Search Results 1-20 of 1769

  • TLR2/4 signaling pathway mediates sperm-induced inflammation in bovine endometrial epithelial cells in vitro

    Ezz Mohamed Aboul , Marey Mohamed Ali , Elweza Ahmed Essam , Kawai Tomoko , Heppelmann Maike , Pfarrer Christiane , Balboula Ahmed Zaky , Motaser Abdelmonem , Imakawa Kazuhiko , Zaabel Samy Moawad , Shimada Masayuki , Miyamoto Akio

    … 0, 0.1, 1, and 10 ng/ml) for 0, 1, 3, or 6 h, followed by evaluating mRNA expression of the pro-inflammatory genes (TNFA, IL-1B, IL-8, and PGES) in BEECs using a real-time PCR. …

    PLoS ONE 14(4), e0214516, 2019-04

    IR 

  • Alteration of specific cytokine expression patterns in patients with breast cancer

    Kawaguchi Kosuke , Sakurai Masashi , Yamamoto Yasuko , Suzuki Eiji , Tsuda Moe , Kataoka Tatsuki R. , Hirata Masahiro , Nishie Mariko , Nojiri Takashi , Kumazoe Motofumi , Saito Kuniaki , Toi Masakazu

    … of breast cancer patients compared to healthy volunteers with (1) VEGF, IL-9, GM-CSF, IL-13, IL-4, and IFNγ, (2) IL-8, IL-10, IL-12, IL-5, IL-7, IL-1α, GCSF, IL-1β, and TNFα and (3) IL-2, Eotaxin, MIP1β, MIP1α, IL-17, and …

    Scientific Reports (9), 2019-02-27

    IR 

  • PAI-1 secreted from metastatic ovarian cancer cells triggers the tumor-promoting role of the mesothelium in a feedback loop to accelerate peritoneal dissemination

    Peng Yang , Kajiyama Hiroaki , Yuan Hong , Nakamura Kae , Yoshihara Masato , Yokoi Akira , Fujikake Kayo , Yasui Hiroaki , Yoshikawa Nobuhisa , Suzuki Shiro , Senga Takeshi , Shibata Kiyosumi , Kikkawa Fumitaka

    ファイル公開:2020-02-01

    Cancer Letters (442), 181-192, 2019-02

    IR 

  • 2′-Fucosyllactose Attenuates Particulate Matter-Induced Inflammation <i>via</i> Inhibition of Hypoxia-Inducible Factor in Keratinocytes

    Lee Kyung-Eun , Ryu Jung Jin , Jo Young Kwan , Yeo Hyeonju , Kang Seunghyun

    … 2FL reduced PM<sub>10</sub>-induced excess expression of interleukin (IL)-6, IL-8, IL-1α and IL-1β in HaCaT keratinocytes. …

    Biological and Pharmaceutical Bulletin 42(10), 1620-1627, 2019

    J-STAGE 

  • Pathogens-derived TLR2/4 ligands disrupt the uterine immune response to bovine sperm <i>in vitro</i>  [in Japanese]

    ELESH Ibrahim Fouad , MAREY Mohamed Ali , MIYAMOTO Akio

    … TNFA, IL-1B, IL-8, PGES, TLR2</i>, and <i>TLR4</i>. … First, the pathologically high doses of PGN (100 ng and 1 mg/ml) and LPS (100 ng and 1 mg/ml) stimulated the mRNA expression of <i>TNFA</i>, <i>IL-1B, IL-8</i> … Sperm alone upregulated <i>TNFA, IL-1B, IL-8</i> …

    The Journal of Reproduction and Development Supplement 112(0), P-77-P-77, 2019

    J-STAGE 

  • Effect of seminal plasma after dialysis or inactivated treatment on endometrial cytokine expression in vitro  [in Japanese]

    OKUYAMA Minami W , UCHIKURA Kenzo , TAJIMA Shigeyuki , NARAHARA Hisashi , NISHIZONO Akira

    … 経産豚の屠畜子宮から単離した子宮内膜上皮細胞の初代培養系において,精漿を10%で培養液に添加し3,12,24時間後におけるインターロイキン(IL)-1β,2,6,8,COX-2のmRNA発現を定量した。 … 【結果と考察】精漿添加後,mRNAの発現量は培養開始時に比べIL-1β,2,8は経時的に上昇し,IL-6およびCOX-2では低下した。 …

    The Journal of Reproduction and Development Supplement 112(0), OR2-8-OR2-8, 2019

    J-STAGE 

  • Aging related factors IL-1α and IL-1β influences inflammatory response in bovine oviduct epithelial cells  [in Japanese]

    NAKAMURA Yuki , NOGUCHI Tatuo , SAKAGAMI Nobutada , IWATA Hisataka , KUWAYAMA Takehito , SHIRASUNA Komei

    … <p>【目的】老化細胞は炎症を誘導する分泌因子(IL-1β,IL-8やTNFα)を高発現し,加齢性疾患に関与する。 … 私達は,若齢のウシ卵管上皮細胞(OEC)と比較し老齢でIL-1αやIL-1β発現が高く,慢性炎症が起きることを報告した。 …

    The Journal of Reproduction and Development Supplement 112(0), OR2-13-OR2-13, 2019

    J-STAGE 

  • Ouabain signaling in oral squamous cell carcinoma cells

    Saito Satsuki , Ohtsu Mariko , Asano Masatake , Ishigami Tomohiko

    … This study examined the effects of ouabain stimulation on spontaneous interleukin (IL)-8 and IL-1α secretion in the HSC3 oral squamous cell carcinoma cell line. … IL-8 secretion was reduced and IL-1α secretion was increased in the cells. …

    Journal of Oral Science, 2019

    J-STAGE 

  • Leptin enhances cytokine/chemokine production by normal lung fibroblasts by binding to leptin receptor

    Watanabe Kaoru , Ohta Ken , Suzukawa Maho , Arakawa Sayaka , Kobayashi Koichi , Igarashi Sayaka , Tashimo Hiroyuki , Nagai Hideaki , Tohma Shigeto , Nagase Takahide

    … Leptin enhanced production of CCL11/Eotaxin, monocyte chemoattractant protein-1 (CCL2/MCP-1), CXCL8/IL-8, interferon gamma-induced protein 10 (CXCL10/IP-10) and IL-6 by NHLFs at both the protein and messenger ribonucleic acid (mRNA) levels. …

    Allergology International 68(Supplement.1), S3-S8, 2019

    J-STAGE 

  • Preventive Effects of <i>Lactobacillus plantarum</i> CQPC07 on Colitis Induced by Dextran Sodium Sulfate in Mice

    Zhang Jing , Chen Xiaoliang , Song Jia-Le , Qian Yu , Yi Ruokun , Mu Jianfei , Zhao Xin , Yang Zhennai

    … Analyses of the sera of mice showed that LP can reduce the level of serum endothelin (ET), substance P (SP), and interleukin-10 (IL-10), enhance the activity of somatostatin (SS) and vasoactive intestinal peptide (VIP), and increase the levels of IL-2. …

    Food Science and Technology Research 25(3), 413-423, 2019

    J-STAGE 

  • Role of endoplasmic reticulum stress in lipopolysaccharide-inhibited mouse granulosa cell estradiol production

    LEI Lanjie , GE Junbang , ZHAO Hui , WANG Xiangguo , YANG Lei

    … Our results showed that LPS increased the pro-inflammatory cytokines [(interleukin (IL)-1β, IL-6, IL-8, and tumor necrosis factor (TNF)-α)], activated ER stress marker protein expression [(glucose-regulated protein 78 (GRP78) and CCAAT/enhancer-binding protein homologous protein (CHOP)], and decreased cytochrome P450 family 19 subfamily A member 1 (Cyp19a1) expression and E<sub>2</sub> …

    Journal of Reproduction and Development, 2019

    J-STAGE 

  • The Relationship between the Use of Cold and Isothermic Blood Cardioplegia Solution for Myocardial Protection during Cardiopulmonary Bypass and the Ischemia–Reperfusion Injury

    Saclı Hakan , Kara Ibrahim , Diler Mevriye Serpil , Percin Bilal , Turan Ahmet Ilksoy , Kırali Kaan

    … 6 (IL-6), IL-8, IL-10, and complement factor 3a (C3a) levels, metabolic parameters, creatine kinase-muscle/brain (CK-MB) and high-sensitivity Troponin I (hsTn-I), and clinical outcomes.</p><p>Results: Comparison of the markers of ischemia–reperfusion injury showed significantly higher levels of the proinflammatory cytokine IL-6 in the early postoperative period as well as IL-8, in …

    Annals of Thoracic and Cardiovascular Surgery, 2019

    J-STAGE 

  • Acute inflammatory and immunologic responses against antigen in chronic bird-related hypersensitivity pneumonitis

    Inoue Yukihisa , Ishizuka Masahiro , Furusawa Haruhiko , Honda Takayuki , Kawahara Tatsuo , Tateishi Tomoya , Miyazaki Yasunari

    … Neutrophil chemoattractants, namely, granulocyte colony-stimulating factor, IL-6, IL-8, IL-17, and CXCL2 significantly increased in both the serum and BALF of the BRHP patients after the IPT. …

    Allergology International 68(3), 321-328, 2019

    J-STAGE 

  • Evaluation of cytokine storms in a Disseminated Intravascular Coagulation monkey model  [in Japanese]

    HIRASAWA Yoshitaka , FUJIWARA Atsushi , TABATA Kazuya , YOSHIDA Kenji , NEGAMA Tsutomu , SHIN-ICH Sato

    … 差反応性を示したIL-6を測定しLuminexの測定値と比較した.</p><p>その結果,DICでのサイトカインストームでは炎症性サイトカインのIL-6,IL-8,TNF-α,抗炎症性サイトカインのIL-10が顕著に上昇した.また,IL-1ra,IL-2,IL-5,IL-6,IL-15, …

    Annual Meeting of the Japanese Society of Toxicology 46.1(0), P-145, 2019

    J-STAGE 

  • Exposure to inorganic arsenic possibly aggravates cutaneous allergy  [in Japanese]

    FUKUYAMA Tomoki , SUZUKI Momoka , OGATA Yuri , KURATA Keigo

    … まず、ヒト好酸球性白血病細胞 (EOL-1) 、ヒト急性単球性白血病細胞 (THP-1) およびヒト表皮正常角化細胞 (PHK16-0b) に無機ヒ素を24時間曝露し、リポ多糖 (LPS) ないしダニ抗原抽出物 (ITEA株式会社) 刺激による炎症性サイトカイン産生量 (IL-1β, IL-8, TNFα) をELISA法により測定した。 …

    Annual Meeting of the Japanese Society of Toxicology 46.1(0), P-143, 2019

    J-STAGE 

  • Induction of extravasation by antimicrotubule agents and mechanism of skin lesions  [in Japanese]

    TAKAISHI Masaki , TAMURA Yushi , YAMAMURO Aiko , HANADA Ayaka , SAGAWA Takumi , TAKEDA Toshiaki , ASANO Satoshi

    … ②正常ヒト皮膚線維芽細胞(SF-TY細胞)にPTX, DOC及びVNRの臨床用薬液の希釈溶液を24時間曝露し、培養上清を回収してELISA法にてIL-6濃度を定量した。 … ③SF-TY細胞にPTX, DOC及びVNRの臨床用薬液の希釈溶液を24, 48時間曝露し、培養上清を回収してELISA法にてIL-8濃度を定量した。 … ②いずれの微小管機能阻害薬の曝露においても、IL-6濃度が有意に上昇した。 …

    Annual Meeting of the Japanese Society of Toxicology 46.1(0), P-218, 2019

    J-STAGE 

  • Development of new therapeutic agents for preterm birth by glycosaminoglycan chain remodeling of urinary trypsin inhibitor

    Tanaka Seigo , Kakizaki Ikuko , Tanaka Kanji , Kodama Tomoe , Ito-Fukuyama Asami , Suto Shinichiro , Takahashi Ryoki , Yokoyama Yoshihito

    … These UTIs were added to UCFs obtained from gynecology operations, and the effects of UTIs on the release of IL-8, IL-6, MMP-8, and MMP-9 were examined.</p><p><b>Results:</b> … UTIs that were not hydrolyzed tended to reduce IL-8 release more strongly than GAG chain-hydrolyzed UTIs. … IL-6 was not affected by GAG chain hydrolysis of UTIs. …

    Hypertension Research in Pregnancy 7(1), 27-35, 2019

    J-STAGE 

  • Distribution and expression of IL-17 and related cytokines in children with <i>Mycoplasma pneumoniae</i> pneumonia

    Fan Huifeng , Lu Bingtai , Yang Diyuan , Zhang Dongwei , Shi Tingting , Lu Gen

    … In this study, we used FCM (Flow Cytometry) to analyze IL-17 and related cytokines in plasma and bronchoalveolar lavage fluid (BALF) samples from 18 patients with general MPP (GMPP) and 30 patients with refractory MPP (RMPP). … The levels of IL-1Ra, IL-6, IL-8, IL-17 and TNF-α were significantly elevated in the BALF of MPP children compared with the plasma (P<0.01). …

    Japanese Journal of Infectious Diseases, 2019

    J-STAGE 

  • 20190520  [in Japanese]

    杉浦 一充

    … t;IL36RN</i>遺伝子あるいは<i>CARD14</i>遺伝子である.<i>IL36RN</i>遺伝子変異により遺伝子産物のIL-36受容体拮抗因子(IL-36Ra)機能欠損を引き起こす.IL-36Ra欠損症の膿疱形成のメカニズムは以下のとおりである.最初にTLR-4リガンド,TNF-α,IL-1β,IL-17A等によりIL-3 …

    The Japanese Journal of Dermatology 129(6), 1311-1315, 2019

    J-STAGE  Ichushi Web 

  • The acute pulmonary toxicity in mice induced by <i>Staphylococcus aureus</i>, particulate matter, and their combination

    Wang Fan , Wang Ruiling , Liu Haifang

    … Meanwhile, the ratio of interleukin (IL)-4 to interferon (INF)-γ, the IL-4 level in BALF, and the IgE concentration in sera were significantly increased in the groups exposed to <i>S</i>. … Substance P and IL-8 in BALF were significantly increased in mice exposed to PM, <i>S. …

    Experimental Animals 68(2), 159-168, 2019

    J-STAGE 

Page Top