Search Results 1-20 of 914

  • Thinking about Pregnancy, Delivery, and Fetus Based on Human Physiology  [in Japanese]

    今中 基晴

    I. はじめに : 医師として産婦人科とりわけ産科医療において、さらに教員としての看護学教育において、一貫して妊娠・分娩を主に女性の一生に携わってきた。今回、特に、ヒトの生理から妊娠・分娩・胎児について考えてきたことを振り返ってみる。……

    大阪市立大学看護学雑誌 (16), 1-8, 2020-03

    IR  DOI  Ichushi Web 

  • Natural Color Pictures of Cross-Sections of Fetal Rat Heart with Tetralogy of Fallot  [in Japanese]

    Momma Kazuo , Maeno Yasuki

    … <p>Bis-diamine is a potent teratogen in rats, with it inducing cono-truncal diseases and thymic hypoplasia which are similar to chromosome 22q11 deletion syndrome (C22DS) in human. … These cardiac cross-sectional anatomies in the fetus with rapid whole-body freezing, cutting with a freezing microtome every 0.5 mm, photographing with photomicroscope (Wild M400) in locking down view were published previously. …

    Pediatric Cardiology and Cardiac Surgery 36(4), 270-276, 2020

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  • An Overview of the Outcomes of Multidisciplinary Computational Anatomy Leading to Development of Diagnosis and Treatment  [in Japanese]

    OHUCHIDA Kenoki , HASHIZUME Makoto

    … the research results of "Computational Anatomy", we have established a multidisciplinary computational anatomy model with a spatial axis of analysis from micro at the cell level to macro at the organ level, a time axis of analysis of various periods for the human life from the development of the fetus to the death, a functional axis of analysis targeting physiological functions and metabolism of cells and organs, and a pathological axis of analysis from normal to pathological diseases such as inflammation and carcinogenic …

    Medical Imaging Technology 38(5), 207-212, 2020

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  • Heart rate variability in Dorper sheep in the fetal and neonatal periods until 120 days of age: use of the technique in the field

    CRUZ-ALEIXO Amanda Sarita , GOMES LOURENÇO Maria Lucia , DE CASTRO FERREIRA LIMA Mayra , HOLANDA DE ALBUQUERQUE Ana Luísa , TORTORELLI TEIXEIRA Raphael , DE PAULA Renata Alves , GRANDI Marina Cecília , LAURENTI FERREIRA Danilo Otávio , HARUMI TSUNEMI Miriam , BIAGIO CHIACCHIO Simone

    … Fetal electrocardiography provides important information regarding the well-being of the fetus since, in human fetuses, there are changes in the behavior of the fetal heart rate during the second and third trimesters of pregnancy due to an increase in parasympathetic activity. … Heart rate variability may be employed as a tool in the evaluation of the fetus and development of lambs, since changes in its behavior may represent an adverse effect to fetal and neonatal health.</p> …

    Journal of Veterinary Medical Science, 2020

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  • Comprehensive evaluation including ultrasound monitoring of fetal hemolytic disease in Rhesus E incompatibility

    Osonoi Kasumi , Kudo Ko , Kobayashi Akie , Matsukura Daisuke , Tanaka Kanji , Terui Kiminori , Ito Etsuro

    … However, the fetus showed no findings of hydrops fetalis. … The neonate developed moderate hemolyticdisease that was treated with phototherapy, a single dose of human intravenous immunoglobulin and four times ofred blood cell transfusions. … A comprehensive evaluation of the fetus for predictionof severity and careful observation for at least six months are crucial in the management of Rhesus E associatedhemolytic disease, considering the limitation of ultrasound monitoring of MCA-PSV. …

    Hirosaki Medical Journal 71(1), 71-74, 2020

    IR  J-STAGE 

  • Transfer Mechanisms of Compounds between Mother and Fetus/Infant Aimed for Optimized Medication during Pregnancy and Breastfeeding  [in Japanese]

    Furugen Ayako

    … <p>Potential risks to the fetus or infant should be considered prior to medication during pregnancy and lactation. … Lastly, we developed a method for quantifying eight BZDs in human breast milk and plasma using LC/MS/MS, and successfully applied it to quantify alprazolam in breast milk and plasma donated by a lactating woman.</p> …

    YAKUGAKU ZASSHI 140(10), 1199-1206, 2020

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  • Perinatal human parvovirus B19 infection─6 fetuses of infected pregnant women─  [in Japanese]

    Nagara Syunsuke , Usui Shinji , Ueda Mako , Yasumi Shunsuke , Yano Ryuichiro , Terazawa Daisuke , Kohno Yoshinori , Yamagishi Atsushi

    … In another case, of the dichorionic diamniotic twin, there were cases in which the first fetus died in utero and the second fetus died due to abortion due to Potter syndrome.</p> …

    Journal of Japan Society of Perinatal and Neonatal Medicine 56(2), 343-346, 2020

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  • Placental barrier: Drug transfer mechanism and its species diferences  [in Japanese]

    TOMI Masatoshi , NOGUCHI Saki , NISHIMURA Tomohiro

    … Species differences between human and rat in fetus-to-mother concentration ratio of digoxin and indomethacin were cancelled by using the unbound concentration ratio in rat. … This can be explained from the fact that the lower albumin concentration in fetal plasma compared with maternal plasma is observed in rat but not in human. … These information enhance possibilities of improving the extrapolation of fetal drug transfer data from rodents to human.</p> …

    Annual Meeting of the Japanese Society of Toxicology 47.1(0), S16-2, 2020

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  • Reproductive and developmental toxicity in a humanized-transgenic mouse with human placental endocrine function  [in Japanese]

    NAKANISHI Tsuyoshi

    … <p>The estrogen level of rodent fetus is much lower than that of human fetus because the rodent placenta doesn't have aromatase which converts androgen to estrogen. … To examine the species differences in estrogen sensitivity between human and rodent fetuses, we have established a humanized-transgenic mouse that expresses aromatase in the placenta using lentiviral gene manipulation. …

    Annual Meeting of the Japanese Society of Toxicology 47.1(0), S16-4, 2020

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  • Committee for Academic Affairs JSSHP Research Award 2019 Basic Research Screening of an Angiotensin II Receptor Blocker with Low Adverse Fetal Effect using Adverse Event Reporting System and Mechanism of the Low Placental Transfer

    Nishimura Tomohiro , Ishikawa Yu , Noguchi Saki , Tomi Masatoshi

    … The transport activity of organic anion transporting polypeptide (OATP) 2B1 was evaluated by using HEK293 cells transiently transfected with cDNA of human OATP2B1. … Ratio of the plasma concentration in the fetus to that in the dam (F/M ratio) was measured. …

    Hypertension Research in Pregnancy 8(1), 3-3, 2020

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  • Toward establishment of regenerative cell therapy for retinitis pigmentosa using iPS cell derived retinal sheet  [in Japanese]

    Akiba Ryutaro , Matsuyama Take , Takahashi Masayo , Mandai Michiko

    … Previous clinical researches using human fetal retina transplantation suggested some functional recovery in vision, but it did not become a standard therapy because of ethical concerns for using fetus tissues. … Further, human ESC derived retinas survived and matured in retinal degeneration monkey models. … in human clinical trial using iPSC derived retina for RP.</p> …

    Folia Pharmacologica Japonica 155(2), 93-98, 2020

    J-STAGE  Ichushi Web 

  • Governmentality and Biocapital:The Utilization of Fetal Tissue and Women's Reproduction  [in Japanese]

    YAMAMOTO Yumiko

    … In many countries, the legal regulation of research use of human fetal tissue is not stricter than the legal regulation of human embryo research. … Especially in Japan, there is no legal rule regarding the use of human fetal tissue, therefore, dead fetuses and aborted fetuses are in various situations not protected from exploitation. … Internationally, researchers tend to use human ES cells or human iPS cells as an alternative to fetal tissue. …

    Journal of Science and Technology Studies 17(0), 104-117, 2019

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  • Reconstruction of human placental barrier on a chip  [in Japanese]

    Miura Shigenori , Takeuchi Shoji

    … system for the analysis of placental barrier function is of great interest in the pharmacokinetic study, because the barrier regulates the permeability not only of nutrients and metabolites but also of drugs and chemicals harmful to the developing fetus. …

    Drug Delivery System 34(4), 261-267, 2019

    J-STAGE  Ichushi Web 

  • Myo-Inositol for the Prevention of Gestational Diabetes Mellitus. A Brief Review

    D'ANNA Rosario , SANTAMARIA Angelo , ALIBRANDI Angela , CORRADO Francesco , DI BENEDETTO Antonino , FACCHINETTI Fabio

    … Recently, a secondary analysis from 3 randomized controlled trials demonstrated that MI may also significantly reduce some of GDM complications such as pre-term birth and macrosomia with a favorable impact on mother and fetus well being.</p> …

    Journal of Nutritional Science and Vitaminology 65(Supplement), S59-S61, 2019

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  • <i>The limit and usefulness of the concept of a person in bioethics </i>  [in Japanese]

    SEGAWA Shingo

    … This concept plays a significant role in the arguments over the moral status of human life particularly in the early stages of life, such as the fetus. … However, since personhood is assumed to be a kind of ability or character (self-consciousness) and being a person is tied to the moral status, it raises the moral dilemma that human beings which are not regarded as a person have no moral status. …

    Bioethics 28(1), 22-30, 2019

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  • Three cases of complete hydatidiform mole coexisting with a live twin fetus  [in Japanese]

    YOSHIZAWA Hikari , EBINA Yasuhiko , IMAFUKU Hitomi , SUZUKI Kaho , WAKAHASHI Senn , MIYAHARA Yoshiya , DEGUCHI Masashi , YAMADA Hideto

    … <p>Complete hydatidiform mole coexisting with a live twin fetus (CHMCF) is very rare, occurring in 1/20,000 to 1/100,000 pregnancies. … After methotrexate treatment, her serum human chorionic gonadotropin (hCG) levels rapidly decreased and the lung metastasis disappeared. …

    ADVANCES IN OBSTETRICS AND GYNECOLOGY 71(1), 9-16, 2019

    J-STAGE  Ichushi Web 

  • Three-Dimensional Imaging of Human Embryonic and Fetal Development  [in Japanese]

    YAMAGUCHI Yutaka , YAMADA Shigehito

    … <p>Kyoto Collection of Human Embryo and Fetus is a valuable collection for human developmental research during pregnancy. … Three-dimensional imaging in non-destructive way are developed and now applied to the human specimens. … Now, morphological changes of embryo and fetus are analyzed by geometric morphometrics as well as conservative morphometric technique using obtained images.</p> …

    Vacuum and Surface Science 62(2), 72-77, 2019

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  • Changes in glucocorticoid receptor-α profile in human placentae from full term and early term births

    Rose'meyer Roselyn B , Bivol Svetlana , Holland Olivia J , Owen Suzzanne J

    … Glucocorticoids (GCs) play a pivotal role in a variety of physiological processes¸ including human reproduction¸ with cortisol levels rising towards term to facilitate fetal growth and parturition. … Research suggests that GCs may regulate the length of gestation¸ with human male and female foetuses responding differentially when exposed to high maternal cortisol concentrations. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO4-11-11, 2018

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  • Benzophenone-3 affects glutaminergic system in the rat brain

    Krzyzanowska Weronika A. , Pomierny Bartosz S. , Starek-Swiechowicz Beata , Broniowska Zaneta , Strach Beata , Bystrowska Beata , Budziszewska Boguslawa

    … After topical application of the ointment containing 5% BP-3, the maximum concentration of this compound in the human serum reached 200-300 micro;g/L and after 24 hours following application it amounted 80-200 microg/L. … BP-3 crosses the blood-placenta barrier and thus may directly affect the fetus. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO4-1-11, 2018

    J-STAGE 

  • Comparative study of the distribution and ramification of the coronary artery

    Dai Yidan , Shimada Kazuyuki , Ren Ke , Fujiwara Motoi , Kuruzawa Kazuhiro , Wang Zhidan , Yi Shuang-Qin

    … To comparative study of the distribution and ramification of the coronary artery, in this study, we evaluated 73 fetus pig hearts to investigate the distribution and ramification of the collateral branches of the left coronary artery (LCA) and the right coronary artery(RCA) in fetus pigs, including its origin,number, location, area of distribution. …

    The Journal of Japan Academy of Health Sciences 21(Supplement), 40-40, 2018

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