Search Results 1-20 of 32

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  • Femtosecond Laser Trimming of CVD-Diamond Coated Punch for Fine Embossing

    Aizawa Tatsuhiko , Shiratori Tomomi , Yoshino Tomoaki , Inohara Tadahiko

    … Fine embossing process into 0.1 mm thick AISI304 sheets with narrow clearance, was utilized to describe their plastic flow around the punch shoulder as well as the geometric distortion by elastic recovery. …

    MATERIALS TRANSACTIONS 61(2), 244-250, 2020

    J-STAGE 

  • G2A Protects Mice against Sepsis by Modulating Kupffer Cell Activation: Cooperativity with Adenosine Receptor 2b  [in Japanese]

    Dong-Keun Song

    … mice showed higher lethality, higher plasma cytokines, and an impaired bacterial clearance in response to a murine model of sepsis (cecal ligation and puncture), which were blocked by GdCl<sub>3</sub>, an inhibitor of Kupffer cells. … Anti-IL-10 Ab reversed the impaired bacterial clearance in G2A<sup>-/-</sup> … IL-10 levels and the impaired bacterial clearance. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society 92(0), JKL-13, 2019

    J-STAGE 

  • Purinergic P2Y<sub>2</sub> receptor is involved in dying cell phagocytosis and mediator production in Toll-like receptor 4-activated microglia

    Hide Izumi , Shiraki Hiroko , Yanase Yuhki , Shirafuji Toshihiko , Tanaka Shigeru , Hide Michihiro , Sakai Norio

    … The activation of Toll-like receptor 4 by lipopolysaccharide (LPS) promotes the production of inflammatory and protective mediators and phagocytosis. … Purinergic receptors play a pivotal role in the regulation of microglial function, but a specific role of purinergic receptors under LPS stimulation remains unclear. … In this study, we examined the change of purinergic receptors after LPS stimulation in microglia. …

    Proceedings for Annual Meeting of The Japanese Pharmacological Society WCP2018(0), PO1-1-115, 2018

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  • Emu Oil Reduces LPS-Induced Production of Nitric Oxide and TNF-α but not Phagocytosis in RAW 264 Macrophages

    Miyashita Tadayoshi , Minami Kazuhiro , Ito Minoru , Koizumi Ryosuke , Sagane Yoshimasa , Watanabe Toshihiro , Niwa Koichi

    … A murine macrophage cell line, RAW 264, was incubated in culture media supplemented with or without emu oil and stimulated with lipopolysaccharide (LPS). … The phagocytic activity of RAW 264 cells in the presence of LPS was unaffected by emu oil. … The results indicated that emu oil reduced the LPS-induced production of NO, TNF-α, and iNOS expression in a dose-dependent manner. …

    Journal of Oleo Science 67(4), 471-477, 2018

    J-STAGE  Ichushi Web 

  • Effects of exercise training on endotoxin clearance and inflammatory response  [in Japanese]

    KOMINE Shoichi , AKIYAMA Kentaro , WARABI Eiji , SHODA Junichi

    … 【目的】NAFLDの発症と進展には腸内細菌由来LPSやステロイドホルモンDHEAの産生・分泌が重要な役割を演じる.一方,運動はKCs貪食能の増大やステロイドホルモンの産生・分泌の変化を誘導しNAFLDを改善する.今回は,運動がLPSに対する生体のクリアランスと炎症応答に与える影響を検討した.また,運動によるステロイドホルモンの変動がKCsの表現形質に与える影響を検討した.【方法】<i><u&g …

    Annual Meeting of the Japanese Society of Toxicology 44.1(0), O-40, 2017

    J-STAGE 

  • Pharmacokinetics of ceftiofur in healthy and lipopolysaccharide-induced endotoxemic newborn calves treated with single and combined therapy

    ALTAN Feray , UNEY Kamil , ER Ayse , CETIN Gul , DIK Burak , YAZAR Enver , ELMAS Muammer

    … After a washout period, the same 6 calves received CS 2 hr after intravenous injection of lipopolysaccharide (LPS+Ceft group). … A third group of 6 calves received the same combination therapy regimen 2 hr after intravenous injection of lipopolysaccharide (LPS+Comb group). …

    Journal of Veterinary Medical Science 79(7), 1245-1252, 2017

    J-STAGE  Ichushi Web 

  • The Effects of the Human Host Defense Peptide LL-37 on Endothelial Cells

    SUZUKI KAORI , NAGAOKA ISAO

    … In this review, we describe the effects of LL-37 on endothelial cells and present the findings of our recent study, which revealed that LL-37 contributes to lipopolysaccharide (LPS) clearance by liver sinusoidal endothelial cells by forming complexes with Gram-negative LPS. …

    Juntendo Medical Journal 62(2), 105-111, 2016

    J-STAGE 

  • Akirin2 is critical for inducing inflammatory genes by bridging IκB-ζ and the SWI/SNF complex.

    Tartey Sarang , Matsushita Kazufumi , Vandenbon Alexis , Ori Daisuke , Imamura Tomoko , Mino Takashi , Standley Daron M , Hoffmann Jules A , Reichhart Jean-Marc , Akira Shizuo , Takeuchi Osamu

    … Consistently, effective clearance of Listeria infection required Akirin2. … BAF60 proteins were also essential for the induction of Il6 in response to LPS stimulation. …

    The EMBO Journal 33(20), 2332-2348, 2014-10-16

    IR 

  • Apoptotic cells suppress mast cell inflammatory responses via the CD300a immunoreceptor

    Nakahashi-Oda Chigusa , Tahara-Hanaoka Satoko , Shoji Masamichi , Okoshi Yasushi , Nakano-Yokomizo Takako , Ohkohchi Nobuhiro , Yasui Teruhito , Kikutani Hitoshi , Honda Shin-ichiro , Shibuya Kazuko , Nagata Shigekazu , Shibuya Akira , 小田 ちぐさ , 田原 聡子 , 大越 靖 , 大河内 信弘 , 本多 伸一郎 , 渋谷 和子 , 渋谷 彰

    … Instead, CD300a delivers an inhibitory signal in mast cells to suppress production of LPS-induced inflammatory cytokines and chemokines. … As a result, CD300a-deficient mice showed increased neutrophil recruitment and improved bacterial clearance in the peritoneal cavity, and survived longer than WT mice. … Antibody blockade of CD300a–PS interactions improved bacterial clearance and extended survival of WT mice subjected to CLP. …

    Journal of experimental medicine 209(8), 1493-1503, 2012-07

    IR 

  • A Rat Model of Early Sepsis: Relationships between Gentamicin Pharmacokinetics and Systemic and Renal Effects of Bacterial Lipopolysaccharide Combined with Interleukin-2

    Studena Sarka , Martinkova Jirina , Slizova Dasa , Krs Otakar , Senkerik Marian , Springer Drahomira , Chládek Jaroslav

    … A rat model of early sepsis induced by lipopolysaccharide (LPS) combined with interleukin-2 (IL-2) was developed. … Creatinine clearance was 2–3 times lower and fractional urea excretion was 3–4 times less in septic rats as compared to controls(<i>p</i><0.05), although urine flow was comparable. …

    Biological and Pharmaceutical Bulletin 35(10), 1703-1710, 2012

    J-STAGE  Ichushi Web 

  • Effect of Lipopolysaccharide on the Xenobiotic-Induced Expression and Activity of Hepatic Cytochrome P450 in Mice

    Moriya Nozomu , Kataoka Hiromi , Fujino Hideki , Nishikawa Jun-ichi , Kugawa Fumihiko

    … Here, to study the xenobiotic-induced fluctuations in CYP during inflammation, we examined the effect of lipopolysaccharide (LPS) treatment on the level of mRNAs encoding hepatic CYPs induced by xenobiotic-activated nuclear receptors, in mice. … LPS treatment caused a significant decrease in the induced expression of the mRNAs for <i>Cyp3a11</i>, <i>2c29</i>, <i>2c55</i>, and <i>1a2</i>, but not for <i>Cyp2b10</i>. …

    Biological and Pharmaceutical Bulletin 35(4), 473-480, 2012

    J-STAGE  Ichushi Web 

  • The Role of Nod1/Nod2 in Host Defense against Microbial Infection  [in Japanese]

    KIM Yun-Gi

    … を活性化し,炎症性サイトカインや抗菌ペプチドなどの産生を誘導し,生体防御に携わる.TLRと,NLRファミリーであるNod1とNod2は,炎症性サイトカイン産生において相乗的に働くことが知られている.一方で,LPSなどのTLRリガンド刺激による単球やマクロファージからの炎症性サイトカインの過剰産生は,組織傷害や敗血症ショックなどの危険性を併せ持つ.生体はこの防衛策として,リガンド曝露後に一時的不応答( …

    Journal of Intestinal Microbiology 25(1), 7-10, 2011-01-01

    J-STAGE  Ichushi Web  References (12)

  • Alteration of Methotrexate Biliary and Renal Elimination during Extrahepatic and Intrahepatic Cholestasis in Rats

    Brcakova Eva , Fuksa Leos , Cermanova Jolana , Kolouchova Gabriela , Hroch Milos , Hirsova Petra , Martinkova Jirina , Staud Frantisek , Micuda Stanislav

    … The steady state pharmacokinetic parameters of MTX were evaluated in rats one (BDO1) or seven (BDO7) days after bile duct obstruction (BDO) or 18 h after administration of lipopolysaccharide (LPS). … In comparison to the respective control groups, biliary and total clearances of MTX were decreased to 12% and 49% in the BDO1 group, to 5% and 56% in the BDO7 animals, and to 42% and 43% in the LPS group, respectively. …

    Biological and Pharmaceutical Bulletin 32(12), 1978-1985, 2009

    J-STAGE  Ichushi Web  Cited by (2)

  • Investigation of Range of Motion of Nexgen LPS Flex Knee Prosthesis: Comparison of Mobile-Bearing and Fixed-Bearing Prostheses  [in Japanese]

    Kido Hidehiko , Shirasawa Kenzo , Irie Manabu , Yamashita Akihisa , Ogata Junya , Mitsuyasu Hiroaki

    … 当科におけるLPS Flex TKAのmobile bearing 55膝とfixed bearing 30膝の術後可動域及び短期成績について比較検討した.術後可動域はmobile群がfixed群に比べ比較的早期に改善したが,最終観察時の屈曲達成率はmobile 105.0%,fixed 105.7%と両群間に有意差なく,共に短期成績は良好であった.深屈曲はmobile bearingの効果のみで達成できるものではなく,手術手技の工夫等様々な要因が関与しており,当科においては特に深屈曲を得るため …

    Orthopedics & Traumatology 56(2), 258-262, 2007

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  • H.E.L.P. in Gram-negative, Refractory Septic Shock: First Clinical Experiences.(Workshop1-12) :

    Samtleben Walter , Boos Karl-Siegfried , Fraunberger Peter , Briegel Josef , Haller Mathias , Arendt Rainer , Peter Klaus , Seidel Dieter

    … Recently, an in-vitro re-evaluation of this method revealed that not only low-density lipoprotein (LDL), lipoprotein (a) and fibrinogen, but also lipopolysaccharides (LPS; … As LPS and TNF-a are involved in the pathogenesis and progression of sepsis we performed in a pilot study nine treatments in four cases with LPS-induced refractory septic shock. … standard/modified procedure): LPS, 49.7/57.2; …

    日本アフェレシス学会雑誌 16(1), 91-96, 1997

    NDL Digital Collections  Ichushi Web 

  • Time-Dependent Changes in the Pharmacokinetics and Renal Excretion of Xanthine Derivative Enprofylline Induced by Bacterial Endotoxin in Rats

    NADAI Masayuki , HASEGAWA Takaaki , WANG Li , HAGHGOO Soheila , NABESHIMA Toshitaka , KATO Nobuo

    … Time-dependent changes in the pharmacokinetics and renal handling of enprofylline induced by bacterial endotoxin (Klebsiella pneumoniae LPS) were investigated in rats. … To evaluate the early effect of LPS on kidney functions and the renal excretion of enprofylline, which is an organic anion drug excreted primarily by an active tubular secretion, LPS (250μg/kg) was infused for 5 min under constant infusion at rates of 2.3 and 23 μg/min/kg for inulin and enprofylline, respectively. …

    Biological and Pharmaceutical Bulletin 18(8), 1089-1093, 1995-08-15

    J-STAGE  Ichushi Web  References (34) Cited by (1)

  • Influence of polymerizable phospholipid vesicles encapsulated hemoglobin on the murine immune system.  [in Japanese]

    MORIZAWA K. , AWAI K. , AKAMA K. , TOKUYAMA S. , SATOH T.

    ヘモグロビンを乗合性脂質膜からなるリポソームに内包した人工酸素運搬体(ARC)の免疫系に対する影響を検討した。SD系ラットにARCを静脈内投与し、網内系機能に対する影響をカーボンクリアランス法、コンゴーレッドクリアランス法及びエンドトキシン致死試験によって評価した。更に脾臓リンパ球画分の幼若化反応及びNK活性に対する影響も併せて検討した。<br>投与1日後に高用量群でカーボンクリアラン …

    Jinko Zoki 24(1), 195-200, 1995-02-15

    J-STAGE  Ichushi Web  References (15)

  • Influence of Endotoxin and Lipid A on the Renal Handling and Accumulation of Gentamicin in Rats.

    HASEGAWA Takaaki , NADAI Masayuki , WANG Li , HAGHGOO Soheila , NABESHIMA Toshitaka , KATO Nobuo

    … The contribution of lipid A, an active component of endotoxin (LPS), to changes in the pharmacokinetics, renal handling and intrarenal accumulation of gentamicin induced by Klebsiella pneumoniae LPS was investigated in rats. … Either LPS (250μg/kg) or lipid A (equivalent to dose of LPS) was infused 2h before the administration of gentamicin (10mg/kg). …

    Biological and Pharmaceutical Bulletin 17(12), 1651-1655, 1994

    J-STAGE  Ichushi Web  Cited by (1)

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