Search Results 1-20 of 50

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  • Functional validation of tensin2 SH2-PTB domain by CRISPR/Cas9-mediated genome editing

    MARUSUGI Kiyoma , NAKANO Kenta , SASAKI Hayato , KIMURA Junpei , YANOBU-TAKANASHI Rieko , OKAMURA Tadashi , SASAKI Nobuya

    … The ICGN mouse is a model of glomerular dysfunction that shows gross morphological changes in the podocyte foot process, accompanied by proteinuria. … Previously, we demonstrated that proteinuria in ICR-derived glomerulonephritis mouse ICGN mice might be caused by a deletion mutation in the tensin2 (<i>Tns2</i>) gene (designated <i>Tns2<sup>nph</sup></i>). …

    Journal of Veterinary Medical Science 78(9), 1413-1420, 2016

    J-STAGE  Ichushi Web 

  • Tensin2-deficient mice on FVB/N background develop severe glomerular disease

    UCHIO-YAMADA Kozue , MONOBE Yoko , AKAGI Ken-ichi , YAMAMOTO Yoshie , OGURA Atsuo , MANABE Noboru

    … <i>Tns2-</i>deficient mice were previously shown to develop mild glomerular injury on a DBA/2 background, but not on a C57BL/6J or a 129/SvJ background, suggesting that glomerular injury by the deletion of <i>Tns2</i> …

    Journal of Veterinary Medical Science 78(5), 811-818, 2016

    J-STAGE  Ichushi Web 

  • <b>Genetic background-dependent diversity in renal failure caused by the tensin2 gene deficiency in the </b><b>mouse </b>

    SASAKI Hayato , MARUSUGI Kiyoma , KIMURA Junpei , KITAMURA Hiroshi , NAGASAKI Ken-Ichi , TORIGOE Daisuke , AGUI Takashi , SASAKI Nobuya

    … A Tns2-null mutation (<i>nph</i>) leads to massive albuminuria following podocyte foot process effacement in the ICGN mice, the origin of the mutation, and the DBA/2J (D2) mice, but not in the C57BL/6J (B6) mice or 129<sup>+</sup><sup><i>Ter</i></sup>/SvJcl (129T) mice. … We produced congenic mice in which <i>Tns2</i><sup><i>nph</i></sup> …

    Biomedical Research 36(5), 323-330, 2015

    IR  J-STAGE  Ichushi Web 

  • Quantitative Trait Loci for Resistance to the Congenital Nephropathy in Tensin 2-Deficient Mice

    Sasaki Hayato , Sasaki Nobuya , Nishino Tomohiro , Nagasaki Ken-ichi , Kitamura Hiroshi , Torigoe Daisuke , Agui Takashi

    … The ICR-derived glomerulonephritis (ICGN) mouse is a chronic kidney disease (CKD) model that is characterized histologically by glomerulosclerosis, vascular sclerosis and tubulointerstitial fibrosis, and clinically by proteinuria and anemia, which are common symptoms and pathological changes associated with a variety of kidney diseases. …

    PLoS ONE 9(6), e99602-1-e99602-9, 2014-06

    IR 

  • A Decrease in Glomerular Endothelial Cells and Endothelial-mesenchymal Transition during Glomerulosclerosis in the <i>Tensin2</i>-deficient Mice (ICGN strain)

    Kato Takashi , Mizuno Shinya , Ito Akihiko

    … The ICR-derived glomerulonephritis (ICGN) mouse is a unique model of nephrotic syndrome, and albuminuria becomes evident in a neonatal stage, due to a genetic mutation of tensin2. … Compared with the non-nephrotic (+/nep) mice, the nephrotic (nep/nep) mice exhibited the reduced expression of PECAM-1, or of VE-cadherin, in glomerular area. …

    ACTA HISTOCHEMICA ET CYTOCHEMICA 47(6), 265-271, 2014

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  • The Kidneys of Infant Mice are not Sensitive to the Food Mycotoxin Contaminant Nivalenol

    Inoue Kaoru , Takahashi Miwa , Kodama Yukio , Nishikawa Akiyoshi , Sugita-Konishi Yoshiko , Yoshida Midori

    … Dietary administration of NIV to adult mice affects the renal glomeruli, but data about NIV toxicity in human infants are limited. … To evaluate the effects of NIV on infant kidneys, 3-week-old male ICR-derived glomerulonephritis (ICGN) and ICR mice were administered 0, 4, 8 or 16 ppm NIV in diet for 4 weeks, and their renal status was compared with age-matched or adult ICR mice. …

    Journal of Toxicologic Pathology 27(1), 57-66, 2014

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  • Usefulness of ICR mice as genetic resources  [in Japanese]

    山本 美江 , 内尾-山田 こずえ , 高野 薫 , 小倉 淳郎 , 浅野 敏彦 , 中川 雅郎

    … k:ICR)mice were introduced into the National Instltute of Infectious Diseases in 1965,and have been bred and produced there.Two inbred mutant mouse strains,MPS and ICGN,were created using(originated from)Yok:ICR mice in 1986.The MPS and ICGN mouse strains have served as theanimal disease models of mycoplasma infectious disease and congenital nephritic syndrome,respectively.Genetic variations were detected by the genetic monitoring of Yok:ICR mice

    岡山実験動物研究会報 (28), 59-62, 2012-04

    IR  Ichushi Web 

  • The 129 genetic background affects susceptibility to glomerulosclerosis in tensin2-deficient mice

    Nishino Tomohiro , Sasaki Nobuya , Nagasaki Ken-ichi , Ichii Osamu , Kon Yasuhiro , Agui Takashi

    … The ICGN mouse strain is a glomerulosclerosis (GS) model that shows significant proteinuria, podocyte morphological abnormalities and increased extracellular matrix accumulation in the glomeruli, which represent the final common pathology associated with a variety of kidney diseases leading to end-stage renal failure. … Previously, we demonstrated that GS in ICGN mice can be attributed to the deletion mutation of the tensin2 (Tns2) gene (Tns2<SUP>nep</SUP>). …

    Biomedical Research 33(1), 53-56, 2012

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  • Scratching Behavior of ICR-Derived Glomerulonephritis (ICGN) Mice

    MIYAMOTO Yohei , UMEUCHI Hideo , KUROKAWA Takahiro , NAKAO Kaoru , OKANO Kiyoshi

    … The ICR-derived glomerulonephritis (ICGN) mouse, an inbred strain with a hereditary nephrotic syndrome, is considered a good animal model of human idiopathic nephrotic syndrome. … ICGN mice show proteinuria at a young age, developing hypoalbuminemia, hyperlipidemia, anemia and edema later on. … In the present study, we examined whether ICGN mice exhibit the scratching behavior reflecting pruritus. …

    Journal of Veterinary Medical Science 72(9), 1243-1245, 2010

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  • Genetic Background Strongly Influences the Severity of Glomerulosclerosis in Mice

    NISHINO Tomohiro , SASAKI Nobuya , NAGASAKI Ken-ichi , AHMAD Zulkifli , AGUI Takashi

    … The ICGN mouse strain is a glomerulosclerosis (GS) model that shows characteristic proteinuria, podocyte morphological abnormalities and increased extracellular matrix accumulation in the glomeruli, which are the final common pathology associated with a variety of kidney diseases leading to end-stage renal failure. … Previously, we performed a quantitative trait locus (QTL) analysis to identify the causative genes for GS in ICGN mice and found the deletion mutation of the <i>tensin2</i> …

    Journal of Veterinary Medical Science 72(10), 1313-1318, 2010

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  • Expression of Macrophage Metalloelastase (MMP-12) in Podocytes of Hereditary Nephrotic Mice (ICGN Strain)

    UCHIO Kozue , SAWADA Kyoko , MANABE Noboru

    … The Institute for Cancer Research (ICR)-derived glomerulonephritis (ICGN) mouse is a good model for renal fibrosis. … In the glomeruli and tubulointerstitium of ICGN mouse kidneys, the components of the extracellular matrix (ECM) accumulated, and matrix metalloproteinases (MMPs) participated in this process. …

    Journal of Veterinary Medical Science 71(3), 305-312, 2009-03-25

    J-STAGE  Ichushi Web  References (26)

  • Amelioration of Anemia in the ICGN Mouse, a Renal Anemia Model, with a Subcutaneous Bolus Injection of Erythropoietin Adsorbed to Hydroxyapatite Matrix

    NAGASAKI Ken-ichi , ITO Shigeo , SASAKI Nobuya , AGUI Takashi , IKOMA Toshiyuki , KATSUDA Shin-ichi , TONEGAWA Toru , TANAKA Junzo , OHYAMA Minami , HAYASHIDA Kosuke , NAKAMURA Teppei , SATO Hidetaka

    … These formulations were examined in genetically anemic model, ICGN (ICR-derived glomerulonephritis) mice. … release test of rhEPO from HAp in ICGN mice, elevated plasma concentration of rhEPO could be maintained for more than 7 days. … These mice showed the amelioration of anemia for more than 3 weeks post-administration without causing any side effect. …

    Journal of Veterinary Medical Science 71(10), 1365-1371, 2009

    J-STAGE  Ichushi Web 

  • Localization of Tissue Transglutaminase (tTG) in Kidney of ICR-Derived Glomerulonephritis (ICGN) Mice

    MIYAMOTO Yohei , MYOMOTO Akira , SAKAGUCHI Yuka , YAMAGUCHI-YAMADA Misuzu , UCHIO-YAMDA Kozue , MANABE Noboru

    … ICR-derived glomerulonephritis (ICGN) mice are a known inbred strain with hereditary nephrotic syndrome and are considered a good animal model of human idiopathic nephrotic syndrome. … ICGN mice show proteinuria at a young age, and hypoalbuminemia, hyperlipidemia, anemia and edema accompanies their symptoms with aging. …

    Experimental Animals 58(4), 375-382, 2009

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  • The possible involvement of tensin2 in the expression and extension of nephrin by glomerular podocytes in mice

    Kato Takashi , Mizuno Shinya , Taketo Makoto Mark , Kurosawa Tsutomu Miki

    … Using tensin2-deficient mice (ICGN/Oa strain), we provide evidence that tensin2 is important for glomerular nephrin expression <I>in vivo</I>. … In heterozygous mice with a single mutated <I>tensin2</I> … In contrast, nephrin expression was impaired, especially in the central zones of glomeruli of homozygous mice (with double mutated <I>tensin2</I> …

    Biomedical Research 29(6), 279-287, 2008

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  • Erythropoietin-Producing Cells in the Liver of ICR-Derived Glomerulonephritis (ICGN) Mice

    YAMAGUCHI YAMADA Misuzu , AKASHI Naotsugu , GOTO Yasufumi , ANAN Sayuri , YAMAMOTO Yoshie , OGURA Atsuo , MANABE Noboru

    … 遺伝性腎疾患モデル(ICGN)マウスは, エリスロポイエチン(EPO)不足に起因する腎性貧血の優れたモデルであり, 発症中期ではEPO mRNAが腎臓だけでなく肝臓でも発現する.低酸素圧はICGNマウスの腎臓と肝臓でのEPO mRNA発現を誘導し, 未だ不明確な肝臓のEPO産生細胞が, 肝実質細胞ではなく非実質細胞であることを高感度in situ hybridization法にて明らかにした. …

    The journal of veterinary medical science 68(1), 65-68, 2006-01-25

    JASI  Ichushi Web  References (18)

  • Erythropoietin-Producing Cells in the Liver of ICR-Derived Glomerulonephritis (ICGN) Mice

    YAMAGUCHI-YAMADA Misuzu , AKASHI Naotsugu , GOTO Yasufumi , ANAN Sayuri , YAMAMOTO Yoshie , OGURA Atsuo , MANABE Noboru

    … The ICR-derived glomerulonephritis (ICGN) mouse is an appropriate model for anemia associated with chronic renal disorder (CRD). … EPO mRNA is expressed in both kidneys and liver of progressing-stage ICGN mice. … Hypoxic stimulation induced the EPO mRNA expression in the liver as well as in the kidneys of ICGN mice. …

    Journal of Veterinary Medical Science 68(1), 65-68, 2006

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  • Dysfunction of Erythropoietin-Producing Interstitial Cells in the Kidneys of ICR-derived Glomerulonephritis (ICGN) Mice

    YAMAGUCHI YAMADA Misuzu , MANABE Noboru , KISO Minako , GOTO Yasufumi , MORI Toshiharu , SAKATA Chinatsu , ANAN Sayuri , NAGAO Masaya , YAMAMOTO Yoshie , OGURA Atsuo

    … から未解明である.ICR系マウスの突然変異体であるICR-derived glomerulonephritis (ICGN)系マウスはすぐれた腎性貧血モデルである.本研究では, EPO産生細胞を高感度in situ hybridization (ISH)法にて検出し, また低酸素(7%酸素, 2時間曝露)応答の違いを定量的リアルタイムRT-PCR法によるEPOmRNA量と血清中EPO濃度を計測して, 成雄性ICR系マウスとICGN系マウス(発症初期)間で比較した.両系統ともEPO産生細胞は腎皮質中間部尿 …

    Journal of Veterinary Medical Science 67(9), 891-899, 2005-09-25

    J-STAGE  JASI  Ichushi Web  References (37)

  • Effect of Human Erythropoietin (hEPO) Treatment on Anemia in ICR-derived Glomerulonephritis (ICGN) Mice

    MIYAMOTO Yohei , KURAMITSU MIYAMOTO Keiko , IWANAGA Ema , UCHIO YAMADA Kozue , YAMAGUCHI YAMADA Misuzu , OGURA Atsuo , MANABE Noboru

    … ICR-derived glomerulonephritis (ICGN) mice are a novel inbred strain with hereditary nephrotic syndrome and are thus considered a good animal model of human idiopathic nephrotic syndrome. … In the present study, we investigated the effect to erythrocyte production by human erythropoietin (hEPO) treatment in ICGN mice during the early nephrotic stage. …

    Experimental Animals 54(2), 181-184, 2005-04-01

    J-STAGE  Ichushi Web  References (16)

  • Decreased Expression of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinase in the Kidneys of Hereditary Nephrotic (ICGN) Mice

    UCHIO YAMADA Kozue , MANABE Noboru , GOTO Yasufumi , ANANN Sayuri , YAMAMOTO Yoshie , TAKANO Kaoru , OGURA Atsuo , MATSUDA Junichiro

    ICGNマウスの腎糸球体および尿細管間質においてECMの過剰蓄積ならびにMMP活性の低下が認められ,MMP活性の低下がICGNマウスの病態進行に関与していると考えられたので,本研究においてMMPおよびTIMPの発現をウェスタンブロット法ならびに免疫染色法にて調べた.健常対照のICRマウス腎臓と比較してICGNマウス腎臓のMMP-2,MMP-9,MT1-MMP,TIMP-1,TIMP-2発現量が減少していた.これらの所見は, …

    The Journal of veterinary medical science 67(1), 35-41, 2005-01-25

    JASI  Ichushi Web  References (20)

  • Decreased Expression of Matrix Metalloproteinases and Tissue Inhibitors of Metalloproteinase in the Kidneys of Hereditary Nephrotic (ICGN) Mice

    UCHIO-YAMADA Kozue , MANABE Noboru , GOTO Yasufumi , ANANN Sayuri , YAMAMOTO Yoshie , TAKANO Kaoru , OGURA Atsuo , MATSUDA Junichiro

    … In glomeruli and tubulointerstitum of hereditary nephrotic (ICR-derived glomerulonephritis: ICGN) mouse kidneys, hyper-accumulation of ECM components occurred, and MMP activity decreased. … In the present study, because lower levels of MMP activity may contribute to the progression of renal fibrosis in ICGN mice, Western blotting analysis and immunohistochemical staining for MMPs and TIMPs were performed to verify the expression levels of these proteins. …

    Journal of Veterinary Medical Science 67(1), 35-41, 2005

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