Search Results 1-20 of 444

  • Non-High-Density Lipoprotein Cholesterol and Risk of Stroke Subtypes and Coronary Heart Disease: The Japan Public Health Center-Based Prospective (JPHC) Study

    Saito Isao , Yamagishi Kazumasa , Kokubo Yoshihiro , Yatsuya Hiroshi , Iso Hiroyasu , Sawada Norie , Inoue Manami , Tsugane Shoichiro

    … however, associations between non-HDL-C and stroke subtypes have not been determined.<b> … Sex-specific hazard ratios (HRs) and 95% confidence intervals (CIs) for the incidence of stroke subtypes and CHD were estimated according to quintiles of non-HDL-C, using Cox proportional hazard models adjusted for other established risk factors.<b> … We identified 1,705 stroke and 296 CHD events over a median 15 yrs of follow-up. …

    Journal of Atherosclerosis and Thrombosis 27(4), 363-374, 2020

    J-STAGE 

  • The Association Between Coronary Artery Calcification and Subclinical Cerebrovascular Diseases in Men: An Observational Study

    Khan Md Maruf Haque , Ohkubo Takayoshi , Nozaki Kazuhiko , Miura Katsuyuki , Ueshima Hirotsugu , for the SESSA Research Group , Fujiyoshi Akira , Shiino Akihiko , Hisamatsu Takashi , Torii Sayuki , Suzuki Sentaro , Kunimura Ayako , Segawa Hiroyoshi , Kadota Aya

    … <p><b>Aim: </b>Coronary artery calcification (CAC) is an independent predictor of stroke and dementia, in which subclinical cerebrovascular diseases (SCVDs) play a vital pathogenetic role. … </b></p><p><b>Methods: </b>In this observational study, 709 men, free of stroke, were sampled from a city in Japan from 2010 to 2014. …

    Journal of Atherosclerosis and Thrombosis, 2020

    J-STAGE 

  • Moderate Levels of N-Terminal Pro-B-Type Natriuretic Peptide is Associated with Increased Risks of Total and Ischemic Strokes among Japanese: The Circulatory Risk in Communities Study

    Ebihara Kenji , Ohira Tetsuya , Sankai Tomoko , Okada Takeo , Kitamura Akihiko , Kiyama Masahiko , Iso Hiroyasu , for the CIRCS Investigators , Yamagishi Kazumasa , Umesawa Mitsumasa , Muraki Isao , Cui Renzhe , Imano Hironori , Kubota Yasuhiko , Hayama-Terada Mina , Shimizu Yuji

    … <p><b>Aim: </b>N-terminal pro-B-type natriuretic peptide (NT-proBNP), frequently used as a biochemical marker for detecting and monitoring heart failure, is also a risk marker for development of coronary heart disease and total stroke. … However, studies that explore subtypes of ischemic stroke with regard to NT-proBNP are scarce. …

    Journal of Atherosclerosis and Thrombosis, 2020

    J-STAGE 

  • Cilostazol use is associated with FIM cognitive improvement during convalescent rehabilitation in patients with ischemic stroke: a retrospective study

    Senda Joe , Ito Keiichi , Kotake Tomomitsu , Kanamori Masahiko , Kishimoto Hideo , Kadono Izumi , Nakagawa-Senda Hiroko , Wakai Kenji , Katsuno Masahisa , Nishida Yoshihiro , Ishiguro Naoki

    … Cilostazol is a phosphodiesterase III-inhibiting antiplatelet agent that is often used to prevent stroke and peripheral artery disease, and its administration has shown significant improvements for cognitive impairment. … We investigate the potential of cilostazol for reducing or restoring cognitive decline during con-valescent rehabilitation in patients with non-cardioembolic ischemic stroke. …

    Nagoya Journal of Medical Science 81(3), 359-373, 2019-08

    IR  DOI 

  • Indication, Risk and Benefit of Anti-Thrombotic Therapy for Patients with Ischemic Cerebrovascular Diseases : Basic Knowledge for Neurosurgeons  [in Japanese]

    Okada Yasushi , Yasaka Masahiro

    … <p>  Anti-thrombotic therapies including aspirin, or dual anti-platelet therapy (DAPT) comprising aspirin and clopidogrel, or intravenous infusion of ozagrel sodium or argatroban are currently available for patients with acute non-cardioembolic stroke. … Based on the clinical condition of the patient with acute ischemic stroke, DAPT is highly recommended, but should be switched to single-agent anti-platelet therapy within a week, or chronically, up to one year from onset. …

    Japanese Journal of Neurosurgery 28(12), 758-767, 2019

    J-STAGE  Ichushi Web 

  • High Prevalence of Cerebral Small Vessel Disease on 7T Magnetic Resonance Imaging in Familial Hypercholesterolemia

    Todate Yusuke , Ishigaki Yasushi , Uwano Ikuko , Yashiro Satoshi , Chida Ai , Hasegawa Yutaka , Oda Tomoyasu , Nagasawa Kan , Honma Hiroyuki , Sasaki Makoto

    … The prevalence of SVD in patients with forms of cerebral damage, such as lacunar infarction, PVH, deep white matter hyperintensities (DWMH), microbleeding, and brain atrophy, was significantly higher among FH patients (control, <i>n</i>=2, 5.7% vs. FH, <i>n</i>=7, 25.0%, <i>p</i><0.001, chi-square test). …

    Journal of Atherosclerosis and Thrombosis 26(12), 1045-1053, 2019

    J-STAGE 

  • Clinical practice of cryptogenic stroke  [in Japanese]

    Iguchi Yasuyuki

    … Embolic strokes of undetermined source are operationally defined as non–lacunar brain infarcts without substantial proximal arterial stenosis or major cardioembolic sources, and they represent 80 to 90% of all cryptogenic strokes. … Patent foramen ovale (PFO) is found in up to half of young adults with cryptogenic stroke, and then percutaneous devices for closure of a PFO should be used for them after careful inspection. …

    Neurological Therapeutics 36(3), 298-302, 2019

    J-STAGE 

  • Different Influences of Statin Treatment in Preventing At-Risk Stroke Subtypes: A Post Hoc Analysis of J-STARS

    Hosomi Naohisa , Minematsu Kazuo , Uchiyama Shinichiro , Matsumoto Masayasu , for J-STARS collaborators , Kitagawa Kazuo , Nagai Yoji , Nakagawa Yoko , Aoki Shiro , Nezu Tomohisa , Kagimura Tatsuo , Maruyama Hirofumi , Origasa Hideki

    … <p><b>Aims: </b>To understand the different influences of statins on the incidence rate of each stroke subtype in association with low-density lipoprotein (LDL) cholesterol levels, we performed a post hoc analysis on the data from the Japan Statin Treatment Against Recurrent Stroke (J-STARS) study.<b> …

    Journal of Atherosclerosis and Thrombosis, 2019

    J-STAGE 

  • Body Mass Index and Risks of Incident Ischemic Stroke Subtypes: The Japan Public Health Center-Based Prospective (JPHC) Study

    Li Yuanying , Yatsuya Hiroshi , Iso Hiroyasu , Yamagishi Kazumasa , Saito Isao , Kokubo Yoshihiro , Sawada Norie , Tsugane Shoichiro

    … The association of body mass index (BMI) with risks of ischemic stroke subtypes have not been established.</p><p><b>Methods:</b> … A total of 42,343 men and 46,413 women aged 40–69 years were followed-up for the incidence of lacunar, large-artery occlusive, and cardioembolic strokes. … During a median of 20.0 years of follow-up, we documented 809 and 481 lacunar, 395 and 218 large-artery occlusive, and 568 and 298 cardioembolic strokes in men and women, respectively. …

    Journal of Epidemiology 29(9), 325-333, 2019

    J-STAGE 

  • Primary prevention of stroke  [in Japanese]

    Mori Kota , Okada Yasushi

    … <p>Hypertension is the major risk factor for stroke. … The meta–analysis including the majority studies for primary stroke prevention has shown that reducing LDL cholesterol with statins reduces the risk of stroke, therefore statin therapy is recommended for patients with dyslipidemia, especially having diabetes mellitus. … Early detection and treatment of atrial fibrillation are valuable prevention for stroke risk reduction in the elderly. …

    Neurological Therapeutics 36(2), 62-66, 2019

    J-STAGE  Ichushi Web 

  • FMC, D-dimer and BNP in patients with acute ischemic stroke  [in Japanese]

    KUNII Atsuko , ABE Mayumi , UENO Makiko , ADACHI Miyuki , IZURU Kazuhiko , IGARASHI Masahiko , KONDO Rei , SAITO Shinjiro

    … The study patients had the following infarction types: atherothrombotic embolism (AT, n = 81), cardiogenic embolism (CE, n = 41), lacunar infarction (LI, n = 46), and others (n = 22). …

    Japanese Journal of Medical Technology 68(2), 269-275, 2019

    J-STAGE  Ichushi Web 

  • Physiological parameters of cerebral small-vessel disease  [in Japanese]

    DOIJIRI Ryosuke , YAMAMURA Osamu , NAGATSUKA Kazuyuki , SAITO Kozue , UCHIYAMA Shinichiro , KITAGAWA Kazuo , TAKEKAWA Hidehiro , TADOKORO Yasuhiro , TSUTSUMI Yukiko , FUJISHIRO Kentaro , MATSUMOTO Masayasu

    Lacunar infarction and intracerebral hemorrhage (ICH) have common characteristics of cerebral small-vessel disease (CSVD) although they are classified as different stroke subtypes. … Therefore, we assessed whether there is a relationship between stroke subtypes and these potential CSVD-related parameters.<br><b>Methods:</b> …

    Neurosonology 32(1), 10-14, 2019

    IR  J-STAGE  Ichushi Web 

  • The trends in cerebral infarction in Yamagata Prefecture, Japan : A study based on 10 years of stroke registry data

    Yamada Yuki , Kokubo Yasuaki , Kondo Rei , Sato Shinya , Kato Takeo , Kubota Isao , Watanabe Masafumi , Kayama Takamasa , Sonoda Yukihiko

    … We studied ten years of stroke data registered with the Yamagata Society on Treatment for Cerebral Stroke(YSTCS). … 24.4%), and lacunar infarction(LI)(n=4,703; … A multiple logistic regression analysis revealed a significant association between old age, female sex, severe symptoms at onset, CE, a previous history of stroke, and a poor prognosis. …

    山形大学紀要. 医学 : 山形医学 = Bulletin of the Yamagata University. Medical science : Yamagata medical journal 36(2), 128-138, 2018-08-15

    IR  DOI  Ichushi Web 

  • Retrospective Analysis of Argatroban in 353 Patients with Acute Noncardioembolic Stroke

    OGURO Hiroaki , MITAKI Shingo , Takayoshi Hiroyuki , ABE Satoshi , Onoda Keiichi , Yamaguchi Shuhei

    … They were examined as to their stroke types, neurological severity according to the NIH Stroke Scale (NIHSS) and clinical outcomes on discharge by the modified Rankin Scale (mRS). … Acute noncardioembolic stroke patients including lacunar infarction and atherothrombotic infarction showed functional recovery by argatroban, but the effectiveness of argatroban was not superior to ozagrel therapy defined by control group. …

    Journal of Stroke and Cerebrovascular Diseases 27(8), 2175-2181, 2018-08

    IR 

  • Approach to Thrombotic Stroke  [in Japanese]

    永金 義成

    京都府立医科大学雑誌 127(6), 375-382, 2018-06

    Ichushi Web 

  • Usefulness of electrocardiography for early discrimination of cardioembolic stroke in patients  [in Japanese]

    HARADA Misato , HASHIMOTO Takeshi , UMEBASHI Katsuyuki , TOMIZONO Masatomo , TAKANAGA Megumi , MOTOYAMA Shinya

    … <p>Introduction—There are three types of cerebral infarction, namely, atherothrombotic brain infarction, lacunar infarction, and cardioembolic stroke (CES). … The types of stroke were divided into two, CES and non-CES (i.e., atherothrombotic brain infarction and lacunar infarction). … Conclusion—We suggest that the combination of electrocardiography and plasma BNP level is useful for the discrimination of cardioembolic stroke.</p> …

    Japanese Journal of Medical Technology 67(5), 668-674, 2018

    J-STAGE  Ichushi Web 

  • Evaluation of Lenticulostriate Arteries Changes by 7 T Magnetic Resonance Angiography in Type 2 Diabetes

    Yashiro Satoshi , Ishigaki Yasushi , Kameda Hiroyuki , Chida Ai , Todate Yusuke , Hasegawa Yutaka , Nagasawa Kan , Uwano Ikuko , Sasaki Makoto , Ogasawara Kuniaki

    … <p><b>Aim: </b>Progress in neuroimaging techniques allows us to investigate the microvasculature characteristics including lenticulostriate arteries (LSA), which are closely associated with lacunar infarction. …

    Journal of Atherosclerosis and Thrombosis 25(10), 1067-1075, 2018

    J-STAGE 

  • Two-Year Survival After First-Ever Stroke in a General Population of 1.4 Million Japanese ― Shiga Stroke Registry ―

    Takashima Naoyuki , Nozaki Kazuhiko , Arima Hisatomi , Kita Yoshikuni , Fujii Takako , Miyamatsu Naomi , Komori Masaru , Sugimoto Yoshihisa , Nagata Satoru , Miura Katsuyuki

    … <p><b><i>Background: </i></b>Stroke is one of the leading causes of disability and mortality in Japan. … The aim of the present analysis was to determine the non-acute survival rate after first-ever stroke using data from a large-scale population-based stroke registry in Japan. …

    Circulation Journal 82(10), 2549-2556, 2018

    J-STAGE  Ichushi Web 

  • Clinical and Imaging Characteristics of Cerebral Infarction in Patients with Nonvalvular Atrial Fibrillation Combined with Cerebral Artery Stenosis

    Sun Wei , Xiao Daoxiong , Huang Zhiping , Guo Xiaofen , Li Guangsheng , Zeng Xiangjun , Lai Zhaohui , Wang Mingqi , Ouyang Yi , Zeng Guoyong , Peng Jidong , Zhong Junyuan

    … Mean age [(75.73±8.46) years vs. (63.44±9.95) years], National Institute of Health stroke scale (NIHSS) score [(8.66±6.73) vs. (4.59±3.51)], CHA<sub>2</sub>DS<sub>2</sub>-VASc score [(2.93±1.40) vs. (0.96±0.98)], history of hypertension (74.4% vs. 30.0%), and history of stroke/ transient ischemic attack (TIA) (55.8% vs. 13.3%) were higher in the stenosis group (<i>n</i>=107) than in the non-stenosis group (<i>n</i>=65) (<i>P</i><0.01). …

    Journal of Atherosclerosis and Thrombosis 25(8), 720-732, 2018

    J-STAGE  Ichushi Web 

  • The Clinical Features of Cerebral Microbleeds in Patients with Cerebral Infarction  [in Japanese]

    WATANABE Mayu , KUROI Yasuhiro , KASUYA Hidetoshi

    … We sought to elucidate the clinical features of CMB by investigating its incidence and distribution in CI patients, and examined relationships among the risk factors for stroke.</p><p><b>Materials and Methods: </b>We retrospectively reviewed 162 CI patients who were treated and underwent head MRI including T2*-weighted images at our hospital in 2016. …

    Journal of Tokyo Women's Medical University 88(3), 90-97, 2018

    IR  J-STAGE  Ichushi Web 

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