Search Results 1-20 of 31

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  • In vivo whole-cell recordings from amygdalar neurons  [in Japanese]

    Sato Yu , Ikegaya Yuji

    … However, the neural basis of the synchronization has not been addressed, mainly because it is difficult to identify projecting neurons using extracellular recordings, which are widely used to record neuronal firing activity. … Patch-clamp recordings, an intracellular recording technique, enable to record synaptic inputs and label the projection of the recorded neurons. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 93(0), 1-YIA-27, 2020

    J-STAGE 

  • Multilevel innervations to the auditory pathway by GABAergic neurons in the mouse basal ganglia

    Zhou Bo , Tomioka Ryohei , Sakimura Kenji , Yanagawa Yuchio , Tamamaki Nobuaki , Song Wen-Jie

    聴覚研究会資料 = Proceedings of the auditory research meeting 49(2), 85-88, 2019-05-25

  • Classification of Inhibitory and Excitatory Neurons of Dissociated Cultures Based on Action Potential Waveforms on High-density CMOS Microelectrode Arrays  [in Japanese]

    Mita Takeshi , Bakkum Douglas , Frey Urs , Hierlemann Andreas , Kanzaki Ryohei , Takahashi Hirokazu

    … <p>Electrophysiological data from <i>in vivo</i> … However, this criterion has not yet been established in dissociated cultured neurons. … In the present study, we used a high-density CMOS microelectrode array to extracellularly investigate neural signals in primary dissociated cultures of rat neocortex, and we characterized AP waveforms to discriminate excitatory and inhibitory neurons. …

    IEEJ Transactions on Electronics, Information and Systems 139(5), 615-624, 2019

    J-STAGE 

  • Spike timing regularity depends on the firing time scale under propofol-induced anesthetic condition

    Kajiwara Mie , Kato Risako , Oi Yoshiyuki , Kobayashi Masayuki

    … <p>Propofol is widely used for general anesthesia and sedation in various medical procedures. … Propofol produces unconsciousness by potentiating γ-aminobutyric acid type A (GABA<sub>A</sub>) receptor-mediated inhibitory synaptic currents, however, little is known how propofol modulates the activities of the cortical local circuits <i>in vivo</i>. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO4-1-72, 2018

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  • Human Pluripotent Stem Cell-Derived Cardiac Tissue-like Constructs for Repairing the Infarcted Myocardium

    Li Junjun , Minami Itsunari , Shiozaki Motoko , Yu Leqian , Yajima Shin , Miyagawa Shigeru , Shiba Yuji , Morone Nobuhiro , Fukushima Satsuki , Yoshioka Momoko , Li Sisi , Qiao Jing , Li Xin , Wang Lin , Kotera Hidetoshi , Nakatsuji Norio , Sawa Yoshiki , Chen Yong , Liu Li

    新規ナノファイバー・iPS細胞由来心筋組織片を用いた再生医療技術の開発 --安全・配向・3次元心筋組織の構築に成功--. 京都大学プレスリリース. 2017-10-30.

    Stem Cell Reports 9(5), 1546-1559, 2017-11-14

    IR 

  • Noradrenergic inhibition of spinal hyperexcitation elicited by cutaneous cold stimuli in rats with oxaliplatin-induced allodynia : electrophysiological and behavioral assessments

    Choi Seunghwan , Yamada Akihiro , Kim Woojin , Kim Sun Kwang , Furue Hidemasa

    The journal of physiological sciences 67(3), 431-438, 2017-05

    Ichushi Web 

  • Revealing neural and circuit pathophysiology of neuropsychiatric disorders  [in Japanese]

    Sugaya Yuki

    … 本稿では,てんかんの病態の解明という具体例を紹介しながら,細胞外電位記録,多点電極による電流源密度解析,パッチクランプ法,optogeneticsといったin vivoにおける研究手法の利点や欠点を簡単に解説する。 …

    Japanese Journal of Biological Psychiatry 28(3), 117-120, 2017

    J-STAGE  Ichushi Web 

  • Effects of General Anesthesia with Propofol on Thalamocortical Sensory Processing in Rats

    Zhang Yi , Li Zhaoduan , Dong Hui , Yu Tian

    … Using the extracellular recording technique, we investigated the changes of spontaneous and stimulation-evoked activities within and between the ventral posteromedial nucleus (VPM) and primary somatosensory cortex barrel field (S1BF) of the rat in vivo during propofol anesthesia. …

    Journal of Pharmacological Sciences 126(4), 370-381, 2014

    J-STAGE  Ichushi Web 

  • In vivo multiple extracellular recording of optogentically evoked rat striatal firing  [in Japanese]

    Ohta Hiroyuki , Yukawa Suguru , Tamura Risa , Tashiro Akimasa , Takeuchi Kyoko , Nishida Yasuhiro

    … We are investigating a firing prolongation of the rat striatal neuron after the repetitive optogenetic stimulation observed in an acute striatal slice. … In this report, we tested whether the prolongation could be observed in vivo. … Wistar Thy-1.2 promoter ChannelRhodopsin-2 Venus Rats were anesthetized and placed in a stereotaxic frame. …

    Transactions of Japanese Society for Medical and Biological Engineering 52(Supplement), OS-71-OS-72, 2014

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  • Effects of subchronic aluminum exposure on spatial memory, ultrastructure and L-LTP of hippocampus in rats

    ZHANG Lifeng , JIN Cuihong , LIU Qiufang , LU Xiaobo , WU Shengwen , YANG Jinghua , DU Yanqiu , ZHENG Linlin , CAI Yuan

    … Long-term potentiation (LTP) is one form of synaptic plasticity in association with cognitive function. … Previous studies have demonstrated that Al impaired early phase long-term potentiation (E-LTP) <i>in vivo</i> … and <i>in vitro</i>. … The present study was designed to observe the effects of subchronic Al exposure on the spatial memory, hippocampus ultrastructure and L-LTP in rats. …

    The Journal of Toxicological Sciences 38(2), 255-268, 2013-04-01

    J-STAGE  Ichushi Web  References (68)

  • Distinct neural firing mechanisms to tonal stimuli offset in the inferior colliculus of mice in vivo.

    … Offset neurons are found in most ascending auditory nuclei; … In this study, we examined offset neural responses to tonal stimuli in the inferior colliculus (IC) in vivo with extracellular and intracellular recording techniques in mice. …

    Neuroscience research 73(3), 224-237, 2012-07

    IR 

  • <b>Descending noradrenergic controls of spinal nociceptive </b><b>synaptic transmission </b>  [in Japanese]

    Sugiyama Daisuke , Imoto Keiji , Kawamata Mikito , Furue Hidemasa

    … There is considerable evidence that the bulbospinal noradrenergic system plays a significant role in pain modulation. … In the superficial dorsal horn of the spinal cord, noradrenaline was reported to act on the presynaptic terminals of primary afferent fibers (Aδ and C fibers) to reduce glutamate release, and on the presynaptic terminals of inhibitory interneurons to facilitate GABA and glycine releases. … Recently, we developed an <i>in vivo</i> …

    PAIN RESEARCH 26(1), 1-9, 2011

    J-STAGE 

  • Estimation of the 3D Neuronal Position by using Multiple-site Recording of Extracellular Action Potential  [in Japanese]

    KUBO Takashi , KATAYAMA Norihiro , KARASHIMA Akihiro , NAKAO Mitsuyuki

    … を与える重要な要因である.本研究では,細胞外活動電位の多点記録からニューロンと電極の3次元的な位置関係を推定する方法を提案する.さらに,多点記録する位置を微小に動かしたときに生ずるニューロンの位置ずれの情報から,電極周辺の機械的ひずみを視覚化する.本手法によりin vivo記録においても脳に埋め込まれた神経電極によるひずみの程度をオンサイトで定量的評価をすることが可能になる. …

    IEICE technical report 108(314), 21-24, 2008-11-14

    Ichushi Web  References (10)

  • Combined microdialysis with single cell recording to study mechanisms and consequences of dendritic peptide release within the rat supraoptic nucleus in vivo

    Ludwig Mike

    … To study the mechanisms and consequences of dendritic peptide release in vivo, we have combined microdialysis with single cell recording. …

    Proceedings of Annual Meeting of the Physiological Society of Japan 2008(0), 021-021, 2008

    J-STAGE 

  • Extracellular S100B modulates kainate-induced gamma oscillation by activating RAGE in vivo

    Sakatani Seiichi , Seto-Ohshima Akiko , Shinohara Yoshiaki , Itohara Shigeyoshi , Hirase Hajime

    … S100B is predominantly synthesized by astrocytes and secreted to the extracellular space. … We have previously shown that the amplitude of kainate-induced gamma oscillation in hippocampal CA1 stratum radiatum is significantly smaller in S100B knockout (KO) mice.To assess the contribution of extracellular S100B to the gamma oscillation, we performed local field potential recording with local infusion of S100B at CA1 str. …

    Proceedings of Annual Meeting of the Physiological Society of Japan 2008(0), 124-124, 2008

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  • Pharmacological Action of N-acylated Muscimol

    Tamura Keita , Ishibashi Hitoshi , Hanaoka Kenjiro , Koyama Minoru , Nagano Tetsuo , Nabekura Junichi , Miyashita Yasushi

    In this study, we synthesized two N-acyl muscimol derivatives and purified them thoroughly. … Their pharmacological effects on neurons were examined by whole-cell patch clamp in vitro and extracellular recording in vivo. … This discrepancy might arise from the difference in the grade of purification to remove residual unreacted muscimol. …

    Proceedings of Annual Meeting of the Physiological Society of Japan 2008(0), 083-083, 2008

    J-STAGE 

  • A novel targeted patch-clamp recordings from mammalian neurons in vivo

    Kitamura Kazuo

    … Making patch-clamp recordings <I>in vivo</I> … Previous methods for targeted patching (Margrie et al., 2003) require neurons to be fluorescently labeled, either by use of transgenic animals or viral transfection.We have developed a new approach for making targeted patch-clamp recordings from unlabeled neurons <I>in vivo</I> …

    Proceedings of Annual Meeting of the Physiological Society of Japan 2007(0), 027-027, 2007

    J-STAGE 

  • Mechanisms for the Anti-nociceptive Actions of the Descending Noradrenergic and Serotonergic Systems in the Spinal Cord

    YOSHIMURA Megumu , FURUE Hidemasa

    … Both behavioral and in vivo extracellular recording studies have sought the loci producing analgesia and clarification of the anti-nociceptive actions. … Although, in vivo studies have provided basic knowledge of these systems, the precise synaptic mechanisms underlying the analgesic actions have not yet been elucidated until recently. …

    Journal of Pharmacological Sciences 101(2), 107-117, 2006-06-20

    J-STAGE  Ichushi Web  References (84) Cited by (4)

  • Extracellular Glutamate Release in the Edentulous Rat Hippocampus following Tetanic Stimulation : in vivo Study by Microdialysis

    OKUDA Keiji , INOUE Hiroshi , SAKUMA Yasushi

    … Loss of molar teeth in rats has been reported to be associated with impairment of spatial memory, which may be related to hypo function of the hippocampus. … In the present study, the glutamate levels in the hippocampus were measured as an index of the functions of the hippocampus, in order to elucidate the neurochemical changes in the brain in edentulous rats.<br><b>Methods:</b> …

    Prosthodontic Research & Practice 5(1), 37-43, 2006-01-01

    J-STAGE  Ichushi Web  References (25) Cited by (4)

  • Involvement of endogenously released ATP in the generation of network-driven spontaneous oscillation in the neonatal hippocampus

    Kato Fusao , Kawamura Masahito , Yamaoka Masayoshi

    … The earliest organized intrinsic activity in the hippocampal network appears during the perinatal period, which is characterized by slow synchronized bursting of the pyramidal neurons and interneurons in forms of giant depolarizing potentials (GDPs) in the slices and "sharp waves" in vivo. … These activities are proposed to be involved in the maturation of the interneuronal networks (Ben-Ari et al., 2004). …

    Proceedings of Annual Meeting of the Physiological Society of Japan 2006(0), 015-015, 2006

    J-STAGE 

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