Kazuhiro

    … <p>Endometriosis is characterized by the ectopic inflammation, growth, and fibrotic changes in the lesion. … Previous study indicates that peritoneal bleeding may accelerate inflammation partially through the activation of protease-activated receptor (PAR) and the prostaglandin (PG) EP2 receptor in endometriosis-like graft of the mouse model. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-SS-12, 2020

    J-STAGE 

  • Regulation of epidermal growth factor receptor of cultured lung epithelial cells by interleukin-1β  [in Japanese]

    Yamamoto Hideyuki , Nakayama Izumi , Higa-Nakamine Sayomi

    … In the present study, we found that treatment of A549 cells with interleukin 1 beta (IL-1β) induced the activation of p38 mitogen-activated protein kinase (MAP kinase) and MAP kinase-activated protein kinase-2 (MAPKAPK-2), and the phosphorylation of epidermal growth factor receptor (EGFR) at serine 1047. … In addition, IL-1β augmented the effects of transforming growth factor beta 1 on changes in the epithelial-mesenchymal transition. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-P-104, 2020

    J-STAGE 

  • Activation of ribosomal p70 S6 kinase by selective serotonin (5-HT)<sub>2B</sub> receptor agonist BW723C86 is mediated by epidermal growth factor/transforming growth factorreceptor tyrosine kinase in primary cultures of adult rat hepatocytes.  [in Japanese]

    Kurihara Kazuki , Moteki Hajime , Ogihara Masahiko , Kimura Mitsutoshi

    … <p>Serotonin (5-HT) can induce hepatocyte DNA synthesis and proliferation by autocrine secretion of transforming growth factor (TGF)-α through 5-HT<sub>2B</sub> … receptor/phospholipase C (PLC)/Ca<sup>2+</sup>. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-P-101, 2020

    J-STAGE 

  • Regulation of anterograde transcytosis of neurotrophin receptors and its role in health and diseases  [in Japanese]

    Yamashita Naoya

    … Upon nerve growth factor (NGF) binds to its receptor TrkA at axon terminals, these complexes are internalized and retrogradely transported back to cell bodies. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-S01-1, 2020

    J-STAGE 

  • The effects of ambrisentan, a selective endothelin ET<sub>A </sub>receptor antagonist for vasogenic edema after traumatic brain injury in mice  [in Japanese]

    Michinaga Shotaro , Ryu Ryotaro , Yamamoto Hayato , Mizuguchi Hiroyuki , Koyama Yutaka

    … Endothelin (ET) is an aggravating factor for the BBB disruption. … In this study, we confirmed the effects of ambrisentan, an ETA receptor antagonist for TBI-induced vasogenic edema. … Expressions of vascular endothelial growth factor-A (VEGF-A) as an aggravating factor for the BBB disruption and angiopoietin-1 (ANG-1) as a protective factor were measured by Real-time PCR. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-P-038, 2020

    J-STAGE 

  • Adverse Outcome Pathway (AOP) development on Wnt/beta-catenin signaling pathway related to cancer  [in Japanese]

    Tanabe Shihori , Aoyagi Kazuhiko , Quader Sabina , Cabral Horacio , Ono Ryuichi , Hirose Akihiko , Yokozaki Hiroshi , Sasaki Hiroki

    … The gene expression of growth factor receptor bound protein 7 (<i>GRB7</i>) and erb-b2 receptor tyrosine kinase 2 (<i>ERBB2</i>) were up-regulated in intestinal-type GC compared to diffuse-type GC. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-LBS-14, 2020

    J-STAGE 

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