Search Results 1-20 of 1324

  • Vitamin K2 Suppresses Proliferation and Inflammatory Cytokine Production in Mitogen-Activated Lymphocytes of Atopic Dermatitis Patients through the Inhibition of Mitogen-Activated Protein Kinases

    Zhang Meiyu , Miura Taro , Suzuki Shunsuke , Chiyotanda Masako , Tanaka Sachiko , Sugiyama Kentaro , Kawashima Hisashi , Hirano Toshihiko

    … At 10–100 µM, vitamin K2 markedly decreased the of Mek1, extracellular signal-regulated kinases (ERK)1/2 mitogen-activated protein kinase, and SAPK/c-Jun N-terminal kinase (JNK) expression in atopic dermatitis PBMCs (<i>p</i> < 0.05). … Vitamin K2 is suggested to attenuate activated T-cell immunity in atopic dermatitis patients through the inhibition of mitogen-activated protein kinase-Mek1-ERK1/2 and SAPK/JNK signaling pathways.</p> …

    Biological and Pharmaceutical Bulletin 44(1), 7-17, 2021

    J-STAGE 

  • Epigallocatechin-3-Gallate Suppresses the Expression of TNF-α-Induced MMP-1 <i>via</i> MAPK/ERK Signaling Pathways in Human Dermal Fibroblasts

    Won Hea-Ryeoun , Lee Pyeongjae , Oh Sol-ra , Kim Yong-Min

    … EGCG also reduced the phosphorylation of extracellular signal regulated kinase (ERK) significantly but not that of p38 activation and c-Jun N-terminal kinase (JNK). …

    Biological and Pharmaceutical Bulletin 44(1), 18-24, 2021

    J-STAGE 

  • Molecular mechanism of cell competition identified in Drosophila  [in Japanese]

    永田 理奈 , 井垣 達吏

    医学のあゆみ 274(5), 406-412, 2020-08-01

    Ichushi Web 

  • Signaling pathways in the coral polyp bail-out response

    Po-Shun Chuang , Satoshi Mitarai

    … Furthermore, in the XIAP, JNK, and NFKB1 genes, we detected a third expression profile showing linear upregulation that becomes maximal at the endpoint salinity level of the experiment (46.0%), indicating activation of anti-apoptotic and cell survival signals during polyp bail-out. …

    Coral Reefs 39(6), 1535-1548, 2020-07-31

    IR 

  • Semaphorin3A-Inhibitor Ameliorates Doxorubicin-Induced Podocyte Injury

    Sang Yizhen , Tsuji Kenji , Inoue-Torii Akiko , Fukushima Kazuhiko , Kitamura Shinji , Wada Jun

    … In addition, c-Jun N-terminal kinase (JNK), known as a downstream of SEMA3A signaling, was activated in Dox-injected mouse podocytes while SEMA3A-I treatment partially blocked the activation. … In vitro, SEMA3A-I protected against Dox-induced podocyte apoptosis and recombinant SEMA3A caused podocyte apoptosis with activation of JNK signaling. …

    International Journal of Molecular Sciences 21(11), 4099, 2020-06-08

    IR 

  • JB Review : Factors regulating axon regeneration via JNK MAP kinase in Caenorhabditis elegans

    Shimizu Tatsuhiro , Hisamoto Naoki

    The journal of biochemistry 167(5), 433-439, 2020-05

  • Smad Phospho-Isoforms for Hepatocellular Carcinoma Risk Assessment in Patients with Nonalcoholic Steatohepatitis

    Suwa Kanehiko , Yamaguchi Takashi , Yoshida Katsunori , Murata Miki , Ichimura Mayuko , Tsuneyama Koichi , Seki Toshihito , Okazaki Kazuichi

    … TGF-βtype I receptor (TβRI) and c-Jun N-terminal kinase (JNK) differentially phosphorylate the mediator Smad3, resulting in 2 distinct phospho-isoforms: C-terminally phosphorylated Smad3 (pSmad3C) and linker-phosphorylated Smad3 (pSmad3L). … In mature hepatocytes, oncogenic signaling via the JNK/pSmad3L pathway antagonizes signaling via the tumor-suppressive TβRI/pSmad3C pathway. …

    Cancers 12(2), 286, 2020-01-24

    IR 

  • Knockdown of long non-coding RNA LINC00473 protects CHON-001 cells against interleukin-1β-induced cell injury

    Ou Dijun , Ding Wenbin , Tong Changjun , Yi Weihong

    … Moreover, JNK/NF-κB signaling pathway was proved to be involved in the cell protective effect of LINC00473 knockdown in IL-1β treated CHON-001 cells.<b> …

    Biological and Pharmaceutical Bulletin, 2020

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  • Functional roles of TRAF2 in cisplatin-induced apoptosis  [in Japanese]

    SHIMADA Tatsuya , TSUCHIDA Mei , YOKOSAWA Takumi , HIRATA Yusuke , NOGUCHI Takuya , MATSUZAWA Atsushi

    … <p>TRAF2 (tumor necrosis factor receptor-associated factor 2) は、NF-κB (nuclear factor-κB) やJNK (c-Jun N-terminal kinase) シグナル経路の主要な制御因子である。 … その結果、TRAF2欠損細胞では、シスプラチン依存的な癌抑制因子p53の安定化とJNKの活性化が減弱し、シスプラチン誘導性アポトーシスに抵抗を示した。 …

    Annual Meeting of the Japanese Society of Toxicology 47.1(0), P-73S, 2020

    J-STAGE 

  • Mechanism involved in the induction of OSM expression by methylmercury in microglia  [in Japanese]

    HOSHI Takayuki , TOYAMA Takashi , NAGANUMA Akira , SAITO Yoshiro , HWANG Gi-Wook

    … STAT3の活性化にはJAK1キナーゼが、一方でcJunの活性化にはASK1/JNKキナーゼ経路がそれぞれ関与するとの報告がある。 … 以上のことから、メチル水銀はJAK1/STAT3およびASK1/JNK/cJunシグナル伝達経路を活性化させることでOSMの発現を誘導していることが示唆された。 …

    Annual Meeting of the Japanese Society of Toxicology 47.1(0), P-8E, 2020

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  • Possible therapeutic agents for diphenylarsinic acid-induced aberrant activation of rat cerebellar astrocytes: heavy metal ion chelating agents  [in Japanese]

    NEGISHI Takayuki , SASAKI Shoto , WAKASUGI Shuya , TAKAGI Ayumi , SHIBATA Tomoka , TSUZUKI Takamasa , YUKAWA Kazunori

    … 々はこれまでに、DPAAがラット小脳由来培養アストロサイト（NRA）において、濃度・時間依存的に細胞増殖亢進と続く細胞死、低濃度長時間曝露（10 μM、96時間）により酸化ストレス応答因子（Nrf2、HO-1、およびHsp70）の発現誘導、MAPキナーゼ（ERK1/2、p38MAPK、SAPK/JNK）のリン酸化亢進、および転写因子（CREB、c-Jun、およびc-Fos）のリン酸化亢進または発現誘導などの細胞内異常活性化を引き起こすことを明らかにしてきた。 …

    Annual Meeting of the Japanese Society of Toxicology 47.1(0), P-205, 2020

    J-STAGE 

  • <i>trans</i>-Fatty acids promote DNA damage-induced apoptosis via the mitochondrial JNK-Sab-ROS axis  [in Japanese]

    INOUE Aya , HIRATA Yusuke , NOGUCHI Takuya , MATSUZAWA Atsushi

    … エライジン酸存在下では、doxorubicin処置時のストレス応答性MAPキナーゼJNK/p38の活性化およびミトコンドリアROS産生が増強した。 …

    Annual Meeting of the Japanese Society of Toxicology 47.1(0), P-17S, 2020

    J-STAGE 

  • Inhibitory effects of Antrodia cinnamomea extract on proliferation and metastasis of endometrial cancer cells  [in Japanese]

    KO Tsui Ling , CHANG Tzu Hsien , CHEN Ya Ling , HSU Hsia Fen , CHANG Chi Chang , HOUNG Jer Yiing

    … In the protein expression, the results revealed that AFE can reduced the expression of MMP-2 and MMP-9 by inhibited the protein expression of phosphorylated p38, JNK, ERK and NF-κB, thereby inhibiting the proliferation and migration of RL95-2 cells.</p><p></p><p></p><p>Keywords: Endometrial cancer cells, Antrodia cinnamomea, inhibition of cell proliferation, cell migration, cell invasion.</p> …

    Annual Meeting of the Japanese Society of Toxicology 47.1(0), P-192, 2020

    J-STAGE 

  • Atriplex nummularia extract suppresses RANKL-activated osteoclastogenesis  [in Japanese]

    KO Tsui Ling , KUO Han Chun , YANG Jyh Ferng , CHANG Chi Chang , WANG Shih Wei , HOUNG Jer Yiing

    … ANE significantly inhibited RANKL-induced activation of NFATc1, TRAF6, NF-κB, JNK, ERK, p38 and MMP-9 during osteoclast differentiation from RAW264.7 cells. …

    Annual Meeting of the Japanese Society of Toxicology 47.1(0), P-201, 2020

    J-STAGE 

  • A mechanism involved in methylmercury induced TNF-α expression in microglia  [in Japanese]

    TOYAMA Takashi , HOSHI Takayuki , SAITO Yoshiro , NAGANUMA Akira , HWANG Gi-Wook

    … ASK1下流のMAPキナーゼであるp38、JNKおよびERKはいずれもメチル水銀によって活性化されていたが、これらの中でp38の阻害剤処理でのみメチル水銀によるTNF-αの発現誘導が抑制された。 …

    Annual Meeting of the Japanese Society of Toxicology 47.1(0), P-112, 2020

    J-STAGE 

  • Inhibition of S1P Receptor 2 Attenuates Endothelial Dysfunction and Inhibits Atherogenesis in Apolipoprotein E-Deficient Mice

    Ganbaatar Byambasuren , Fukuda Daiju , Shinohara Masakazu , Yagi Shusuke , Kusunose Kenya , Yamada Hirotsugu , Soeki Takeshi , Hirata Ken-ichi , Sata Masataka

    … S1P2 antagonist attenuated the phosphorylation of JNK in the abdominal aorta compared with vehicle (<i>p</i>＜0.05). … In HUVEC, S1P promoted inflammatory molecule expression such as MCP-1 and VCAM-1 <i>p</i>＜0.001), which was attenuated by S1P2 antagonist or a JNK inhibitor (<i>p</i>＜0.01). … S1P2 antagonist also inhibited S1P-induced JNK phosphorylation in HUVEC (<i>p</i>＜0.05).<b> …

    Journal of Atherosclerosis and Thrombosis, 2020

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  • Citrus flavonoids as a target for the prevention of pancreatic β-cells dysfunction in diabetes.  [in Japanese]

    K. Kaneko Yukiko , Kan Toshiyuki , Ishikawa Tomohisa

    … に対しても効果を示す可能性を検証した．膵β細胞株INS-1を用いた検討により，ノビレチンが濃度依存的にグルコース誘発インスリン分泌を促進すること，およびタプシガルギンにより誘発されるcaspase-3およびJNKの活性化を抑制し，抗アポトーシス作用を示すこと，さらに，インスリン分泌促進作用はEpac阻害薬，抗アポトーシス作用はプロテインキナーゼA阻害薬によりそれぞれ抑制されることが示された．一方，肥満2 …

    Folia Pharmacologica Japonica 155(4), 209-213, 2020

    J-STAGE  Ichushi Web 

  • Endoplasmic reticulum stress mediated apoptosis via JNK in MWCNT-exposed <i>in vitro</i> systems: size, surface functionalization and cell type specificity

    Chatterjee Nivedita , Choi Jinhee

    … By applying specific pharmaceutical inhibitors, relevant biomarkers gene and proteins expressions, we found that possibly MWCNT induce activation of IRE1α-XPB1 pathway-mediated ER-stress response, which in turn trigger apoptosis through JNK activation in both type of cells but with variable intensity. …

    The Journal of Toxicological Sciences 45(6), 305-317, 2020

    J-STAGE 

  • Induction of PD-L1 by Nitric Oxide <i>via</i> JNK Activation in A172 Glioblastoma Cells

    Kiriyama Yoshimitsu , Tani Anna , Kadoya Minako , Okamoto Ryoko , Nochi Hiromi

    <p>Glioblastoma comprises 54% of all the gliomas derived from glial cells and are lethally malignant tumors of the central nervous system (CNS). Glioma cells disrupt the blood–brain barrier, lea …

    Biological and Pharmaceutical Bulletin 43(6), 1020-1022, 2020

    J-STAGE 

  • <i>Dendrobium officinale</i> Attenuates Myocardial Fibrosis <i>via</i> Inhibiting EMT Signaling Pathway in HFD/STZ-Induced Diabetic Mice

    Zeng Jie , Li Dongning , Li Zhubo , Zhang Jie , Zhao Xiaoyan

    … In addition, the result of immunoblot indicated that DOE increased the expression of peroxisome proliferator activated receptor-α (PPAR-α), phosphorylation of insulin receptor substrate 1 (p-IRS1) and E-cadherin and repressed the expression of transforming growth factor β1 (TGF-β1), phosphorylation of c-Jun N-terminal kinase (p-JNK), Twist, Snail1 and Vimentin. …

    Biological and Pharmaceutical Bulletin 43(5), 864-872, 2020

    J-STAGE 

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